导热复合材料降低填料之间界面热阻研究进展

复合材料热导率增强的低效率源于其内部存在界面热阻——填料与树脂基体之间的界面热阻及填料之间的界面热阻。目前大多数研究都集中于降低填料与树脂基体之间的界面热阻,而高填充量下填料之间的界面热阻才是影响复合材料热导率的关键因素。文中从增加填料之间的接触面积和提高填料之间的键接强度两方面综述了近年来降低填料之间界面热阻的研究进展,为高导热复合材料的设计和制备提供参考。

A molecular dynamics study on mechanical performance and deformation mechanisms in nanotwinned NiCo-based alloys with nano-precipitates under high temperatures

Molecular dynamics simulations are performed to investigate the mechanical behavior of nanotwinned NiCo-based alloys containing coherent L12 nano-precipitates at different temperatures,as well as the interactions between the dislocations and nano-precipitates within the nanotwins.The simulation results demonstrate that both the yield stress and flow stress in the nanotwinned NiCo-based alloys with nano-precipitates decrease as the temperature rises,because the higher temperatures lead to the generation of more defects during yielding and lower dislocation density during plastic deformation.Moreover,the coherent L12 phase exhibits excellent thermal stability,which enables the hinderance of dislocation motion at elevated temperatures via the wrapping and cutting mechanisms of dislocations.The synergistic effect of nanotwins and nano-precipitates results in more significant strengthening behavior in the nanotwinned NiCo-based alloys under high temperatures.In addition,the high-temperature mechanical behavior of nanotwinned NiCo-based alloys with nano-precipitates is sensitive to the size and volume fraction of the microstructures.These findings could be helpful for the design of nanotwins and nano-precipitates to improve the high-temperature mechanical properties of NiCo-based alloys.

Modulation on electrostatic potential to build a firm bridge at NiO_(x)/perovskite interface for efficient and stable perovskite solar cells

The NiO_(x)/perovskite interface in NiO_(x)-based inverted perovskite solar cells(PSCs)is one of the main issues that restrict device performance and long-term stability,as the unwanted interfacial defects and undesirable redox reactions cause severe interfacial non-radiative recombination and open-circuit voltage(Voc)loss.Herein,a series of self-assembled molecules(SAMs)are employed to bind,bridge,and stabilize the NiO_(x)/perovskite interface by regulating the electrostatic potential.Based on systematically theoretical and experimental studies,4-pyrazolecarboxylic acid(4-PCA)is proven as an efficient molecule to simultaneously passivate the NiO_(x)and perovskite surface traps,release the interfacial tensile stress as well as quench the detrimental interface redox reactions,thus effectively suppressing the interfacial non-radiative recombination and enhancing the quality of perovskite crystals.Consequently,the PSCs with 4-PCA treatment exhibited an eminently increased Voc,leading to a significant increase in power conversion efficiency from 21.28%to 23.77%.Furthermore,the unencapsulated devices maintain 92.6%and 81.3%of their initial PCEs after storing in air with a relative humidity of 20%–30%for 1000 h and heating at 65℃for 500 h in a N_(2)-filled glovebox,respectively.

Clinical characteristics and response to tyrosine kinase inhibitors of patients with non-small cell lung cancer harboring uncommon epidermal growth factor receptor mutations

Objective： To investigate the clinical features of patients with non-small cell lung cancer（NSCLC） harboring uncommon epidermal growth factor receptor（EGFR） mutations, and the treatment outcomes of EGFR tyrosine kinase inhibitors（TKIs） in these patients.Methods： We retrospectively analyzed the data of 128 NSCLC patients pathologically diagnosed with uncommon EGFR mutation in the Department of Pathology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences ＆ Peking Union Medical College and Beijing Hospital from January 2010 to December 2015, including 40 advanced patients who received EGFR-TKI.Results： Among the total 128 patients, 11 patients were non-adenocarcinoma, including squamous carcinoma（3.9%）, adenosquamous carcinoma（2.3%）, large cell carcinoma（0.8%）, and composite neuroendocrine carcinoma（1.6%）. Single mutations accounted for 75.0%（96/128）, including G719X（29.7%）, S768I（18.0%）, 20 exon insertion（13.3%）, L861Q（12.5%）, De novo T790M（0.8%）, and T725（0.8%）. Thirty-two patients harbored complex mutations. Forty advanced patients received EGFR-TKI, the objective response rate（ORR） was 20.0%,the disease control rate（DCR） was 85.0%, and the progression-free survival（PFS） was 6.4 [95% confidence interval（95% CI）, 4.8–7.9] months. The exploratory analysis of tumor response and PFS in 33 patients with G719X/S768I/L861 Q subtypes showed that ORR was 21.2%（7/33）, the DCR was 93.9%（31/33）, and PFS was 7.6（95% CI, 5.8–9.4） months. Patients with exon 20 insertion mutation and De novo T790 M experienced rapid disease progression with PFS no more than 2.7 months.Conclusions： Uncommon EGFR-mutant NSCLCs are heterogeneous, EGFR-TKIs can have different efficacy in this specific subtype, and thus further individual assessment is required for each case.

