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P62基因对恶性黑色素瘤细胞侵袭的影响及机制研究 被引量:1
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作者 易娟娟 招玉玲 +7 位作者 谢蒲辉 唐妍 黄惠珍 郑丽 蔡艳桃 杨竞 张晶 毛越苹 《中国现代医学杂志》 CAS 2020年第10期14-17,共4页
目的探讨P62基因在恶性黑色素瘤A375细胞迁移、侵袭中的作用及其机制。方法取对数生长期的恶性黑色素瘤A375细胞,采用干扰P62基因表达的siRNA及阴性对照siRNA分别转染A375细胞。采用Transwell法检测干扰组及对照组的细胞迁移、侵袭能力,... 目的探讨P62基因在恶性黑色素瘤A375细胞迁移、侵袭中的作用及其机制。方法取对数生长期的恶性黑色素瘤A375细胞,采用干扰P62基因表达的siRNA及阴性对照siRNA分别转染A375细胞。采用Transwell法检测干扰组及对照组的细胞迁移、侵袭能力,Western blotting检测干扰组及对照组Wnt/β-catenin信号通路的表达。结果干扰组细胞Transwell迁移、侵袭能力较对照组下降(P<0.05);且干扰组Wnt/β-catenin及下游通路因子(P62、ZEB1、β-catenin、TCF4、c-Myc、c-Jun及CCND1)均受抑制(P<0.05)。结论P62可能通过调控Wnt/β-catenin及下游通路促进黑色素瘤细胞的迁移、侵袭。 展开更多
关键词 黑色素瘤 实验性 癌基因 肿瘤浸润
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Effects of phosphorus addition on the properties of Sn-9Zn lead-free solder alloy 被引量:7
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作者 hui-zhen huang Xiu-qin Wei +1 位作者 Dun-qiang Tan Lang Zhou 《International Journal of Minerals,Metallurgy and Materials》 SCIE EI CAS CSCD 2013年第6期563-567,共5页
This article explores tile effects of phosphorus addition on the wettability between Sn-9Zn solder alloy and Cu substrates, the oxidation behavior and the corrosion behavior of Sn-9Zn solder alloy. Spreading test was ... This article explores tile effects of phosphorus addition on the wettability between Sn-9Zn solder alloy and Cu substrates, the oxidation behavior and the corrosion behavior of Sn-9Zn solder alloy. Spreading test was used to characterize the wettability of Sn-9Zn-xP solder alloys to Cu substrates. The oxidation and corrosion behaviors of Sn- 9Zn-xP solder alloys were determined by means of weight gaining, and secondary ion mass spectrometry was used to analyze the oxygen content. The role and mechanism of P in the solder alloys were also discussed. It is found that the addition of P can significantly improve the wettability of the solder alloys. Incorporating P into Sn-9Zn solder alloy obviously decreases the oxygen content and enhances the oxidation and corrosion resistance. Microstructure observations show that an appropriate amount of P can greatly refine coarse rod-like Zn-rich phases in Sn-gZn solder alloy. 展开更多
关键词 lead-free solder PHOSPHORUS WETTABILITY oxidntion CORROSION
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