Objective To explore the mechanisms involved in the ligustrazine alleviation of the pulmonary artery hypertension(PAH) in patients of chronic obstructive pulmonary disease(COPD) associated with chronic cor pulmonale(C...Objective To explore the mechanisms involved in the ligustrazine alleviation of the pulmonary artery hypertension(PAH) in patients of chronic obstructive pulmonary disease(COPD) associated with chronic cor pulmonale(CCP) during exacerbation.Methods Seventy patients of COPD and CCP with acute exacerbation were randomly and equally divided into control group and treatment group.The control group received standard treatment with antibiotics,antiasthmatic and expectorant medications,and oxygenation;and the ligustrazine treatment group received ligustrazine treatment(80 mg/d;i.v.;for 2 weeks) in addition to the standard treatment.Before and at the end of 2 week treatment,the clinic responses of the two regimens were evaluated,plasma levels of endothelin-1(ET-1) and nitric oxide(NO) were determined;arterial oxygen partial pressure(PaO_2),mean pulmonary arterial pressure(mPAP),outflow tract of right ventricle(RVOT),and internal diameter of right ventricle(RV) were measured.Results Good clinic benefits were achieved in both the standard and ligustrazine regimens,plasma level of ET-1,values of mPAP,RV and RVOT decreased significantly,plasma level of NO and PaO_2 values decreased(all P<0.01 vs pretreatment to all parameters).Compared with the control group,ligustrazine greatly enhanced the clinic efficacy from 77.1%to 97.1%(P<0.05),and also resulted in more significant changes of all these parameters(P<0.01 vs control group for all parameters).For both groups,the levels of plasma ET-1 were positively correlated with values of mPAP,RVOT,and RV(r = 0.710,0.853,and 0.766,respectively,all P = 0.000),and negatively correlated with plasma NO and PaO_2(r =- 0.823,and- 0.752,respectively,all P = 0.000).Conclusion Ligustrazine is effective in treating pulmonary artery hypertension during acute exacerbation of COPD and CCP in patients from the plateau area.The observed changes in the plasma levels of NO and ET-1 in response to ligustrazine treatment suggest that ligustrazine may act through the selective effect on pulmonary blood vessels to enhance the synthesis and release of NO and suppress those of ET-1 from lung vascular endothelial cells,thus reducing pulmonary artery pressure and decreasing pulmonary arterial hypertension.展开更多
AIM:To observe the changes in Schlemm’s canal(SC),trabecular meshwork(TM),and anterior chamber relevant parameters after small incision lenticule extraction(SMILE) of myopia patients.METHODS:A total of 58 eyes from 3...AIM:To observe the changes in Schlemm’s canal(SC),trabecular meshwork(TM),and anterior chamber relevant parameters after small incision lenticule extraction(SMILE) of myopia patients.METHODS:A total of 58 eyes from 30 patients who underwent SMILE were divided into a low and moderate myopia group(group A,32 eyes) and a high myopia group(group B,26 eyes).The diameter and area of the SC,the width and thickness of TM obtained by CIRRUS HD-OCT5000,and the related anterior chamber parameters obtained by Pentacam anterior segment analysis system,accommodation amplitude(AMP) were observed pre-and postoperatively.The preoperative intraocular pressure(IOP) and postoperative correction of intraocular pressure(IOPcc) were measured.RESULTS:The diameter and area of the SC in the two groups were significantly increased postoperatively(all P<0.01).The TM width of the patients in the two groups were increased at 1mo after surgery(both P<0.01),but the TM thickness did not change(P>0.05).The corneal curvature,central anterior chamber depth,and anterior chamber volume decreased after SMILE surgery(all P<0.01).There was a weak negative correlation between the SC area change and AMP change in group A(r=-0.362,P<0.01).The postoperative IOP decreased after correction by Shah formula(P<0.05).CONCLUSION:SC and TM in myopia patients change in the early postoperative stage of SMILE and the IOP is decline.展开更多
