Objective:To explore the relationship between social isolation,psychological resilience,and psychological well-being in community-dwelling older adults.Methods:A questionnaire survey was conducted with 265 community-d...Objective:To explore the relationship between social isolation,psychological resilience,and psychological well-being in community-dwelling older adults.Methods:A questionnaire survey was conducted with 265 community-dwelling older adults using the Social Isolation Scale for the Elderly(C-SIS),the 10-item Brief Psychological Resilience Scale,and the Comprehensive Happiness Questionnaire(MHQ).The results were statistically analyzed using SPSS 27.0.Results:The highest score on the Social Isolation Scale for Community Elderly was 23,with a mean entry score of 2.36±0.62.A score of 14 was the cut-off point,with scores of≤14 classified as social isolation.There were 136 cases with scores below 14,resulting in a social isolation incidence rate of 51.3%.The median(P50)psychological resilience score was 27,indicating a higher level of resilience.The total score on the Psychological Well-being Scale was 161,suggesting a moderate to slightly higher level of well-being.Social isolation had a direct negative effect on psychological well-being,while psychological resilience had a positive effect.Conclusion:Older adults should be supported in reducing the incidence of social isolation and increasing psychological resilience to enhance psychological well-being and promote successful aging.展开更多
This study examines the dependence of Arctic stratospheric polar vortex(SPV)variations on the meridional positions of the sea surface temperature(SST)anomalies associated with the first leading mode of North Pacific S...This study examines the dependence of Arctic stratospheric polar vortex(SPV)variations on the meridional positions of the sea surface temperature(SST)anomalies associated with the first leading mode of North Pacific SST.The principal component 1(PC1)of the first leading mode is obtained by empirical orthogonal function decomposition.Reanalysis data,numerical experiments,and CMIP5 model outputs all suggest that the PC1 events(positive-minus-negative PC1 events),located relatively northward(i.e.,North PC1 events),more easily weaken the Arctic SPV compared to the PC1 events located relatively southward(i.e.,South PC1 events).The analysis indicates that the North PC1-related Aleutian low anomaly is located over the northern North Pacific and thus enhances the climatological trough,which strengthens the planetary-scale wave 1 at mid-to-high latitudes and thereby weakens the SPV.The weakened stratospheric circulation further extends into the troposphere and favors negative surface temperature anomalies over Eurasia.By contrast,the South PC1-related Aleutian low anomaly is located relatively southward,and its constructive interference with the climatological trough is less efficient at high latitudes.Thus,the South PC1 events could not induce an evident enhancement of the planetary-scale waves at high latitudes and thereby a weakening of the SPV on average.The Eurasian cooling associated with South PC1 events(positive-minus-negative PC1 events)is also not prominent.The results of this study suggest that the meridional positions of the PC1 events may be useful for predicting the Arctic SPV and Eurasian surface temperature variations.展开更多
During the Asian summer monsoon(ASM)season,the process of stratosphere-troposphere exchange significantly affects the concentration and spatial distribution of chemical constituents in the upper troposphere and lower ...During the Asian summer monsoon(ASM)season,the process of stratosphere-troposphere exchange significantly affects the concentration and spatial distribution of chemical constituents in the upper troposphere and lower stratosphere(UTLS).However,the effect of the intensity of the Asian summer monsoon anticyclone(ASMA)on the horizontal distribution of chemical species within and around the ASMA,especially on the daily time scale,remains unclear.Here,the authors use the MERRA-2 reanalysis dataset and Aura Microwave Limb Sounder observations to study the impact of ASMA intensity on chemical distributions at 100 hPa during the ASM season.The intraseasonal variation of ASMA is classified into a strong period(SP)and weak period(WP),which refer to the periods when the intensity of ASMA remains strong and weak,respectively.The relatively low ozone(O_(3))region is found to be larger at 100 hPa during SPs,while its mixing ratio is lower than during WPs in summer.In June,analysis shows that the O_(3) horizontal distribution is mainly related to the intensity of AMSA,especially during SPs in June,while deep convections also impact the O_(3) horizontal distribution in July and August.These results indicate that the intraseasonal variation of the ASMA intensity coupled to deep convection can significantly affect the chemical distribution in the UTLS region during the ASM season.展开更多
