Objective:To investigate the clinical effect of Tongxinluo combined with trimetazidine on cardiac function in patients with acute ST-segment elevation myocardial infarction after percutaneous coronary intervention.Met...Objective:To investigate the clinical effect of Tongxinluo combined with trimetazidine on cardiac function in patients with acute ST-segment elevation myocardial infarction after percutaneous coronary intervention.Method: From March 2014 to September 2016, we selected 190 patients with ST-segment elevation myocardial infarction with percutaneous coronary intervention, according to the admission time is divided into observation group and control group, the control group was treated with conventional therapy (aspirin, isosorbide dinitrate, metoprolol tartrate, clopidogrel sulfate, captopril, atorvastatin calcium and diuretics) and trimetazidine, observation group in the control group based on Tongxinluo combined treatment, each group of 95 cases, and hs-CRP, aldosterone, NT-proBNP, TNF-α, IL-6, and cardiac function (LVEDV,LVESV,LVEF,SV) were compared.Result: The Hs-CRP in the observation group was significantly lower than that in the control group;The aldosterone in the observation group was significantly lower than that in the control group;The levels of NT-proBNP, TNF-α and IL-6 in the observation group were significantly lower than those in the control group;LVVEV and LVESV were significantly lower in the observation group than in the control group, LVEF and SV were significantly higher than those in the control group.Conclusion:Tongxinluo combined with trimetazidine in patients with acute ST-segment elevation myocardial infarction after percutaneous coronary intervention in patients with clinical effect is better, stable plaque, effectively improve microcirculation and cardiac function, recommended a wide range of clinical application.展开更多
In this paper,theoretical and numerical methods are combined to investigate the two-dimensional,cylindrical indentation of an elastic soft layer bonded on a rigid substrate.By incorporating the Gurtin-Murdoch’s theor...In this paper,theoretical and numerical methods are combined to investigate the two-dimensional,cylindrical indentation of an elastic soft layer bonded on a rigid substrate.By incorporating the Gurtin-Murdoch’s theory of surface elasticity into the Kerr model,we account for surface effects on the indentation behavior of a soft layer.The governing differential relation between the surface pressure and displacement of the film-substrate system is derived.For an incompressible thin layer,the explicit solutions are derived,which are simple and easy-to-use.Finite element simulations are performed using an explicit restart algorithm to study the indentation properties of the layer-substrate system and to examine the validity and accuracy of the theoretical solutions.This work holds promise for applications in mechanical characterization of soft materials,such as biological tissues and cells.展开更多
文摘Objective:To investigate the clinical effect of Tongxinluo combined with trimetazidine on cardiac function in patients with acute ST-segment elevation myocardial infarction after percutaneous coronary intervention.Method: From March 2014 to September 2016, we selected 190 patients with ST-segment elevation myocardial infarction with percutaneous coronary intervention, according to the admission time is divided into observation group and control group, the control group was treated with conventional therapy (aspirin, isosorbide dinitrate, metoprolol tartrate, clopidogrel sulfate, captopril, atorvastatin calcium and diuretics) and trimetazidine, observation group in the control group based on Tongxinluo combined treatment, each group of 95 cases, and hs-CRP, aldosterone, NT-proBNP, TNF-α, IL-6, and cardiac function (LVEDV,LVESV,LVEF,SV) were compared.Result: The Hs-CRP in the observation group was significantly lower than that in the control group;The aldosterone in the observation group was significantly lower than that in the control group;The levels of NT-proBNP, TNF-α and IL-6 in the observation group were significantly lower than those in the control group;LVVEV and LVESV were significantly lower in the observation group than in the control group, LVEF and SV were significantly higher than those in the control group.Conclusion:Tongxinluo combined with trimetazidine in patients with acute ST-segment elevation myocardial infarction after percutaneous coronary intervention in patients with clinical effect is better, stable plaque, effectively improve microcirculation and cardiac function, recommended a wide range of clinical application.
文摘In this paper,theoretical and numerical methods are combined to investigate the two-dimensional,cylindrical indentation of an elastic soft layer bonded on a rigid substrate.By incorporating the Gurtin-Murdoch’s theory of surface elasticity into the Kerr model,we account for surface effects on the indentation behavior of a soft layer.The governing differential relation between the surface pressure and displacement of the film-substrate system is derived.For an incompressible thin layer,the explicit solutions are derived,which are simple and easy-to-use.Finite element simulations are performed using an explicit restart algorithm to study the indentation properties of the layer-substrate system and to examine the validity and accuracy of the theoretical solutions.This work holds promise for applications in mechanical characterization of soft materials,such as biological tissues and cells.
