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Molisch反应:发现、原理及应用 被引量:1
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作者 郝志友 陈辉 +4 位作者 曹彦刚 孙彦君 李红伟 郑晓珂 冯卫生 《大学化学》 CAS 2021年第12期63-67,共5页
Molisch反应发现于1886年,此后对糖和苷类化合物的研究提供了强大的定性鉴别工具。本文回顾了Molisch反应的发现过程、反应机理研究及应用,并对该反应在未来的应用进行了展望。
关键词 Molisch反应 反应原理 应用
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Harnessing eco-friendly additives to manipulate zinc-ion solvation structures towards stable zinc metal batteries
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作者 lingmei Wang Hao Shen +7 位作者 Wuzhu Sun Tianle Zheng hongwei li Jicheng Yan Lemeng Ding Zhongti Sun Jingyu Sun Chao li 《Journal of Energy Chemistry》 SCIE EI CAS CSCD 2024年第11期114-122,共9页
Considerable research efforts have been dedicated to investigating the side reactions and the growth of Zn dendritic in aqueous zinc-ion batteries(AZIBs).The incorporation of organic solvents as additives in electroly... Considerable research efforts have been dedicated to investigating the side reactions and the growth of Zn dendritic in aqueous zinc-ion batteries(AZIBs).The incorporation of organic solvents as additives in electrolytes has yielded highly promising results.Nevertheless,their pervasive use has been hindered by concerns regarding their toxicity,flammability,and economic viability.Herein,we propose the utilization of γ-valerolactone(γ-V),a novel eco-friendly solvent,as an alternative for conventional organic additives to improve the performance of Zn anode.Experimental investigations and theoretical analyses have verified that γ-V additives can diminish the Zn^(2+)-desolvation energy and enhance Zn^(2+) transport kinetics.The adsorbed γ-V molecules modulate the nucleation and diffusion of Zn^(2+),facilitating Zn growth along the(002) crystal plane,thus inhibiting dendrite formation and side reactions.Consequently,the modified electrolyte with 3% γ-V exhibit highly reversible cycling for 2800 h at1 mA cm^(-2) and 1 mA h cm^(-2) in Zn//Zn symmetric cell.The Zn//KVOH coin cells deliver a capacity retention of 74.7% after 1000 cycles at 5 A g^(-1).The Zn//KVOH pouch cells maintain a capacity retention of78.7% over 90 cycles at 3 A g^(-1).Notably,the γ-V additives also effectively alleviate the self-discharge phenomenon.This work provides valuable insights on the development of aqueous zinc-ion batteries with superior safety through the modulation of electrolytes using eco-friendly additives. 展开更多
关键词 Aqueous zinc-ion batteries Eco-friendly electrolyte additive γ-Valerolactone Zn anode Renewable energy storage
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Anti-explosion performance and dynamic response of an innovative multi-layer composite explosion containment vessel
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作者 Zhen Wang Heng Chen +3 位作者 Qi Yuan Wenbin Gu Xingbo Xie hongwei li 《Defence Technology(防务技术)》 SCIE EI CAS CSCD 2024年第6期105-121,共17页
An innovative multi-layer composite explosion containment vessel(CECV)utilizing a sliding steel platealuminum honeycomb-fiber cloth sandwich is put forward to improve the anti-explosion capacity of a conventional sing... An innovative multi-layer composite explosion containment vessel(CECV)utilizing a sliding steel platealuminum honeycomb-fiber cloth sandwich is put forward to improve the anti-explosion capacity of a conventional single-layer explosion containment vessel(SECV).Firstly,a series of experiments and finite element(FE)simulations of internal explosions are implemented to understand the basic anti-explosion characteristics of a SECV and the rationality of the computational models and methods is verified by the comparison between the experimental results and simulation results.Based on this,the CECV is designed in detail and a variety of FE simulations are carried out to investigate effects of the sandwich structure,the explosive quantity and the laying mode of the fiber cloth on anti-explosion performance and dynamic response of the CECV under internal explosions.Simulation results indicate that the end cover is the critical position for both the SECV and CECV.The maximum pressure of the explosion shock wave and the maximum strain of the CECV can be extremely declined compared to those of the SECV.As a result,the explosive quantity the CECV can sustain is up to 20 times of that the SECV can sustain.Besides,as the explosive quantity increases,the internal pressure of the CECV keeps growing and the plastic deformation and failure of the sandwich structure become more and more severe,yielding plastic strain of the CECV in addition to elastic strain.The results also reveal that the laying angles of the fiber cloth's five layers have an impact on the anti-explosion performance of the CECV.For example,the CECV with fiber cloth layered in 0°/45°/90°/45°/0°mode has the optimal anti-capacity,compared to 0°/0°/0°/0°/0°and 0°/30°/60°/30°/0°modes.Overall,owing to remarkable anti-explosion capacity,this CECV can be regarded as a promising candidate for explosion resistance. 展开更多
