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沥青混合料目标配合比级配优选的灰度模型评价法
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作者 程郅策 纪伦 +2 位作者 郭宏斌 郝晟 谭忆秋 《哈尔滨工业大学学报》 EI CAS CSCD 北大核心 2024年第7期11-18,36,共9页
沥青混合料目标配合比级配组成设计时有多种选择,存在如何获得最优级配的问题,这关乎配合比设计的质量,直接影响铺面质量和路面的服役寿命,为此需要一种科学方法进行级配优选。基于优选理论,分析混合料性能指标特征,构建非定量指标、常... 沥青混合料目标配合比级配组成设计时有多种选择,存在如何获得最优级配的问题,这关乎配合比设计的质量,直接影响铺面质量和路面的服役寿命,为此需要一种科学方法进行级配优选。基于优选理论,分析混合料性能指标特征,构建非定量指标、常规定量指标及路用性能指标3层次优选指标体系;设计3组典型级配,开展典型性能试验和分析,得到各评价指标值;采用德尔斐专家调查法进行隶属度、盲度分析和总体认识度指标赋权;采用灰度模型理论,对评价指标进行归一化处理,对各指标进行关联度分析,逐级对灰度模型体系进行综合评价和排序,根据排序结果最终选出最优的目标配合比级配。研究中,提出了灰度模型分析法的指标体系和流程,并讨论了方法中分辨系数的取值对优选结果的影响。结果表明:该方法可系统全面分析级配组成对应的性能指标体系,可筛选出符合路用性能指标的最优特征,可为沥青混合料目标配合比设计的级配优选提供一种有效技术方法。 展开更多
关键词 沥青混合料 目标配合比 级配优选 灰度模型 关联度
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Harnessing eco-friendly additives to manipulate zinc-ion solvation structures towards stable zinc metal batteries
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作者 Lingmei Wang hao shen +7 位作者 Wuzhu Sun Tianle Zheng Hongwei Li Jicheng Yan Lemeng Ding Zhongti Sun Jingyu Sun Chao Li 《Journal of Energy Chemistry》 SCIE EI CAS CSCD 2024年第11期114-122,共9页
Considerable research efforts have been dedicated to investigating the side reactions and the growth of Zn dendritic in aqueous zinc-ion batteries(AZIBs).The incorporation of organic solvents as additives in electroly... Considerable research efforts have been dedicated to investigating the side reactions and the growth of Zn dendritic in aqueous zinc-ion batteries(AZIBs).The incorporation of organic solvents as additives in electrolytes has yielded highly promising results.Nevertheless,their pervasive use has been hindered by concerns regarding their toxicity,flammability,and economic viability.Herein,we propose the utilization of γ-valerolactone(γ-V),a novel eco-friendly solvent,as an alternative for conventional organic additives to improve the performance of Zn anode.Experimental investigations and theoretical analyses have verified that γ-V additives can diminish the Zn^(2+)-desolvation energy and enhance Zn^(2+) transport kinetics.The adsorbed γ-V molecules modulate the nucleation and diffusion of Zn^(2+),facilitating Zn growth along the(002) crystal plane,thus inhibiting dendrite formation and side reactions.Consequently,the modified electrolyte with 3% γ-V exhibit highly reversible cycling for 2800 h at1 mA cm^(-2) and 1 mA h cm^(-2) in Zn//Zn symmetric cell.The Zn//KVOH coin cells deliver a capacity retention of 74.7% after 1000 cycles at 5 A g^(-1).The Zn//KVOH pouch cells maintain a capacity retention of78.7% over 90 cycles at 3 A g^(-1).Notably,the γ-V additives also effectively alleviate the self-discharge phenomenon.This work provides valuable insights on the development of aqueous zinc-ion batteries with superior safety through the modulation of electrolytes using eco-friendly additives. 展开更多
关键词 Aqueous zinc-ion batteries Eco-friendly electrolyte additive γ-Valerolactone Zn anode Renewable energy storage
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Prospective Cohort Investigation on Physical Activity of Osteoporosis Outcomes(PAOPO)in Jidong:Objectives,Study Design,and Baseline Characteristics
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作者 Jingzhi Yang hao shen +13 位作者 Sicheng Wang Long Bai Zhen Geng Yingying Jing Ke Xu Yuhe Liu Wenqian Wu hao Zhang Yuanwei Zhang Zuhao Li Chuandong Wang Guangchao Wang Xiao Chen Jiacan Su 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2024年第9期1067-1079,共13页
Objective The aim of this study was to investigate the prospective association between physical activity(PA),independently or in conjunction with other contributing factors,and osteoporosis(OP)outcomes.Methods The Phy... Objective The aim of this study was to investigate the prospective association between physical activity(PA),independently or in conjunction with other contributing factors,and osteoporosis(OP)outcomes.Methods The Physical Activity in Osteoporosis Outcomes(PAOPO)study was a community-based cohort investigation.A structured questionnaire was used to gather the participants’sociodemographic characteristics.Bone mineral density(BMD)measurements were performed to assess OP outcomes,and the relationship between BMD and OP was evaluated within this cohort.Results From 2013 to 2014,8,471 participants aged 18 years and older were recruited from Tangshan,China’s Jidong community.Based on their PA level,participants were categorized as inactive,moderately active,or very active.Men showed higher physical exercise levels than women across the activity groups.BMD was significantly higher in the very active group than in the moderately active and inactive groups.Individuals aged>50 years are at a higher risk of developing OP and osteopenia.Conclusion The PAOPO study offers promising insights into the relationship between PA and OP outcomes,encouraging the implementation of PA in preventing and managing OP. 展开更多
