Background:Approximately 10%–30%of patients with Hodgkin’s lymphoma(HL)experience relapse or refractory(R/R)disease after first-line standard therapy.Brentuximab vedotin(BV)and immune checkpoint inhibitors(ICIs)have...Background:Approximately 10%–30%of patients with Hodgkin’s lymphoma(HL)experience relapse or refractory(R/R)disease after first-line standard therapy.Brentuximab vedotin(BV)and immune checkpoint inhibitors(ICIs)have important roles in the salvage treatment of R/R HL.However,subsequent treatment for HL refractory to BV and/or ICI treatment is challenging.Methods:We retrospectively analyzed patients in two institutions who had R/R HL,experienced BV or ICI treatment failure,and received radiotherapy(RT)thereafter.The overall response rate(ORR),duration of response(DOR),progression-free survival(PFS),and overall survival(OS)were analyzed.Results:Overall,19 patients were enrolled.First-line systemic therapy comprised doxorubicin,bleomycin,vinblastine,and dacarbazine(ABVD,84.2%);AVD plus ICIs(10.5%);and bleomycin,etoposide,doxorubicin,cyclophosphamide,vincristine,procarbazine,and prednisone(BEACOPP,5.3%).After first-line therapy,15(78.9%)and four patients(21.1%)had refractory disease and relapsed,respectively.After R/R HL diagnosis,six(31.6%),two(10.5%),and 11(57.9%)patients received BV and ICIs concurrently,BV monotherapy,and ICI monotherapy,respectively.All patients received intensity-modulated RT(n=12,63.2%)or volumetric modulated arc therapy(VMAT;n=7,36.8%).The ORR as well as the complete response(CR)rate was 100%;the median DOR to RT was 17.2 months(range,7.9–46.7 months).Two patients showed progression outside the radiation field;one patient had extensive in-field,out-of-field,nodal,and extranodal relapse.With a median follow-up time of 16.2 months(range,9.2–23.2 months),the 1-year PFS and OS were 84.4%and 100%,respectively.PFS was associated with extranodal involvement(P=0.019)and gross tumor volume(P=0.044).All patients tolerated RT well without adverse events of grade≥3.Conclusion:RT is effective and safe for treating HL refractory to BV or ICIs and has the potential to be part of a comprehensive strategy for HL.展开更多
目的探究血清miR-135b和miR-145在未破裂颅内动脉瘤(unruptured intracranial aneurysm,UIA)患者中的表达水平及临床价值。方法选取2018年5月~2020年3月邯郸市第一医院神外三科收治的102例UIA患者作为研究组,另选同期健康体检者95例作...目的探究血清miR-135b和miR-145在未破裂颅内动脉瘤(unruptured intracranial aneurysm,UIA)患者中的表达水平及临床价值。方法选取2018年5月~2020年3月邯郸市第一医院神外三科收治的102例UIA患者作为研究组,另选同期健康体检者95例作为对照组,同时收集受试者一般资料进行比较。实时荧光聚合酶链反应(qRT-PCR)法检测血清中miR-135b和miR-145表达水平;ROC曲线分析血清miR-135b和miR-145对UIA的诊断价值;Logistic回归分析UIA形成的影响因素。结果研究组中高血压(62.75%)、高血脂(60.00%)、吸烟史(64.76%)、饮酒史(70.59%)患者所占比例高于对照组(46.72%,44.21%,47.37%,53.68%),差异均有统计学意义(χ^(2)=5.361,4.986,6.139,5.993,均P<0.05);研究组患者血清miR-135b(0.79±0.20)表达水平低于对照组(1.03±0.27),血清miR-145水平(1.28±0.24)高于对照组(0.99±0.22),差异均有统计学意义(t=7.122,8.821,均P<0.05);与动脉瘤个数为1及动脉瘤直径<7mm的患者相比,动脉瘤个数≥2及动脉瘤直径≥7mm的患者血清中miR-135b表达水平(0.68±0.18 vs 0.84±0.21,0.71±0.17mm vs 0.85±0.22mm)降低,miR-145水平(1.37±0.31mm vs 1.24±0.21mm,1.37±0.30mm vs 1.21±0.19mm)升高,差异均有统计学意义(t=2.472~3.689,均P<0.05);血清miR-135b,miR-145以及二者联合诊断UIA的曲线下面积(AUC)分别为0.788,0.836和0.907,二者联合的诊断效能优于其各自单独检测(Z=4.236,3.226,均P<0.05);Logistic回归分析结果显示,高血压(OR=1.326,95%CI=1.044~1.684)、吸烟史(OR=1.457,95%CI=1.077~1.970)、饮酒史(OR=1.879,95%CI=1.113~3.171)、血清miR-135b水平<0.94(OR=0.758,95%CI=0.612~0.939)、血清miR-145水平≥1.22(OR=1.433,95%CI=1.113~1.845)均是UIA的影响因素(均P<0.05)。结论UIA患者血清miR-135b水平下调,miR-145水平上调,二者与UIA的形成和发展存在相关性,且二者联合检测对UIA形成的诊断效能较高。展开更多
In clinic, most patients with middle-late cancer suffer from cancer pain, which seriously affects the confidence and compliance of treatment. However, the side effects of the three-step analgesic therapy, which is wid...In clinic, most patients with middle-late cancer suffer from cancer pain, which seriously affects the confidence and compliance of treatment. However, the side effects of the three-step analgesic therapy, which is widely used at present, are gradually manifested, aggravating patients' resistance to treatment. The role of Moxibustion in relieving pain has been gradually recognized and used in various professional fields. Because of its advantages of non-toxic side effects, simple operation, economic benefits, pain relief and immunity enhancement, moxibustion has been paid more and more attention.展开更多