Influence of nano-diamond content on the microstructure,mechanical and thermal properties of the ZK60 composites

The effect of nano diamond(ND)content on the microstructure,mechanical properties,and thermal conductivity of ZK60+x(x=0,0.05,0.1,0.15,0.2 wt.%)ND composites were investigated.The microstructures of ND/ZK60 composites were observed,which indicated that the nanoscale MgZn_(2) and ND particles distributed evenly in theα-Mg matrix.The tensile yield strength(TYS)and compressive yield strength(CYS)of the composites first increased remarkably and then decreased with further increasing the ND content.Due to the surface area of the matrix-diamond interface increased and the grains sizes of composites decreased with the amount of ND increase,which cause the coefficient of thermal expansion(CTE)of the composites reduced significantly.Meanwhile,the thermal conductivity of the composite material decreases from 129 W·m^(−1)·K^(−1) to 116 W·m^(−1)·K^(−1) with the content of ND increasing from 0.05%to 2.0%.The thermal conductivity of the composites increases to the maximum and then decrease with the increase of temperature(in temperature range of 273-573 K).The ZK60+0.05 ND showed superior mechanical and thermal conductivity property,TYS of 343.97 MPa,CYS of 341.74 MPa,elongation of 15.71%,CTE of 7.3×10^(−6)K^(−1),and thermal conductivity of 129 W·m^(−1)·K^(−1) at room temperature.It is demonstrated that the ND content has an obvious influence on the microstructure,mechanical properties,and thermal conductivity of ND/ZK60 composites.

Isolation, Identification and Pathogenicity Analysis of Streptococcus suis Type 2

[Objectives]This study aimed to investigate the pathogenicity,growth characteristics and drug resistance of Streptococcus suis type 2.[Methods]Bacterial isolation and identification,biochemical experiments,determination of growth curve and correlation curve between OD 600 values and viable counts,drug susceptibility tests,pathogenicity analysis,and histopathological observations were carried out.[Results]The Streptococcus strain isolated from infected pigs was identified as Streptococcus suis type 2,which was named TA01 strain.TA01 strain reached the growth peak at 6-8 h post-incubation,and viable counts gradually declined after 8 h of incubation.The correlation equation between OD 600 values and viable counts is y=24.659 x-1.076 1,R^2=0.996 7.TA01 strain was sensitive to penicillin,erythromycin,florfenicol and oxacillin,and resistant to ciprofloxacin,polymyxin B and clindamycin.According to the results of pathogenicity analysis,all the mice in 3.6×10^9 cfu/mouse group died within 48,and these dead mice exhibited acute pyaemia septica.Based on the Reed-Muench formula,it was calculated that LD 50 of TA01 strain was 1.137×10^8 cfu/mouse.Pathological examination showed obvious blue-stained bacteria clusters,accompanied by neutrophil infiltration.[Conclusions]TA01 strain was a virulent strain of Streptococcus suis type 2.Compared with Streptococcus strains which were isolated and reported in China,TA01 strain exhibited strong virulence and rapid proliferation.

