Energy-Saving Distributed Flexible Job Shop Scheduling Optimization with Dual Resource Constraints Based on Integrated Q-Learning Multi-Objective Grey Wolf Optimizer

The distributed flexible job shop scheduling problem(DFJSP)has attracted great attention with the growth of the global manufacturing industry.General DFJSP research only considers machine constraints and ignores worker constraints.As one critical factor of production,effective utilization of worker resources can increase productivity.Meanwhile,energy consumption is a growing concern due to the increasingly serious environmental issues.Therefore,the distributed flexible job shop scheduling problem with dual resource constraints(DFJSP-DRC)for minimizing makespan and total energy consumption is studied in this paper.To solve the problem,we present a multi-objective mathematical model for DFJSP-DRC and propose a Q-learning-based multi-objective grey wolf optimizer(Q-MOGWO).In Q-MOGWO,high-quality initial solutions are generated by a hybrid initialization strategy,and an improved active decoding strategy is designed to obtain the scheduling schemes.To further enhance the local search capability and expand the solution space,two wolf predation strategies and three critical factory neighborhood structures based on Q-learning are proposed.These strategies and structures enable Q-MOGWO to explore the solution space more efficiently and thus find better Pareto solutions.The effectiveness of Q-MOGWO in addressing DFJSP-DRC is verified through comparison with four algorithms using 45 instances.The results reveal that Q-MOGWO outperforms comparison algorithms in terms of solution quality.

Response of warm season secondary pollutants to emissions and meteorology in the North China Plain region during 2018-2022

自2013年起中国空气质量虽改善,但华北平原(NCP)重污染仍存在且二次污染加剧,而人们对其成因和变化了解有限.本研究利用2018-2022年数据,借助CMAQ模型探讨此污染响应.结果显示,在2018-2022年间,PM_(2.5)浓度显著下降31%-37%,O_(3)和NO_(2)的年下降速率分别为1%和0.5%SIA和SOA也显著减少,每年分别减少9%和6%PM_(2.5)主要因排放减少而下降,而O_(3)则受气象影响而波动.硫酸盐和铵下降的主因是减排,而硝酸盐对气象变化敏感排放和气象变化对SOA的总体减少同样重要,但人为SOA对排放控制敏感生物SOA易受气象变化影响.研究强调了控制人为排放对缓解NCP地区夏季二次污染的重要性.

Temporal transcriptomics reveal the molecular mechanism of dormancy and germination regulated by temperature in Paris polyphylla seed

The mature seed of Paris polyphylla var.chinensis(PPC)is morphophysiologically dormant and develops differently under warm and cold temperatures.To elucidate the molecular mechanisms underlying temperature-dependent regulation of PPC seed dormancy and germination,we investigated the dynamic changes in PPC seed transcript levels under warm and cold temperature stratifications(WS and CS,respectively)by time-resolved RNA sequencing,focusing on genes related to hormone metabolism and signaling and cell wall remodeling(CWRM)and encoding transcription factors/regulators(TFs/TRs).A total of 48765 and 47836 differentially expressed genes(DEGs)were associated with WS and CS,respectively.Of these,17581 and 16652 DEGs,respectively,unique to WS and CS,and 5386 were common to both temperature stratifications across nine analyzed growth stages.The expression of hormone metabolism and signaling,TF/TR,and CWRM genes were closely associated with temperature.More genes related to gibberellin(GA),cytokinin,auxin,and brassinosteroid biosynthetic were upregulated in WS as compared to CS seeds,while genes related to dormancy release and germination were downregulated in WS seeds.However,only GA and abscisic acid levels were altered in PPC seeds breaking morphophysiological dormancy(MPD).Overall,37 TF and five TR families were upregulated whereas 24 TF and 16 TR families were downregulated in WS as compared to CS seeds.Most CWRM families were highly expressed under WS as compared to CS,suggesting that they promote endosperm weakening and embryo growth of WS seeds and facilitate MPD release and germination.A coexpression analysis revealed positive correlations between TFs/TRs and DEGs involved in hormone metabolism and signaling and CWRM.These results provided a basis for investigating the interaction between the endosperm and underdeveloped embryo in the regulation of PPC seed germination and seedling emergence.

