Dynamic interactive bitwise meta-holography with ultra-high computational and display frame rates

Interactive holography offers unmatched levels of immersion and user engagement in the field of future display.Despite of the substantial progress has been made in dynamic meta-holography,the realization of real-time,highly smooth interactive holography remains a significant challenge due to the computational and display frame rate limitations.In this study,we introduced a dynamic interactive bitwise meta-holography with ultra-high computational and display frame rates.To our knowledge,this is the first reported practical dynamic interactive metasurface holographic system.We spa-tially divided the metasurface device into multiple distinct channels,each projecting a reconstructed sub-pattern.The switching states of these channels were mapped to bitwise operations on a set of bit values,which avoids complex holo-gram computations,enabling an ultra-high computational frame rate.Our approach achieves a computational frame rate of 800 kHz and a display frame rate of 23 kHz on a low-power Raspberry Pi computational platform.According to this methodology,we demonstrated an interactive dynamic holographic Tetris game system that allows interactive gameplay,color display,and on-the-fly hologram creation.Our technology presents an inspiration for advanced dynamic meta-holography,which is promising for a broad range of applications including advanced human-computer interaction,real-time 3D visualization,and next-generation virtual and augmented reality systems.

Investigating Müller glia reprogramming in mice: a retrospective of the last decade, and a look to the future

Müller glia,as prominent glial cells within the retina,plays a significant role in maintaining retinal homeostasis in both healthy and diseased states.In lower vertebrates like zebrafish,these cells assume responsibility for spontaneous retinal regeneration,wherein endogenous Müller glia undergo proliferation,transform into Müller glia-derived progenitor cells,and subsequently regenerate the entire retina with restored functionality.Conversely,Müller glia in the mouse and human retina exhibit limited neural reprogramming.Müller glia reprogramming is thus a promising strategy for treating neurodegenerative ocular disorders.Müller glia reprogramming in mice has been accomplished with remarkable success,through various technologies.Advancements in molecular,genetic,epigenetic,morphological,and physiological evaluations have made it easier to document and investigate the Müller glia programming process in mice.Nevertheless,there remain issues that hinder improving reprogramming efficiency and maturity.Thus,understanding the reprogramming mechanism is crucial toward exploring factors that will improve Müller glia reprogramming efficiency,and for developing novel Müller glia reprogramming strategies.This review describes recent progress in relatively successful Müller glia reprogramming strategies.It also provides a basis for developing new Müller glia reprogramming strategies in mice,including epigenetic remodeling,metabolic modulation,immune regulation,chemical small-molecules regulation,extracellular matrix remodeling,and cell-cell fusion,to achieve Müller glia reprogramming in mice.

Optimizing nitrogen management can improve stem lodging resistance and stabilize the grain yield of japonica rice in rice-crayfish coculture systems

Nitrogen(N)significantly affects rice yield and lodging resistance.Previous studies have primarily investigated the impact of N management on rice lodging in conventional rice monoculture(RM);however,few studies have performed such investigations in rice-crayfish coculture(RC).We hypothesized that RC would increase rice lodging risk and that optimizing N application practices would improve rice lodging resistance without affecting food security.We conducted a two-factor(rice farming mode and N management practice)field experiment from2021 to 2022 to test our hypothesis.The rice farming modes included RM and RC,and the N management practices included no nitrogen fertilizer,conventional N application,and optimized N treatment.The rice yield and lodging resistance characteristics,such as morphology,mechanical and chemical characteristics,anatomic structure,and gene expression levels,were analyzed and compared among the treatments.Under the same N application practice,RC decreased the rice yield by 11.1-24.4% and increased the lodging index by 19.6-45.6% compared with the values yielded in RM.In RC,optimized N application decreased the plant height,panicle neck node height,center of gravity height,bending stress,and lodging index by 4.0-4.8%,5.2-7.8%,0.5-4.5%,5.5-10.5%,and 1.8-19.5%,respectively,compared with those in the conventional N application practice.Furthermore,it increased the culm diameter,culm wall thickness,breaking strength,and non-structural and structural carbohydrate content by 0.8-4.9%,2.2-53.1%,13.5-19.2%,2.2-24.7%,and 31.3-87.2%,respectively.Optimized N application increased sclerenchymal and parenchymal tissue areas of the vascular bundle at the culm wall of the base second internode.Furthermore,optimized N application upregulated genes involved in lignin and cellulose synthesis,thereby promoting lower internodes on the rice stem and enhancing lodging resistance.Optimized N application in RC significantly reduced the lodging index by 1.8-19.5%and stabilized the rice yield(>8,570 kg ha~(-1)on average).This study systematically analyzed and compared the differences in lodging characteristics between RM and RC.The findings will aid in the development of more efficient practices for RC that will reduce N fertilizer application.