The last decades have witnessed a rapid development of noninvasive plant phenotyping,capable of detecting plant stress scale levels from the subcellular to the whole population scale.However,even with such a broad ran...The last decades have witnessed a rapid development of noninvasive plant phenotyping,capable of detecting plant stress scale levels from the subcellular to the whole population scale.However,even with such a broad range,most phenotyping objects are often just concerned with leaves.This review offers a unique perspective of noninvasive plant stress phenotyping from a multi-organ view.First,plant sensing and responding to abiotic stress from the diverse vegetative organs(leaves,stems,and roots)and the interplays between these vital components are analyzed.Then,the corresponding noninvasive optical phenotyping techniques are also provided,which can prompt the practical implementation of appropriate noninvasive phenotyping techniques for each organ.Furthermore,we explore methods for analyzing compound stress situations,as field conditions frequently encompass multiple abiotic stressors.Thus,our work goes beyond the conventional approach of focusing solely on individual plant organs.The novel insights of the multi-organ,noninvasive phenotyping study provide a reference for testing hypotheses concerning the intricate dynamics of plant stress responses,as well as the potential interactive effects among various stressors.展开更多
基金supported by grants from the Major Scientific Research Program for Young and Middle-aged Health Professionals of Fujian Province,China(grant number:2022ZQNZD002)the Fujian Key Laboratory of Intelligent Imaging and Precision Radiotherapy for Tumors(Fujian Medical University)and Clinical Research Center for Radiology and Radiotherapy of Fujian Province(Digestive,Hematological and Breast Malignancies).
文摘Background:Approximately 10%–30%of patients with Hodgkin’s lymphoma(HL)experience relapse or refractory(R/R)disease after first-line standard therapy.Brentuximab vedotin(BV)and immune checkpoint inhibitors(ICIs)have important roles in the salvage treatment of R/R HL.However,subsequent treatment for HL refractory to BV and/or ICI treatment is challenging.Methods:We retrospectively analyzed patients in two institutions who had R/R HL,experienced BV or ICI treatment failure,and received radiotherapy(RT)thereafter.The overall response rate(ORR),duration of response(DOR),progression-free survival(PFS),and overall survival(OS)were analyzed.Results:Overall,19 patients were enrolled.First-line systemic therapy comprised doxorubicin,bleomycin,vinblastine,and dacarbazine(ABVD,84.2%);AVD plus ICIs(10.5%);and bleomycin,etoposide,doxorubicin,cyclophosphamide,vincristine,procarbazine,and prednisone(BEACOPP,5.3%).After first-line therapy,15(78.9%)and four patients(21.1%)had refractory disease and relapsed,respectively.After R/R HL diagnosis,six(31.6%),two(10.5%),and 11(57.9%)patients received BV and ICIs concurrently,BV monotherapy,and ICI monotherapy,respectively.All patients received intensity-modulated RT(n=12,63.2%)or volumetric modulated arc therapy(VMAT;n=7,36.8%).The ORR as well as the complete response(CR)rate was 100%;the median DOR to RT was 17.2 months(range,7.9–46.7 months).Two patients showed progression outside the radiation field;one patient had extensive in-field,out-of-field,nodal,and extranodal relapse.With a median follow-up time of 16.2 months(range,9.2–23.2 months),the 1-year PFS and OS were 84.4%and 100%,respectively.PFS was associated with extranodal involvement(P=0.019)and gross tumor volume(P=0.044).All patients tolerated RT well without adverse events of grade≥3.Conclusion:RT is effective and safe for treating HL refractory to BV or ICIs and has the potential to be part of a comprehensive strategy for HL.