关键词 Explosive container Honeycomb-fiber cloth ANTI-EXPLOSION Aluminum honeycomb core COMPOSITE
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Differential mRNA expression profiling of oral squamous cell carcinoma by high-throughput RNA sequencing 被引量:4
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作者 liangyu Ge Siyu liu +3 位作者 Long Xie Lei Sang Changyan Ma hongwei li 《The Journal of Biomedical Research》 CAS CSCD 2015年第5期397-404,共8页
Differentially expressed genes are thought to regulate the development and progression of oral squamous cell carcinomas (OSCC). The purpose of this study was to screen differentially expressed mRNAs in OSCC and matc... Differentially expressed genes are thought to regulate the development and progression of oral squamous cell carcinomas (OSCC). The purpose of this study was to screen differentially expressed mRNAs in OSCC and matched paraneoplastic normal tissues, and to explore the intrinsic mechanism of OSCC development and progres- sion. We obtained the differentially expressed mRNA expression profiles in 10 pairs of fresh-frozen OSCC tissue specimens and matched paraneoplastic normal tissue specimens by high-throughput RNA sequencing. By using Gene Ontology enrichment analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses, the functional significance of the differentially expressed genes were analyzed. We identified 1,120 sig- nificantly up-regulated mRNAs and 178 significantly down-regulated mRNAs in OSCC, compared to normal tissue. The differentially expressed mRNAs were involved in 20 biological processes and 68 signal pathways. Compared to adjacent normal tissue, the expression of MAGEAll was up-regulated; TCHH was down-regulated. These find- ings were verified by real-time PCR. These differentially expressed mRNAs may function as oncogenes or tumor suppressors in the development and progression of OSCC. This study provides novel insights into OSCC. However, further work is needed to determine if these differentially expressed mRNAs have potential roles as diagnostic bio- markers and candidate therapeutic targets for OSCC. 展开更多
关键词 oral squamous cell carcinoma high-throughput RNA sequencing MRNA Gene Ontology KEGG pathway
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Quantitative analysis of sialic acids in Chinese conventional foods by HPLC-FLD 被引量:6
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作者 hongwei li Xingdan Fan 《Open Journal of Preventive Medicine》 2014年第2期57-63,共7页
Background: Sialic acids are a family of ninecarbon sugar compounds with carboxylic acyl derivatives. It exists in bacteria, fish, mammals and other living organisms, participates in and regulates many important life ... Background: Sialic acids are a family of ninecarbon sugar compounds with carboxylic acyl derivatives. It exists in bacteria, fish, mammals and other living organisms, participates in and regulates many important life events, such as cell recognition, membrane flow, endocytosis and so on. Sialic acid is usually located in the outermost layer of the sugar part of the cell membrane and the key positions of secreted glycoconjugates (glycolipids, glycoprotein and lipopolysaccharide). Sialic acid (Sia) is an important material foundation for variety of the structure and founction of glycoconjugates. Sia has been known as nearly 50 members, including N-acetylneuraminic acid (Neu5Ac), N-glycoulylneuraminic acid (Neu5Gc) and deaminoneuraminic acid (KDN) as its core monomer. The rest of the sialic acids are derived from these three monomers. The contents of Sia in Chinese food products are unknown. Objective: To determine the contents of Sia in raw and cooked red meat, seafood, poultry and so on. Design: The following food products were purchased from a Chinese supermarket: pork, beef, lamb, salmon, cod, tuna, cow milk, cheese, butter, duck, chicken and chicken eggs. Human milk was collected from Xiamen Maternity and Child Health Care Hospital (Xiamen, China). All tissues were homogenized and hydrolyzed with 0.05 M, 0.1 M and 0.2 M TFA for 150 min at 80°C in dark, respectively. The concentrations of Neu5Ac, Neu5Gc and KDN were determined by using HPLC with fluorescence detector. Results: The contents of total Sia (μg/g tissue or μg/mL liquid sample) in Chinese raw meat were highest in lamb (269.60), followed by pork (254.88), duck (200.63), chicken (162.86) and beef (88.03). The percentages of Neu5Gc were 36.08%, 26.48%, 0%, 0% and 28.40%, respectively. Cod contained higher levels of Sia (171.63) than salmon (104.43) and tuna (77.98). Only Neu5Ac was 50 found in detected aquatic product. Egg yolk contained the highest level of Sia (682.04), and a higher level of Sia (390.67) was found in the egg white. Also our result showed that human milk contained extremely high level of Sia (602.55). Neu5Ac was the predominant form of Sia in all the deteced samples. KDN was found in cow milk only among the samples, the content was 1.14 μg/g. Conclusion: The highest content of Sia in examined Chinese foods was found in 56 eggs, followed by lamb, pork, duck, cod, chicken, salmon, beef and tuna. Knowledge of the Sia content in conventional foods may help us to better understand possible medical disorders involving the uptake of the “non-human” Neu5Gc from our diet. 展开更多