Long noncoding RNAs HAND2-AS1 ultrasound microbubbles suppress hepatocellular carcinoma progression by regulating the miR-873-5p/tissue inhibitor of matrix metalloproteinase-2 axis

BACKGROUND Increasing data indicated that long noncoding RNAs(lncRNAs)were directly or indirectly involved in the occurrence and development of tumors,including hepatocellular carcinoma(HCC).Recent studies had found that the expression of lncRNA HAND2-AS1 was downregulated in HCC tissues,but its role in HCC progression is unclear.Ultrasound targeted microbubble destruction mediated gene transfection is a new method to overexpress genes.AIM To study the role of ultrasound microbubbles(UTMBs)mediated HAND2-AS1 in the progression of HCC,in order to provide a new reference for the treatment of HCC.METHODS In vitro,we transfected HAND2-AS1 siRNA into HepG2 cells by UTMBs,and detected cell proliferation,apoptosis,invasion and epithelial-mesenchymal transition(EMT)by cell counting kit-8 assay,flow cytometry,Transwell invasion assay and Western blotting,respectively.In addition,we transfected miR-837-5p mimic into UTMBs treated cells and observed the changes of cell behavior.Next,the UTMBs treated HepG2 cells were transfected together with miR-837-5p mimic and tissue inhibitor of matrix metalloproteinase-2(TIMP2)overexpression vector,and we detected cell proliferation,apoptosis,invasion and EMT.In vivo,we established a mouse model of subcutaneous transplantation of HepG2 cells and observed the effect of HAND2-AS1 silencing on tumor formation ability.RESULTS We found that UTMBs carrying HAND2-AS1 restricted cell proliferation,invasion,and EMT,encouraged apoptosis,and HAND2-AS1 silencing eliminated the effect of UTMBs.Additionally,miR-873-5p targets the gene HAND2-AS1,which also targets the 3’UTR of TIMP2.And miR-873-5p mimic counteracted the impact of HAND2-AS1.Further,miR-873-5p mimic solely or in combination with pcDNA-TIMP2 had been transformed into HepG2 cells exposed to UTMBs.We discovered that TIMP2 reversed the effect of miR-873-5p mimic caused by the blocked signalling cascade for matrix metalloproteinase(MMP)2/MMP9.In vivo results showed that HAND2-AS1 silencing significantly inhibited tumor formation in mice.CONCLUSION LncRNA HAND2-AS1 promotes TIMP2 expression by targeting miR-873-5p to inhibit HepG2 cell growth and delay HCC progression.

Research Progress of Drug Therapy for Diabetes

Diabetes is mainly a series of symptoms of glucose metabolism disorder caused by relative or absolute insufficiencies of insulin.Most patients are accompanied by protein,fat,water and electrolyte disorders,including diabetes type 1 and diabetes type 2,of which diabetes type 2 accounts for more than 90%.The incidence rate of diabetes is high,the course of disease is long,and it is difficult to cure.Most patients need long-term medication.This study analyzed the clinical manifestations and predisposing factors of diabetes,and explored the progress of drug treatment of diabetes,which is summarized as follows.