Biodegradation usually obscures or even radically alters the original characteristics of oil biomarkers.The mixing of oil from multiple sources makes each source difficult to trace.Identifying the source of biodegrade...Biodegradation usually obscures or even radically alters the original characteristics of oil biomarkers.The mixing of oil from multiple sources makes each source difficult to trace.Identifying the source of biodegraded oil from multiple sources has always been a hard nut to crack.Rising to this challenge,in this study-we carried out a comprehensive investigation of biodegradation impacts,oil-source correlation,and oil charging history to trace the source and reveal the mixing process of biodegraded oil in the Toutunhe Formation(J_(2)t)in the eastern Junggar Basin,NW China.The oil of this area was biodegraded to different extent,consequently,many commonly used biomarker parameters(e.g.Pr/Ph,Pr/n C_(17))became less powerful for oil-source correlation.To address this problem,the resistance of many biomarkers to biodegradation was analyzed,and those of high bio resistance were selected to generate a more reliable oil-source correlation.The results revealed that biodegraded oil was a mixture of oil sourced from Lucaogou Formation(P_(2)l)and Xiaoquangou Formation(T_(2-3)xq).Core sample observation,microscopic fluorescent analysis and fluid inclusion analysis were combined to analyze comprehensively oil charging history.The analysis of accumulation process exhibited that the existing oil in J_(2)t was a mixture originated from the P_(2)l and T_(2-3)xq source rocks in two separate charging stages when it underwent a complicated process of charging,biodegradation,recharging and mixing.展开更多
Objective: To assess the effectiveness and safety of manipulation intervention for degenerative lumbar spondylolisthesis(DLS).Methods: This is a systematic review and meta-analysis. A full-scale retrieval method was p...Objective: To assess the effectiveness and safety of manipulation intervention for degenerative lumbar spondylolisthesis(DLS).Methods: This is a systematic review and meta-analysis. A full-scale retrieval method was performed until February 1, 2021, including nine databases. The homogeneity of different studies was summarized using the Review Manager. The quality of studies was determined with the Cochrane risk-of-bias tool.The evidence quality was graded with the Grading of Recommendations, Assessment, Development, and Evaluations approach.Results: A total of 6 studies involving 524 participants were included. The review demonstrated that manipulation has statistically significant improvements for treating DLS according to Japanese Orthopedic Association scores(mean difference, 3.76;95% confidence interval, 2.63 to 4.90;P <.001) and visual analog scale scores(mean difference,-1.50;95% confidence interval,-1.66 to-1.33;P <.001)compared to the control group. One study reported that the difference in the Oswestry Disability Index between the traction group and the combination of manipulation and traction group was statistically significant(P <.05), while another reported that manipulation treatment can significantly improve the lumbar spine rotation angle on X-ray images compared with the baseline data(P <.05). Moreover, the manipulation group(experimental group) had fewer adverse events than the lumbar traction group(control group).Conclusion: Manipulation intervention is more effective and safer for DLS. Nevertheless, large-scale randomized controlled trials are required to confirm the current conclusions.展开更多
Objective:To explore the related factors that may affect the efficacy of traditional Chinese medicine in treating degenerative lumbar spondylolisthesis.Methods:A total of 535 patients with DLS who were treated in Wang...Objective:To explore the related factors that may affect the efficacy of traditional Chinese medicine in treating degenerative lumbar spondylolisthesis.Methods:A total of 535 patients with DLS who were treated in Wangjing Hospital of China Academy of Chinese Medical Sciences and other hospitals from June 2011 to October 2014 were selected.The central random system was used to randomly divide the treatment group and control group.This study included 267 patients in the treatment group using the traditional Chinese medicine program((lumbar spine reduction and lumbar spine rehabilitation),36 cases of severely missing data were excluded,and a total of 231 DLS patients were included.Observation indicators were selected using the Visual Analog Scale(VAS)and the Japanese Orthopaedic Association(JOA)for the evaluation of lumbar vertebral disorders.The clinical efficacy was evaluated using the JOA lumbar pain curative effect evaluation standard[7].[(Joa score after treatment-JOA score before treatment]/(out of 29 points-JOA score before treatment)]×100%.The JOA score and the change of the efficacy index of the patients were observed.According to the JOA efficacy index after the treatment,it was divided into significant effect(≥50%)and poor effect(<50%).Single-factor screening and multi-factor Logistic regression analysis were used.Gender,age,course of disease,BMI index,slip-off segment,slip-off direction,back pain VAS score,total JOA score,back pain-score,lower limb pain and numbness-score,walking ability-score,straight leg elevation test-score,Feeling-scoring,muscle strength-scoring,supine turn-scoring,standing action-scoring,washing action-scoring,standing posture and continuous standing-scoring,long