Evolutionary trend analysis and knowledge structure mapping of endothelial dysfunction in sepsis:a bibliometrics study

BACKGROUND:A pathophysiological feature of septic organ failure is endothelial dysfunction in sepsis(EDS).The physiological and pathological mechanism of sepsis is considered to be vascular leakage caused by endothelial dysfunction.These pathological changes lead to systemic organ injury.However,an analysis using bibliometric methods has not yet been conducted in the field of EDS.This study was conducted to provide an overview of knowledge structure and research trends in the fi eld of EDS.METHODS:Based on previous research,a literature search was performed in the Web of Science Core Collection(WoSCC)for publications associated with EDS published between the year 2003 and 2023.Various types of data from the publications,such as citation frequency,authorship,keywords and highly cited articles,were extracted.The"Create Citation Report"feature in the WoSCC was employed to calculate the Hirsch index(h-index)and average citations per item(ACI)of authors,institutions,and countries.To conduct bibliometric and visualization analyses,three bibliometric tools were used,including R-bibliometrix,CiteSpace(co-citation analysis of references),and VOSviewer(co-authorship analysis of institutions,co-authorship analysis of authors,co-occurrence analysis of keywords).RESULTS:After excluding invalid records,the study finaly included 4,536 publications with 135,386 citations.Most of these publications originated in the USA,China,Germany,Canada,and Japan.Harvard University emerged as the most prolifi c institution,while professor Jong-Sup Bae and his research team at Kyungpook National University emerged as authors with the greatest infl uence.The"protein C","tissue factor","thrombin","glycocalyx",“acute kidney injury”,“syndecan-1”and“biomarker”were identifi ed as prominent areas of research.Future research may focus on molecular mechanisms(such as as vascular endothelial[VE]-cadherin regulation)and therapeutic interventions to enhance endothelial repair and function.CONCLUSION:Our findings show a growing interest in EDS research.Key areas for future research include signaling pathways,molecular mechanisms,endothelial repair,and interactions between endothelial cells and other cell types in sepsis.

Coverage Optimization of LTE Networks Based on Antenna Tilt Adjusting Considering Network Load

In this paper,we investigate the coverage optimization for LTE networks considering the network load. The network coverage is defined as the number of served users of evolved Node B(eNB)which is determined by e NBs' antenna tilt angles(ATA). The coverage is optimized by optimizing the number of served users based on the Modified Particle Swarm Optimization(MPSO)algorithm. Simulation results show that both the number of served users by each e NB and the system throughput are significantly increased. As well,the average load and the bandwidth efficiency of the network are improved.

Observation and optimization of 2 μm mode‐locked pulses in all‐fiber net anomalous dispersion laser cavity

We integrally demonstrate 2μm mode-locked pulses performances in all-fiber net anomalous dispersion cavity.Stable mode-locking operations with the center wavelength around 1950–1980 nm can be achieved by using the nonlinear polarization rotation structure and properly designing the dispersion management component.Conventional soliton is firstly obtained with a total anomalous dispersion cavity.Due to the contribution of commercial ultra-high numerical aperture fibers,net dispersion is reduced to-0.077 ps2.So that stretched pulse with 19.4 nm optical bandwidth is obtained and the de-chirped pulse-width can reach 312 fs using extra-cavity compression.Under pump power greater than 890 mW,stretched pulse can evolve into noise-like pulse with 41.3 nm bandwidth.The envelope and peak of such broadband pulse can be compressed with up to 2.2 ps and 145 fs,respectively.The single pulse energy of largely chirped stretched and noise-like pulse can reach 1.785 nJ and 1.53 nJ,respectively.Furthermore,extra-cavity compression can also contribute to a significant increase of peak power.

Optical System Design of Inter-Spacecraft Laser Interferometry Telescope

The fundamental measurement of space gravitational wave detection is to monitor the relative motion between pairs of freely falling test masses using heterodyne laser interferometry to a precision of 10 pm. The masses under test are millions of kilometers apart. The inter-spacecraft laser interferometry telescope deliver laser efficiently from one spacecraft to another. It is an important component of the gravitational wave detection observatory. It needs to meet the requirements of large compression ratio, high image quality and extraordinary stray light suppression ability. Based on the primary aberration theory, the method of the large compression ratio off-axis four-mirror optical system design is explored. After optimization, the system has an entrance pupil of 200 mm, compression ratio of 40 times, scientific field of view (FOV) of ±8 μrad. To facilitate suppressing the stray light and delivering the laser beam to the back-end scientific interferometers, the intermediate images and the real exit pupils are spatially available. Over the full FOV, the maximum root mean square (RMS) wavefront error is less than 0.007λ, PV value is less than 0.03λ (λ = 1064 nm). The image quality is approached to the diffraction-limit. The TTL noise caused by the wavefront error of the telescope is analyzed. The TTL noise in the image space of 300 μrad range is less than 1 × 10-10 m whose slope is lower than 0.6 μm/rad, which is under the noise budget of the laser interferometer space antenna (LISA), satisfying the requirements of space gravitational wave detection.

Single-wall carbon nanotube assisted all-optical wavelength conversion at 2.05μm

We fully demonstrate the special requirements of a mid-infrared all-optical wavelength converter.The construction mechanism of a 2.05μm all-optical wavelength converter based on the single-wall carbon nanotube[SWCNT]is proposed.Systematic experiments are carried out,and the converter device is successfully developed.With the assistance of SWCNT-coated microfiber,the conversion efficiency up to-45.57 d B is realized,and the tuning range can reach9.72 nm.The experimental results verify the correctness of the proposed mechanism and the feasibility of the converter device so that it can be a new technical approach for all-optical wavelength conversion beyond 2μm.We believe the research can extend the application of this composite waveguide in the field of all-optical communication.