The Tibetan Plateau(TP)is an area sensitive to climate change,where the ozone distribution affects the atmospheric environment of the TP and its surrounding regions.The relatively low total column ozone over the TP in...The Tibetan Plateau(TP)is an area sensitive to climate change,where the ozone distribution affects the atmospheric environment of the TP and its surrounding regions.The relatively low total column ozone over the TP in boreal summer and its spatiotemporal variations have received extensive attention.In this study,five-year balloon-borne measurements of ozone over Lhasa in boreal summer are used to investigate the influences of the apparent heat source(Q1)on the ozone vertical structure over the plateau.The mechanisms for the above processes are also explored.The results show that the tropospheric ozone mixing ratio over Lhasa decreases when the total atmospheric Q1 in the troposphere over the TP is relatively high.Strengthened ascending motions are accompanied by enhanced Q1 over the main TP region.Consequently,the tropospheric ozone mixing ratio over Lhasa decreases when Q1 is higher in summer,which is attributed to the upward transport of the ozone-poor surface air.展开更多
Longitudinal bone growth relies on endochondral ossification in the cartilaginous growth plate,where chondrocytes accumulate and synthesize the matrix scaffold that is replaced by bone.The chondroprogenitors in the re...Longitudinal bone growth relies on endochondral ossification in the cartilaginous growth plate,where chondrocytes accumulate and synthesize the matrix scaffold that is replaced by bone.The chondroprogenitors in the resting zone maintain the continuous turnover of chondrocytes in the growth plate.Malnutrition is a leading cause of growth retardation in children;however,after recovery from nutrient deprivation,bone growth is accelerated beyond the normal rate,a phenomenon termed catch-up growth.Although nutritional status is a known regulator of long bone growth,it is largely unknown whether and how chondroprogenitor cells respond to deviations in nutrient availability.Here,using fate-mapping analysis in Axin2CreERT2 mice,we showed that dietary restriction increased the number of Axin2+chondroprogenitors in the resting zone and simultaneously inhibited their differentiation.Once nutrient deficiency was resolved,the accumulated chondroprogenitor cells immediately restarted differentiation and formed chondrocyte columns,contributing to accelerated growth.Furthermore,we showed that nutrient deprivation reduced the level of phosphorylated Akt in the resting zone and that exogenous IGF-1 restored the phosphorylated Akt level and stimulated differentiation of the pooled chondroprogenitors,decreasing their numbers.Our study of Axin2CreERT2 revealed that nutrient availability regulates the balance between accumulation and differentiation of chondroprogenitors in the growth plate and further demonstrated that IGF-1 partially mediates this regulation by promoting the committed differentiation of chondroprogenitor cells.展开更多
基金Medical Discipline Cultivation Program of Hebei University(Project No.Medicine+X 2022X01)。
文摘Objective:To explore the relationship between social isolation,psychological resilience,and psychological well-being in community-dwelling older adults.Methods:A questionnaire survey was conducted with 265 community-dwelling older adults using the Social Isolation Scale for the Elderly(C-SIS),the 10-item Brief Psychological Resilience Scale,and the Comprehensive Happiness Questionnaire(MHQ).The results were statistically analyzed using SPSS 27.0.Results:The highest score on the Social Isolation Scale for Community Elderly was 23,with a mean entry score of 2.36±0.62.A score of 14 was the cut-off point,with scores of≤14 classified as social isolation.There were 136 cases with scores below 14,resulting in a social isolation incidence rate of 51.3%.The median(P50)psychological resilience score was 27,indicating a higher level of resilience.The total score on the Psychological Well-being Scale was 161,suggesting a moderate to slightly higher level of well-being.Social isolation had a direct negative effect on psychological well-being,while psychological resilience had a positive effect.Conclusion:Older adults should be supported in reducing the incidence of social isolation and increasing psychological resilience to enhance psychological well-being and promote successful aging.
基金the National Natural Science Foundation of China(Grant Nos.42130601,42075060,and 41875046).
文摘This study examines the dependence of Arctic stratospheric polar vortex(SPV)variations on the meridional positions of the sea surface temperature(SST)anomalies associated with the first leading mode of North Pacific SST.The principal component 1(PC1)of the first leading mode is obtained by empirical orthogonal function decomposition.Reanalysis data,numerical experiments,and CMIP5 model outputs all suggest that the PC1 events(positive-minus-negative PC1 events),located relatively northward(i.e.,North PC1 events),more easily weaken the Arctic SPV compared to the PC1 events located relatively southward(i.e.,South PC1 events).The analysis indicates that the North PC1-related Aleutian low anomaly is located over the northern North Pacific and thus enhances the climatological trough,which strengthens the planetary-scale wave 1 at mid-to-high latitudes and thereby weakens the SPV.The weakened stratospheric circulation further extends into the troposphere and favors negative surface temperature anomalies over Eurasia.By contrast,the South PC1-related Aleutian low anomaly is located relatively southward,and its constructive interference with the climatological trough is less efficient at high latitudes.Thus,the South PC1 events could not induce an evident enhancement of the planetary-scale waves at high latitudes and thereby a weakening of the SPV on average.The Eurasian cooling associated with South PC1 events(positive-minus-negative PC1 events)is also not prominent.The results of this study suggest that the meridional positions of the PC1 events may be useful for predicting the Arctic SPV and Eurasian surface temperature variations.
