Objective To observe the value of real-time shear wave elastography(SWE)combined with biochemical indicators for evaluating liver injury in patients with chronic kidney disease(CKD).Methods Totally 210 patients with C...Objective To observe the value of real-time shear wave elastography(SWE)combined with biochemical indicators for evaluating liver injury in patients with chronic kidney disease(CKD).Methods Totally 210 patients with CKD(CKD group)and 64 healthy subjects(control group)were retrospectively enrolled.Patients in CKD group were further divided into CKD1—5 subgroups according to CKD stages.SWE parameters of liver and kidney,including mean value,the maximum value and the median value of Young's modulus(EQI mean,EQI max and EQI med)were compared between CKD subgroups and control group.Spearman correlation analysis were performed to explore the correlations of liver and kidney SWE parameters with CKD stage,as well as of liver SWE parameters with biochemical indicators.Multivariate logistic regression analysis was used to screen independent predictors of liver injury in CKD patients.Receiver operating characteristic curves were drawn,the area under the curves(AUC)were calculated to evaluate the efficacy of the independent predictors alone and their combination for assessing liver injury in CKD patients.Results Significant differences of liver and kidney SWE parameters were found among CKD subgroups and control group(all P≤0.001).Pairwise comparison showed that liver SWE parameters in CKD5 subgroup and liver EQI max in CKD4 subgroup were all higher than those in control group(all P<0.003).Kidney SWE parameters in CKD3 subgroup were all higher than those in control group,while in CKD4 subgroup were all higher than those in control group and CKD1—3 subgroup(all P<0.003).Kidney EQI mean and EQI med in CKD5 subgroup were all higher than those in control group and CKD1—4 subgroup,while kidney EQI max in CKD5 subgroup were higher than those in control group and CKD1—3 subgroup(all P<0.003).Liver and kidney SWE parameters were lowly-moderately and positively correlated with CKD stages(r=0.364—0.665,all P<0.001).Liver SWE parameters of CKD were weakly and positively correlated with alkaline phosphatase(ALP)(r=0.229—0.248,all P<0.01).Theγ-glutamyl transferase,ALP and liver EQI max were all independent predictors of liver injury in CKD patients(all P<0.01),with AUC for evaluating liver injury in CKD patients alone of 0.645,0.756 and 0.741,respectively,lower than that of their combination(0.851,all P<0.01).Conclusion Real-time SWE combined with liver function indicators could reflect degree of liver injury in patients with different CKD stages.展开更多
In this paper, we theoretically and numerically study a combined monopole–dipole measurement mode to show its capability to overcome the issues encountered in conventional single-well imaging, i.e., the low signal-to...In this paper, we theoretically and numerically study a combined monopole–dipole measurement mode to show its capability to overcome the issues encountered in conventional single-well imaging, i.e., the low signal-to-noise ratio of the reflections and azimuth ambiguity. First, the azimuth ambiguity, which exists extensively in conventional single-well imaging, is solved with an improved imaging procedure using combined monopole–dipole logging data in addition to conventional logging data. Furthermore, we demonstrate that the direct waves propagating along the boreholes with strong energy, can be effectively eliminated with the proposed combined monopole–dipole measurement mode. The reflections are therefore predominant in the combined monopole–dipole data even before the signals are filtered; thus, the reflections' arrival times in each receiver are identified, which may help minimize the difficulties in filtering conventional logging data. The optimized processing flow of the combined measurement mode logging image is given in this paper. The proposed combined monopole–dipole measurement mode may improve the accuracy of single-well imaging.展开更多
Most sedimentary formations with fine layers can be characterized as transversely isotropic media.The evaluation of shear-wave anisotropy is critical in logging-while-drilling(LWD)applications.We developed a joint met...Most sedimentary formations with fine layers can be characterized as transversely isotropic media.The evaluation of shear-wave anisotropy is critical in logging-while-drilling(LWD)applications.We developed a joint method to simultaneously invert formation shear-wave anisotropy and vertical shear velocity using LWD monopole and dipole dispersion data.Theoretical analysis demonstrates that formation shear-wave anisotropy significantly aff ects the dispersion characteristics of Stoneley and formation flexural waves.The inversion objective function was constructed based on the change in dispersion characteristics and was weighted by the spectra of multipole waves.Numerical results using synthetic examples demonstrate that the joint inversion method can not only alleviate the non-uniqueness problem but also help improve the accuracy of the inversion results.The comparison of diff erent signal-to-noise ratio inversion results proved that the weighted inversion method is more accurate and stable.展开更多