关键词 QUANTITATIVE Analysis Sialic ACIDS HPLC-FLD
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Transcriptome analysis of salt-stress response in three seedling tissues of common wheat 被引量:2
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作者 Qiaoling Luo Wan Teng +5 位作者 Shuang Fang hongwei li Bin li Jinfang Chu Zhensheng li Qi Zheng 《The Crop Journal》 SCIE CAS CSCD 2019年第3期378-392,共15页
Xiaoyan 60(XY60) is a new wheat variety bred in the laboratory of Zhensheng Li.After salt treatment, seedlings of XY60 maintain green leaves and produce longer roots than the high yielding cultivar Zhongmai 175(ZM175)... Xiaoyan 60(XY60) is a new wheat variety bred in the laboratory of Zhensheng Li.After salt treatment, seedlings of XY60 maintain green leaves and produce longer roots than the high yielding cultivar Zhongmai 175(ZM175).To explain these different phenotypes we carried out an RNA-Seq analysis using 12 samples from three tissues of both varieties subjected to salt and control treatments.By comparing data from the salt treated plants with the control, 703, 979, and 1197 differentially expressed genes(DEGs) were detected in new leaves, old leaves, and roots of XY60, respectively.The corresponding numbers for ZM175 were 613, 1401, and 1301.The most significantly enriched Gene Ontology(GO) terms and KEGG pathways were associated with polyunsaturated fatty acid(PUFA) metabolism in both new and old leaves from XY60.They were associated with photosynthesis and energy metabolism in ZM175.The most significantly enriched KEGG pathway in roots of both varieties was “glucosinolate biosynthesis”.In addition, jasmonic acid(JA) concentration in XY60 was higher than in ZM175, although it increased significantly in both varieties following salt treatment.Trends in relative expression levels of AOS, MYC2, and JAZ revealed by qRT-PCR were concordant with those from RNA-Seq.Our results suggest that PUFAs may contribute to salt tolerance in common wheat by enhancing the photosynthetic system and JA-related pathways. 展开更多
关键词 Jasmonic acid PHOTOSYNTHESIS RNA-Seq Salt tolerance TRITICUM AESTIVUM
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土埋条件下生物基锦纶56与锦纶6纤维的老化行为
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作者 李宏伟 王刚 +2 位作者 吴雅楠 郝新敏 郭亚飞 《高分子材料科学与工程》 EI CAS CSCD 北大核心 2023年第8期120-125,共6页
为探究生物基锦纶56与锦纶6纤维在土壤填埋条件下是否会发生老化甚至降解,研究了土壤填埋时间、水分输入量和活性污泥含量对织物性能的影响。结果表明,在室温、不含活性污泥的土壤中填埋老化40周后,生物基锦纶56织物降强率小于15%;在室... 为探究生物基锦纶56与锦纶6纤维在土壤填埋条件下是否会发生老化甚至降解,研究了土壤填埋时间、水分输入量和活性污泥含量对织物性能的影响。结果表明,在室温、不含活性污泥的土壤中填埋老化40周后,生物基锦纶56织物降强率小于15%;在室温、含50%活性污泥和0.5 L/d水分输入量的条件下,生物基锦纶56织物在土埋16周后强力下降约35%,进一步增加土埋时间(到40周)、活性污泥含量和输水量,织物强力不再降低。老化后纤维表面出现明显的刻蚀和凹陷,结晶度增加了3%~6%,表明老化过程主要发生在纤维的无定形区。石油基锦纶6织物在相同实验条件下,强力下降均低于9%,表明生物基锦纶56纤维更容易在土埋条件下发生老化现象。 展开更多
关键词 生物基锦纶56 锦纶6 老化 土壤填埋 活性污泥
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Two Dimensional Fully Nonlinear Numerical Wave Tank Based on the BEM
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作者 Zhe Sun Yongjie Pang hongwei li 《Journal of Marine Science and Application》 2012年第4期437-446,共10页
The development of a two dimensional numerical wave tank (NWT) with a rocker or piston type wavemaker based on the high order boundary element method (BEM) and mixed Eulerian-Lagrangian (MEL) is examined. The ca... The development of a two dimensional numerical wave tank (NWT) with a rocker or piston type wavemaker based on the high order boundary element method (BEM) and mixed Eulerian-Lagrangian (MEL) is examined. The cauchy principle value (CPV) integral is calculated by a special Gauss type quadrature and a change of variable. In addition the explicit truncated Taylor expansion formula is employed in the time-stepping process. A modified double nodes method is assumed to tackle the comer problem, as well as the damping zone technique is used to absorb the propagation of the free surface wave at the end of the tank. A variety of waves are generated by the NWT, for example; a monochromatic wave, solitary wave and irregular wave. The results confirm the NWT model is efficient and stable. 展开更多
关键词 numerical wave tank (NWT) boundary element method (BEM) nonlinear free surface condition mixed Eulerian-Lagrangian damping zone cauchy principle value(CPV)
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Death Characteristics of Neurological Diseases in Inner Mongolia between 2008 and 2015
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作者 Yujia Ma Yonggang Qian +13 位作者 Zhiqiang Sun Mingzhu Niu Du Yu hongwei li Ruijie Wu Ying Yang Hairong Zhang Xiaoling Sun Qingxia Wang Lei Jia Jing Wen Yu Feng Maolin Du Juan Sun 《Open Journal of Preventive Medicine》 2019年第3期21-28,共8页