关键词 OSTEOPOROSIS Physical activity Risk factors Cohort study
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The Completeness of Accreting Neutron Star Binary Candidates from the Chinese Space Station Telescope
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作者 hao shen Shun-Yi Lan Xiang-Cun Meng 《Research in Astronomy and Astrophysics》 SCIE CAS CSCD 2024年第9期28-36,共9页
A neutron star(NS)has many extreme physical conditions,and one may obtain some important information about an NS via accreting neutron star binary(ANSB)systems.The upcoming Chinese Space Station Telescope(CSST)provide... A neutron star(NS)has many extreme physical conditions,and one may obtain some important information about an NS via accreting neutron star binary(ANSB)systems.The upcoming Chinese Space Station Telescope(CSST)provides an opportunity to search for a large sample of ANSB candidates.Our goal is to check the completeness of the potential ANSB samples from CSST data.In this paper,we generate some ANSBs and normal binaries under the CSST photometric system by binary evolution and binary population synthesis method and use a machine learning method to train a classification model.Although the Precision(94.56%)of our machine learning model is as high as before study,the Recall is only about 63.29%.The Precision/Recall is mainly determined by the mass transfer rate between the NSs and their companions.In addition,we also find that the completeness of ANSB samples from CSST photometric data by the machine learning method also depends on the companion mass and the age of the system.ANSB candidates with a low initial mass companion star(0.1 M_(⊙)to 1 M_(⊙))have a relatively high Precision(94.94%)and high Recall(86.32%),whereas ANSB candidates with a higher initial mass companion star(1.1 M_(⊙)to 3 M_(⊙))have similar Precision(93.88%)and quite low Recall(42.67%).Our results indicate that although the machine learning method may obtain a relatively pure sample of ANSBs,a completeness correction is necessary for one to obtain a complete sample. 展开更多
关键词 stars:neutron X-rays:binaries methods:analytical
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Semi-hydro-equivalent design and performance extrapolation between 100 kJ-scale and NIF-scale indirect drive implosion
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作者 Huasen Zhang Dongguo Kang +5 位作者 Changshu Wu Liang hao hao shen Shiyang Zou Shaoping Zhu Yongkun Ding 《Matter and Radiation at Extremes》 SCIE EI CSCD 2024年第1期25-34,共10页
Extrapolation of implosion performance between different laser energy scales is investigated for indirect drive through a semi-hydroequivalent design.Since radiation transport is non-hydro-equivalent,the peak radiatio... Extrapolation of implosion performance between different laser energy scales is investigated for indirect drive through a semi-hydroequivalent design.Since radiation transport is non-hydro-equivalent,the peak radiation temperature of the hohlraum and the ablation velocity of the capsule ablator are not scale-invariant when the sizes of the hohlraum and the capsule are scale-varied.A semi-hydro-equivalent design method that keeps the implosion velocity V_(i),adiabat α_(F),and P_(L)/R_(hc)^(2) (where P_(L) is the laser power and R_(hc) is the hohlraum and capsule scale length)scale-invariant,is proposed to create hydrodynamically similar implosions.The semi-hydro-equivalent design and the scaled implosion performance are investigated for the 100 kJ Laser Facility(100 kJ-scale)and the National Ignition Facility(NIF-scale)with about 2 MJ laser energy.It is found that the one-dimensional implosion performance is approximately hydro-equivalent when V_(i) and α_(F) are kept the same.Owing to the non-hydro-equivalent radiation transport,the yield-over-clean without α-particle heating(YOC_(noα))is slightly lower at 100 kJ-scale than at NIF-scale for the same scaled radiation asymmetry or the same initial perturbation of the hydrodynamic instability.The overall scaled two-dimensional implosion performance is slightly lower at 100 kJ-scale.The general Lawson criterion factor scales asχ_(noα) ^(2D)∼S^(1.06±0.04)(where S is the scale-variation factor)for the semi-hydro-equivalent implosion design with a moderate YOC_(noα).Our study indicates that χ_(noα)≈0.379 is the minimum requirement for the 100 kJ-scale implosion to demonstrate the ability to achieve marginal ignition at NIF-scale. 展开更多
