Transition metal sulfides have high theoretical capacities and are considered as potential anode materials for sodium-ion batteries.However,due to low inherent conductivity and significant volume expansion,the electro...Transition metal sulfides have high theoretical capacities and are considered as potential anode materials for sodium-ion batteries.However,due to low inherent conductivity and significant volume expansion,the electrochemical performance is greatly limited.In this study,a nickel/manganese sulfide material(Ni_(0.96)S_(x)/MnS_(y)-NC)with adjustable sulfur vacancies and heterogeneous hollow spheres was prepared using a simple method.The introduction of a concentration-adjustable sulfur vacancy enables the generation of a heterogeneous interface between bimetallic sulfide and sulfur vacancies.This interface collectively creates an internal electric field,improving the mobility of electrons and ions,increasing the number of electrochemically active sites,and further optimizing the performance of Na~+storage.The direction of electron flow is confirmed by Density functional theory(DFT)calculations.The hollow nano-spherical material provides a buffer for expansion,facilitating rapid transfer kinetics.Our innovative discovery involves the interaction between the ether-based electrolyte and copper foil,leading to the formation of Cu_9S_5,which grafts the active material and copper current collector,reinforcing mechanical supporting.This results in a new heterostructure of Cu_9S_5 with Ni_(0.96)S_(x)/MnS_(y),contributing to the stabilization of structural integrity for long-cycle performance.Therefore,Ni_(0.96)S_(x)/MnS_(y)-NC exhibits excellent electrochemical properties following our modification route.Regarding stability performance,Ni0_(.96)S_(x)/MnS_(y)-NC demonstrates an average decay rate of 0.00944%after 10,000 cycles at an extremely high current density of 10000 mA g^(-1),A full cell with a high capacity of 304.2 mA h g^(-1)was also successfully assembled by using Na_(3)V_(2)(PO_(4))_(3)/C as the cathode.This study explores a novel strategy for interface/vacancy co-modification in the fabrication of high-performance sodium-ion batteries electrode.展开更多
Objective To assess the efficiency and safety of a novel sodium-glucose co-transporter 2(SGLT2) inhibitor—SGLT2 inhibitors,in combination with insulin for type 1 diabetes mellitus(T1DM). Methods We searched Medline,E...Objective To assess the efficiency and safety of a novel sodium-glucose co-transporter 2(SGLT2) inhibitor—SGLT2 inhibitors,in combination with insulin for type 1 diabetes mellitus(T1DM). Methods We searched Medline,Embase,and the Cochrane Collaboration Library to identify the eligible studies published between January 2010 and July 2016 without restriction of language. The Food and Drug Administration(FDA) data and Clinical Trials(http://www.clinicaltrials.gov) were also searched. The included studies met the following criteria:randomized controlled trials; T1DM patients aged between 18 and 65 years old; patients were treated with insulin plus SGLT2 inhibitors for more than 2 weeks; patients' glycosylated hemoglobin(HbA1c) levels were between 7% and 12%. The SGLT2 inhibitors group was treated with SGLT2 inhibitors plus insulin,and the placebo group received placebo plus insulin treatment. The outcomes should include one of the following items:fasting blood glucose,HbA1c,glycosuria,or adverse effects. Data were analyzed by two physicians independently. The risk of bias was evaluated by using the Cochrane Collaboration's Risk of Bias tool and heterogeneity among studies was assessed using Chi-square test. Random effect model was used to analyze the treatment effects with Revman 5.3. Results Three trials including 178 patients were enrolled. As compared to the placebo group,SGLT2 inhibitor absolutely decreased fasting blood glucose [mean differences(MD)-2.47 mmol/L,95% confidence interval(CI)-3.65 to-1.28,P<0.001] and insulin dosage(standardized MD-0.75 U,95%CI-1.17 to-0.33,P<0.001). SGLT2 inhibitors could also increase the excretion of urine glucose(MD 131.09 g/24 h,95%CI 91.79 to 170.39,P<0.001). There were no significant differences in the incidences of hyperglycemia [odds ratio(OR) 1.82,95%CI 0.63 to 5.29,P=0.27],urinary tract infection(OR 0.95,95%CI 0.19 to 4.85,P=0.95),genital tract infection(OR 0.27,95%CI 0.01 to 7.19,P=0.43),and diabetic ketoacidosis(OR 6.03,95%CI 0.27 to 135.99,P=0.26) between the two groups. Conclusion SGLT2 inhibitors combined with insulin might be an efficient and safe treatment modality for T1DM patients.展开更多