敲低特异性环状非编码RNA显著抑制骨肉瘤的进展

骨肉瘤是一种间充质组织来源的恶性肿瘤,好发于儿童和青少年,发生肺转移常导致患者死亡。关于骨肉瘤进展的机制仍不清楚。因此,迫切需要开发新的骨肉瘤治疗靶点和治疗模式。异常表达的非编码环状RNA(circRNA)对骨肉瘤的发生和发展至关重要。本研究的目的是探索一种新的circRNA circ_000203在骨肉瘤中的表达和作用,阐明其潜在机制。我们发现,在骨肉瘤细胞系和组织中circ_000203高表达,并且circ_000203敲低显著抑制了体外和体内的骨肉瘤进展。此外,我们发现circ_000203是miR-26b-5p的海绵,而miR-26b-5p是骨形态发生蛋白受体2(BMPR2)的上游调节因子。因此,BMPR2的过表达可以减轻对骨肉瘤进展的抑制作用。这表明,敲低circ_000203可通过miRNA介导的BMPR2下调抑制骨肉瘤的进展。我们的发现为理解骨肉瘤的发生和发展提供了重要的见解。

Spatial and Temporal Variations in the Atmospheric Age Distribution of Primary and Secondary Inorganic Aerosols in China

The aging timescale of particles is a key parameter in determining their impacts on air quality,human health,and climate.In this study,a one-year simulation of the age distributions of the primary and secondary inorganic fine particulate matter(PM_(2.5))components was conducted over China using an age-resolved Community Multiscale Air Quality(CMAQ)model.The results indicate that primary PM_(2.5)(PPM)and ammonium mainly originate from fresh local emissions,with approximately 60%-80%concentrated in 0-24 h age bins in most of China throughout the year.The average age is about15-25 h in most regions in summer,but increases to 40-50 h in southern region of China and the Sichuan Basin(SCB)in winter.Sulfate is more aged than PPM,indicating an enhanced contribution from regional transport.Aged sulfate with atmospheric age>48 h account for 30%-50%of total sulfate in most regions and seasons,and the concentrations in the>96 h age bin can reach up to 15μg·m-3 in SCB during winter.Dramatic seasonal variations occur in the Yangtze River Delta,Pearl River Delta,and SCB,with highest average age of 60-70 h in winter and lowest of 40-45 h in summer.The average age of nitrate is 20-30 h in summer and increases to 40-50 h in winter.The enhanced deposition rate of nitric acid vapor combined with the faster chemical reaction rate of nitrogen oxides leads to a lower atmospheric age in summer.Additionally,on pollution days,the contributions of old age bins(>24 h)increase notably for both PPM and secondary inorganic aerosols in most cities and seasons,suggesting that regional transport plays a vital role during haze events.The age information of PM_(2.5),provided by the age-resolved CMAQ model,can help policymakers design effective emergent emission control measures to eliminate severe haze episodes.

Consumption Based Source Apportionment Indicates Different Regional Contributions to O3 Concentrations and Health Effects

China is confronting aggravated ozone(O_(3))pollution,leading to adverse health impacts.This study quantifies the regional contributions to O_(3)in China using two approaches;estimating(1)where goods are produced(the production method),and(2)where goods are consumed(the consumption method).The production method predicts higher local source contribution than the consumption method;this difference can be attributed to exports.Occurrence of high-O_(3)episodes suggests a major contribution to O_(3)concentration as a result of trade activities.Based on the consumption method,9219 out of 18532 daily premature mortalities were caused by local sources in north China,while it increased to 14471 of the production method when neglecting contributions due to export and consumption in other regions.This study suggests that O_(3)control should consider both where goods are consumed and emissions are emitted,especially taking account of international trade activities.

肿瘤化疗致胃肠不适或恶心呕吐的预防用药临床指南系统评价

目的系统评价预防化疗相关恶心呕吐或胃肠不适相关指南,为临床治疗提供循证参考。方法计算机检索PubMed、EMbase、中国生物医学文献数据库(CBM)、万方数据库(Wanfang Data)、中国知网(CNKI)、维普中文科技期刊数据库(VIP)、美国国立指南数据库(NGC)、国际指南数据库(GIN)、TRIP指南数据、英国国家优化卫生与保健研究所(NICE)网站以及国内外各大医学会和行业机构网站。按照纳入与排除标准筛选文献,采用指南研究与评价的评审工具Ⅱ(AGREEⅡ)评价纳入指南的方法学质量,使用组内相关系数(ICC)进行评价员间一致性检验,分析比较各指南推荐的异同。结果最终纳入指南6篇,制定时间2004—2016年,其中美国2篇,中国、英国、西班牙、瑞士各1篇。指南最终推荐级别为B级4个,C级2个。在AGREEⅡ6个领域中"清晰性"平均得分最高,得分较低的是"制定的严谨性"和"应用性"。对于不同等级催吐风险的抗肿瘤药物引起的恶心呕吐,各指南推荐的化疗第1天预防用药种类基本一致。当患者出现消化不良症状,为预防胃酸过多症和消化性溃疡,可使用H2受体阻断药或质子泵抑制药进行抗酸治疗,从而减少恶心呕吐等不良反应。结论各指南AGREEⅡ6个领域评分各有高低,在今后相关指南的制定中应重视指南制定的严谨性和应用性。肿瘤化疗患者不推荐常规使用质子泵抑制药。