sedentary-scoring,weight lifting and holding-scoring,walking-scoring 2.Bladder function-scores were assigned to logistic regression models for univariate analysis,and meaningful independent variables were screened for multivariate logistic regression.Results:No serious adverse reactions occurred in the patients included in this study.According to the comparison of JOA scores before and after treatment,the results of the index of efficacy index showed that the effective rate of DLS in this project was 96.6%,and a significant effect of 77.6%was achieved.Univariate Logistic regression analysis showed that the duration of disease,supine turn-scoring,washing action-scoring,prolonged sedentary-scoring,weight lifting and keeping-scoring had statistically significant effects on the inclusion of patients with significant efficacy(P<0.05);single factor logistic regression analysis of total score of JOA score before treatment was not statistically significant(P=0.215),but because it is important for evaluating the patient's condition,it was included in multifactor logistic regression analysis at the same time.Course of onset,supine turn-scoring,washing action-scoring,prolonged sedentary-scoring,weight lifting and holding-scoring,JOA score before treatment.Six independent variables were substituted into the two-class logistic regression model for multivariate analysis..Multivariate logistic regression analysis showed that the effects of total JOA score and supine turn-scoring before treatment on the efficacy of patients were statistically significant(P<0.05).There are many factors influencing the efficacy of traditional Chinese medicine treatment of DLS,and the probability of obtaining a significant effect for each additional point of JOA score and supine turn-score before treatment increases by 1.167 and 0.410 times,respectively.Conclusion:The clinical application of lumbar spine reduction combined with lumbar rehabilitation exercises in patients with degenerative lumbar spondylolisthesis with a higher total JOA score or a lower limit of supine turning can achieve better clinical results.This finding has certain guiding significance for the clinical application of this therapy in the treatment of DLS,and is beneficial to improving patient satisfaction and clinical effectiveness.展开更多
Knee osteoarthritis(KOA)is the highest incidence of osteoarthritis,which seriously affects the quality of life of patients.In order to update the understanding of the disease,clear diagnostic criteria and appropriate ...Knee osteoarthritis(KOA)is the highest incidence of osteoarthritis,which seriously affects the quality of life of patients.In order to update the understanding of the disease,clear diagnostic criteria and appropriate treatment were proposed.In 2018 and 2019,the European Society for Clinical and Economic Aspects of Osteoporosis,Osteoarthritis and Musculoskeletal Diseases(ESCEO),the Association of the Scientific Medical Societies in Germany(AWMF)and Brazil successively formulated guidelines for knee osteoarthritis,which determined different guidance suggestions through systematic evaluation of a large number of literatures and evidence-based medical evidence analysis.This paper compares and interprets the guidelines,and discusses them according to the actual situation of our country for the reference of clinicians.展开更多
Objective:To systematically evaluate the efficacy and safety of Duhuo Jisheng decoction combined with manipulation in the treatment of lumbar disc herniation.Method:We systematically searched 8 databases at home and a...Objective:To systematically evaluate the efficacy and safety of Duhuo Jisheng decoction combined with manipulation in the treatment of lumbar disc herniation.Method:We systematically searched 8 databases at home and abroad.Literature quality of the included studies was evaluated by the bias risk assessment tool of Cochrane collaboration network,and the Meta-analysis was performed by RevMan 5.3 software.Result:A total of 427 related literature were retrieved,and 12 studies were eventually included,involving 1153 patients.All studies were in Chinese.Meta-analysis results showed that the total effective rate of Duhuo Jisheng decoction combined with manipulation in the treatment of LDH was better than that of the control group(RR=1.23,95%CI[1.17,1.29],P<0.00001).Subgroup analysis showed that Duhuo Jisheng decoction combined with manipulation had a more significant effect than conventional treatment(RR=1.34,95%CI[1.20,1.50],P<0.00001),nonsteroidal anti-inflammatory drugs(RR=1.24,95%CI[1.12,1.37],P<0.0001),and Yaotongning capsules(RR=1.19,95%CI[1.10,1.29],P<0.0001).It has obvious advantages in improving VAS scores(MD=-1.19,95%CI-1.19[-1.87,-0.51],P=0.0006),but it has no obvious advantages in improving JOA scores(MD=2.6595%CI[0.06,5.24],P=0.05).In terms of safety,Duhuo Jisheng decoction combined with manipulation treatment reported fewer adverse events.Conclusion:The Duhuo Jisheng decoction combined with manipulation treatment can effectively relieve the clinical symptoms of patients with lumbar disc herniation,with obvious clinical efficacy,and fewer adverse events.But in view of the limitations of clinical studies,there are some limitations in this study,and more studies with high quality of evidence are needed to further confirm its efficacy and safety.展开更多