构建Cu台阶位促进电催化CO_(2)还原制醇类化学品的研究

电催化CO_(2)制备高附加值的化学品是解决当前碳排放问题的可行技术路线之一.其中,合成醇类化合物因具有广泛用途和高价值而备受关注.在电催化CO_(2)还原合成多碳醇反应中,关键中间体*CH_(2)CHO容易发生热力学有利的脱氧反应而生成C2H4,降低了醇类产物的选择性.由于电催化CO_(2)还原是一个表面结构敏感的反应,因此可以通过设计Cu基催化剂的特定表面结构,实现对反应路径的有效调节,从而提升醇类产物的选择性.本课题组前期通过密度泛函理论(DFT)计算和主成分分析法等对Cu基催化剂的构效关系进行解析,说明配位不饱和的台阶位点有望高效地促进醇类产物的生成.本文进一步从实验角度,证明了配位不饱和的台阶位点是生成醇类产物的活性位点.本文采用CO分子作为还原剂制备了CuO衍生的金属Cu催化剂(COD-Cu),利用CO分子对Cu表面的重构作用,获得了具有丰富台阶位点的Cu催化剂.而通过H_(2)还原制备的金属Cu催化剂(HOD-Cu)对照样表面则多为平面位点.X射线衍射和原位拉曼光谱结果表明,CuO前驱体经过CO或H_(2)还原后被完全还原为金属态,并且在电化学还原条件下依旧呈现金属态,排除了催化剂价态对反应的影响.扫描电镜结果表明,两种催化剂的形貌没有明显区别,排除了催化剂形貌对反应的影响.高分辨透射电镜结果表明,COD-Cu表面因为CO的重构作用,产生相较于HOD-Cu更多的台阶位点,这与CO原位红外光谱结果一致(COD-Cu催化剂在2080 cm~(–1)波数处具有明显的台阶位点CO吸附峰).电化学CO_(2)还原活性测试结果表明,COD-Cu表现出更高的醇类产物选择性,相较于HOD-Cu,法拉第效率与部分电流密度均提升了5倍以上,醇类产物的法拉第效率达到40.5%,部分电流密度达到56.3 mAcm~(-2),产物中醇/烯烃比值为2.2.这表明台阶位点对调控反应路径促进醇类生成具有重要作用.结合原位衰减全反射表面增强傅里叶变换红外吸收光谱的阶跃电位和Ar气吹扫实验结果表明,COD-Cu因具有更多的台阶位点而表现出更高的催化CO_(2)到*CO反应活性,并有效促进后续的C–C偶联反应.通过热退火实验制备了具有不同台阶位点含量的COD-Cu催化剂,其台阶位点的含量与醇类产物的选择性保持良好的线性关系,进一步验证了台阶位点是促进醇类产物生成活性位点的结论.DFT结果也表明,台阶位点可以有效的提升关键中间体*CH_(2)CHO中C–O键强度,从而抑制C–O键断裂,促进醇类产物的生成.综上,本文提出了一种通过催化剂活性位点设计调控电催化CO_(2)还原反应路径的有效策略,为解析催化剂构效关系、明确活性位点提供参考.得益于催化科学的快速发展,具有高活性的CO_(2)还原电催化剂不断涌现,未来可在发展活性位点精细化调控方法、开发新型原位瞬态表征技术、创新催化剂失活机制原位研究方法等方面做出更多的努力.

Acousto-optic scanning spatial-switching multiphoton lithography

Nano-3D printing has obtained widespread attention owing to its capacity to manufacture end-use components with nano-scale features in recent years.Multiphoton lithography(MPL)is one of the most promising 3D nanomanufacturing technologies,which has been widely used in manufacturing micro-optics,photonic crystals,microfluidics,meta-surface,and mechanical metamaterials.Despite of tremendous potential of MPL in laboratorial and industrial applications,simultaneous achievement of high throughput,high accuracy,high design freedom,and a broad range of material structuring capabilities remains a long-pending challenge.To address the issue,we propose an acousto-optic scanning with spatial-switching multispots(AOSS)method.Inertia-free acousto-optic scanning and nonlinear swept techniques have been developed for achieving ultrahigh-speed and aberration-free scanning.Moreover,a spatial optical switch concept has been implemented to significantly boost the lithography throughput while maintaining high resolution and high design freedom.An eight-foci AOSS system has demonstrated a record-high 3D printing rate of 7.6×10^(7)voxel s^(-1),which is nearly one order of magnitude higher than earlier scanning MPL,exhibiting its promise for future scalable 3D nanomanufacturing.