基金sponsored by Strategic Priority Research Program of the Chinese Academy of Science[grant No.XDA17010106]the National Key Research and Development Program of China[grant Nos.2018YFC1505703 and 2018YFC1506704].
文摘During the Asian summer monsoon(ASM)season,the process of stratosphere-troposphere exchange significantly affects the concentration and spatial distribution of chemical constituents in the upper troposphere and lower stratosphere(UTLS).However,the effect of the intensity of the Asian summer monsoon anticyclone(ASMA)on the horizontal distribution of chemical species within and around the ASMA,especially on the daily time scale,remains unclear.Here,the authors use the MERRA-2 reanalysis dataset and Aura Microwave Limb Sounder observations to study the impact of ASMA intensity on chemical distributions at 100 hPa during the ASM season.The intraseasonal variation of ASMA is classified into a strong period(SP)and weak period(WP),which refer to the periods when the intensity of ASMA remains strong and weak,respectively.The relatively low ozone(O_(3))region is found to be larger at 100 hPa during SPs,while its mixing ratio is lower than during WPs in summer.In June,analysis shows that the O_(3) horizontal distribution is mainly related to the intensity of AMSA,especially during SPs in June,while deep convections also impact the O_(3) horizontal distribution in July and August.These results indicate that the intraseasonal variation of the ASMA intensity coupled to deep convection can significantly affect the chemical distribution in the UTLS region during the ASM season.
基金This research was supported by the second Tibetan Plateau Scientific Expedition and Research Program(STEP)[grant number 2019QZKK0604]the National Natural Science Foundation of China[grant numbers 91837311,41705025,and 41705021].
文摘The Tibetan Plateau(TP)is an area sensitive to climate change,where the ozone distribution affects the atmospheric environment of the TP and its surrounding regions.The relatively low total column ozone over the TP in boreal summer and its spatiotemporal variations have received extensive attention.In this study,five-year balloon-borne measurements of ozone over Lhasa in boreal summer are used to investigate the influences of the apparent heat source(Q1)on the ozone vertical structure over the plateau.The mechanisms for the above processes are also explored.The results show that the tropospheric ozone mixing ratio over Lhasa decreases when the total atmospheric Q1 in the troposphere over the TP is relatively high.Strengthened ascending motions are accompanied by enhanced Q1 over the main TP region.Consequently,the tropospheric ozone mixing ratio over Lhasa decreases when Q1 is higher in summer,which is attributed to the upward transport of the ozone-poor surface air.
基金partially supported by the National Institute of Arthritis and Musculoskeletal and Skin Diseases of the National Institutes of Health under Award Number R01AR062908(to MEI),R01AR056837(to MI),R01AR073181(to SO),and R21AR077654(to SO)the departmental fund of the University of Maryland(to MI,ME-I)。
文摘Longitudinal bone growth relies on endochondral ossification in the cartilaginous growth plate,where chondrocytes accumulate and synthesize the matrix scaffold that is replaced by bone.The chondroprogenitors in the resting zone maintain the continuous turnover of chondrocytes in the growth plate.Malnutrition is a leading cause of growth retardation in children;however,after recovery from nutrient deprivation,bone growth is accelerated beyond the normal rate,a phenomenon termed catch-up growth.Although nutritional status is a known regulator of long bone growth,it is largely unknown whether and how chondroprogenitor cells respond to deviations in nutrient availability.Here,using fate-mapping analysis in Axin2CreERT2 mice,we showed that dietary restriction increased the number of Axin2+chondroprogenitors in the resting zone and simultaneously inhibited their differentiation.Once nutrient deficiency was resolved,the accumulated chondroprogenitor cells immediately restarted differentiation and formed chondrocyte columns,contributing to accelerated growth.Furthermore,we showed that nutrient deprivation reduced the level of phosphorylated Akt in the resting zone and that exogenous IGF-1 restored the phosphorylated Akt level and stimulated differentiation of the pooled chondroprogenitors,decreasing their numbers.Our study of Axin2CreERT2 revealed that nutrient availability regulates the balance between accumulation and differentiation of chondroprogenitors in the growth plate and further demonstrated that IGF-1 partially mediates this regulation by promoting the committed differentiation of chondroprogenitor cells.