Hierarchical intercalation of tetrafluoroborate anion into graphite electrode from sulfolane

The anion storage behavior of graphite positive electrode in a dual-ion battery is closely related to the solvation of anion in the corresponding electrolyte solution.The classical electrolyte solutions of Li BF_(4)^(-)sulfolane(SL)have long been recognized in the community of lithium batteries and still appear promising in dual-ion batteries.Nevertheless,the solvation of BF_(4)^(-)by SL has seldom been addressed before.In this study,the solvation states of SL-BF_(4)^(-)are adjusted by varying LiBF_(4)concentration or introducing auxiliary salts of LiPF_6or SBPBF_(4)(SBP:spiro-(1,1')-bipyrrolidinium)in the electrolyte solutions of Li/graphite dualion cells.The electrochemical storage processes of SL-BF_(4)^(-)anions in graphite electrodes are investigated through in situ X-ray diffraction measurements.Two kinds of graphite intercalation compounds(GICs)with contrastive intercalation gallery heights(IGHs)have been discovered,which are ascribed to the storage of different kinds of SL-BF_(4)^(-)anions in graphite electrode.The interactions between ions and SL in the electrolyte solutions are characterized by Fourier transform infrared spectroscopy and then correlated with the performance of Li/graphite cells.

Intercalation of multiply solvated hexafluorophospate anion into graphite electrode from mixtures of methyl acetate,ethyl methyl and ethylene carbonates

Graphite is a universal host material for ion intercalation. Li+-graphite intercalation compounds (GICs) have been successfully utilized as the anode material in commercial lithium-ion batteries.Similarly, anion-graphite intercalation compounds (AGICs) have been coming into their own in dual-ion batteries [1]. It is imperative to deepen an understanding of anion storage mechanisms in graphite electrode.

Structural similarity-based prediction of the potential active ingredients and mechanism of action of traditional Chinese medicine formulations used to anti-aging

Objective:To predict the potential active ingredients (PAIs) and mechanism of action of traditional Chinese medicine formulations used to delay aging.Methods:We incorporated the use of quantum-chemistry calculations and machine learning to predict the active ingredients of some Chinese herbal medicines used to delay aging.Then,a network-pharmacology approach was used to uncover how these PAls delayed aging.Results:Twelve PAls with anti-aging effects were discovered:androsterone,MHP,cortisone,propyl methyl trisulfide,retinol,retinal,cortisol,11-cis-Retinol (2R,3R)-3-hydroxyproline,4,5alpha-Dihydrocortisone (2S)-2-ammonio-6-ureidohexanoate and17alpha,21-Dihydroxy-5beta-pregnane-3,11,20-trione.Enrichment analyses indicated that a putative compound target and aging target were significantly associated with:regulation of the immune system;insulin receptor signaling pathway;regulation of the mitotic cell cycle;response to nutrient levels;response to oxidative stress;release of cytochrome c from mitochondria;learning or memory;inflammatory response.Conclusions:A novel method was proposed to predict the PAls of anti-aging herbal medicines by incorporating quantum-chemistry calculations and machine learning.Then,a network-pharmacology approach was used to uncover how these PAls delay aging.The information provided by our study on PAls may aid the discovery of anti-aging drugs.

Efficacy and safety of single-bolus tenecteplase compared with front-loaded alteplase in Chinese patients with acute myocardial infarction

Background and Objective Previous study showed tenecteplase and alteplaxe were equovalent for 30-day mortality in the treatment of acute myocardial infarction.The purpose of this open-label,randomized,multi-center,angiographic trial was to assess the efficacy and safety of tenecteplase compared with alteplase in Chinese patients with acute myocardial infarction.Methods We recruited patients with acute ST-elevation myocardial infarction presenting within 6 hours of symptom onset from October,2002 to March,2004,in 5 hospitals in Beijing.After giving informed consent,patients were randomly assigned a single-bolus injection of tenecteplase(30-50 mg according to body weight)or front loaded alteplase(100 mg),and underwent coronary angiography at 90 min after starting the study drug.All patients received aspirin and heparin(target activated partial thromboplastin time 50-70 s).The primary efficacy end point was the rate of TIMI grade 3 flow at 90 minutes.Other efficacy end points included TIMI grade 2/3 flow at 90 minutes.Safety end points included all stroke,intracranial hemorrhage(ICH),moderate/severe hemorrhage(except for ICH),all-cause mortality at 30-days,and major non-fatal cardiac events at 30 days.Results Overall 110 patients were eligible for statistical analysis,with 58 patients assigned to receive tenecteplase and 52 patients to alteplase.Tenecteplase produced a rate of TIMI grade 3 flow at 90 minutes after the start of thrombolysis(68.4%)similar to that of alteplase(66.7%,P=1.0);the rates of TIMI grade 2 or 3 were similar for patients treated with tenecteplase versus alteplase(89.5%versus 80.4%,respectively,P=0.278).At 30 days,rates for all strokes were similar for the two groups(5.17%for tenecteplase and 1.92%for alteplase,P=0.62);rates of ICH were 3.45%and 1.92%(tenecteplase and rt-PA,P=1.00)respectively.The rate of moderate/severe hemorrhage was 8.62%with tenecteplase and 5.77%with alteplase(P=0.72);total mortality was almost identical in the two groups(13.8%versus 9.6%,respectively,P=0.565)while the rates of non-fatal cardiac complications were 10.35%and 11.54%(tenecteplase and alteplase,P=1.0).Conclusions The efficacy of a single-bolus,weight-adjusted tenecteplase fibrinolytic regimen is equivalent to front-loaded alteplase in terms of the rates of TIMI grade 3 flow,and TIMI 2 or 3 flow,but the 30-day mortality and ICH in both groups was so high that the use of tenecteplase is not permitted in China.These negative safety results might be due to the high rate of percutaneous coronary intervention(PCI)and high dose of bolus heparin and suboptimal concomitant medical therapy during hospitalization,so further studies are needed to confirm the safety for tenecteplase in Chinese patients.