Objective:To review and evaluate the quality of the randomized controlled trials of exercise for the treatment of cervical radiculopathy with the present internationally recognized CONSORT statement, which provides re...Objective:To review and evaluate the quality of the randomized controlled trials of exercise for the treatment of cervical radiculopathy with the present internationally recognized CONSORT statement, which provides reference and basis for the improvement of clinical research on exercise for intervening cervical radiculopathy in the future.Methods: A computer-based search of large domestic databases, including CNKI, Wanfang database and VIP database screened out literature that meet the requirements and used CONSORT statement for quality assessment.Results: According to the prescribed inclusion and exclusion criteria, 30 articles were retrieved in accordance with the standard. No literature was referred to the randomized controlled trial, 2 documents clearly defined the type of test design, 1 documents carried out the calculation of sample size, 13 documents clearly randomly assigned, 1 literature implemented the blind method, in the 7 literature, baseline information was shown in tabular form, and no reference was made to trial registration, trial protocol and funding.Conclusion:There are some aspects of randomized controlled trials on exercise for the treatment of cervical radiculopathy. However, there are some aspects that need to be improved. In the future randomized controlled trial report, the CONSORT statement should be highly valued and carefully considered to improve the accuracy and credibility of the research.展开更多
THE 47th session of the UN Human Rights Council concluded on July 14 in Geneva,Switzerland.China’s stance on human rights was widely supported and responded to at the session,and the country also received high evalua...THE 47th session of the UN Human Rights Council concluded on July 14 in Geneva,Switzerland.China’s stance on human rights was widely supported and responded to at the session,and the country also received high evaluation for its sense of responsibility to drive the progress of human rights of the world.展开更多
This paper introduces the film "Kung Fu Panda," which contains the elements of Chinese culture and Western culture, respectively, from the philosophical thinking, animal image, folk life and expression of Chinglish ...This paper introduces the film "Kung Fu Panda," which contains the elements of Chinese culture and Western culture, respectively, from the philosophical thinking, animal image, folk life and expression of Chinglish and etiquette introduced Chinese elements, from individualism, fatalism and character introduced western culture reflected in the movie.The success of the film in the world shows that the new trend of the integration of Chinese and Western culture in the context of globalization. At the end of the paper, it gives the inspiration of the film "Kung Fu Panda" to the Chinese culture communication.展开更多
目的:了解重症监护病房(Intensive Care Unit,ICU)护士面对患者死亡的情感体验,探究存在替代性创伤反应的ICU护士面对患者死亡的情感体验。方法:本研究采用描述性现象学的研究设计,选取ICU存在替代性创伤反应(灾难救助者替代性创伤问卷...目的:了解重症监护病房(Intensive Care Unit,ICU)护士面对患者死亡的情感体验,探究存在替代性创伤反应的ICU护士面对患者死亡的情感体验。方法:本研究采用描述性现象学的研究设计,选取ICU存在替代性创伤反应(灾难救助者替代性创伤问卷各因子及总分超过理论中值)的责任护士16例,对其个体生活的参考框架、自我能力、自我资源、心理需求与认知图式和意象进行深入访谈,运用Colaizzi7步分析法进行资料分析。结果:ICU护士面对患者死亡的情感体验归纳为应激刺激下的自我防御和持续浸润后的情感内耗2个主题,其中应激刺激下的自我防御包括无意识的短暂封闭和个人化的情绪反应;持续浸润后的情绪内耗包括镜像复制患方情绪、尸体料理触发终结感、安慰家属束手无策、难以避免承担责任、消磨职业的归属感以及家庭成员关系严峻。结论:本研究总结了ICU护士面对患者死亡的双重情感体验,即应激刺激下的自我防御和持续浸润后的情感内耗。展开更多