Multi-foci metalens for spectra and polarization ellipticity recognition and reconstruction

Multispectral and polarized focusing and imaging are key functions that are vitally important for a broad range of optical applications.Conventional techniques generally require multiple shots to unveil desired optical information and are implemented via bulky multi-pass systems or mechanically moving parts that are difficult to integrate into compact and integrated optical systems.Here,a design of ultra-compact transversely dispersive metalens capable of both spectrum and polarization ellipticity recognition and reconstruction in just a single shot is demonstrated with both coherent and incoherent light.Our design is well suited for integrated and high-speed optical information analysis and can significantly reduce the size and weight of conventional devices while simplifying the process of collecting optical information,thereby promising for various applications,including machine vision,minimized spectrometers,material characterization,remote sensing,and other areas which require comprehensive optical analysis.

数字化转型对企业绩效的影响与展望——基于citespace中外文献数据库的可视化对比分析

本文利用Citespace软件对2013—2022年近十年数字化转型与企业绩效领域中310篇CNKI数据库和2003篇WOS数据库有效文献进行计量分析。通过对文献作者、机构、关键词等方面的研究,从研究热点来看,国内外研究热点不尽相同,中国学者更注重研究数字化转型对企业财务绩效和创新绩效的影响以及作用机制,而国外学术界更注重数字化转型的战略导向、技术问题以及创新管理。从作者合作来看,在过去十年间,学者、机构间的合作较为松散,合作网络还未形成,有待加强。通过对近十年来国内外数字化转型与企业绩效研究状况的分析,本文对我国该领域未来的研究趋势进行了展望。

Controllable growth of wafer-scale PdS and PdS_(2) nanofilms via chemical vapor deposition combined with an electron beam evaporation technique

Palladium(Pd)-based sulfides have triggered extensive interest due to their unique properties and potential applications in the fields of electronics and optoelectronics.However,the synthesis of large-scale uniform PdS and PdS_(2)nanofilms(NFs)remains an enormous challenge.In this work,2-inch wafer-scale PdS and PdS_(2) NFs with excellent stability can be controllably prepared via chemical vapor deposition combined with electron beam evaporation technique.The thickness of the pre-deposited Pd film and the sulfurization temperature are critical for the precise synthesis of PdS and PdS_(2) NFs.A corresponding growth mechanism has been proposed based on our experimental results and Gibbs free energy calculations.The electrical transport properties of PdS and PdS_(2) NFs were explored by conductive atomic force microscopy.Our findings have achieved the controllable growth of PdS and PdS_(2) NFs,which may provide a pathway to facilitate PdS and PdS_(2) based applications for next-generation high performance optoelectronic devices.

复方樟柳碱联合抗VEGF药物治疗视网膜分支静脉阻塞黄斑水肿

目的:评价复方樟柳碱注射液联合抗VEGF药物治疗视网膜分支静脉阻塞黄斑水肿的有效性及安全性,并探索联合用药的优势。方法:选取60例视网膜静脉阻塞患者,随机分为联合组和对照组各30例。对照组实行一次常规抗VEGF注射治疗,联合组在抗VEGF注射治疗同时采用复方樟柳碱注射液进行治疗,每天注射1支,14d休息2d,再注射14d,共28支。对比两组的治疗效果、有效性及安全性。结果:对照组、联合组患者在注射前后不同时间点矫正视力比较,差异有统计学意义(F_(时间)=185. 05,P_(时间)<0. 01;F_(分组)=3. 34,P_(分组)=0. 025),联合治疗后在第30、90d的矫正视力提高程度较对照组均有显著差异(P<0.05)。对照组和联合组患眼注射前后不同时间点CRT比较,差异有统计学意义(F_(时间)=286. 2,P_(时间)<0. 01; F_(分组)=12. 46,P_(分组)<0. 01),两组患者的视力及CRT在治疗第15d均无显著差异。结论:复方樟柳碱联合抗VEGF药物治疗可提高对视网膜静脉阻塞黄斑水肿患者的治疗效果。

Toward Wisdom-Evolutionary and Primitive-Concise 6G:A New Paradigm of Semantic Communication Networks