Objective Vascular inflammation is an important component of the pathophysiology in cardiovascular diseases,such as atherosclerosis,hypertension,and aneurysms.In the last decade,microRNAs(miRNAs)have been revealed as ...Objective Vascular inflammation is an important component of the pathophysiology in cardiovascular diseases,such as atherosclerosis,hypertension,and aneurysms.In the last decade,microRNAs(miRNAs)have been revealed as novel regulators of vascular inflammation.Each miR NA suppresses a subset of genes,forming a complex regulatory network.Here,we performed miR microarray to profile miRNAs expression in coronary artery disease(CAD)patients and healthy controls and identified differentially expressed miR in CAD patients.MiR-197-3p is one of up regulated miRNAs,in this study we investigate its biological functions in vascular inflammation.展开更多
Smart contracts hold billions of dollars in digital currency,and their security vulnerabilities have drawn a lot of attention in recent years.Traditional methods for detecting smart contract vulnerabilities rely prima...Smart contracts hold billions of dollars in digital currency,and their security vulnerabilities have drawn a lot of attention in recent years.Traditional methods for detecting smart contract vulnerabilities rely primarily on symbol execution,which makes them time-consuming with high false positive rates.Recently,deep learning approaches have alleviated these issues but still face several major limitations,such as lack of interpretability and susceptibility to evasion techniques.In this paper,we propose a feature selection method for uplifting modeling.The fundamental concept of this method is a feature selection algorithm,utilizing interpretation outcomes to select critical features,thereby reducing the scales of features.The learning process could be accelerated significantly because of the reduction of the feature size.The experiment shows that our proposed model performs well in six types of vulnerability detection.The accuracy of each type is higher than 93%and the average detection time of each smart contract is less than 1 ms.Notably,through our proposed feature selection algorithm,the training time of each type of vulnerability is reduced by nearly 80%compared with that of its original.展开更多
Central diabetes insipidus(CDI)is a rare disease characterized by the excretion of copious amounts of diluted urine(polyuria),excess water intake(polydipsia),and a rise in serum sodium concentration(hypernatremia)(Chr...Central diabetes insipidus(CDI)is a rare disease characterized by the excretion of copious amounts of diluted urine(polyuria),excess water intake(polydipsia),and a rise in serum sodium concentration(hypernatremia)(Christ-Crain et al.,2019).The neuropeptide arginine-vasopressin(AVP)is synthesized as a preprohormone along with its carrier protein neurophysin II(NPII)in hypothalamic supraoptic(SON)and paraventricular(PVN)magnocellular neurons,stored in the posterior pituitary,and secreted into the circulation.展开更多
To the Editor:The atherogenic index of plasma(AIP)is derived from the logarithmic conversion of the ratio of triglyceride(TG)to high-density lipoprotein cholesterol(HDL-C).It comprehensively reflects plasma lipid home...To the Editor:The atherogenic index of plasma(AIP)is derived from the logarithmic conversion of the ratio of triglyceride(TG)to high-density lipoprotein cholesterol(HDL-C).It comprehensively reflects plasma lipid homeostasis.AIP has been reported to be related to cardiovascular disease(CVD)in population-based studies,^([1])and is regarded as a potential independent predictor for CVD risk in clinical practice.Currently,there are limited data on the characteristics of AIP values in China.We examined the differences in AIP values among ethnic groups based on multiethnic Chinese population data.The reference values of AIP in Chinese adults were established,and their variation tendencies according to age were identified.展开更多
To the Editor:Cortisol is closely related to hemostasis.[1]In patients with hyperadrenalism,that is,Cushing syndrome(CS),a reduction in the activated partial thromboplastin time(APTT),an increased level of coagulation...To the Editor:Cortisol is closely related to hemostasis.[1]In patients with hyperadrenalism,that is,Cushing syndrome(CS),a reduction in the activated partial thromboplastin time(APTT),an increased level of coagulation factors,and an increased risk of thrombosis have been repeatedly reported.[1,2]However,no studies reported the hemostatic status of patients with hypoadrenalism which is commonly seen in patients with pituitary diseases.展开更多