关键词 performance transport slightly
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Prognostic analysis of related factors of adverse reactions to immunotherapy in advanced gastric cancer and establishment of a nomogram model
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作者 Xu-Xu He Bang Du +1 位作者 Tao Wu hao shen 《World Journal of Gastrointestinal Oncology》 SCIE 2024年第4期1268-1280,共13页
BACKGROUND Immunotherapy for advanced gastric cancer has attracted widespread attention in recent years.However,the adverse reactions of immunotherapy and its relationship with patient prognosis still need further stu... BACKGROUND Immunotherapy for advanced gastric cancer has attracted widespread attention in recent years.However,the adverse reactions of immunotherapy and its relationship with patient prognosis still need further study.In order to determine the association between adverse reaction factors and prognosis,the aim of this study was to conduct a systematic prognostic analysis.By comprehensively evaluating the clinical data of patients with advanced gastric cancer treated by immunotherapy,a nomogram model will be established to predict the survival status of patients more accurately.AIM To explore the characteristics and predictors of immune-related adverse reactions(irAEs)in advanced gastric cancer patients receiving immunotherapy with programmed death protein-1(PD-1)inhibitors and to analyze the correlation between irAEs and patient prognosis.METHODS A total of 140 patients with advanced gastric cancer who were treated with PD-1 inhibitors in our hospital from June 2021 to October 2023 were selected.Patients were divided into the irAEs group and the non-irAEs group according to whether or not irAEs occurred.Clinical features,manifestations,and prognosis of irAEs in the two groups were collected and analyzed.A multivariate logistic regression model was used to analyze the related factors affecting the occurrence of irAEs,and the prediction model of irAEs was established.The receiver operating characteristic(ROC)curve was used to evaluate the ability of different indicators to predict irAEs.A Kaplan-Meier survival curve was used to analyze the correlation between irAEs and prognosis.The Cox proportional risk model was used to analyze the related factors affecting the prognosis of patients.RESULTS A total of 132 patients were followed up,of whom 63(47.7%)developed irAEs.We looked at the two groups’clinical features and found that the two groups were statistically different in age≥65 years,Ki-67 index,white blood cell count,neutrophil count,and regulatory T cell(Treg)count(all P<0.05).Multivariate logistic regression analysis showed that Treg count was a protective factor affecting irAEs occurrence(P=0.030).The ROC curve indicated that Treg+Ki-67+age(≥65 years)combined could predict irAEs well(area under the curve=0.753,95%confidence interval:0.623-0.848,P=0.001).Results of the Kaplan-Meier survival curve showed that progressionfree survival(PFS)was longer in the irAEs group than in the non-irAEs group(P=0.001).Cox proportional hazard regression analysis suggested that the occurrence of irAEs was an independent factor for PFS(P=0.006).CONCLUSION The number of Treg cells is a separate factor that affects irAEs in advanced gastric cancer patients receiving PD-1 inhibitor immunotherapy.irAEs can affect the patients’PFS and result in longer PFS.Treg+Ki-67+age(≥65 years old)combined can better predict the occurrence of adverse reactions. 展开更多
关键词 Advanced gastric cancer Prognostic analysis IMMUNOTHERAPY Nomogram model
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我国学前教育经费投入资源配置效率评价——基于空间计量经济学的实证检验 被引量:18
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作者 方超 沈豪 熊筱燕 《学前教育研究》 CSSCI 北大核心 2018年第8期3-16,共14页
利用我国2000~2015年的省级面板数据,基于教育生产函数构建投入—产出指标体系,采用随机前沿生产函数与空间计量经济学的实证研究方法,评价我国学前教育经费投入资源配置的静态效率与空间效率,结果发现,我国学前教育产出的技术效率(TE... 利用我国2000~2015年的省级面板数据,基于教育生产函数构建投入—产出指标体系,采用随机前沿生产函数与空间计量经济学的实证研究方法,评价我国学前教育经费投入资源配置的静态效率与空间效率,结果发现,我国学前教育产出的技术效率(TE)具有时间可变性,并且其变动趋势与区域经济发展水平并不具有一致性;财政性教育经费投入与事业性收入均能优化学前教育的资源配置效率,政府与市场投入每上升1单位值,可分别将产出效率提高47.8%与15.8%,并且两种投入的结构效应在东、中、西部地区分别产生了互补或替代的作用;政府与市场投入在地理空间上具有全域自相关性,但局域自相关性却存在显著差异,财政性教育经费投入与事业性收入每上升1单位值,可分别将临近省域学前教育的产出效率提高28%与8.7%,不过地方政府之间的"锦标赛"现象在间接效应中造就了"贫者愈贫,富者愈富"的马太效应。政府应稳步增加学前教育投入,尤其应加大对"老、少、边、贫"地区的转移支付力度,鼓励、引导和规范民营资本的运作,创新学前教育供给模式,在提升省域学前教育资源配置效率的同时切实保障"幼有所育"目标的实现。 展开更多
关键词 学前教育 经费投入 资源配置效率 空间计量经济学
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PRMTs在肿瘤发生、发展中的作用及机制 被引量:3
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作者 沈昊 张玲 刘修恒 《中国现代医学杂志》 CAS 2020年第1期45-51,共7页