Hydro-Chemical Processes in Lake Qinghai throughout Climate Warming: In Situ Investigations of the Largest Lake in China

In the wake of climate warming, the water level of Lake Qinghai has been continuously and rapidly declining during the past decades, causing the regional government and citizens to worry about its future as a water resource. To understand the lake evolution process, the hydro-chemical characteristics of Lake Qinghai were investigated in August of 2008. The results show that Na+ and Cl- are the dominant cations and anions in the lake water, respectively, and hydrochemistry type is Cl-- Na+ with an obvious characteristic of a saline lake. The Gibbs plot illuminates that evaporation/crystallization is responsible for the chemical composition of the lake water. The variation in hydro-chemical regime might be attributed to the reduced lake levels between 1960s and 2000s. The lake level significantly correlated with the precipitation and evaporation in the Lake Qinghai catchment. In addition, changes of the lake level in the future are simulated according to climate warming scenarios from the IPCC report. The simulated results suggest that the lake level could rise again in the following decades due to the increased precipitation under the climate warming conditions, which is already a trend in the lake level observation data.

业绩考核制度与中央企业全要素生产率——基于一项准自然实验的研究

全要素生产率是反映资源配置效率与质量的重要指标,特别是在"双循环"的背景下,对于国民经济发展具有重要影响的央企如何提高其全要素生产率是政府部门及学界关注的重要问题。业绩考核制度对于央企高管决策具有导向性影响,通过准自然实验的方法,检验了业绩考核制度与央企全要素生产率的关系,并发现业绩考核制度有利于改善企业全要素生产率。机制检验结果表明,其中潜在的作用路径为提高央企信息透明度和创新水平。进一步研究发现,在不同的作用环境中,业绩考核制度与央企全要素生产率的关系存在差异,即这一促进作用更多地反映在法制环境较好、市场竞争更充分的环境中。研究结论不仅丰富了全要素生产率影响因素的相关文献,而且为国资监管部门制定相关政策提供了参考。

现代楼房养猪智能化环境控制及疾病预防技术概述

如今,非洲猪瘟的疫情对国内养猪行业影响巨大,猪场的生物安全备受关注,我国的养猪模式在此基础上发生了改变,由原来的小户散养逐渐转型为集约化、集团化养殖;近年来,国家对土地资源的管控使得养殖用地愈发紧张,我国对猪肉的高需求量得不到满足,"楼房养殖"这一概念逐渐被推出到大家的视野中。文章主要分析了楼房养殖的现状、优势、痛点的问题;并对楼房养殖的智能化环境控制和疾病预防技术进行介绍。

Critical illness polyneuropathy and myopathy:a systematic review

Critical illness polyneuropathy and critical illness myopathy are frequent complications of severe illness that involve sensorimotor axons and skeletal muscles, respectively. Clinically, they manifest as limb and respiratory muscle weakness. Critical illness polyneuropathy/myopathy in isolation or combination increases intensive care unit morbidity via the inability or difficulty in weaning these patients off mechanical ventilation. Many patients continue to suffer from decreased exercise capacity and compromised quality of life for months to years after the acute event. Substantial progress has been made lately in the understanding of the pathophysiology of critical illness polyneuropathy and myopathy. Clinical and ancillary test results should be carefully interpreted to differentiate critical illness polyneuropathy/myopathy from similar weaknesses in this patient population. The present review is aimed at providing the latest knowledge concerning the pathophysiology of critical illness polyneuropathy/myopathy along with relevant clinical, diagnostic, differentiating, and treatment information for this debilitat- ing neurological disease.

