This paper considers a linear-quadratic(LQ) meanfield game governed by a forward-backward stochastic system with partial observation and common noise,where a coupling structure enters state equations,cost functionals ...This paper considers a linear-quadratic(LQ) meanfield game governed by a forward-backward stochastic system with partial observation and common noise,where a coupling structure enters state equations,cost functionals and observation equations.Firstly,to reduce the complexity of solving the meanfield game,a limiting control problem is introduced.By virtue of the decomposition approach,an admissible control set is proposed.Applying a filter technique and dimensional-expansion technique,a decentralized control strategy and a consistency condition system are derived,and the related solvability is also addressed.Secondly,we discuss an approximate Nash equilibrium property of the decentralized control strategy.Finally,we work out a financial problem with some numerical simulations.展开更多
Hepatocellular carcinoma(HCC) is responsible for a significant number of cancer-related deaths worldwide and its incidence is increasing. Locoregional treatments, which are precision procedures guided by imaging to sp...Hepatocellular carcinoma(HCC) is responsible for a significant number of cancer-related deaths worldwide and its incidence is increasing. Locoregional treatments, which are precision procedures guided by imaging to specifically target liver tumors, play a critical role in the management of a substantial portion of HCC cases. These therapies have become an essential element of the HCC treatment landscape, with transarterial chemoembolization(TACE)being the treatment of choice for patients with intermediate to advanced stages of the disease. Other locoregional therapies, like radiofrequency ablation, are highly effective for small, early-stage HCC. Nevertheless, the advent of targeted immunotherapy has challenged these established treatments. Tyrosine kinase inhibitors(TKIs) and immune checkpoint inhibitors(ICIs) have shown remarkable efficacy in clinical settings. However, their specific uses and the development of resistance in subsequent treatments have led clinicians to reevaluate the future direction of HCC therapy. This review concentrates on the distinct features of both systemic and novel locoregional therapies. We investigate their effects on the tumor microenvironment at the molecular level and discuss how targeted immunotherapy can be effectively integrated with locoregional therapies. We also examine research findings from retrospective studies and randomized controlled trials on various combined treatment regimens, assessing their validity to determine the future evolution of locoregional therapies within the framework of personalized, comprehensive treatment.展开更多
Grapevine is one of the most economically important crops worldwide.However,the previous versions of the grapevine reference genome tipically consist of thousands of fragments with missing centromeres and telomeres,li...Grapevine is one of the most economically important crops worldwide.However,the previous versions of the grapevine reference genome tipically consist of thousands of fragments with missing centromeres and telomeres,limiting the accessibility of the repetitive sequences,the centromeric and telomeric regions,and the study of inheritance of important agronomic traits in these regions.Here,we assembled a telomere-to-telomere(T2T)gap-free reference genome for the cultivar PN40024 using PacBio HiFi long reads.The T2T reference genome(PN_T2T)is 69 Mb longer with 9018 more genes identified than the 12X.v0 version.We annotated 67%repetitive sequences,19 centromeres and 36 telomeres,and incorporated gene annotations of previous versions into the PN_T2T assembly.We detected a total of 377 gene clusters,which showed associations with complex traits,such as aroma and disease resistance.Even though PN40024 derives from nine generations of selfing,we still found nine genomic hotspots of heterozygous sites associated with biological processes,such as the oxidation–reduction process and protein phosphorylation.The fully annotated complete reference genome therefore constitutes an important resource for grapevine genetic studies and breeding programs.展开更多
板状燃料元件用于研究堆中表现出良好的辐照性能。通过对国内外一些使用板状燃料元件研究堆堵流事故实例的调研,发现板状燃料元件板间的栅距通常很小,堆芯冷却剂流道狭窄,堵流事故的发生大都由异物进入流道或燃料肿胀引起。选取中国先...板状燃料元件用于研究堆中表现出良好的辐照性能。通过对国内外一些使用板状燃料元件研究堆堵流事故实例的调研,发现板状燃料元件板间的栅距通常很小,堆芯冷却剂流道狭窄,堵流事故的发生大都由异物进入流道或燃料肿胀引起。选取中国先进研究堆(China Advanced Research Reactor,CARR)作为特征研究对象,采用RELAP5/MOD3.2热工计算程序,对CARR堆芯、堆本体、单盒组件、堆外冷却回路等进行了热工水力模拟计算,结果表明:当反应堆功率提升时,堵塞的流道内燃料组件温度上升,冷却剂开始发生沸腾,功率会发生明显波动。通过中子注量率与功率的监控以及燃料温度的分析,有助于及早探知和预防堵流事故的进一步发展扩大。展开更多
阿尔及利亚比林核研究中心重水反应堆(Multi-purposes Heavy Water Research Reactor,MHWRR)实施了仪表、控制和电气数字化升级改造,改造后的首次临界启动对改造工程具有重要意义。为保证反应堆启动安全,需要解决升级改造后在极低光激...阿尔及利亚比林核研究中心重水反应堆(Multi-purposes Heavy Water Research Reactor,MHWRR)实施了仪表、控制和电气数字化升级改造,改造后的首次临界启动对改造工程具有重要意义。为保证反应堆启动安全,需要解决升级改造后在极低光激中子水平下临界启动中存在的核测量盲区问题,首先对长期停堆后堆内剩余光激中子源强、核测量盲区以及临界棒位进行了理论计算与分析研究,在此基础上提出了在无外加启动中子源条件下首次临界启动的实验技术方案。在无参考数据的情况下,实验进程完全按理论设计的预期进行,临界启动一次成功;启动过程中核功率参数得到有效监测,启动测量装置与堆外电离室测量范围衔接完备,临界棒位理论值与实验值的误差小于0.84%,实验结果与理论计算结果符合良好,表明了这项实验技术的合理可行。展开更多
基金supported by the National Key Research and Development Program of China(2022YFA1006103,2023YFA1009203)the National Natural Science Foundation of China(61925306,61821004,11831010,61977043,12001320)+2 种基金the Natural Science Foundation of Shandong Province(ZR2019ZD42,ZR2020ZD24)the Taishan Scholars Young Program of Shandong(TSQN202211032)the Young Scholars Program of Shandong University。
文摘This paper considers a linear-quadratic(LQ) meanfield game governed by a forward-backward stochastic system with partial observation and common noise,where a coupling structure enters state equations,cost functionals and observation equations.Firstly,to reduce the complexity of solving the meanfield game,a limiting control problem is introduced.By virtue of the decomposition approach,an admissible control set is proposed.Applying a filter technique and dimensional-expansion technique,a decentralized control strategy and a consistency condition system are derived,and the related solvability is also addressed.Secondly,we discuss an approximate Nash equilibrium property of the decentralized control strategy.Finally,we work out a financial problem with some numerical simulations.