蛋白精氨酸甲基转移酶(PRMTs)具有催化细胞中多种蛋白质特定精氨酸残基甲基化的功能,参与了包括信号转导、转录调控和DNA重组等重要的生物学过程,其中蛋白精氨酸甲基转移酶5(PRMT5)是研究最为深入的PRMTs家族成员,在多种类型的肿瘤中高... 蛋白精氨酸甲基转移酶(PRMTs)具有催化细胞中多种蛋白质特定精氨酸残基甲基化的功能,参与了包括信号转导、转录调控和DNA重组等重要的生物学过程,其中蛋白精氨酸甲基转移酶5(PRMT5)是研究最为深入的PRMTs家族成员,在多种类型的肿瘤中高表达,其通过催化特定精氨酸残基单甲基化和对称双甲基化,在调控各种生物学过程中发挥关键作用,包括调控靶基因的转录、控制关键的生长调节途径、调控转录因子的表达等。本综述系统介绍PRMT5通过甲基化细胞中的各种蛋白,发挥表观遗传调节酶的作用,其异常表达在肿瘤的发生、发展及侵袭过程中的作用及其机制。未来,PRMT5可以作为肿瘤检测和治疗的新靶点。 展开更多
关键词 蛋白精氨酸甲基转移酶 肿瘤 致癌基因 机制 生物标志物
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纳米复合材料结合分子影像技术及其在口腔鳞状细胞癌热疗中的应用 被引量:4
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作者 林李芃 徐凯 +6 位作者 袁峥鼎 郝申 谭新 滕荣 陈卓 闫翔宇 王永 《中国介入影像与治疗学》 北大核心 2019年第7期439-443,共5页
肿瘤热疗是近年来新兴的以低毒副作用、高治愈率为主要特征的纳米医学治疗手段。局部热疗,尤其是结合手术、放化疗等常规手段,对治疗包括口腔鳞状细胞癌(OSCC)在内的恶性肿瘤有效,但仍存在一些问题,如热剂量控制、靶向治疗区域筛选以及... 肿瘤热疗是近年来新兴的以低毒副作用、高治愈率为主要特征的纳米医学治疗手段。局部热疗,尤其是结合手术、放化疗等常规手段,对治疗包括口腔鳞状细胞癌(OSCC)在内的恶性肿瘤有效,但仍存在一些问题,如热剂量控制、靶向治疗区域筛选以及区分正常细胞与癌细胞等。近年来,随着纳米技术的发展,多功能纳米复合材料已用于头颈部癌症的局部热疗,结合分子影像学手段靶向示踪癌细胞并通过局部热疗进行同步追踪治疗,可有效提高治疗的精准性,延长患者生存时间。本文主要对纳米复合材料结合分子影像技术靶向示踪及其在OSCC热疗中的研究进展进行综述。 展开更多
关键词 口腔肿瘤 鳞状细胞 纳米复合材料 分子影像技术 热疗
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Direct experimental detection of hydrogen radicals in non-oxidative methane catalytic reaction 被引量:3
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作者 Jianqi hao Pierre Schwach +10 位作者 Lulu Li Xiaoguang Guo Junben Weng Hailei Zhang hao shen Guangzong Fang Xin Huang Xiulian Pan Chunlei Xiao Xueming Yang Xinhe Bao 《Journal of Energy Chemistry》 SCIE EI CAS CSCD 2021年第1期372-376,I0012,共6页
Non-oxidative conversion of methane to olefins,aromatics and hydrogen(MTOAH) has been reported recently over metal single sites such as iron and platinum.The reaction was proposed to involve catalytic activation of me... Non-oxidative conversion of methane to olefins,aromatics and hydrogen(MTOAH) has been reported recently over metal single sites such as iron and platinum.The reaction was proposed to involve catalytic activation of methane followed by gas phase C-C coupling of methyl radicals.This study using H atom Rydberg Tagging time-of-flight technique provides direct experimental evidence for the formation of hydrogen radicals during MTOAH reaction over a catalytic quartz wall reactor containing embedded iron species(denoted as Fe-reactor).Fe-reactor gives 7.3% methane conversion at 1273 K with 41.2% selectivity toward C2(ethane,ethylene and acetylene) and 31.8% toward BTX(benzene,toluene and xylene),respectively.The enhancing effects of hydrogen radicals on overall MTOAH performance are validated by cofeeding hydrogen donor benzene,which provides an additional route of methane activation apart from catalytic activation. 展开更多
关键词 Non-oxidative methane conversion Catalytic Fe-reactor H radical Experimental detection Methane activation
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Effect of axial vertical vibration on degeneration of lumbar intervertebral discs in modified bipedal rats: An in-vivo study 被引量:3
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作者 Xiao Liang hao shen +7 位作者 Wei-Dong Shi Shan Ren Wei Jiang hao Liu Peng Yang Zhi-Yong Sun Jun Lin Hui-Lin Yang 《Asian Pacific Journal of Tropical Medicine》 SCIE CAS 2017年第7期781-784,共4页
Objective: To assess the effects of axial vibrations on gene expression and lumbar intervertebral disc degeneration in vivo. Methods: A modified bipedal rat model was established using a brachial plexus rhizotomy appr... Objective: To assess the effects of axial vibrations on gene expression and lumbar intervertebral disc degeneration in vivo. Methods: A modified bipedal rat model was established using a brachial plexus rhizotomy approach to imitate human upright posture. The experimental animals were randomly divided into three groups: control, vertical vibration, and whole-body vibration. Gene expression in degeneration of the intervertebral discs was assessed by reverse transcription-quantitative polymerase chain reaction. Results: The expression of aggrecan, Col1α1, Col2α1, and decorin were shown to be up-regulated in 14-week-old rats in the vertical vibration and whole-body vibration groups, whereas biglycan and versican expression was down-regulated in 14-week-old rats of the two experimental groups. Furthermore, biglycan and versican expression levels were shown to be lower in the whole-body vibration group than in the vertical vibration group(P<0.05). Conclusions: This in-vivo study demonstrated that vibrations can influence the expression of anabolic genes. Furthermore, whole-body vibrations seem to have a greater effect in this regard than vertical vibrations. A new method is expected to relieve the low back pain of the patients through our research. 展开更多