Preparation of N‐vacancy‐doped g‐C_3N_4 with outstanding photocatalytic H_2O_2 production ability by dielectric barrier discharge plasma treatment

Dielectric barrier discharge（DBD） plasma is considered to be a promising method to synthesize solid catalysts. In this work, DBD plasma was used to synthesize a nitrogen‐vacancy‐doped g‐C3N4 catalyst in situ for the first time. X‐ray diffraction, N2 adsorption, ultraviolet–visible spectroscopy, scanning electron microscopy, transmission electron microscopy, X‐ray photoelectron spectrosco‐py, electrochemical impedance spectroscopy, electron paramagnetic resonance, O2 tempera‐ture‐programmed desorption, and photoluminescence were used to characterize the obtained cat‐alysts. The photocatalytic H2O2 production ability of the as‐prepared catalyst was investigated. The results show that plasma treatment influences the morphology, structure, and optical properties of the as‐prepared catalyst. Nitrogen vacancies are active centers, which can adsorb reactant oxygen molecules, trap photoelectrons, and promote the transfer of photoelectrons from the catalyst to the adsorbed oxygen molecules for the subsequent reduction reaction. This work provides a new strat‐egy for synthesizing g‐C3N4‐based catalysts.

GNP6,a novel allele of MOC1,regulates panicle and tiller development in rice

The yield of rice is mostly affected by three factors,namely,panicle number,grain number and grain weight.Variation in panicle and grain numbers is mainly caused by tiller and panicle branches generated from axillary meristems(AMs).MOC1 encodes a putative GRAS family nuclear protein that regulates AM formation.Although several alleles of MOC1 have been identified,its variation in germplasm resources remains unclear.In the present study we characterized a novel mocl allele named gnp6 which has a thymine insertion in the coding sequence of the SAW motif in the GRAS domain.This mutation causes arrested branch formation.The SAW motif is necessary for nuclear localization of GNP6/MOC1 where it functions as a transcription factor or co-regulator.Haplotype analysis showed that the coding region of GNP6/MOC1 was conserved without any non-synonymous mutations in 240 rice accessions.However,variation in the promoter region might affect the expression of it and its downstream genes.Joint haplotype analysis of GNP6/MOC1 and MOC3 showed that haplotype combinations H9,H10 and H11,namely MOC1-Hap1 in combination with MOC3-Hap3,MOC3-Hap4 or MOC3-Hap5 could be bred to promote branch formation.These findings will enrich the genetic resources available for rice breeders.

Genetic control of panicle architecture in rice

Rice panicle architecture affects grain number per panicle and thereby grain yield.Many genes involved in control of panicle architecture have been identified in the past decades.According to their effect on phenotype,these genes are divided into three categories:panicle branch and lateral spikelets,multifloret spikelets,and panicle type.We review these genes,describe their genetic regulatory network,and propose a strategy for using them in rice breeding.These findings on rice panicle architecture may facilitate related studies in other crops.

A Cell Condition-Sensitive Frequency Segmentation Method Based on the Sub-Band Instantaneous Energy Spectrum of Aluminum Electrolysis Cell Voltage

Cell voltage is a widely used signal that can be measured online from an industrial aluminum electrolysis cell.A variety of parameters for the analysis and control of industrial cells are calculated using the cell voltage.In this paper,the frequency segmentation of cell voltage is used as the basis for designing filters to obtain these parameters.Based on the qualitative analysis of the cell voltage,the sub-band instantaneous energy spectrum(SIEP)is first proposed,which is then used to quantitatively represent the characteristics of the designated frequency bands of the cell voltage under various cell conditions.Ultimately,a cell condition-sensitive frequency segmentation method is given.The proposed frequency segmentation method divides the effective frequency band into the[0,0.001]Hz band of lowfrequency signals and the[0.001,0.050]Hz band of low-frequency noise,and subdivides the lowfrequency noise into the[0.001,0.010]Hz band of metal pad abnormal rolling and the[0.01,0.05]Hz band of sub-low-frequency noise.Compared with the instantaneous energy spectrum based on empirical mode decomposition,the SIEP more finely represents the law of energy change with time in any designated frequency band within the effective frequency band of the cell voltage.The proposed frequency segmentation method is more sensitive to cell condition changes and can obtain more elaborate details of online cell condition information,thus providing a more reliable and accurate online basis for cell condition monitoring and control decisions.

Tumor necrosis factor-alpha in experimental autoimmune neuritis

Tumor necrosis factor-α （TNF-α） plays a key role in the pathogenesis of experimental autoimmune neuritis （EAN） as well as Guillain-Barre syndrome. The proposed pathogenesis of TNF-α associated neuropathies involves immune-mediated attack to blood-nerve barrier, aggravated production of pro-inflammatory cytokines, and the induction of Schwann cells apoptosis. TNF-α may play a regulatory role by increasing production of interleukin-1 in macrophages, attenuating T cell receptor signaling and regulating apoptosis of potentially autoreactive T cells in EAN. The data suggest that antagonizing TNF-α functions or suppressing TNF-α production may be useful in the acute phase of EAN treatment, but further studies are required.