基金financially supported by the National Nature Science Foundation of Jiangsu Province(BK20221259)。
文摘Transition metal sulfides have high theoretical capacities and are considered as potential anode materials for sodium-ion batteries.However,due to low inherent conductivity and significant volume expansion,the electrochemical performance is greatly limited.In this study,a nickel/manganese sulfide material(Ni_(0.96)S_(x)/MnS_(y)-NC)with adjustable sulfur vacancies and heterogeneous hollow spheres was prepared using a simple method.The introduction of a concentration-adjustable sulfur vacancy enables the generation of a heterogeneous interface between bimetallic sulfide and sulfur vacancies.This interface collectively creates an internal electric field,improving the mobility of electrons and ions,increasing the number of electrochemically active sites,and further optimizing the performance of Na~+storage.The direction of electron flow is confirmed by Density functional theory(DFT)calculations.The hollow nano-spherical material provides a buffer for expansion,facilitating rapid transfer kinetics.Our innovative discovery involves the interaction between the ether-based electrolyte and copper foil,leading to the formation of Cu_9S_5,which grafts the active material and copper current collector,reinforcing mechanical supporting.This results in a new heterostructure of Cu_9S_5 with Ni_(0.96)S_(x)/MnS_(y),contributing to the stabilization of structural integrity for long-cycle performance.Therefore,Ni_(0.96)S_(x)/MnS_(y)-NC exhibits excellent electrochemical properties following our modification route.Regarding stability performance,Ni0_(.96)S_(x)/MnS_(y)-NC demonstrates an average decay rate of 0.00944%after 10,000 cycles at an extremely high current density of 10000 mA g^(-1),A full cell with a high capacity of 304.2 mA h g^(-1)was also successfully assembled by using Na_(3)V_(2)(PO_(4))_(3)/C as the cathode.This study explores a novel strategy for interface/vacancy co-modification in the fabrication of high-performance sodium-ion batteries electrode.
文摘Objective To assess the efficiency and safety of a novel sodium-glucose co-transporter 2(SGLT2) inhibitor—SGLT2 inhibitors,in combination with insulin for type 1 diabetes mellitus(T1DM). Methods We searched Medline,Embase,and the Cochrane Collaboration Library to identify the eligible studies published between January 2010 and July 2016 without restriction of language. The Food and Drug Administration(FDA) data and Clinical Trials(http://www.clinicaltrials.gov) were also searched. The included studies met the following criteria:randomized controlled trials; T1DM patients aged between 18 and 65 years old; patients were treated with insulin plus SGLT2 inhibitors for more than 2 weeks; patients' glycosylated hemoglobin(HbA1c) levels were between 7% and 12%. The SGLT2 inhibitors group was treated with SGLT2 inhibitors plus insulin,and the placebo group received placebo plus insulin treatment. The outcomes should include one of the following items:fasting blood glucose,HbA1c,glycosuria,or adverse effects. Data were analyzed by two physicians independently. The risk of bias was evaluated by using the Cochrane Collaboration's Risk of Bias tool and heterogeneity among studies was assessed using Chi-square test. Random effect model was used to analyze the treatment effects with Revman 5.3. Results Three trials including 178 patients were enrolled. As compared to the placebo group,SGLT2 inhibitor absolutely decreased fasting blood glucose [mean differences(MD)-2.47 mmol/L,95% confidence interval(CI)-3.65 to-1.28,P<0.001] and insulin dosage(standardized MD-0.75 U,95%CI-1.17 to-0.33,P<0.001). SGLT2 inhibitors could also increase the excretion of urine glucose(MD 131.09 g/24 h,95%CI 91.79 to 170.39,P<0.001). There were no significant differences in the incidences of hyperglycemia [odds ratio(OR) 1.82,95%CI 0.63 to 5.29,P=0.27],urinary tract infection(OR 0.95,95%CI 0.19 to 4.85,P=0.95),genital tract infection(OR 0.27,95%CI 0.01 to 7.19,P=0.43),and diabetic ketoacidosis(OR 6.03,95%CI 0.27 to 135.99,P=0.26) between the two groups. Conclusion SGLT2 inhibitors combined with insulin might be an efficient and safe treatment modality for T1DM patients.