Background: There are no studies of death from neurological diseases found, however, neurological diseases were the leading cause of disability-adjusted life years in 2015 worldwide. Aim: The scientific aim of this st... Background: There are no studies of death from neurological diseases found, however, neurological diseases were the leading cause of disability-adjusted life years in 2015 worldwide. Aim: The scientific aim of this study is to analyze the death characteristics of neurological diseases in Inner Mongolia occurring between 2008 and 2015. Methods: The data collected from Death Registry System (DRS) were categorized by gender, ethnicity, age, and death location. The subjects were divided into age groups for every 10 years from the age of 20. Mortality and gender: age-specific mortality was calculated for every 100,000 people from 2008 to 2015. Results: We found that Alzheimer’s disease has the highest proportion which equated to over one-fifth of all neurological diseases. Males displayed a higher mortality rate than females in all neurological diseases. The neurological diseases mortality showed a total potential year of life lost (PYLL) of about 20,151 years, and it was 2.03 times higher for male than that for female. The average potential years of life lost (APYLL) showed 17.72 years, and APYLL in males was 3.34 years longer than in females. More than 60% of the deaths resulting from the neurological disease occur at home for both males and females. Conclusion: Alzheimer disease is the most serious disease of all neurological diseases, however, cerebral palsy and epilepsy also displayed the highest loss of life for residents. Mortality of neurological diseases was generally higher in males than in females, and this increased with age. 展开更多
关键词 NEUROLOGICAL DISEASES MORTALITY INNER Mongolia
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Document Analysis of Correlation between Climate and Stroke
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作者 hongwei li Yonggang Qian +17 位作者 Shubi Wang Hairong Zhang Wenfang Gou Mingzhu Niu Di Yu Ruijie Wu liqun Gao Baofeng Chi Qingxia Wang Wenli Hao Wuyuntana li Tao Yan liwei Niu Yan liu Jing Zhao Yuan Jin Maolin Du Juan Sun 《Open Journal of Epidemiology》 2019年第1期82-88,共7页
Aim: The aim of the research is to determine characteristic of the correlation between climate and stroke through the analysis of relevant documents. Methods: We found 115 researches of temperature and season on strok... Aim: The aim of the research is to determine characteristic of the correlation between climate and stroke through the analysis of relevant documents. Methods: We found 115 researches of temperature and season on stroke mortality/incidence and these were categorized according to location, meteorology, date span, data source and research sites’ latitudes. We divided the globe into 5 temperature zones based on latitude ranges: 0 - 10, 10 - 23.5, 23.5 - 40, 40 - 50, and >50 degrees, and allotted a zone to each country. Stroke mortality by five temperature zones was calculated per 100,000 people. Results: 70% of the researches came from latitudes greater than 40 degrees with 92% of researches located in Europe, USA, and Asia. The mortality range was 42 - 63 per 105 individuals within latitudes 0 - 40 degrees. In latitudes 40 - 66.5 degrees, a linear upward trend (y = 69.82x &#8722;22.823, R2 = 0.99) was noticed. More than 75% of the research reports indicated a negative correlation between climate and stroke, and the proportion was almost 6 and 7 times greater than that of the fluctuation and non-correlation, respectively. The most frequently used research methods were regression analysis and time series analysis. Conclusion: All of the research results confirmed that lower temperature is associated with higher mortality and incidence of stroke, while higher latitude is correlated with higher stroke mortality, consistent with the temperature zones. 展开更多
关键词 CLIMATE STROKE CORRELATION
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Analysis of the nonlinear dynamic characteristics of two-phase flow based on an improved matrix pencil method
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作者 hongwei li Junpeng liu +1 位作者 Yunlong Zhou Bin Sun 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2016年第6期737-748,共12页