BACKGROUND Acute upper gastrointestinal bleeding is a common medical emergency that has a 10%hospital mortality rate.According to the etiology,this disease can be divided into acute varicose veins and nonvaricose vein...BACKGROUND Acute upper gastrointestinal bleeding is a common medical emergency that has a 10%hospital mortality rate.According to the etiology,this disease can be divided into acute varicose veins and nonvaricose veins.Bleeding from esophageal varices is a life-threatening complication of portal hypertension.Portal hypertension is a clinical syndrome defined as a portal venous pressure that exceeds 10 mmHg.Cirrhosis is the most common cause of portal hypertension,and thrombosis of the portal system not associated with liver cirrhosis is the second most common cause of portal hypertension in the Western world.Primary myeloproliferative disorders are the main cause of portal venous thrombosis,and somatic mutations in the Janus kinase 2 gene(JAK2 V617F)can be found in approximately 90% of polycythemia vera,50% of essential thrombocyrosis and 50% of primary myelofibrosis.CASE SUMMARY We present a rare case of primary myelofibrosis with gastrointestinal bleeding as the primary manifestation that presented as portal-superior-splenic mesenteric vein thrombosis.Peripheral blood tests revealed the presence of the JAK2 V617F mutation.Bone marrow biopsy ultimately confirmed the diagnosis of myelofibrosis(MF-2 grade).CONCLUSION In patients with acute esophageal variceal bleeding due to portal hypertension and vein thrombosis without cirrhosis,the possibility of myeloproliferative neoplasms should be considered,and the JAK2 mutation test should be performed.展开更多
基金supported by the Key scientific and technological project in Qinghai Province,China (2006-N-143)
文摘Objective To explore the mechanisms involved in the ligustrazine alleviation of the pulmonary artery hypertension(PAH) in patients of chronic obstructive pulmonary disease(COPD) associated with chronic cor pulmonale(CCP) during exacerbation.Methods Seventy patients of COPD and CCP with acute exacerbation were randomly and equally divided into control group and treatment group.The control group received standard treatment with antibiotics,antiasthmatic and expectorant medications,and oxygenation;and the ligustrazine treatment group received ligustrazine treatment(80 mg/d;i.v.;for 2 weeks) in addition to the standard treatment.Before and at the end of 2 week treatment,the clinic responses of the two regimens were evaluated,plasma levels of endothelin-1(ET-1) and nitric oxide(NO) were determined;arterial oxygen partial pressure(PaO_2),mean pulmonary arterial pressure(mPAP),outflow tract of right ventricle(RVOT),and internal diameter of right ventricle(RV) were measured.Results Good clinic benefits were achieved in both the standard and ligustrazine regimens,plasma level of ET-1,values of mPAP,RV and RVOT decreased significantly,plasma level of NO and PaO_2 values decreased(all P<0.01 vs pretreatment to all parameters).Compared with the control group,ligustrazine greatly enhanced the clinic efficacy from 77.1%to 97.1%(P<0.05),and also resulted in more significant changes of all these parameters(P<0.01 vs control group for all parameters).For both groups,the levels of plasma ET-1 were positively correlated with values of mPAP,RVOT,and RV(r = 0.710,0.853,and 0.766,respectively,all P = 0.000),and negatively correlated with plasma NO and PaO_2(r =- 0.823,and- 0.752,respectively,all P = 0.000).Conclusion Ligustrazine is effective in treating pulmonary artery hypertension during acute exacerbation of COPD and CCP in patients from the plateau area.The observed changes in the plasma levels of NO and ET-1 in response to ligustrazine treatment suggest that ligustrazine may act through the selective effect on pulmonary blood vessels to enhance the synthesis and release of NO and suppress those of ET-1 from lung vascular endothelial cells,thus reducing pulmonary artery pressure and decreasing pulmonary arterial hypertension.
基金Supported by the National Natural Science Foundation of China (No.81974133)。
文摘AIM:To observe the changes in Schlemm’s canal(SC),trabecular meshwork(TM),and anterior chamber relevant parameters after small incision lenticule extraction(SMILE) of myopia patients.METHODS:A total of 58 eyes from 30 patients who underwent SMILE were divided into a low and moderate myopia group(group A,32 eyes) and a high myopia group(group B,26 eyes).The diameter and area of the SC,the width and thickness of TM obtained by CIRRUS HD-OCT5000,and the related anterior chamber parameters obtained by Pentacam anterior segment analysis system,accommodation amplitude(AMP) were observed pre-and postoperatively.The preoperative intraocular pressure(IOP) and postoperative correction of intraocular pressure(IOPcc) were measured.RESULTS:The diameter and area of the SC in the two groups were significantly increased postoperatively(all P<0.01).The TM width of the patients in the two groups were increased at 1mo after surgery(both P<0.01),but the TM thickness did not change(P>0.05).The corneal curvature,central anterior chamber depth,and anterior chamber volume decreased after SMILE surgery(all P<0.01).There was a weak negative correlation between the SC area change and AMP change in group A(r=-0.362,P<0.01).The postoperative IOP decreased after correction by Shah formula(P<0.05).CONCLUSION:SC and TM in myopia patients change in the early postoperative stage of SMILE and the IOP is decline.
