期刊文献+
共找到4篇文章
< 1 >
每页显示 20 50 100
Two cases of persistent shallow anterior chamber after cataract surgery combined with goniosynechialysis
1
作者 Kang-Yi Yang Zhi-Qiao Liang +1 位作者 Xuan-Zhu Chen hui-juan wu 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2023年第2期312-315,共4页
Dear Editor,Two cases of primary angle-closure glaucoma(PACG)with persistent shallow anterior chamber after phacoemulsification,intraocular lens(IOL)implantation and goniosynechialysis(GSL)were presented.PACG,which ma... Dear Editor,Two cases of primary angle-closure glaucoma(PACG)with persistent shallow anterior chamber after phacoemulsification,intraocular lens(IOL)implantation and goniosynechialysis(GSL)were presented.PACG,which mainly presents with mechanical obstruction of the trabecular meshwork,is clinically characterized by elevated intraocular pressure(IOP)secondary to the apposition of peripheral iris or a synechial closure of the angle[1].A previous study reported that angle-closure glaucoma eyes experienced widening and deepening of anterior chamber angles following cataract extraction and IOL implantation,which could probably normalize the IOP[2].A randomized controlled trial demonstrated that in comparison with laser peripheral iridotomy(LPI),clear-lens extraction showed greater advantages in efficacy and cost-effectiveness and could be proposed as the first-line initial treatment for PACG[3]. 展开更多
关键词 CATARACT CASES GLAUCOMA
下载PDF
The Hippo pathway and its correlation with acute kidney injury 被引量:3
2
作者 Chi Zhang Chuan-Lei Li +4 位作者 Ke-Xin Xu Zhi-Huang Zheng Guo-Zhe Cheng hui-juan wu Jun Liu 《Zoological Research》 SCIE CAS CSCD 2022年第5期897-910,共14页
Acute kidney injury(AKI) is a significant clinical complication with a substantial impact on morbidity and mortality, for which therapeutic options remain limited. The Hippo signaling pathway is an evolutionarily cons... Acute kidney injury(AKI) is a significant clinical complication with a substantial impact on morbidity and mortality, for which therapeutic options remain limited. The Hippo signaling pathway is an evolutionarily conserved pathway implicated in cell proliferation, dedifferentiation, and apoptosis via phosphorylation and inactivation of its downstream effectorsYes-associatedprotein(YAP)/transcriptional co-activator with PDZ-binding motif(TAZ). Recent studies have revealed that the Hippo pathway plays a pivotal role in the pathogenesis and repair of AKI. The Hippo pathway can mediate renal dysfunction through modulation of mitochondrial apoptosis under AKI conditions. Transient activation of YAP/TAZ in the acute phase of AKI may benefit renal recovery and regeneration, whereas persistent activation of YAP/TAZ in severe AKI may lead to maladaptive repair and transition to chronic kidney disease. This review aims to summarize recent findings on the associations between the Hippo pathway and AKI and to identify new therapeutic targets and strategies for AKI. 展开更多
关键词 Hippo pathway Acute kidney injury(AKI) Maladaptive repair FIBROSIS Chronic kidney disease(CKD)
下载PDF
Sulfur Dioxide Inhibits Extracellular Signal-regulated Kinase Signaling to Attenuate Vascular Smooth Muscle Cell Proliferation in Angiotensin II-induced Hypertensive Mice 被引量:8
3
作者 hui-juan wu Ya-Qian Huang +5 位作者 Qing-Hua Chen Xiao-Yu Tian Jia Liu Chao-Shu Tang Hong-Fang Jin Jun-Bao Du 《Chinese Medical Journal》 SCIE CAS CSCD 2016年第18期2226-2232,共7页
Background: Clarifying the mechanisms underlying vascular smooth muscle cell (VSMC) proliferation is important for the prevention and treatment of vascular remodeling and the reverse of hyperplastic lesions. Previo... Background: Clarifying the mechanisms underlying vascular smooth muscle cell (VSMC) proliferation is important for the prevention and treatment of vascular remodeling and the reverse of hyperplastic lesions. Previous research has shown that the gaseous signaling molecule sulfur dioxide (SO2) inhibits VSMC proliferation, but the mechanism for the inhibition of the angiotensin Ⅱ (Angll)-induced VSMC proliferation by SO, has not been fully elucidated. This study was designed to investigate if SO2 inhibited VSMC proliferation in mice with hypertension induced by Angll. Methods: Thirty-six male C57 mice were randomly divided into control, Angll, and Angll + SO2 groups. Mice in Angll group and Angl I + SO2 group received a capsule-type Angll pump implanted under the skin of the back at a slow-release dose of 1000 ng-kg^-1min In addition, mice in Angll + SO2 received intraperitoneal injections of SO., donor. Arterial blood pressure of tail artery was determined. The thickness of the aorta was measured by elastic fiber staining, and proliferating cell nuclear antigen (PCNA) and phosphorylated-extracellular signal-regulated kinase (P-ERK) were detected in aortic tissues. The concentration of SO~ in serum and aortic tissue homogenate supernatant was measured using high-performance liquid chromatography with fluorescence determination. In the in vio'o study, VSMC of A7R5 cell lines was divided into six groups: control, Angll, Angll + SO2 PD98059 (an inhibitor of ERK phosphorylation), Angll + PD98059, and Angll + SO, + PD98059. Expression of PCNA, ERK, and P-ERK was determined by Western blotting. Results: In animal experiment, compared with the control group, Angll markedly increased blood pressure (P 〈 0.01 ) and thickened the aortic wall in mice (P 〈 0.05) with an increase in the expression of PCNA (P 〈 0.05). SO2 however, reduced the systemic hypertension and the wall thickness induced by AnglI (P 〈 0.05). It inhibited the increased expression of PCNA and P-ERK induced by AnglI (P 〈 0.05). In cell experiment, PD98059, an ERK phosphorylation inhibitor, blocked the inhibitory effect of SO, on VSMC proliferation (P 〈 0.05). Conclusions: ERK signaling is involved in the mechanisms by which SO, inhibits VSMC proliferation in Angll-induced hypertensive mice via ERK signaling. 展开更多
关键词 Angiotensin II HYPERTENSION PROLIFERATION Sulfur Dioxide Vascular Smooth Muscle Cell
原文传递
A non-precious metal catalyst for oxygen reduction prepared by heat-treating a mechanical mixture of carbon black,melamine and cobalt chloride 被引量:1
4
作者 Yu-Jun Si Zhong-Ping Xiong +2 位作者 Chang-Guo Chen Ping Liu hui-juan wu 《Chinese Chemical Letters》 SCIE CAS CSCD 2013年第12期1109-1111,共3页
A non-precious metal catalyst CoMe]C for the oxygen reduction reaction is prepared by heat-treating a mechanical mixture of carbon black, melamine and cobalt chloride at 600 under nitrogen atmosphere for 2 h. The cata... A non-precious metal catalyst CoMe]C for the oxygen reduction reaction is prepared by heat-treating a mechanical mixture of carbon black, melamine and cobalt chloride at 600 under nitrogen atmosphere for 2 h. The catalytic activity of CoMe/C is characterized by the electrochemical linear sweep voltammetry technique. The onset reduction potential of the catalyst is 0.55 V (vs. SCE) at a scanning rate of 5 mV/s in 0.5 mol/L H2SO4 solution. The formation of the ORR activity sites of CoMe/C is facilitated by metallic β- cobalt. 展开更多
关键词 Oxygen reduction Non-precious metal catalyst Preparation Mechanical method
原文传递
上一页 1 下一页 到第
使用帮助 返回顶部