The sixth generation(6G)mobile networks will reshape the world by offering instant,efficient,and intelligent hyper-connectivity,as envisioned by the previously proposed Ubiquitous-X 6G networks.Such hyper-massive and global connectivity will introduce tremendous challenges into the operation and management of 6G networks,calling for revolutionary theories and technological innovations.To this end,we propose a new route to boost network capabilities toward a wisdom-evolutionary and primitive-concise network(WePCN)vision for the Ubiquitous-X 6G network.In particular,we aim to concretize the evolution path toward the WePCN by first conceiving a new semantic representation framework,namely semantic base,and then establishing an intelligent and efficient semantic communication(IE-SC)network architecture.In the IE-SC architecture,a semantic intelligence plane is employed to interconnect the semantic-empowered physical-bearing layer,network protocol layer,and application-intent layer via semantic information flows.The proposed architecture integrates artificial intelligence and network technologies to enable intelligent interactions among various communication objects in 6G.It features a lower bandwidth requirement,less redundancy,and more accurate intent identification.We also present a brief review of recent advances in semantic communications and highlight potential use cases,complemented by a range of open challenges for 6G.

Intense Pulsed Light Therapy for Patients with Meibomian Gland Dysfunction and Ocular Demodex Infestation

To observe the clinical changes of meibomian gland dysfunctipn(MGD)and ocular Demodex infestation after intense pulsed light(IPL)treatment to further examine the mechanism of IPL treating patients with MGD and ocular Demodex infestation.The medical records of 25 patients(49 eyes)with MGD treated with IPL,were retrospectively examined to determine outcomes.Associated ocular-surface parameters(ocular surface disease index,OSD1;lipid layer thickness,LLT;noninvasive first breakup time,NIF-BUT;noninvasive average breakup time,NIAvg?BUT;tear film breakup area,TBUA;Schirmer I Test,SIT;corneal fluorescein staining,CFS),eyelid margin abnormalities,meibum quality and expressibility,MG morphological parameters(macrostructure and microstructure),and the number of Demodex infestation were examined before and after treatment.The MG microstructure and the Demodex infestation were examined via in vivo confocal microscopy(IVCM).The results showed that there were statistically significant differences in associated ocular-surface parameters(all P<0.05)before and after IPL treatment,except SIT(P=0.065).Eyelid margin abnormalities,meibum quality and expressibility obviously improved in upper and lower eyelid after IPL treatment(all P<0.0001).MG macrostructure(MG dropouts)decreased in upper(P=0.002)and lower eyelid(P=0.001)after IPL treatment.The nine parameters of MG microstructure in upper and lower eyelid all distinctly improved after IPL treatment(all P<0.0001).The mean number of Demodex mites on the upper lid margin(6.59±7.16 to 3.12±3.81/9 eyelashes)and lower lid margin(2.55±2.11 to 1.29±1.53/9 eyelashes)significantly reduced after IPL treatment(all P<0.0001).The Demodex eradication rate was 20%(8/40)in upper lid margin and 34.15%(14/41)in lower lid margin.These findings indicate that IPL shows great therapeutic potential for patients of MGD and ocular Demodex infestation.

Recent advances in optical dynamic metaholography

Holography,with the capability of recording and reconstructing wavefronts of light,has emerged as an ideal approach for future deep-immersive naked-eye display.However,the shortcomings(e.g.,small field of view,twin imaging,multiple or-ders of diffraction)of traditional dynamic holographic devices bring many challenges to their practical applications.Metasurfaces,planar artificial materials composed of subwavelength unit cells,have shown great potential in light field manipulation,which is useful for overcoming these drawbacks.Here,we review recent progress in the field of dynamic metasurface holography,from realization methods to design strategies,mainly including typical research works on dy-namic meta-holography based on tunable metasurfaces and multiplexed metasurfaces.Emerging applications of dynam-ic meta-holography have been found in 3D display,optical storage,optical encryption,and optical information pro-cessing,which may accelerate the development of light field manipulation and micro/nanofabrication with higher dimen-sions.A number of potential applications and possible development paths are also discussed at the end.