文摘Objective Vascular inflammation is an important component of the pathophysiology in cardiovascular diseases,such as atherosclerosis,hypertension,and aneurysms.In the last decade,microRNAs(miRNAs)have been revealed as novel regulators of vascular inflammation.Each miR NA suppresses a subset of genes,forming a complex regulatory network.Here,we performed miR microarray to profile miRNAs expression in coronary artery disease(CAD)patients and healthy controls and identified differentially expressed miR in CAD patients.MiR-197-3p is one of up regulated miRNAs,in this study we investigate its biological functions in vascular inflammation.
基金funded by the National Natural Science Foundation of China No.61902157 and No.62002139.
文摘Smart contracts hold billions of dollars in digital currency,and their security vulnerabilities have drawn a lot of attention in recent years.Traditional methods for detecting smart contract vulnerabilities rely primarily on symbol execution,which makes them time-consuming with high false positive rates.Recently,deep learning approaches have alleviated these issues but still face several major limitations,such as lack of interpretability and susceptibility to evasion techniques.In this paper,we propose a feature selection method for uplifting modeling.The fundamental concept of this method is a feature selection algorithm,utilizing interpretation outcomes to select critical features,thereby reducing the scales of features.The learning process could be accelerated significantly because of the reduction of the feature size.The experiment shows that our proposed model performs well in six types of vulnerability detection.The accuracy of each type is higher than 93%and the average detection time of each smart contract is less than 1 ms.Notably,through our proposed feature selection algorithm,the training time of each type of vulnerability is reduced by nearly 80%compared with that of its original.
基金supported by grants from the National Key Research and Development Program(2019YFA0707100 and 2021ZD0203901 to Y.Q.Zhang and R.Tian)the Strategic Priority Research Program B of the Chinese Academy of Sciences(XDBS1020100 to Y.Q.Zhang)the National Science Foundation of China(31830036 and 31921002 to Y.Q.Zhang)。
文摘Central diabetes insipidus(CDI)is a rare disease characterized by the excretion of copious amounts of diluted urine(polyuria),excess water intake(polydipsia),and a rise in serum sodium concentration(hypernatremia)(Christ-Crain et al.,2019).The neuropeptide arginine-vasopressin(AVP)is synthesized as a preprohormone along with its carrier protein neurophysin II(NPII)in hypothalamic supraoptic(SON)and paraventricular(PVN)magnocellular neurons,stored in the posterior pituitary,and secreted into the circulation.
文摘To the Editor:The atherogenic index of plasma(AIP)is derived from the logarithmic conversion of the ratio of triglyceride(TG)to high-density lipoprotein cholesterol(HDL-C).It comprehensively reflects plasma lipid homeostasis.AIP has been reported to be related to cardiovascular disease(CVD)in population-based studies,^([1])and is regarded as a potential independent predictor for CVD risk in clinical practice.Currently,there are limited data on the characteristics of AIP values in China.We examined the differences in AIP values among ethnic groups based on multiethnic Chinese population data.The reference values of AIP in Chinese adults were established,and their variation tendencies according to age were identified.
基金This work was supported by grants from the National Key R&D Program of China(No.2018YFA0108600)the Beijing Natural Science Foundation(No.7182134)+2 种基金the CAMS Initiative for Innovative Medicine(CAMS-I2M)(No.2016-I2M-1-017)the CAMS Young Talents Award Project(No.2018RC320003)the Beijing Nova Program(No.Z181100006218003).
文摘To the Editor:Cortisol is closely related to hemostasis.[1]In patients with hyperadrenalism,that is,Cushing syndrome(CS),a reduction in the activated partial thromboplastin time(APTT),an increased level of coagulation factors,and an increased risk of thrombosis have been repeatedly reported.[1,2]However,no studies reported the hemostatic status of patients with hypoadrenalism which is commonly seen in patients with pituitary diseases.