Gas–liquid two-phase flow is complex and has uncertainty in phase interfaces, which make the two-phase flow look very complicated. Even though the flow behavior(e.g. coalescence, crushing and separation) of single bu... Gas–liquid two-phase flow is complex and has uncertainty in phase interfaces, which make the two-phase flow look very complicated. Even though the flow behavior(e.g. coalescence, crushing and separation) of single bubble or bubble groups in the liquid phase looks random, combining some established characteristics and methodologies can find regularities among the randomness. In order to excavate the nonlinear dynamic characteristics of gas–liquid two-phase flow, the authors developed an improved matrix pencil(IMP) method to analyze the pressure difference signals of the two-phase flow. This paper elucidates the influence of signal length on MP calculation results and the anti-noise-interference ability of the MP method. An IMP algorithm was applied to the fluctuation signals of gas–liquid two-phase flow to extract the mode frequency and damping ratio, which were combined with the component energy index(CEI) entropy to identify the different flow patterns. It is also found that frequency, damping ratio, CEI entropy and stability diagram together not only identify flow patterns, but also provide a new way to examine and understand the evolution mechanism of physical dynamics embedded in flow patterns. Combining these characteristics and methods, the evolution of the nonlinear dynamic physical behavior of gas bubbles is revealed. 展开更多
关键词 Matrix pencil (MP) methodComponent energy index (CEI)Stability diagramFlow pattem identificationFlow dynamics
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Genomic basis of selective breeding from the closest wild relative of large-fruited tomato
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作者 Junwei Yang Yun liu +6 位作者 Bin liang Qinqin Yang Xuecheng li Jiacai Chen hongwei li Yaqing Lyu Tao lin 《Horticulture Research》 SCIE CSCD 2023年第8期254-264,共11页
The long and intricate domestication history of the tomato(Solanum lycopersicum)includes selection sweeps that have not been fully explored,and these sweeps show significant evolutionary trajectories of domestication ... The long and intricate domestication history of the tomato(Solanum lycopersicum)includes selection sweeps that have not been fully explored,and these sweeps show significant evolutionary trajectories of domestication traits.Using three distinct selection strategies,we represented comprehensive selected sweeps from 53 Solanum pimpinellifolium(PIM)and 166 S.lycopersicum(BIG)accessions,which are defined as pseudo-domestication in this study.We identified 390 potential selection sweeps,some of which had a significant impact on fruit-related traits and were crucial to the pseudo-domestication process.During tomato pseudo-domestication,we discovered a minor–effect allele of the SlLEA gene related to fruit weight(FW),as well as the major haplotypes of fw2.2/cell number regulator(CNR),fw3.2/SlKLUH,and fw11.3/cell size regulator(CSR)in cultivars.Furthermore,18 loci were found to be significantly associated with FW and six fruit-related agronomic traits in genome-wide association studies.By examining population differentiation,we identified the causative variation underlying the divergence of fruit flavonoids across the large-fruited tomatoes and validated BRI1-EMS-SUPPRESSOR 1.2(SlBES1.2),a gene that may affect flavonoid content by modulating the MYB12 expression profile.Our results provide new research routes for the genetic basis of fruit traits and excellent genomic resources for tomato genomics-assisted breeding. 展开更多
关键词 BREEDING CULTIVAR TRAITS
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Two-cut system suggested for tall wheatgrass to balance herbage yield and quality in the coastal saline–alkaline land around the Bohai Sea
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作者 Wei li Qiang Xiao +4 位作者 hongwei li Hao Chang Qi Zheng Bin li Zhensheng li 《Grassland Research》 2024年第2期132-146,共15页
Background:Tall wheatgrass is a perennial salt-tolerant bunchgrass,which is a promising candidate for establishing a“Coastal Grass Belt”in China,particularly in the coastal saline–alkaline soils surrounding the Boh... Background:Tall wheatgrass is a perennial salt-tolerant bunchgrass,which is a promising candidate for establishing a“Coastal Grass Belt”in China,particularly in the coastal saline–alkaline soils surrounding the Bohai Sea.Methods:Seven harvesting treatments were performed to explore the optimal harvesting time and frequency for tall wheatgrass in coastal area.The dry matter yield(DMY)and forage nutritional values were investigated for each cut.The correlation between harvesting time and frequency thereof among the investigated traits was also determined.Results:The results showed that the two-cut on June 18 and October 29 produced the highest DMY.Another two-cut on May 26 and October 29 produced a relatively high crude protein(CP)yield.The DMY,contents of neutral detergent fiber(NDF),acid detergent fiber(ADF),and crude cellulose(CC)as well as CP yield were positively correlated to plant height,while the CP content and the relative feed value(RFV)were negatively correlated to plant height.The accumulating growing degree days,accumulated precipitation,and sunshine duration were positively correlated with plant height,DMY,contents of NDF,ADF,and CC as well as CP yield,but negatively correlated with CP content and RFV for the first cut.Conclusions:The two-cut treatment at the end of May and October may be suitable for tall wheatgrass in the“Coastal Grass Belt”targeted area. 展开更多