Estimation of Building’s Life Cycle Carbon Emissions Based on Life Cycle Assessment and Building Information Modeling: A Case Study of a Hospital Building in China

Throughout the life cycle, the buildings emit a great deal of carbon dioxide into the atmosphere, which directly leads to aggravation in the greenhouse effect and becomes a severe threat to the environment and humans. Researchers have made numerous efforts to accurately calculate emissions to reduce the life cycle carbon emissions of residential buildings. Nevertheless, there are still difficulties in quickly estimating carbon emissions in the design stage without specific data. To fill this gap, the study, based on Life Cycle Assessment (LCA) and Building Information Modeling (BIM), proposed a quick method for estimating Building’s Life Cycle Carbon Emissions (BLCCE). Taking a hospital building in Chuzhou City, Anhui Province, China as an example, it tested its possibility to estimate BLCCE. The results manifested that: 1) the BLCCE of the project is 40,083.56 tCO2-eq, and the carbon emissions per square meter per year are 119.91 kgCO2-eq/(m2·y);2) the stage of construction, operational and demolition account for 7.90%, 91.31%, and 0.79% of BLCCE, respectively;3) the annual carbon emissions per square meter of hospital are apparently higher than that of villa, residence, and office building, due to larger service population, longer daily operation time, and stricter patient comfort requirements. Considering the lack of BLCCE research in Chinese hospitals, this case study will provide a valuable reference for the estimated BLCCE of hospital building.

Felicitous Labellings of Some Network Models

Building up graph models to simulate scale-free networks is an important method since graphs have been used in researching scale-free networks. One use labelled graphs for distinguishing objects of communication and information networks. In this paper some methods are given for constructing larger felicitous graphs from smaller graphs having special felicitous labellings, and some network models are shown to be felicitous.

Excess Heat Triggered by Different Current in a D/Pd Gas-Loading System

In order to study the relationship between the triggering current, deuterium pressure and the excess heat, a series of experiments were made in a D/Pd gas-loading system. By comparing the system constants （k = AT//kP） in both nitrogen and deuterium atmosphere we found an optimum current （8 A） and a deuterium pressure （9 x 104 Pa） in which the system could release a maximum excess power （more than 80 W）. The reproducibility was 16/16 and the excess energy released in the longest experiment was about 300 MJ within 40 days, which was corresponding to 104 eV for each palladium atom. Analysis of the palladium surface with a SEM （scanning electron microscopy） and an EDS （energy dispersive spectrometer） revealed that some new surface topographical feature with concentrations of unexpected elements （such as Ag, Sn, Pb and Ca） appeared after the current triggering. The results implied that the excess heat might come from a nuclear transmutation.