关键词 Intervertebral disc Vibration Animal model Gene expression
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Quick to remember, slow to forget: rapid recall responses of memory CD8^+ T cells 被引量:2
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作者 Joanna R DiSpirito hao shen 《Cell Research》 SCIE CAS CSCD 2010年第1期13-23,共11页
The functional roles of memory B and T lymphocytes underlie the phenomenal success of prophylactic vaccinations, which have decreased morbidities and mortalities from infectious diseases globally over the last 50 year... The functional roles of memory B and T lymphocytes underlie the phenomenal success of prophylactic vaccinations, which have decreased morbidities and mortalities from infectious diseases globally over the last 50 years. However, it is becoming increasingly appreciated that memory cells are also capable of mediating the pathology associated with autoimmune disorders and transplant rejection, and may pose a significant barrier to future clinical advancement in immunoregulation. Therefore, understanding the unique properties of memory lymphocytes (as compared to their naive precursors) is a major area of investigation. Here, we focus on one of those singular properties of memory T cells (TM)-rapid recall. As will be discussed in more detail, rapid recall refers to the ability of quiescent TM cells to efficiently and robustly express‘effector functions' following stimulation. Studies that have advanced our understanding of TM cells' rapid recall using CD4^+ T cells have been expertly reviewed elsewhere, so we will focus primarily on studies of CD8^+ T cells. We will first review the different ways that CD8^+ TM cells can be generated, followed by discussing how this influences their functional properties in the settings of immune protection and pathology. Then, rapid recall ability will be discussed, with emphasis placed on what is currently known about the mechanisms that underlie this unique property of TM cells. 展开更多
关键词 CD8^+ TM TN TCR
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Nutritional evaluation,fatty acid analysis and anticancer properties investigation of seeds from kan-zaw,a potential diet oil and medicinal plant 被引量:1
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作者 Moe Moe Lwin Ye Jin +7 位作者 Xianpeng Yang hao shen Chao Qi Yizhong Wang Phyo Phyo Zin Oo Za Khai Tuang Shiyou Lü Wannian Yang 《Oil Crop Science》 CSCD 2021年第3期122-127,共6页
Payenapara lleloneura Kurz.(Kan-zaw),an endemic medicinal plant only found in Tanintharyi Region of Myanmar,is widely used in the treatment of various cancer and different ailments.In the present research,the seeds we... Payenapara lleloneura Kurz.(Kan-zaw),an endemic medicinal plant only found in Tanintharyi Region of Myanmar,is widely used in the treatment of various cancer and different ailments.In the present research,the seeds were phytochemical investigated for their nutritional potential for their use as functional foods or novel diet oil resources.Nutritional evaluation showed that the seeds are rich in fats and carbohydrates(soluble sugars and starch).Fatty acid analyses showed that the seeds accumulate very richα-eleostearic acid(α-ESA,18:3^(Δ9 cis,11-trans),13 trans),an important conjugated fatty acid,up to more than 70% of total fatty acids.The seed oil derived from the Kan-zaw tree contains approximately 3.25% β-eleostearic acid(18:3^(Δ9 trans,11 trans,13 trans)),an unusual conjugated fatty acid that imparts a potent anticancer application and industrially important drying qualities to Kan-zaw oil.Physicochemical properties of the Kan-zaw seeds were examined;petroleum ether(60–90℃)extract of seed oils were also investigated for the saponification value,iodine value and estimation of acid value.Further,the present study investigated cytotoxic potential of ethanol,methanol,acetone,chloroform Kan-zaw seed extracts and commercial Kan-zaw oil against human cervical cancer cell line(HeLa).The Kan-zaw extracts and oil have shown significant anticancer activity on HeLa cells. 展开更多
关键词 Payenapara lleloneura Kurz. Kan-zaw seeds Nutritional evaluation Fatty acid analysis Physicochemical properties Anticancer activity
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High Expression of CDCA7 Promotes Cell Proliferation, Migration, Invasion and Apoptosis in Non-Small-Cell Lung Cancer 被引量:1
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作者 Chun Yan Yang Lei Wang +4 位作者 Deng Cai Mu Fang Fang Li hao shen Xin Rui Yang Shang Yong Zheng 《Journal of Nutritional Oncology》 2020年第2期78-86,共9页