基金supported by a grant from National Science Foundation for Young Scientists of China(Grant No.41702143)Natural Science Foundation of Shandong Province of China(ZR2016DL06+3 种基金ZR2017LD005)the Fundamental Research Funds for the Central Universities(17CX02006A)the Foundation of Shandong Provincial Key Laboratory of Depositional Mineralization&Sedimentary Mineral(DMSM2017063)the major science and technology project of Xinjiang Petroleum Administration Bureau of CNPC(2017E-0401)。
文摘Biodegradation usually obscures or even radically alters the original characteristics of oil biomarkers.The mixing of oil from multiple sources makes each source difficult to trace.Identifying the source of biodegraded oil from multiple sources has always been a hard nut to crack.Rising to this challenge,in this study-we carried out a comprehensive investigation of biodegradation impacts,oil-source correlation,and oil charging history to trace the source and reveal the mixing process of biodegraded oil in the Toutunhe Formation(J_(2)t)in the eastern Junggar Basin,NW China.The oil of this area was biodegraded to different extent,consequently,many commonly used biomarker parameters(e.g.Pr/Ph,Pr/n C_(17))became less powerful for oil-source correlation.To address this problem,the resistance of many biomarkers to biodegradation was analyzed,and those of high bio resistance were selected to generate a more reliable oil-source correlation.The results revealed that biodegraded oil was a mixture of oil sourced from Lucaogou Formation(P_(2)l)and Xiaoquangou Formation(T_(2-3)xq).Core sample observation,microscopic fluorescent analysis and fluid inclusion analysis were combined to analyze comprehensively oil charging history.The analysis of accumulation process exhibited that the existing oil in J_(2)t was a mixture originated from the P_(2)l and T_(2-3)xq source rocks in two separate charging stages when it underwent a complicated process of charging,biodegradation,recharging and mixing.
基金supported by grants from the Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine (ZYYCXTD-C-202003)the China Academy of Chinese Medical Sciences Evidence-based Capacity Improvement Project (ZZ13-024-7)
文摘Objective: To assess the effectiveness and safety of manipulation intervention for degenerative lumbar spondylolisthesis(DLS).Methods: This is a systematic review and meta-analysis. A full-scale retrieval method was performed until February 1, 2021, including nine databases. The homogeneity of different studies was summarized using the Review Manager. The quality of studies was determined with the Cochrane risk-of-bias tool.The evidence quality was graded with the Grading of Recommendations, Assessment, Development, and Evaluations approach.Results: A total of 6 studies involving 524 participants were included. The review demonstrated that manipulation has statistically significant improvements for treating DLS according to Japanese Orthopedic Association scores(mean difference, 3.76;95% confidence interval, 2.63 to 4.90;P <.001) and visual analog scale scores(mean difference,-1.50;95% confidence interval,-1.66 to-1.33;P <.001)compared to the control group. One study reported that the difference in the Oswestry Disability Index between the traction group and the combination of manipulation and traction group was statistically significant(P <.05), while another reported that manipulation treatment can significantly improve the lumbar spine rotation angle on X-ray images compared with the baseline data(P <.05). Moreover, the manipulation group(experimental group) had fewer adverse events than the lumbar traction group(control group).Conclusion: Manipulation intervention is more effective and safer for DLS. Nevertheless, large-scale randomized controlled trials are required to confirm the current conclusions.
基金Special project of Chinese medicine funded by national administration of Chinese traditional medicine(No.2014BAI08B06)
文摘Objective:To explore the related factors that may affect the efficacy of traditional Chinese medicine in treating degenerative lumbar spondylolisthesis.Methods:A total of 535 patients with DLS who were treated in Wangjing Hospital of China Academy of Chinese Medical Sciences and other hospitals from June 2011 to October 2014 were selected.The central random system was used to randomly divide the treatment group and control group.This study included 267 patients in the treatment group using the traditional Chinese medicine program((lumbar spine reduction and lumbar spine rehabilitation),36 cases of severely missing data were excluded,and a total of 231 DLS patients were included.Observation indicators were selected using the Visual Analog Scale(VAS)and the Japanese Orthopaedic Association(JOA)for the evaluation of lumbar vertebral disorders.The clinical efficacy was evaluated using the JOA lumbar pain curative effect evaluation standard[7].