Phosphine-free synthesis of FeTe2 nanoparticles and self-assembly into tree-like nanoarchitectures

Manipulating the self-assembly of transition metal telluride nanocrystals(NCs) creates opportunities for exploring new properties and device applications. Iron ditelluride(FeTe2) has recently emerged as a new class of magnetic semiconductor with three-dimensional(3D) magnetic ordering and narrow band gap structure, yet the self-assembly of FeTe2 NCs has not been achieved. Herein, the tree-like FeTe2 nanoarchitectures with orthorhombic crystal structure have been successfully synthesized by hot-injection solvent thermal approach using phosphine-free Te precursor. The morphology, size, and crystal structure have been investigated using transmission electron microscopy(TEM), high-resolution TEM(HRTEM),and powder x-ray diffraction(XRD). We study the formation process of tree-like FeTe2 NCs according to trace the change of the sample morphology with the reaction time. It was found that the FeTe2 nanoparticles show oriented aggregation and self-assembly behavior with the increase of reaction time, which is attributed to size-dependent magnetism properties of the samples. The magnetic interaction is thought to be the driving force of nanoparticle self-organization.

How bead shapes affect the plasma streamer characteristics in packed-bed dielectric barrier discharges:a kinetic modeling study

Different shapes of dielectric packing beads could affect streamer propagating direction,plasma streamer behavior,and streamer types,such as surface discharge,surface-to-surface discharge,and volume discharge.In this paper,a 2D particle-in-cell/Monte Carlo collision model is used to investigate the effect of the bead shapes on streamer characteristics in packed-bed dielectric barrier discharges.We calculate the electron density,ion density,excitation rate,ionization rate and the electric field with different bead shapes in two cases of seed electron configurations.The results demonstrate that both the configurations of seed electrons and the shape of beads could influence plasma properties.In the case of seed electrons located directly above the beads,the streamer cannot be generated with square beads,while weak surface ionization waves(SIWs)are developed with circle and triangle beads,when the distance between the seed electrons and the upper plate is as close as 0.02 mm.Whereas,the distance between the seed electrons and the upper plate is 0.06 mm,the streamers can be generated with all three bead shapes,but SIWs are still weak.This is because different shapes of beads induce different electric field and surface charging along the dielectric bead surfaces,determining the generation of SIWs.In the case of seed electrons placed between two beads,streamers can propagate in all three bead shape configurations,and the SIWs are enhanced.

Effects of lactic acid bacteria-fermented formula milk supplementation on ileal microbiota,transcriptomic profile,and mucosal immunity in weaned piglets

Background:Lactic acid bacteria(LAB)participating in milk fermentation naturally release and enrich the fermented dairy product with a broad range of bioactive metabolites,which has numerous roles in the intestinal health-promot-ing of the consumer.However,information is lacking regarding the application prospect of LAB fermented milk in the animal industry.This study investigated the effects of lactic acid bacteria-fermented formula milk(LFM)on the growth performance,intestinal immunity,microbiota composition,and transcriptomic responses in weaned piglets.A total of 24 male weaned piglets were randomly divided into the control(CON)and LFM groups.Each group consisted of 6 replicates(cages)with 2 piglets per cage.Each piglet in the LFM group were supplemented with 80 mL LFM three times a day,while the CON group was treated with the same amount of drinking water.Results:LFM significantly increased the average daily gain of piglets over the entire 14 d(P<0.01)and the average daily feed intake from 7 to 14 d(P<0.05).Compared to the CON group,ileal goblet cell count,villus-crypt ratio,sIgA,and lactate concentrations in the LFM group were significantly increased(P<0.05).Transcriptomic analysis of ileal mucosa identified 487 differentially expressed genes(DEGs)between two groups.Especially,DEGs involved in the intestinal immune network for IgA production pathways,such as polymeric immunoglobulin receptor(PIGR),were significantly up-regulated(P<0.01)by LFM supplementation.Moreover,trefoil factor 2(TFF2)in the LFM group,one of the DEGs involved in the secretory function of goblet cells,was also significantly up-regulated(P<0.01).Sequenc-ing of the 16S rRNA gene of microbiota demonstrated that LFM led to selective enrichment of lactate-producing and short-chain fatty acid(SCFA)-producing bacteria in the ileum,such as an increase in the relative abundance of Entero-coccus(P=0.09)and Acetitomaculum(P<0.05).Conclusions:LFM can improve intestinal health and immune tolerance,thus enhancing the growth performance of weaned piglets.The changes in microbiota and metabolites induced by LFM might mediate the regulation of the secretory function of goblet cells.