Objective Increased expression of CDCA7 is associated with a poorer prognosis in patients with non-small-cell lung cancer(NSCLC).This study was performed to investigate the effects of down-regulating cell division cyc... Objective Increased expression of CDCA7 is associated with a poorer prognosis in patients with non-small-cell lung cancer(NSCLC).This study was performed to investigate the effects of down-regulating cell division cycle-associated 7(CDCA7)gene expression on the proliferation,migration,invasion,cell cycle and apoptosis of human NSCLC cell lines.Methods Cultured A549 and NCI-H292 cells were transfected with si NC(control group)or si CDCA7(experimental group).Cell activity was detected using the CCK-8 and a Real Time Cell Analyzer(RTCA).Cell migration and invasion were also measured by RTCA.In addition,flow cytometry was used to assess the cell cycle progression and apoptosis in the cells,and Western blotting was used to detect the expression level of proteins in key signaling pathways.Results Compared with the cells transfected with si NC,the cell proliferation was significantly reduced(P<0.05),the migration and invasion were decreased,and the cell cycle was blocked in the G0/G1 phase(P<0.05)in the cells transfected with si CDCA7.The number of cells undergoing apoptosis was also increased(P<0.05).Western blotting revealed that P-ERK,Cyclin-D1,Vimentin and Bcl-2 were all downregulated.However,the expression of E-cadherin was not affected by the down-regulation of CDCA7,suggesting that it is upstream of this gene.Conclusion Silencing the CDCA7 gene inhibited the proliferation,migration and invasion of A549 and NCI-H292 cells,hindered the cell cycle transition to the S phase,and promoted cell apoptosis.These findings indicate that CDCA7 may represent a new therapeutic target for NSCLC. 展开更多
关键词 NSCLC CDCA7 Proliferation MIGRATION INVASION APOPTOSIS
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Effect of beta-tricalcium phosphate/poly-1-lactide composites on radial bone defects of rabbit
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作者 Zhao-Jin Zhu hao shen +3 位作者 Yong-Ping Wang Yao Jiang Xian-Long Zhang Guang-Yin Yuan 《Asian Pacific Journal of Tropical Medicine》 SCIE CAS 2013年第9期753-756,共4页
Objective:To explore the effect ofβ-TCP/PLLA scaffold in repairing rabbit radial lone defects.Methods:Thirty New Zealand rabbits were divided intoβ-TCP/PLLA group(group A),pure PLLA group(group B)and contrast group(... Objective:To explore the effect ofβ-TCP/PLLA scaffold in repairing rabbit radial lone defects.Methods:Thirty New Zealand rabbits were divided intoβ-TCP/PLLA group(group A),pure PLLA group(group B)and contrast group(group C)randomly.The rabbits were sacrificed respectively after 4.8.12,24 weeks and the X-ray film was performed at the same time to evaluate the repair effect in different groups.Retiults:X-ray film showed there was uneven low density bone callus development in defect region after 4 weeks in group A.The defect region was filled with neonate osseous tissue completely during 12-24 weeks.X-ray score revealed that repair of bone defect results significantly better than group B and group C.Conclusions:Theβ-PCP/PLLA composite is capable of repairing radial lone lone defects.β-TCP/PLLA scaffold is significant because of rapid degradation ability,good histocompatihility and osteogenic action. 展开更多
关键词 β-TCP/PLLA Large segment of simulated-bioactive BONE SUBSTITUTE BONE defect
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2D Janus polymer nanosheets for enhancing oil recovery:From material ppreparation to property evaluation
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作者 hao shen Zi-hao Yang +6 位作者 Guan-Zhong Wang Yi-Lin Xiong Qi-Chao Lv Qi Cao Qi-Qi Niu Yi-Bo Wang Zhao-xia Dong 《Petroleum Science》 SCIE EI CAS CSCD 2023年第3期1584-1597,共14页
Janus amphiphilic polymer nanosheets(JAPNs)with anisotropic morphology and distinctive perfor-mance have aroused widespread interest.However,due to the difficulty in synthesis and poor dispersion stability,JAPNs have ... Janus amphiphilic polymer nanosheets(JAPNs)with anisotropic morphology and distinctive perfor-mance have aroused widespread interest.However,due to the difficulty in synthesis and poor dispersion stability,JAPNs have been scarcely reported in the field of enhancing oil recovery(EOR).Herein,a kind of organic-based flexible JAPNs was prepared by paraffin emulsion methods.The lateral sizes of JAPNs were ranging from hundreds of nanometers to several micrometers and the thickness was about 3 nm.The organic-based nanosheets were equipped with remarkably flexible structures,which could improve their injection performance.The dispersion and interfacial properties of JAPNs were studied systematically.By