[(Joa score after treatment-JOA score before treatment]/(out of 29 points-JOA score before treatment)]×100%.The JOA score and the change of the efficacy index of the patients were observed.According to the JOA efficacy index after the treatment,it was divided into significant effect(≥50%)and poor effect(<50%).Single-factor screening and multi-factor Logistic regression analysis were used.Gender,age,course of disease,BMI index,slip-off segment,slip-off direction,back pain VAS score,total JOA score,back pain-score,lower limb pain and numbness-score,walking ability-score,straight leg elevation test-score,Feeling-scoring,muscle strength-scoring,supine turn-scoring,standing action-scoring,washing action-scoring,standing posture and continuous standing-scoring,long sedentary-scoring,weight lifting and holding-scoring,walking-scoring 2.Bladder function-scores were assigned to logistic regression models for univariate analysis,and meaningful independent variables were screened for multivariate logistic regression.Results:No serious adverse reactions occurred in the patients included in this study.According to the comparison of JOA scores before and after treatment,the results of the index of efficacy index showed that the effective rate of DLS in this project was 96.6%,and a significant effect of 77.6%was achieved.Univariate Logistic regression analysis showed that the duration of disease,supine turn-scoring,washing action-scoring,prolonged sedentary-scoring,weight lifting and keeping-scoring had statistically significant effects on the inclusion of patients with significant efficacy(P<0.05);single factor logistic regression analysis of total score of JOA score before treatment was not statistically significant(P=0.215),but because it is important for evaluating the patient's condition,it was included in multifactor logistic regression analysis at the same time.Course of onset,supine turn-scoring,washing action-scoring,prolonged sedentary-scoring,weight lifting and holding-scoring,JOA score before treatment.Six independent variables were substituted into the two-class logistic regression model for multivariate analysis..Multivariate logistic regression analysis showed that the effects of total JOA score and supine turn-scoring before treatment on the efficacy of patients were statistically significant(P<0.05).There are many factors influencing the efficacy of traditional Chinese medicine treatment of DLS,and the probability of obtaining a significant effect for each additional point of JOA score and supine turn-score before treatment increases by 1.167 and 0.410 times,respectively.Conclusion:The clinical application of lumbar spine reduction combined with lumbar rehabilitation exercises in patients with degenerative lumbar spondylolisthesis with a higher total JOA score or a lower limit of supine turning can achieve better clinical results.This finding has certain guiding significance for the clinical application of this therapy in the treatment of DLS,and is beneficial to improving patient satisfaction and clinical effectiveness.
基金International cooperation project of State Administration of traditional Chinese medicine(gzyygj2018032)Special cultural project of international cooperation of State Administration of traditional Chinese medicine(gzyygj2019054)+3 种基金Scientific research projects in key fields of the 13th five year plan of the Chinese Academy of traditional Chinese medicine(zz10-015,zz10-022)Independent topic selection of graduate innovation and Entrepreneurship(2019-jyb-xscxcy-05)NSFC project(201908110307)Doctoral innovation fund of Chinese Academy of traditional Chinese medicine(cx201905)
文摘Knee osteoarthritis(KOA)is the highest incidence of osteoarthritis,which seriously affects the quality of life of patients.In order to update the understanding of the disease,clear diagnostic criteria and appropriate treatment were proposed.In 2018 and 2019,the European Society for Clinical and Economic Aspects of Osteoporosis,Osteoarthritis and Musculoskeletal Diseases(ESCEO),the Association of the Scientific Medical Societies in Germany(AWMF)and Brazil successively formulated guidelines for knee osteoarthritis,which determined different guidance suggestions through systematic evaluation of a large number of literatures and evidence-based medical evidence analysis.This paper compares and interprets the guidelines,and discusses them according to the actual situation of our country for the reference of clinicians.
基金Key projects of the national natural science foundation of China(No.81930118)National support program for leading talents in traditional Chinese medicine--"Qi-huang scholars"program+1 种基金Key research projects of the 13th five-year plan of the China academy of Chinese medical sciences(No.ZZ10-022)Jiangxi province postdoctoral subsidy project(No.2018RC13).
文摘Objective:To systematically evaluate the efficacy and safety of Duhuo Jisheng decoction combined with manipulation in the treatment of lumbar disc herniation.Method:We systematically searched 8 databases at home and abroad.Literature quality of the included studies was evaluated by the bias risk assessment tool of Cochrane collaboration network,and the Meta-analysis was performed by RevMan 5.3 software.Result:A total of 427 related literature were retrieved,and 12 studies were eventually included,involving 1153 patients.All studies were in Chinese.Meta-analysis results showed that the total effective rate of Duhuo Jisheng decoction combined with manipulation in the treatment of LDH was better than that of the control group(RR=1.23,95%CI[1.17,1.29],P<0.00001).Subgroup analysis showed that Duhuo Jisheng decoction combined with manipulation had a more significant effect than conventional treatment(RR=1.34,95%CI[1.20,1.50],P<0.00001),nonsteroidal anti-inflammatory drugs(RR=1.24,95%CI[1.12,1.37],P<0.0001),and Yaotongning capsules(RR=1.19,95%CI[1.10,1.29],P<0.0001).It has obvious advantages in improving VAS scores(MD=-1.19,95%CI-1.19[-1.87,-0.51],P=0.0006),but it has no obvious advantages in improving JOA scores(MD=2.6595%CI[0.06,5.24],P=0.05).In terms of safety,Duhuo Jisheng decoction combined with manipulation treatment reported fewer adverse events.Conclusion:The Duhuo Jisheng decoction combined with manipulation treatment can effectively relieve the clinical symptoms of patients with lumbar disc herniation,with obvious clinical efficacy,and fewer adverse events.But in view of the limitations of clinical studies,there are some limitations in this study,and more studies with high quality of evidence are needed to further confirm its efficacy and safety.