Atmospheric stable and fexible Sn-based perovskite solar cells via a bioinspired antioxidative crystal template

Sn-based perovskite solar cells(PSCs)demonstrate a potential development in eco-friendly devices due to their hypotoxicity.However,poor stability and crystalline quality are still the challenges for achieving high-performance and long-term operating devices.In this work,inspired by biological protein,nickelporphyrin(Ni-P)with electron cloud on conjugate ring is applied into Sn-based perovskite to prevent perovskite from being eroded.The synergistic effect of water and oxygen is broken in grain boundaries and surface so that the stability of PSCs can be improved obviously,despite there is hardly any barrier for water to erode.Simultaneously,the electron-rich molecules can passivate the defects of perovskite such as iodine vacancy.Moreover,the ester group in Ni-P molecule can bind with SnI;to form complex and then restrain nucleation.Combining with the template effect of 2D molecular,the crystallization of perovskite films is optimized.Therefore,the Sn-based PSCs with Ni-P achieve a stabilized power conversion efficiency(PCE)of 7.79%with negligible hysteresis in fexible devices,respectively.Moreover,the PSCs can maintain 80%of the pristine PCE after 300 h under air environment.

Association between the physical stability of flurbiprofen suspension and the interaction of HPMC/SDS

The anionic surfactant sodium dodecylsulfate(SDS) has improved the physical stability of flurbiprofen(FBP) suspension, which was suspended by 0.2%(w/v) hydroxypropylmethyl cellulose(HPMC, K4 M). Therefore, the physical stability of FBP suspensions and the interaction of HPMC/SDS were studied, and a certain association between them was revealed. The antisolvent precipitation method was used to prepare suspensions. The apparent drug concentration from different sites was evaluated to get the dispersion of drug actually. The process of flocculation and deflocculation with the addition of SDS was caught by analyzing the morphology of the suspended particles. The physical stability of the FBP suspensions was characterized mainly by measuring the re-dispersion time, the zeta potential and particle size. Meanwhile, conductivity measurements were carried out to obtain the characteristic concentrations of SDS in HPMC/SDS system. The viscosities, the abilities for improving the solubility and wettability of FBP in the separate and mixed HPMC/SDS solutions were also contrasted respectively. The suspensions prepared with HPMC/SDS possessed better physical stability. The suspensions were uniform when the concentration of SDS was between the critical adsorption concentration(CAC) and the polymer saturation point(PSP). After PSP, the uniformity became worse and worse until the SDS was enough to form a deflocculation state. Besides, the re-dispersion time of FBP suspensions was longest when the concentration of SDS around CAC and shorter by shorter after the critical micelle concentration(CMC). The article provided a new sight on the relation between the interaction of excipient matrix and pharmaceutical preparations.

Propagation characteristics of parallel dark solitons in silicon-on-insulator waveguide

The propagation characteristic of two identical and parallel dark solitons in a silicon-on-insulator(SOI)waveguide is simulated numerically using the split-step Fourier method.The parallel dark solitons imposed by the initial chirp are investigated mainly by changing their power,their relative time delay.The simulation shows that the time delay deforms the parallel dark soliton pulse,forming a bright-like soliton in the transmission process and making the transmission quality down.By increasing the power of one dark soliton,the energy of the other dark soliton can be increased,and larger increase in a soliton’s power leads to larger increase in the energy of the other.When the initial chirp is introduced into one of the dark solitons,higher energy consumption is observed.In particular,positive chirps resulting in pulse broadening width while negative chirps narrowing,with an obvious compression effect on the other dark soliton.Finally,large negative chirps are found to have a profound impact on parallel and nonparallel dark solitons.

Linear gyrokinetic simulations of reversed shear Alfvén eigenmodes and ion temperature gradient modes in DIII-D tokamak

Global linear gyrokinetic simulations using realistic DIII-D tokamak geometry and plasma profiles find co-existence of unstable reversed shear Alfvén eigenmodes(RSAE)with low toroidal mode number n and electromagnetic ion temperature gradient(ITG)instabilities with higher toroidal mode number n.For intermediate n?=?[10,12],RSAE and ITG co-exist and overlap weakly in the radial domain with similar growth rates but different real frequencies.Both RSAE and ITG growth rates decrease less than 5%when compressible magnetic perturbations are neglected in the simulations.The ITG growth rates increase less than 7%when fast ions are not included in the simulations.Finally,the effects of trapped electrons on the RSAE are negligible.