modification of crosslinking agent containing multiple amino groups,the JAPNs had excellent hydro-philicity and salt resistance compared with conventional inorganic or composite nanosheets.The settling time of nanosuspension with NaCl and CaCl_(2) at a low salinity of 1000 mg/L was over 240 h.The value could also remain 124 h under the salinity of 10,000 mg/L NaCl.With the dual functionalities of Janus amphiphilic nature and nanoparticles'Pickering effect,JAPNs could change rock wettability and form emulsions as"colloidal surfactants",In particular,a new technology called optical microrheology was pioneered to explore the destabilization state of nanosuspensions for the first time.Since precipitation lagged behind aggregation,especially for stable suspension systems,the onset of the unstable behavior was difficult to be detected by conventional methods,which should be the indicator of reduced effec-tiveness for nanofluid products.In addition,the oil displacement experiments demonstrated that the JAPNs could enhance oil recovery by 17.14%under an ultra-low concentration of 0.005%and were more suitable for low permeability cores.The findings can help for a better understanding of the material preparation of polymer nanosheets.We also hope that this study could shed more light on the nano-flooding technology for EOR. 展开更多
关键词 2D materials Polymer nanosheets Enhance oil recovery Janus nature Amphiphilic property
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Prediction of load-displacement performance of grouted anchors in weathered granites using FastICA-MARS as a novel model
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作者 hao shen Jinhui Li +1 位作者 Sixin Wang Zewei Xie 《Geoscience Frontiers》 SCIE CAS CSCD 2021年第1期415-423,共9页
With the rising needs of better prediction of the load-displacement performance of grouted anchors in an era of developing large-scale underground infrastructures,the existing methods in literature lack an accurate an... With the rising needs of better prediction of the load-displacement performance of grouted anchors in an era of developing large-scale underground infrastructures,the existing methods in literature lack an accurate analytical model for the real-life projects or rigorous understanding of the parameters such as grouting pressures.This paper proposes Fast ICA-MARS as a novel data-driven approach for the prediction of the load-displacement performance of uplift-resisting grouted anchors.The hybrid and data-driven Fast ICA-MARS approach integrates the multivariate adaptive regression splines(MARS)technique with the Fast ICA algorithm which is for Independent Component Analysis(ICA).A database of 4315 observations for 479 different anchors from 7 different projects is established.The database is then used to train,validate and compare the Fast ICA-MARS approach with the classical MARS approach.The developed Fast ICA-MARS model can provide more accurate predictions than MARS.Moreover,the developed Fast ICA-MARS model is easy to interpret since the evaluation of the parameter importance of the independent components can be conducted along with the considerations of the correlations with the original variables.It is noteworthy to point out that the grouting pressures play a central role in the proposed model,which is considered of paramount importance in engineering practices but has not been properly taken into account in any prior analytical or empirical predictive models for the load-displacement relationships. 展开更多
关键词 Grouted anchors Load-displacement relationships Pull-out tests FASTICA MARS
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H_(∞) state estimation for Markov jump neural networks with transition probabilities subject to the persistent dwell-time switching rule
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作者 hao shen Jia-Cheng Wu +1 位作者 Jian-Wei Xia Zhen Wang 《Chinese Physics B》 SCIE EI CAS CSCD 2021年第6期88-95,共8页
We investigate the problem of H_(∞) state estimation for discrete-time Markov jump neural networks. The transition probabilities of the Markov chain are assumed to be piecewise time-varying, and the persistent dwell-... We investigate the problem of H_(∞) state estimation for discrete-time Markov jump neural networks. The transition probabilities of the Markov chain are assumed to be piecewise time-varying, and the persistent dwell-time switching rule,as a more general switching rule, is adopted to describe this variation characteristic. Afterwards, based on the classical Lyapunov stability theory, a Lyapunov function is established, in which the information about the Markov jump feature of the system mode and the persistent dwell-time switching of the transition probabilities is considered simultaneously.Furthermore, via using the stochastic analysis method and some advanced matrix transformation techniques, some sufficient conditions are obtained such that the estimation error system is mean-square exponentially stable with an H_(∞) performance level, from which the specific form of the estimator can be obtained. Finally, the rationality and effectiveness of the obtained results are verified by a numerical example. 展开更多
