An infrared (IR) imaging simulation framework based on the strap-down platform is proposed for midcourse ballistic targets. It overcomes the shortcoming of the existing algorithms, which cannot simulate IR imaging f...An infrared (IR) imaging simulation framework based on the strap-down platform is proposed for midcourse ballistic targets. It overcomes the shortcoming of the existing algorithms, which cannot simulate IR imaging from the entire midcourse process. The proposed framework includes three steps, target characteristic modeling, motion modeling, and imaging modeling. In imaging modeling, the staring focal plane is taken into account due to its wide employment. In order to obtain IR images of high fidelity, especially that the fluctuation of the target signal-to-noise ratio (SNR) is reasonably similar to the actual one, this paper proposes an improved IR imaging simulation method. The proposed method considers two critical factors of the pixel plane, occupy-empty ratio and defect elements, which affect the imaging of targets markedly but are neglected in previous work. Finally, the IR image sequence of high fidelity is obtained. And the correlative parameters of simulation can be set according to the given scene. Thus the generated images can satisfy the needs of algorithms validation for tracking and recognition.展开更多
The dynamic characteristics related to micro-motions, such as mechanical vibration or rotation, play an essential role in classifying and recognizing ballistic targets in the midcourse, and recent researches explore w...The dynamic characteristics related to micro-motions, such as mechanical vibration or rotation, play an essential role in classifying and recognizing ballistic targets in the midcourse, and recent researches explore ways of extracting the micro-motion features from radar signals of ballistic targets. In this paper, we focus on how to investigate the micro-motion dynamic characteristics of the ballistic targets from the signals based on infrared (IR) detection, which is mainly achieved by analyzing the periodic fluctuation characteristics of the target IR irradiance intensity signatures. Simulation experiments demonstrate that the periodic characteristics of IR signatures can be used to distinguish different micro motion types and estimate related parameters. Consequently, this is possible to determine the micro-motion dynamics of ballistic targets based on IR detection.展开更多
Objective: To investigate the reversal effect of CQ11, a chloroquine derivative, on multidrug resistance (MDR) in doxorubicin (DOX)-resistant human breast carcinoma cell line MCF/DOX. Methods: Cells of a human b...Objective: To investigate the reversal effect of CQ11, a chloroquine derivative, on multidrug resistance (MDR) in doxorubicin (DOX)-resistant human breast carcinoma cell line MCF/DOX. Methods: Cells of a human breast cancer cell line, MCF, and its DOX-resistant variant, MCF/DOX, were cultivated with DOX and/or CQ11. The cytotoxicity of drugs in vitro was assayed by MTT method. The accumulation of DOX in these cells was detected by fluorescence spectrophotometer. Results: MCF/DOX cells were 119 times more resistant to DOX in comparison with M CF cells. After simultaneous treatment with CQ 11 at the concentrations of 1.0, 2.5 and 5.0 μmol/L, the IC50 of DOX for MCF/DOX cells decreased from 3.1 ±0.47 μmot/L to 0.58 ± 0.032, 0.19 ± 0.012 and 0.081 ± 0.015 μmol/L, respectively, thus, increasing the DOX sensitivity by 5.3-fold (P 〈 0.01), 16- fold (P 〈 0.01) and 38-fold (P 〈 0.01), respectively. In the accumulation assay of DOX, simultaneous incubation of MCF/DOX cells with CQ11 significantly increased the DOX accumulation in MCF/DOX cells. No such results were found in parental MCF cells. Conclusion: CQ11 had strong MDR reversal effect by enhancing intracellular DOX accumulation in MCF/DOX cells, indicating that CQ11 may be a promising MDR chemosensitivity.展开更多
文摘An infrared (IR) imaging simulation framework based on the strap-down platform is proposed for midcourse ballistic targets. It overcomes the shortcoming of the existing algorithms, which cannot simulate IR imaging from the entire midcourse process. The proposed framework includes three steps, target characteristic modeling, motion modeling, and imaging modeling. In imaging modeling, the staring focal plane is taken into account due to its wide employment. In order to obtain IR images of high fidelity, especially that the fluctuation of the target signal-to-noise ratio (SNR) is reasonably similar to the actual one, this paper proposes an improved IR imaging simulation method. The proposed method considers two critical factors of the pixel plane, occupy-empty ratio and defect elements, which affect the imaging of targets markedly but are neglected in previous work. Finally, the IR image sequence of high fidelity is obtained. And the correlative parameters of simulation can be set according to the given scene. Thus the generated images can satisfy the needs of algorithms validation for tracking and recognition.
文摘The dynamic characteristics related to micro-motions, such as mechanical vibration or rotation, play an essential role in classifying and recognizing ballistic targets in the midcourse, and recent researches explore ways of extracting the micro-motion features from radar signals of ballistic targets. In this paper, we focus on how to investigate the micro-motion dynamic characteristics of the ballistic targets from the signals based on infrared (IR) detection, which is mainly achieved by analyzing the periodic fluctuation characteristics of the target IR irradiance intensity signatures. Simulation experiments demonstrate that the periodic characteristics of IR signatures can be used to distinguish different micro motion types and estimate related parameters. Consequently, this is possible to determine the micro-motion dynamics of ballistic targets based on IR detection.
基金the National Natural Science Foundation of China (No. 39800181)the Research Foundation of Jiaxing Science and Technology Bureau (No. 2007AY2033)the Research Foundation of Jiaxing College (No. 70107032)
文摘Objective: To investigate the reversal effect of CQ11, a chloroquine derivative, on multidrug resistance (MDR) in doxorubicin (DOX)-resistant human breast carcinoma cell line MCF/DOX. Methods: Cells of a human breast cancer cell line, MCF, and its DOX-resistant variant, MCF/DOX, were cultivated with DOX and/or CQ11. The cytotoxicity of drugs in vitro was assayed by MTT method. The accumulation of DOX in these cells was detected by fluorescence spectrophotometer. Results: MCF/DOX cells were 119 times more resistant to DOX in comparison with M CF cells. After simultaneous treatment with CQ 11 at the concentrations of 1.0, 2.5 and 5.0 μmol/L, the IC50 of DOX for MCF/DOX cells decreased from 3.1 ±0.47 μmot/L to 0.58 ± 0.032, 0.19 ± 0.012 and 0.081 ± 0.015 μmol/L, respectively, thus, increasing the DOX sensitivity by 5.3-fold (P 〈 0.01), 16- fold (P 〈 0.01) and 38-fold (P 〈 0.01), respectively. In the accumulation assay of DOX, simultaneous incubation of MCF/DOX cells with CQ11 significantly increased the DOX accumulation in MCF/DOX cells. No such results were found in parental MCF cells. Conclusion: CQ11 had strong MDR reversal effect by enhancing intracellular DOX accumulation in MCF/DOX cells, indicating that CQ11 may be a promising MDR chemosensitivity.