文摘目的探究血清miR-135b和miR-145在未破裂颅内动脉瘤(unruptured intracranial aneurysm,UIA)患者中的表达水平及临床价值。方法选取2018年5月~2020年3月邯郸市第一医院神外三科收治的102例UIA患者作为研究组,另选同期健康体检者95例作为对照组,同时收集受试者一般资料进行比较。实时荧光聚合酶链反应(qRT-PCR)法检测血清中miR-135b和miR-145表达水平;ROC曲线分析血清miR-135b和miR-145对UIA的诊断价值;Logistic回归分析UIA形成的影响因素。结果研究组中高血压(62.75%)、高血脂(60.00%)、吸烟史(64.76%)、饮酒史(70.59%)患者所占比例高于对照组(46.72%,44.21%,47.37%,53.68%),差异均有统计学意义(χ^(2)=5.361,4.986,6.139,5.993,均P<0.05);研究组患者血清miR-135b(0.79±0.20)表达水平低于对照组(1.03±0.27),血清miR-145水平(1.28±0.24)高于对照组(0.99±0.22),差异均有统计学意义(t=7.122,8.821,均P<0.05);与动脉瘤个数为1及动脉瘤直径<7mm的患者相比,动脉瘤个数≥2及动脉瘤直径≥7mm的患者血清中miR-135b表达水平(0.68±0.18 vs 0.84±0.21,0.71±0.17mm vs 0.85±0.22mm)降低,miR-145水平(1.37±0.31mm vs 1.24±0.21mm,1.37±0.30mm vs 1.21±0.19mm)升高,差异均有统计学意义(t=2.472~3.689,均P<0.05);血清miR-135b,miR-145以及二者联合诊断UIA的曲线下面积(AUC)分别为0.788,0.836和0.907,二者联合的诊断效能优于其各自单独检测(Z=4.236,3.226,均P<0.05);Logistic回归分析结果显示,高血压(OR=1.326,95%CI=1.044~1.684)、吸烟史(OR=1.457,95%CI=1.077~1.970)、饮酒史(OR=1.879,95%CI=1.113~3.171)、血清miR-135b水平<0.94(OR=0.758,95%CI=0.612~0.939)、血清miR-145水平≥1.22(OR=1.433,95%CI=1.113~1.845)均是UIA的影响因素(均P<0.05)。结论UIA患者血清miR-135b水平下调,miR-145水平上调,二者与UIA的形成和发展存在相关性,且二者联合检测对UIA形成的诊断效能较高。
基金National Natural Science Foundation of China(81673862,81660833,81760814).
文摘In clinic, most patients with middle-late cancer suffer from cancer pain, which seriously affects the confidence and compliance of treatment. However, the side effects of the three-step analgesic therapy, which is widely used at present, are gradually manifested, aggravating patients' resistance to treatment. The role of Moxibustion in relieving pain has been gradually recognized and used in various professional fields. Because of its advantages of non-toxic side effects, simple operation, economic benefits, pain relief and immunity enhancement, moxibustion has been paid more and more attention.
基金supported by the Natural Science Foundation of Fujian Province,China(2022J01611)Subsidy for the Construction of Fujian Key Laboratory of Agricultural Information Sensing Technology(KJG22052A)+2 种基金Agricultural Artificial Intelligence(133/71202020)Subtropical Fruit Intelligent Production Service Team(11899170167)the Program of Interdisciplinary Integration Promoting the Development of Intelligent Agriculture(Horticulture)(No.000-71202103B).
文摘The last decades have witnessed a rapid development of noninvasive plant phenotyping,capable of detecting plant stress scale levels from the subcellular to the whole population scale.However,even with such a broad range,most phenotyping objects are often just concerned with leaves.This review offers a unique perspective of noninvasive plant stress phenotyping from a multi-organ view.First,plant sensing and responding to abiotic stress from the diverse vegetative organs(leaves,stems,and roots)and the interplays between these vital components are analyzed.Then,the corresponding noninvasive optical phenotyping techniques are also provided,which can prompt the practical implementation of appropriate noninvasive phenotyping techniques for each organ.Furthermore,we explore methods for analyzing compound stress situations,as field conditions frequently encompass multiple abiotic stressors.Thus,our work goes beyond the conventional approach of focusing solely on individual plant organs.The novel insights of the multi-organ,noninvasive phenotyping study provide a reference for testing hypotheses concerning the intricate dynamics of plant stress responses,as well as the potential interactive effects among various stressors.