局部T晚期与N晚期鼻咽癌患者的预后比较

目的:回顾性分析局部T晚期与N晚期鼻咽癌患者的预后情况,为临床鼻咽癌治疗提供参考.方法:选取2011年12月至2017年11月西部战区总医院经病理确诊为鼻咽癌的局部T晚期患者102例、局部N晚期患者162例的临床病例资料,分为两组并分析患者的预后情况.结果:局部T晚期与N晚期患者5年总生存率(overall survival,OS)分别为82.8%与75.8%(P=0.271)、无疾病进展生存率(progression-free survival,PFS)分别为73.7%与62.8%(P=0.043),无局部复发生存率(local relapse-free survival,LRFS)分别为87.6%与91.6%(P=0.646)、无远处转移生存率(distant metastasis-free survival,DMFS)分别为87.7%与79.5%(P=0.066),两组间PFS差异具有统计学意义.结论:局部N晚期鼻咽癌患者的DMFS、OS、PFS均有下降趋势,临床上局部N晚期鼻咽癌患者应更强调系统性治疗以及分层治疗的意义,以争取更高的OS并降低远处转移.

Machine Learning Empowered Beam Management for Intelligent Reflecting Surface Assisted MmWave Networks

Recently,intelligent reflecting surface(IRS)assisted mmWave networks are emerging,which bear the potential to address the blockage issue of the millimeter wave(mmWave)communication in a more cost-effective way.In particular,IRS is built by passive and programmable electromagnetic elements that can manipulate the mmWave propagation channel into a more favorable condition that is free of blockage via judicious joint base station(BS)-IRS transmission design.However,the coexistence of IRSs and mmWave BSs complicates the network architecture,and thus poses great challenges for efficient beam management(BM)that is one critical prerequisite for high performance mmWave networks.In this paper,we systematically evaluate the key issues and challenges of BM for IRS-assisted mmWave networks to bring insights into the future network design.Specifically,we carefully classify and discuss the extensibility and limitations of the existing BM of conventional mmWave towards the IRS-assisted new paradigm.Moreover,we propose a novel machine learning empowered BM framework for IRS-assisted networks with representative showcases,which processes environmental and mobility awareness to achieve highly efficient BM with significantly reduced system overhead.Finally,some interesting future directions are also suggested to inspire further researches.

Repeated febrile convulsions impair hippocampal neurons and cause synaptic damage in immature rats: neuroprotective effect of fructose-1,6-diphosphate

Fructose-1,6-diphosphate is a metabolic intermediate that promotes cell metabolism. We hypothesize that fructose-1,6-diphosphate can protect against neuronal damage induced by febrile convulsions. Hot-water bathing was used to establish a repetitive febrile convulsion model in rats aged 21 days, equivalent to 3–5 years in humans. Ninety minutes before each seizure induction, rats received an intraperitoneal injection of low- or high-dose fructose-1,6-diphosphate（500 or 1,000 mg/kg, respectively）. Low- and high-dose fructose-1,6-diphosphate prolonged the latency and shortened the duration of seizures. Furthermore, high-dose fructose-1,6-diphosphate effectively reduced seizure severity. Transmission electron microscopy revealed that 24 hours after the last seizure, high-dose fructose-1,6-diphosphate reduced mitochondrial swelling, rough endoplasmic reticulum degranulation, Golgi dilation and synaptic cleft size, and increased synaptic active zone length, postsynaptic density thickness, and synaptic interface curvature in the hippocampal CA1 area. The present findings suggest that fructose-1,6-diphosphate is a neuroprotectant against hippocampal neuron and synapse damage induced by repeated febrile convulsion in immature rats.

Evaluation of paliperidone on social function in patients with chronic schizophrenia