Objective Medulloblastoma(MB)is the most common primary central nervous system malignancy in children.Nonetheless,there is no standard treatment for recurrent MB.The purpose of this study was to investigate the clinic...Objective Medulloblastoma(MB)is the most common primary central nervous system malignancy in children.Nonetheless,there is no standard treatment for recurrent MB.The purpose of this study was to investigate the clinical value and toxicity of recombinant human endostatin injection(Endostar~?)combined with craniospinal radiotherapy for the treatment of recurrent MB in children.Methods This study retrospectively analyzed 13 patients with recurrent MB aged 5–18 years.Endostar?7.5 mg/m~2/d was synchronized during craniospinal radiotherapy for 7 children with a portable micro uniform speed infusion pump.Endostar~?was applied 3 days prior to the initiation of radiotherapy.The drug was in continuous use for 7 days.Similarly,the withdrawal of the drug took place over 7 days.This represented a cycle.During radiotherapy,the application was repeated until the end of radiotherapy(experimental group).In the other 6 cases,only craniospinal radiotherapy was used(control group).Results The complete remission rate was 71.4%in the experimental group and 16.7%in the control group.The median progression-free survival(PFS)was 14 months(95%CI:0.0–29.60)and 19 months(95%CI:0.0–39.53)in the experimental and control groups,respectively.The median overall survival(OS)was 19 months(95%CI:0.0–38.20)and 23 months(95%CI:2.47–43.53)in the experimental and control groups,respectively.The most common adverse events included grade 1 thrombocytopenia(7.7%),grade 3 neutropenia(38.5%),and grade 1 anemia(30.8%).Conclusion Endostar~?synchronizing craniospinal radiotherapy significantly improved the complete response rate of children with recurrent MB.It did not increase the side effects of radiation therapy.However,it did not improve the PFS or OS.展开更多
文摘Objective To observe the value of real-time shear wave elastography(SWE)combined with biochemical indicators for evaluating liver injury in patients with chronic kidney disease(CKD).Methods Totally 210 patients with CKD(CKD group)and 64 healthy subjects(control group)were retrospectively enrolled.Patients in CKD group were further divided into CKD1—5 subgroups according to CKD stages.SWE parameters of liver and kidney,including mean value,the maximum value and the median value of Young's modulus(EQI mean,EQI max and EQI med)were compared between CKD subgroups and control group.Spearman correlation analysis were performed to explore the correlations of liver and kidney SWE parameters with CKD stage,as well as of liver SWE parameters with biochemical indicators.Multivariate logistic regression analysis was used to screen independent predictors of liver injury in CKD patients.Receiver operating characteristic curves were drawn,the area under the curves(AUC)were calculated to evaluate the efficacy of the independent predictors alone and their combination for assessing liver injury in CKD patients.Results Significant differences of liver and kidney SWE parameters were found among CKD subgroups and control group(all P≤0.001).Pairwise comparison showed that liver SWE parameters in CKD5 subgroup and liver EQI max in CKD4 subgroup were all higher than those in control group(all P<0.003).Kidney SWE parameters in CKD3 subgroup were all higher than those in control group,while in CKD4 subgroup were all higher than those in control group and CKD1—3 subgroup(all P<0.003).Kidney EQI mean and EQI med in CKD5 subgroup were all higher than those in control group and CKD1—4 subgroup,while kidney EQI max in CKD5 subgroup were higher than those in control group and CKD1—3 subgroup(all P<0.003).Liver and kidney SWE parameters were lowly-moderately and positively correlated with CKD stages(r=0.364—0.665,all P<0.001).Liver SWE parameters of CKD were weakly and positively correlated with alkaline phosphatase(ALP)(r=0.229—0.248,all P<0.01).Theγ-glutamyl transferase,ALP and liver EQI max were all independent predictors of liver injury in CKD patients(all P<0.01),with AUC for evaluating liver injury in CKD patients alone of 0.645,0.756 and 0.741,respectively,lower than that of their combination(0.851,all P<0.01).Conclusion Real-time SWE combined with liver function indicators could reflect degree of liver injury in patients with different CKD stages.