文摘Objective:To review and evaluate the quality of the randomized controlled trials of exercise for the treatment of cervical radiculopathy with the present internationally recognized CONSORT statement, which provides reference and basis for the improvement of clinical research on exercise for intervening cervical radiculopathy in the future.Methods: A computer-based search of large domestic databases, including CNKI, Wanfang database and VIP database screened out literature that meet the requirements and used CONSORT statement for quality assessment.Results: According to the prescribed inclusion and exclusion criteria, 30 articles were retrieved in accordance with the standard. No literature was referred to the randomized controlled trial, 2 documents clearly defined the type of test design, 1 documents carried out the calculation of sample size, 13 documents clearly randomly assigned, 1 literature implemented the blind method, in the 7 literature, baseline information was shown in tabular form, and no reference was made to trial registration, trial protocol and funding.Conclusion:There are some aspects of randomized controlled trials on exercise for the treatment of cervical radiculopathy. However, there are some aspects that need to be improved. In the future randomized controlled trial report, the CONSORT statement should be highly valued and carefully considered to improve the accuracy and credibility of the research.
文摘THE 47th session of the UN Human Rights Council concluded on July 14 in Geneva,Switzerland.China’s stance on human rights was widely supported and responded to at the session,and the country also received high evaluation for its sense of responsibility to drive the progress of human rights of the world.
文摘This paper introduces the film "Kung Fu Panda," which contains the elements of Chinese culture and Western culture, respectively, from the philosophical thinking, animal image, folk life and expression of Chinglish and etiquette introduced Chinese elements, from individualism, fatalism and character introduced western culture reflected in the movie.The success of the film in the world shows that the new trend of the integration of Chinese and Western culture in the context of globalization. At the end of the paper, it gives the inspiration of the film "Kung Fu Panda" to the Chinese culture communication.
文摘目的:了解重症监护病房(Intensive Care Unit,ICU)护士面对患者死亡的情感体验,探究存在替代性创伤反应的ICU护士面对患者死亡的情感体验。方法:本研究采用描述性现象学的研究设计,选取ICU存在替代性创伤反应(灾难救助者替代性创伤问卷各因子及总分超过理论中值)的责任护士16例,对其个体生活的参考框架、自我能力、自我资源、心理需求与认知图式和意象进行深入访谈,运用Colaizzi7步分析法进行资料分析。结果:ICU护士面对患者死亡的情感体验归纳为应激刺激下的自我防御和持续浸润后的情感内耗2个主题,其中应激刺激下的自我防御包括无意识的短暂封闭和个人化的情绪反应;持续浸润后的情绪内耗包括镜像复制患方情绪、尸体料理触发终结感、安慰家属束手无策、难以避免承担责任、消磨职业的归属感以及家庭成员关系严峻。结论:本研究总结了ICU护士面对患者死亡的双重情感体验,即应激刺激下的自我防御和持续浸润后的情感内耗。
文摘BACKGROUND Acute upper gastrointestinal bleeding is a common medical emergency that has a 10%hospital mortality rate.According to the etiology,this disease can be divided into acute varicose veins and nonvaricose veins.Bleeding from esophageal varices is a life-threatening complication of portal hypertension.Portal hypertension is a clinical syndrome defined as a portal venous pressure that exceeds 10 mmHg.Cirrhosis is the most common cause of portal hypertension,and thrombosis of the portal system not associated with liver cirrhosis is the second most common cause of portal hypertension in the Western world.Primary myeloproliferative disorders are the main cause of portal venous thrombosis,and somatic mutations in the Janus kinase 2 gene(JAK2 V617F)can be found in approximately 90% of polycythemia vera,50% of essential thrombocyrosis and 50% of primary myelofibrosis.CASE SUMMARY We present a rare case of primary myelofibrosis with gastrointestinal bleeding as the primary manifestation that presented as portal-superior-splenic mesenteric vein thrombosis.Peripheral blood tests revealed the presence of the JAK2 V617F mutation.Bone marrow biopsy ultimately confirmed the diagnosis of myelofibrosis(MF-2 grade).CONCLUSION In patients with acute esophageal variceal bleeding due to portal hypertension and vein thrombosis without cirrhosis,the possibility of myeloproliferative neoplasms should be considered,and the JAK2 mutation test should be performed.