Background The impairment of social function is widespread in the patients with chronic schizophrenia, which seriously affects family, life and work conditions.Aims The main purpose of this study was to investigate the efficacy of paliperidone in the treatment of social function in chronic schizophrenia.Methods A total of 81 patients who met the standard criteria for schizophrenia and long-term hospitalised inpatients were randomly divided into the treatment group and normal control group following a 1-year prospective follow-up study. The reatment group(41 cases) used paliperidone extended-release tablets for reducing dosage, as appropriate, based on the original treatment strategy; and the control group(40 cases) used the former drugs. All patients were assessed using the Positive and Negative Symptom Scales(PANSS), and the Treatment Emergent Symptom Scale(TESS) was used to assess adverse drug reactions. The Hospitalised Psychiatric Patients' Social Functions Rating Scale(SSPI) was used to assess social function of participants before and after 8 weeks, 6 months and 1 year of treatment.Results At baseline there were no significant differences between the two groups in age, duration of illness, educational background and dosage of antipsychotic drugs(converted into chlorpromazine equivalency). There was statistically significant difference in PANSS positive symptoms by interaction effect(Fgroup×time=18.24, df=3237, p<0.001) and time effect(Ftime=21.66, df=3, p<0.01) and the difference in PANSS positive symptoms by grouping effect(Fgroup=0.68, df=1, p=0.41) was not statistically significant. The difference of grouping effect of PANSS negative symptoms(Fgroup=9.93, df=1, p=0.002), time effect(Ftime=279.15, df=3, p<0.001) and interaction effect(Fgroup×time=279.15, df=3237, p<0.001) were statistically significant. There were statistically significant differences in the grouping effect(Fgroup=6.59, df=1, p=0.012), time effect(Ftime=152.97, df=3, p<0.001) and interaction effect(Fgroup×time=148.82, df=3237, p<0.001) of PANSS general pathological symptoms, the same as the total score of the PANSS, which showed large differences in grouping effect(Fgroup=7.04, df=1, p=0.001), time effect(Ftime=210.78, df=3, p<0.001) and interaction effect(Fgroup×time=205.20, df=3237, p<0.01). We found in the total SSPI score, grouping effect(Fgroup=31.70, df=1, p<0.001), time effect(Ftime=161.84, df=3, p<0.001) and interaction effect(Fgroup×time=132.74, df=3237, p<0.001) were demonstrated to be significantly different. Even though adverse reactionsoccurred 7 times in the treatment group and 44 times in the control group based on the Treatment Emergent Symptom Scale(TESS), incidence rate was significantly lower than that of the control group(χ2=18.854, p<0.001).Conclusion Paliperidone can safely and effectively improve negative symptoms and social function in patients with chronic schizophrenia.

Urgent Tracheal Resection and Reconstruction Assisted by Temporary Cardiopulmonary Bypass:a Case Report

SEVERE tracheal stenosis can not only cause criti- cal medical problems such as severe shortness of breath, hypoxia, and even orthopnea, but also impose overwhelming challenges on thephysicians, particularly the anesthesiologist. Life-threa- tening airway obstruction can make the patient＇s gas ex- change extremely difficult. Though several options could be offered regarding the treatment of tracheal stenosis, normally, tracheal resection and following reconstruction is the first choice for severe airway stenosis.1 Successful surgical intervention relies on the close communication and cooperation between surgeons and anesthesiologists.

An optimal dose of tea polyphenols protects against global cerebral ischemia/reperfusion injury

Previous studies addressing the protection of tea polyphenols against cerebral ischemia/ reperfusion injury often use focal cerebral ischemia models, and the optimal dose is not unified. In this experiment, a cerebral ischemia/reperfusion injury rat model was established using a modified four-vessel occlusion method. Rats were treated with different doses of tea polyphenols （25, 50, 100, 150, 200 mg/kg） via intraperitoneal injection. Results showed that after 2, 6, 12, 24, 48 and 72 hours of reperfusion, peroxide dismutase activity and total antioxidant capacity in brain tissue gradually increased, while malondialdehyde content gradually decreased after tea polyphenol intervention. Tea polyphenols at 200 mg/kg resulted in the most apparent changes. Terminal deoxynucleotidyl transferase-mediated nick end labeling and flow cytometry showed that 200 mg/kg tea polyphenols significantly reduced the number and percentage of apoptotJc cells in the hippocampal CA1 region of rats after cerebral ischemia/reperfusion injury. The open field test and elevated plus maze experiments showed that tea polyphenols at 200 mg/kg strengthened exploratory behavior and reduced anxiety of cerebral ischemia/reperfusion injured rats. Experimental findings indicate that tea polyphenols protected rats against cerebral ischemia/ reperfusion injury and 200 mg/kg is regarded as the optimal dose.