基金supported by the National Natural Science Foundation of China(Nos.11574347,11374322,11134011,11734017,and 91630309)PetroChina Innovation Foundation(No.2016D-5007-0304)
文摘In this paper, we theoretically and numerically study a combined monopole–dipole measurement mode to show its capability to overcome the issues encountered in conventional single-well imaging, i.e., the low signal-to-noise ratio of the reflections and azimuth ambiguity. First, the azimuth ambiguity, which exists extensively in conventional single-well imaging, is solved with an improved imaging procedure using combined monopole–dipole logging data in addition to conventional logging data. Furthermore, we demonstrate that the direct waves propagating along the boreholes with strong energy, can be effectively eliminated with the proposed combined monopole–dipole measurement mode. The reflections are therefore predominant in the combined monopole–dipole data even before the signals are filtered; thus, the reflections' arrival times in each receiver are identified, which may help minimize the difficulties in filtering conventional logging data. The optimized processing flow of the combined measurement mode logging image is given in this paper. The proposed combined monopole–dipole measurement mode may improve the accuracy of single-well imaging.
基金supported by the National Natural Science Foundation of China (Grant No.12174421)the Hubei Key Laboratory of Advanced Aerospace Propulsion Technology (Grant No.KFJJ2020-02).
文摘Most sedimentary formations with fine layers can be characterized as transversely isotropic media.The evaluation of shear-wave anisotropy is critical in logging-while-drilling(LWD)applications.We developed a joint method to simultaneously invert formation shear-wave anisotropy and vertical shear velocity using LWD monopole and dipole dispersion data.Theoretical analysis demonstrates that formation shear-wave anisotropy significantly aff ects the dispersion characteristics of Stoneley and formation flexural waves.The inversion objective function was constructed based on the change in dispersion characteristics and was weighted by the spectra of multipole waves.Numerical results using synthetic examples demonstrate that the joint inversion method can not only alleviate the non-uniqueness problem but also help improve the accuracy of the inversion results.The comparison of diff erent signal-to-noise ratio inversion results proved that the weighted inversion method is more accurate and stable.
基金Supported by a grant from the Chongqing Science and Health Joint Medical Research Foundation of China(No.2019MSXM079)。
文摘Objective Medulloblastoma(MB)is the most common primary central nervous system malignancy in children.Nonetheless,there is no standard treatment for recurrent MB.The purpose of this study was to investigate the clinical value and toxicity of recombinant human endostatin injection(Endostar~?)combined with craniospinal radiotherapy for the treatment of recurrent MB in children.Methods This study retrospectively analyzed 13 patients with recurrent MB aged 5–18 years.Endostar?7.5 mg/m~2/d was synchronized during craniospinal radiotherapy for 7 children with a portable micro uniform speed infusion pump.Endostar~?was applied 3 days prior to the initiation of radiotherapy.The drug was in continuous use for 7 days.Similarly,the withdrawal of the drug took place over 7 days.This represented a cycle.During radiotherapy,the application was repeated until the end of radiotherapy(experimental group).In the other 6 cases,only craniospinal radiotherapy was used(control group).Results The complete remission rate was 71.4%in the experimental group and 16.7%in the control group.The median progression-free survival(PFS)was 14 months(95%CI:0.0–29.60)and 19 months(95%CI:0.0–39.53)in the experimental and control groups,respectively.The median overall survival(OS)was 19 months(95%CI:0.0–38.20)and 23 months(95%CI:2.47–43.53)in the experimental and control groups,respectively.The most common adverse events included grade 1 thrombocytopenia(7.7%),grade 3 neutropenia(38.5%),and grade 1 anemia(30.8%).Conclusion Endostar~?synchronizing craniospinal radiotherapy significantly improved the complete response rate of children with recurrent MB.It did not increase the side effects of radiation therapy.However,it did not improve the PFS or OS.
