The construction of demonstration digital archives is a key project for the innovative development of the archival industry vigorously promoted by the National Archives Administration. Taking the construction of the S...The construction of demonstration digital archives is a key project for the innovative development of the archival industry vigorously promoted by the National Archives Administration. Taking the construction of the Smart Archives in Dongcheng District, Beijing as an example, this paper deeply explores the work objectives, functional requirements, and technical means of creating a demonstration digital archive. One is scientific planning, which is building the basic framework of digital archives. Proposed the infrastructure of “three major supports, five major platforms, and three major guarantees”. The second is to highlight key points and improve the basic functions of digital archives. Including hardware construction, software configuration, digitization of library archives, electronic archive management, sharing and utilization of digital archive information, and formulation of management systems for digital archives. The third is to strive for practical results and deepen the construction of smart libraries. This includes vigorously promoting the construction of smart archive centers, establishing a comprehensive management platform for smart libraries, and introducing new-generation information technology to achieve the integration of smart libraries in order to explore some mature experiences and methods that can be referenced for the creation of demonstration digital archives.展开更多
文摘The construction of demonstration digital archives is a key project for the innovative development of the archival industry vigorously promoted by the National Archives Administration. Taking the construction of the Smart Archives in Dongcheng District, Beijing as an example, this paper deeply explores the work objectives, functional requirements, and technical means of creating a demonstration digital archive. One is scientific planning, which is building the basic framework of digital archives. Proposed the infrastructure of “three major supports, five major platforms, and three major guarantees”. The second is to highlight key points and improve the basic functions of digital archives. Including hardware construction, software configuration, digitization of library archives, electronic archive management, sharing and utilization of digital archive information, and formulation of management systems for digital archives. The third is to strive for practical results and deepen the construction of smart libraries. This includes vigorously promoting the construction of smart archive centers, establishing a comprehensive management platform for smart libraries, and introducing new-generation information technology to achieve the integration of smart libraries in order to explore some mature experiences and methods that can be referenced for the creation of demonstration digital archives.
基金supported by the National Key Research and Development Program of China(2019YFA0904400)the National Natural Science Foundation of China(81822027,81630090,and 81902108)。
文摘延长基于蛋白质治疗药物的半衰期可以提高药物疗效。然而,基因治疗本质上是长期表达所需的治疗性药物,药物半衰期对基因治疗疗效的影响尚不清楚。在这项腺相关病毒(adeno-associated virus,AAV)基因治疗研究中,通过与免疫球蛋白G1(immunoglobulin G 1,IgG1)可溶性单体Fc区(soluble monomeric IgG1 fragment crystallizable,sFc)或Fc区融合,设计了几种能够延长半衰期的蛋白质。研究表明,延长AAV递送的小分子双功能蛋白和成纤维细胞生长因子21(fibroblast growth factor 21,FGF21)的半衰期显著增加了它们在血液循环中的浓度。此外,AAV递送FGF21延长其半衰期使2型糖尿病动物模型中肝损伤和血糖显著降低,并改善了葡萄糖耐量和胰岛素敏感性。这些结果证明了延长药物半衰期的基因治疗在应对人类疾病中的治疗潜力。