关键词 Markov jump neural networks persistent dwell-time switching rule H_(∞)state estimation meansquare exponential stability
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Discontinuous event-trigger scheme for global stabilization of state-dependent switching neural networks with communication delay
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作者 Yingjie Fan Zhen Wang +1 位作者 Jianwei Xia hao shen 《Chinese Physics B》 SCIE EI CAS CSCD 2021年第3期119-128,共10页
This paper is concerned with the global stabilization of state-dependent switching neural networks(SDSNNs)viadiscontinuous event-triggered control with network-induced communication delay.Aiming at decreasing triggeri... This paper is concerned with the global stabilization of state-dependent switching neural networks(SDSNNs)viadiscontinuous event-triggered control with network-induced communication delay.Aiming at decreasing triggering times,a discontinuous event-trigger scheme is utilized to determine whether the sampling information is required to be sent outor not.Meanwhile,under the effect of communication delay,the trigger condition and SDSNNs are transformed into twotractable models by designing a fictitious delay function.Then,using the Lyapunov–Krasovskii stability theory,someinequality estimation techniques,and extended reciprocally convex combination method,two sufficient criteria are established for ensuring the global stabilization of the resulting closed-loop SDSNNs,respectively.A unified framework isderived that has the ability to handle the simultaneous existence of the communication delay,the properties of discontinuousevent-trigger scheme,as well as feedback controller design.Additionally,the developed results demonstrate a quantitativerelationship among the event trigger parameter,communication delay,and triggering times.Finally,two numerical examples are presented to illustrate the usefulness of the developed stabilization scheme. 展开更多
关键词 global stabilization state-dependent switching neural networks discontinuous event-trigger scheme communication delay
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Central pontine myelinolysis mimicking glioma in diabetes:A case report
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作者 Xiao-Yong Shi Meng-Ting Cai +1 位作者 hao shen Jin-Xia Zhang 《World Journal of Clinical Cases》 SCIE 2021年第18期4837-4843,共7页
BACKGROUND Central pontine myelinolysis(CPM)usually occurs during rapid correction of serum osmolality,typically with brainstem lesions presenting uniform signals following enhancement on magnetic resonance imaging(MR... BACKGROUND Central pontine myelinolysis(CPM)usually occurs during rapid correction of serum osmolality,typically with brainstem lesions presenting uniform signals following enhancement on magnetic resonance imaging(MRI).We report a case of CPM caused by diabetes,which was characterized by glioma-like imaging features and the patient responded well to corticosteroids.CASE SUMMARY A 49-year-old man with type 2 diabetes was admitted due to numbness and weakness for 6 mo with progressive aggravation for 2 wk.His complete blood count,serum electrolytes,renal and liver function parameters were within the normal range.MRI showed mass lesions in the brainstem,with unusually inhomogeneous signal intensity after contrast-enhanced scans.His symptoms worsened after hypoglycemic therapy.Due to his clinical history and examination results,CPM was considered the most likely diagnosis.Treatment with corticosteroids was administered with a methylprednisolone pulse in the acute phase followed by dose tapering.During the 8-mo follow-up period,his clinical symptoms and imaging features significantly improved.CONCLUSION Diabetes could rarely be accompanied by CPM,and patients who experience this neurological complication could benefit from corticosteroid treatment.Clinicians should recognize the special relationship between diabetes and CPM,and improve awareness of early identification and appropriate treatment. 展开更多
关键词 Central pontine myelinolysis DIABETES IMAGING GLIOMA CORTICOSTEROIDS Case report
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