关键词 Coastal Grass Belt Elytrigia elongata saline and alkaline soils tall wheatgrass Thinopyrum ponticum
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人源免疫重建PDX模型构建及其在肿瘤免疫治疗中的应用进展 被引量:2
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作者 李宏伟 高先春 +2 位作者 窦建华 闫君雅 聂勇战 《中国肿瘤临床》 CAS CSCD 北大核心 2022年第11期541-547,共7页
免疫治疗已成为肿瘤治疗领域最具潜力的手段之一。由于肿瘤存在高度异质性等特点,导致免疫治疗响应率偏低,疗效有限。因此,迫切需要具有预测性的临床前模型,用于推动合理、安全的免疫治疗策略开发。传统体内、外肿瘤研究模型受限于人源... 免疫治疗已成为肿瘤治疗领域最具潜力的手段之一。由于肿瘤存在高度异质性等特点,导致免疫治疗响应率偏低,疗效有限。因此,迫切需要具有预测性的临床前模型,用于推动合理、安全的免疫治疗策略开发。传统体内、外肿瘤研究模型受限于人源免疫系统的缺失。因此,构建同时具有人源免疫系统和肿瘤的研究模型成为热点。将患者来源肿瘤移植入人源免疫系统重建小鼠体内肿瘤、免疫双人源化模型,具有可重现人体内免疫细胞与肿瘤间相互作用的优势,成为生理和病理条件下模拟人体肿瘤免疫治疗疗效的新模型。本文主要对多种类型人源化免疫重建PDX模型构建、优缺点及其在肿瘤免疫治疗研究中的最新应用进展进行综述。 展开更多
关键词 免疫人源化小鼠 造血干细胞 肿瘤免疫学 免疫治疗
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A Review on Ultrasonic-Assisted Forming:Mechanism,Model,and Process 被引量:8
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作者 Guangda Shao hongwei li Mei Zhan 《Chinese Journal of Mechanical Engineering》 SCIE EI CAS CSCD 2021年第5期147-170,共24页
Compared with conventional forming processes,ultrasonic-assisted forming technology with a high frequency and small amplitude can significantly improve the forming quality of materials.Owing to the advantages of reduc... Compared with conventional forming processes,ultrasonic-assisted forming technology with a high frequency and small amplitude can significantly improve the forming quality of materials.Owing to the advantages of reduced forming force,improved surface quality,avoidance of forming defects,and strengthened surface structure,ultrasonic-assisted forming technology has been applied to increasingly advanced forming processes,such as incremental forming,spinning,and micro-forming.However,in the ultrasonic-assisted forming process,there are multiple ultrasonic mechanisms,such as the volume effect and surface effect.The explanation of the effect of ultrasonic vibration(UV)on plastic deformation remains controversial,hindering the development of related technologies.Recently,many researchers have proposed many new theories and technologies for ultrasonic-assisted forming.To summarize these developments,systematic discussions on mechanisms,theoretical models,and forming performances are provided in this review.On this basis,the limitations of the current study are discussed.In addition,an outlook for ultrasonic-assisted forming is proposed:efficient and stable UV systems,difficulty forming components with complex geometry,explanation of the in-depth mechanism,a systematic theoretical prediction model,and multi-field-coupling energy-assisted forming are considered to be hot spots in future studies.The present review enhances existing knowledge of ultrasonic-assisted forming,and facilitates a fast reference for related researchers. 展开更多
关键词 Ultrasonic vibration FORMING MECHANISM MODEL Processing performance
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Outcomes of robotic surgery for pancreatic ductal adenocarcinoma 被引量:3
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作者 Qian Zhan Xiaxing Deng +5 位作者 Yuanchi Weng Jiabin Jin Zhichong Wu hongwei li Baiyong Shen Chenghong Peng 《Chinese Journal of Cancer Research》 SCIE CAS CSCD 2015年第6期604-610,共7页
Authors introduction: Qian Zhan, female, who was born in Sept, 1979. She studied in the Shanghai Second Medical University during 1998 to 2005. She majored in Clinical Medicine, and earned her master degree in 2005. ... Authors introduction: Qian Zhan, female, who was born in Sept, 1979. She studied in the Shanghai Second Medical University during 1998 to 2005. She majored in Clinical Medicine, and earned her master degree in 2005. In 2005, she went to the Beaujon Hospital of Paris 7th Universit3. in France, as a foreign intern. Later, she came to postgraduate work and residencies in the general surgery department of Shanghai Ruijin Hospital. Her clinical work is focused on multidisciplinary especially postoperative management for the patients with pancreatic cancer. In addition, she is a lead researcher in the pancreatic cancer group for nano based drug delivery, systems. Chenghong Peng, male, who was born in Apr, 1957. He worked in the 2nd Affiliated Hospital of Zhejiang University School of Medicine during 1989 to 2002. In 2002, Chenghong Peng came m Shanghai Ruiiin Hospital and began to take charge of general surgery department. As a pioneer in the hepatobifiopancreatic field, Chenghong Peng devoted himself in the basic and clinical research of pancreatic tmnors. He brings forth new ideas by creating "Pancreatic multiple treatment collaborating groups", which integrate the advantages of gasn'oenterology, department, endoscopy department, radiology department, pathology deparnnent and SICU. He constantly strives for excellence in pancreatic surgery. In the previous five years, he performed more than 300 cases