Petrogenesis, geochemistry and geological significance of Paleocene Granite in South Gangdese, Tibet

The Gangdese magmatic belt,located along the southern margin of the Lhasa terrane,plays a critical role in understanding the tectonic framework associated with the Indian-Asian slab collision.In this paper,a chronology of zircon U-Pb and geochemical analysis of the rock of the Cuobulaguo granitic mass in the southern of the Gangdese,Tibet,revealed a series of results.The results show that the LA-ICP-MS monzonitic granite zircon U-Pb ages are 61-59 Ma,which corresponds to the same period as the magmatic arc of the southern limit of Gangdese.In terms of geochemical composition,the granite is rich inω(SiO2)70.09%to 72.64%,with a highω(Al2O3)14.40%to 15.99%,a lowω(TiO2)0.08%to 0.24%,ω(MgO)0.41%to 0.76%,ω(Fe2O)6.82%to 29.9%,ω(P2Os)0.07%to 0.12%,andω(CaO)1.06%to 1.75%.The granite mainly belongs to the high-K calc-alkaline series.The light rare earth element(LREE)content of skeletal granite is between 133.69×10^-6〜226.64×10^-6 and the heavy rare earth element(HREE)content is between 17.36×10^-6 and 32.11×10^-6.LREE/HREE is between 5.05 and 7.83.It is enriched in light rare earth elements(LREE)and large ion lithophile elements,such as Rb,K,U,etc.,depletes high field strength elements,such as P,Nb,and Ta,and has the geochemical composition of arc magmatic rocks.In addition,the aluminum saturation index(A/CNK=1.06 to 1.11)of Cuobulaguo granite,belongs toⅠ-type granite.The comprehensive analysis showed that with the beginning of the collision between the Indian-Asian continental,the subduction ocean plate was separated from the continental plate due to gravity,resulting in an increase in the asthenosphere,which made partial fusion of the lithospheric mantle.It invaded the bottom of the lower crust,which in turn induced a partial melting of the lower crust to form granite.

大型施工企业司库体系的框架、工具及运行机制——以中铁十二局为例

司库的理论基础是营运资金管理理论、内部资本市场理论和风险管理理论。在这些理论指导下,我国司库体系建设已经进入第三阶段,即大司库体系阶段。本文以大型施工企业中铁十二局为例,结合中铁十二局司库体系建设的实践,阐述了司库体系运行的结构框架、司库体系运行的信息化工具及十二项主要功能,并根据其运行工具和功能,进一步论述了司库体系运行的六大机制。中铁十二局的司库体系运行效果较好,具有一定的先进性和典型性,积累了比较成熟的运行经验,值得借鉴和推广。

A Fuzzy Probability-based Markov Chain Model for Electric Power Demand Forecasting of Beijing, China

In this study, a fuzzy probability-based Markov chain model is developed for forecasting regional long-term electric power demand. The model can deal with the uncertainties in electric power system and reflect the vague and ambiguous during the process of power load forecasting through allowing uncertainties expressed as fuzzy parameters and discrete intervals. The developed model is applied to predict the electric power demand of Beijing from 2011 to 2019. Different satisfaction degrees of fuzzy parameters are considered as different levels of detail of the statistic data. The results indicate that the model can reflect the high uncertainty of long term power demand, which could support the programming and management of power system. The fuzzy probability Markov chain model is helpful for regional electricity power system managers in not only predicting a long term power load under uncertainty but also providing a basis for making multi-scenarios power generation/development plans.

Frontiers and future perspectives of neuroimmunology

Neuroimmunology is an interdisciplinary branch of biomedical science that emerges from the intersection of studies on the nervous system and the immune system.The complex interplay between the two systems has long been recognized.Research efforts directed at the underlying functional interface and associated pathophysiology,however,have garnered attention only in recent decades.In this narrative review,we highlight significant advances in research on neuroimmune interplay and modulation.A particular focus is on early-and middle-career neuroimmunologists in China and their achievements in frontier areas of"neuroimmune interface","neuro-endocrine-immune network and modulation","neuroimmune interactions in diseases","meningeal lymphatic and glymphatic systems in health and disease",and"tools and methodologies in neuroimmunology research".Key scientific questions and future directions for potential breakthroughs in neuroimmunology research are proposed.