文摘Hepatocellular carcinoma(HCC) is responsible for a significant number of cancer-related deaths worldwide and its incidence is increasing. Locoregional treatments, which are precision procedures guided by imaging to specifically target liver tumors, play a critical role in the management of a substantial portion of HCC cases. These therapies have become an essential element of the HCC treatment landscape, with transarterial chemoembolization(TACE)being the treatment of choice for patients with intermediate to advanced stages of the disease. Other locoregional therapies, like radiofrequency ablation, are highly effective for small, early-stage HCC. Nevertheless, the advent of targeted immunotherapy has challenged these established treatments. Tyrosine kinase inhibitors(TKIs) and immune checkpoint inhibitors(ICIs) have shown remarkable efficacy in clinical settings. However, their specific uses and the development of resistance in subsequent treatments have led clinicians to reevaluate the future direction of HCC therapy. This review concentrates on the distinct features of both systemic and novel locoregional therapies. We investigate their effects on the tumor microenvironment at the molecular level and discuss how targeted immunotherapy can be effectively integrated with locoregional therapies. We also examine research findings from retrospective studies and randomized controlled trials on various combined treatment regimens, assessing their validity to determine the future evolution of locoregional therapies within the framework of personalized, comprehensive treatment.
基金This work was supported by the National Natural Science Fund for Excellent Young Scientists Fund Program(Overseas)to Y.Z.,the National Key Research and Development Program of China(grant 2019YFA0906200)the Agricultural Science and Technology Innovation Program(CAAS-ZDRW202101)+1 种基金the Shenzhen Science and Technology Program(grant KQTD2016113010482651)the BMBF-funded de.
文摘Grapevine is one of the most economically important crops worldwide.However,the previous versions of the grapevine reference genome tipically consist of thousands of fragments with missing centromeres and telomeres,limiting the accessibility of the repetitive sequences,the centromeric and telomeric regions,and the study of inheritance of important agronomic traits in these regions.Here,we assembled a telomere-to-telomere(T2T)gap-free reference genome for the cultivar PN40024 using PacBio HiFi long reads.The T2T reference genome(PN_T2T)is 69 Mb longer with 9018 more genes identified than the 12X.v0 version.We annotated 67%repetitive sequences,19 centromeres and 36 telomeres,and incorporated gene annotations of previous versions into the PN_T2T assembly.We detected a total of 377 gene clusters,which showed associations with complex traits,such as aroma and disease resistance.Even though PN40024 derives from nine generations of selfing,we still found nine genomic hotspots of heterozygous sites associated with biological processes,such as the oxidation–reduction process and protein phosphorylation.The fully annotated complete reference genome therefore constitutes an important resource for grapevine genetic studies and breeding programs.
文摘板状燃料元件用于研究堆中表现出良好的辐照性能。通过对国内外一些使用板状燃料元件研究堆堵流事故实例的调研,发现板状燃料元件板间的栅距通常很小,堆芯冷却剂流道狭窄,堵流事故的发生大都由异物进入流道或燃料肿胀引起。选取中国先进研究堆(China Advanced Research Reactor,CARR)作为特征研究对象,采用RELAP5/MOD3.2热工计算程序,对CARR堆芯、堆本体、单盒组件、堆外冷却回路等进行了热工水力模拟计算,结果表明:当反应堆功率提升时,堵塞的流道内燃料组件温度上升,冷却剂开始发生沸腾,功率会发生明显波动。通过中子注量率与功率的监控以及燃料温度的分析,有助于及早探知和预防堵流事故的进一步发展扩大。
文摘阿尔及利亚比林核研究中心重水反应堆(Multi-purposes Heavy Water Research Reactor,MHWRR)实施了仪表、控制和电气数字化升级改造,改造后的首次临界启动对改造工程具有重要意义。为保证反应堆启动安全,需要解决升级改造后在极低光激中子水平下临界启动中存在的核测量盲区问题,首先对长期停堆后堆内剩余光激中子源强、核测量盲区以及临界棒位进行了理论计算与分析研究,在此基础上提出了在无外加启动中子源条件下首次临界启动的实验技术方案。在无参考数据的情况下,实验进程完全按理论设计的预期进行,临界启动一次成功;启动过程中核功率参数得到有效监测,启动测量装置与堆外电离室测量范围衔接完备,临界棒位理论值与实验值的误差小于0.84%,实验结果与理论计算结果符合良好,表明了这项实验技术的合理可行。