of pancreatectomy each year, and has accomplished more than 2,000 cases of pancreatectomy altogether, among which the resectable rate is 74%. Besides, he is also committed to laparoscopic surgery and robotic surgeD,. He has achieved more than 200 laparoscopic hepatectomies, 150 laparoscopic pancreatectomies and 500 robotic hepatobiliopancreatic surgeries (350 robotic pancreatic surgeries included), which keeps leading position in China. In 2011, Chenghong Peng has won the first prize in 3rd international congress of CRSA, which marked that our achievement in robotic surgery was recognized by oversea peers.Background: To explore the effectiveness, safety, and efficacy of the robot-assisted surgery in the radical resection of pancreatic ductal adenocarcinoma (PDAC). Methods: The clinical data of 72 patients with PDAC who underwent radical resection using the da Vinci Surgical System from April 2010 to December 2014 were retrospectively analyzed. Results: Among these 72 patients, three were converted to conventional laparotomy due to the vascular invasion or due to the difficulties in tissue isolation from the surrounding organs. Among 39 patients who underwent the pancreatoduodenectomy, the average operative time was 395.3±118.8 min, and the mean intra-operative blood loss was 447.3±269.9 mL. Among 31 patients who underwent the distal pancreatectomy (DP), the average operative time was 185.5±74.1 min, and the mean intra-operative blood loss was 267.1±305.3 mL. In two patients who received the middle pancreatectomy (NIP), the average operative time was 225 rain and mean intra-operative blood loss was 100 mL. Among all the 72 patients, an average of 4.2±2.6 lymph nodes were dissected, with an average hospital stay of 22.6±10.7 days. Complications were observed in 18 patients, which included pancreatic fistula (n=11), bile leak (n=5), anastomotic bleeding (n:2), pancreatic fistula complicated with portal vein thrombosis (n=1), and anastomotic bleeding complicated with acute renal failure (n=l). Except that one patient died due to post-operative bleeding and acute renal failure, all the other patients were cured after conservative treatment. These 72 patients were followed for 1-45 (15.6±5.8) months, during which 10 patients died. Eleven patients suffered from recurrence or metastasis, among which 6 had local recurrence, 4 had liver metastasis, and 1 had ascites accompnaied with incision site tumor metastasis. Conclusions- Radical resection of PDAC by robotic surgical system is safe and feasible. It has less surgical trauma and enables faster post-operative recovery, and therefore can achieve the lymph node dissection scope and tumor resection margin required by the standards of radical resection for pancreatic cancer. Nevertheless, its long-term efficacy requires further validation. 展开更多
关键词 Robot-assisted surgery radical resection pancreatic ductal adenocarcinoma (PDAC)
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High-performance junction field-effect transistor based on black phosphorus/β-Ga2O3 heterostructure 被引量:2
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作者 Chang li Cheng Chen +6 位作者 Jie Chen Tao He hongwei li Zeyuan Yang liu Xie Zhongchang Wang Kai Zhang 《Journal of Semiconductors》 EI CAS CSCD 2020年第8期52-58,共7页
Black phosphorous(BP),an excellent two-dimensional(2D)monoelemental layered p-type semiconductor material with high carrier mobility and thickness-dependent tunable direct bandgap structure,has been widely applied in ... Black phosphorous(BP),an excellent two-dimensional(2D)monoelemental layered p-type semiconductor material with high carrier mobility and thickness-dependent tunable direct bandgap structure,has been widely applied in various devices.As the essential building blocks for modern electronic and optoelectronic devices,high quality PN junctions based on semiconductors have attracted widespread attention.Herein,we report a junction field-effect transistor(JFET)by integrating narrow-gap p-type BP and ultra-wide gap n-typeβ-Ga2O3 nanoflakes for the first time.BP andβ-Ga2O3 form a vertical van der Waals(vdW)heterostructure by mechanically exfoliated method.The BP/β-Ga2O3 vdW heterostructure exhibits remarkable PN diode rectifying characteristics with a high rectifying ratio about 107 and a low reverse current around pA.More interestingly,by using the BP as the gate andβ-Ga2O3 as the channel,the BP/β-Ga2O3 JFET devices demonstrate excellent n-channel JFET characteristics with the on/off ratio as high as 107,gate leakage current around as low as pA,maximum transconductance(gm)up to 25.3μS and saturation drain current(IDSS)of 16.5μA/μm.Moreover,it has a pinch-off voltage of–20 V and a minimum subthreshold swing of 260 mV/dec.These excellent n-channel JFET characteristics will expand the application of BP in future nanoelectronic devices. 展开更多
关键词 two-dimensional semiconductor black phosphorous β-gallium oxide vdWs heterostructure junction field-effect transistor
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Analysis of Spatial Distribution of Agricultural Meteorological Conditions in Sanjiang Plain during Nearly 50 Years 被引量:1
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作者 hongwei li Zhujun Tian +1 位作者 Wei Yang Xian li 《Meteorological and Environmental Research》 CAS 2013年第4期59-63,共5页
[ Objective] The study aimed to analyze the spatial distribution of agricultural meteorological conditions in Sanjiang Plain during nearly 50 years. [ Method] Accumulated temperature of Sanjiang Plain was computed bas... [ Objective] The study aimed to analyze the spatial distribution of agricultural meteorological conditions in Sanjiang Plain during nearly 50 years. [ Method] Accumulated temperature of Sanjiang Plain was computed based on meteorological observation data from different meteorological stations in Sanjiang Plain, including temperature, precipitation, sunshine time, etc. A spatial interpolation map involving varieties of meteorological elements in neady 50 years was generated based on the Kriging interpolation, and the spatial distribution characteristics of those meteorological ele- ments were analyzed. [ Result] Temperature of Sanjiang Plain decreased with the increase of latitude and altitude, and the annual average temper- atura varied from 2.5 to 4.5 ~(3 generally, showing a zonal distribution. Precipitation of Sanjiang Plain changed spatially and the annual average pre- cipitation varied from 500 to 600 mm symmetrically in northwest-southeast direction. Spatial distribution of the annual average wind speed in San- jiang Plain was identical with the spatial pattern of topography here, and the annual average wind speed changed from 3.0 to 3.6 rn/s in most re- gions. Relative air humidity of Sanjiang Plain in summer half year was relatively high and always above 65%. The maximum sunshine hours of San- jiang Plain in one year distributed similarly to the annual changing curve of solar declination, and both of them presented a normal distribution and changed with geographic latitude. The days from the beginning to the end of daily average temperature ~〉 10 ~C in Sanjiang Plain were 135 -146 d, and its distribution presented a latitudinal trend, with certain vertical zonality. [ Conclusion] The research could provide scientific references for the reasonable arrangement of agricultural production and effective prevention of meteorological disasters in Sanjiang Plain. 展开更多
关键词 Sanjiang Plain TEMPERATURE Agricultural meteorological conditions Daily average temperature China
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Near-infrared-II deep tissue fluorescence microscopy and application 被引量:1
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作者 Pengfei liu Rong Zhao +4 位作者 hongwei li Tianyu Zhu Yuan li Hao Wang Xiao-Dong Zhang 《Nano Research》 SCIE EI CSCD 2023年第1期692-714,共23页
Fluorescence imaging has become an essential tool in biomedical research.However,non-invasive deep-tissue threedimensional optical in vivo imaging with the high spatiotemporal resolution is challenging due to the inte... Fluorescence imaging has become an essential tool in biomedical research.However,non-invasive deep-tissue threedimensional optical in vivo imaging with the high spatiotemporal resolution is challenging due to the interaction between photons and tissues.Beam shaping has been used to tailor microscopy techniques to enhance microscope performance.The nearinfrared window(NIR)between 700 and 1,700 nm,generally emphasized as the NIR-II(1,000–1,700 nm)window,has been developed into a promising bio-optical solution chosen as the lower interaction effect in this spectrum,showing potential in basic biological research and clinical application.In this review,we summarize the existing methods to increase penetration depth and extensively describe biological microscopy techniques,NIR-II spectral windows,and fluorophores.Strategies to improve bioimaging performance and NIR-II imaging applications are introduced.Based on the current research achievements,we elucidate the main challenges and provide some recommendations and prospects for deep tissue penetration fluorescence for future biomedical applications. 展开更多
关键词 deep tissue penetration MICROSCOPY near-infrared II imaging FLUOROPHORE
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不同合成路线耦合制备沸石分子筛
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作者 赵新红 王浩 +3 位作者 丁梦琦 李红伟 季东 李贵贤 《化学进展》 SCIE CAS CSCD 北大核心 2024年第4期525-536,共12页
沸石分子筛作为一种重要的多孔材料,由于其特殊的孔道结构、适宜的酸性以及较高的水热稳定性,在吸附、离子交换和催化等领域具有广泛的应用。沸石的经典水热合成路线存在沸石产率低、合成成本高、污染严重等问题。将各种经典沸石合成路... 沸石分子筛作为一种重要的多孔材料,由于其特殊的孔道结构、适宜的酸性以及较高的水热稳定性,在吸附、离子交换和催化等领域具有广泛的应用。沸石的经典水热合成路线存在沸石产率低、合成成本高、污染严重等问题。将各种经典沸石合成路线与近年来发展的非常规合成路线有机结合起来则是解决上述问题及实现合成沸石技术创新的一条重要途径。为此,本文首先介绍了近年来开发的一系列非常规沸石合成路线的原理及特点,其次简要介绍了沸石分子筛合成路线耦合的概念,然后重点阐述了微波合成、无溶剂合成、晶种导向法与其他路线耦合制备沸石分子筛的最新进展,最后对利用这些耦合路线合成沸石分子筛过程中存在的问题进行了分析与展望。 展开更多
关键词 微波合成 离子热合成 无溶剂合成 晶种导向合成 耦合
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