This study employs advanced electrochemical and surface characterization techniques to investigate the impact of electrochemical hydrogen charging on the corrosion behavior and surface film of the Ti-6Al-4V alloy.The ...This study employs advanced electrochemical and surface characterization techniques to investigate the impact of electrochemical hydrogen charging on the corrosion behavior and surface film of the Ti-6Al-4V alloy.The findings revealed the formation ofγ-TiH andδ-TiH_(2) hydrides in the alloy after hydrogen charging.Prolonging hydrogen charging resulted in more significant degradation of the alloy microstructure,leading to deteriorated protectiveness of the surface film.This trend was further confirmed by the electrochemical measurements,which showed that the corrosion resistance of the alloy progressively worsened as the hydrogen charging time was increased.Consequently,this work provides valuable insights into the mechanisms underlying the corrosion of Ti-6Al-4V alloy under hydrogen charging conditions.展开更多
Cardiovascular disease(CVD)is the leading cause of death in the world,with a high incidence and a youth-oriented tendency.RNA modification is ubiquitous and indispensable in cell,maintaining cell homeostasis and funct...Cardiovascular disease(CVD)is the leading cause of death in the world,with a high incidence and a youth-oriented tendency.RNA modification is ubiquitous and indispensable in cell,maintaining cell homeostasis and function by dynamically regulating gene expression.Accumulating evidence has revealed the role of aberrant gene expression in CVD caused by dysregulated RNA modification.In this review,we focus on nine common RNA modifications:N^(6)-methyladenosine(m^(6)A),N^(1)-methyladenosine(m^(1)A),5-methylcytosine(m^(5)C),N^(7)-methylguanosine(m^(7)G),N^(4)-acetylcytosine(ac^(4)C),pseudouridine(Ψ),uridylation,adenosine-to-inosine(A-to-I)RNA editing,and modifications of U34 on tRNA wobble.We summarize the key regulators of RNA modification and their effects on gene expression,such as RNA splicing,maturation,transport,stability,and translation.Then,based on the classification of CVD,the mechanisms by which the disease occurs and progresses through RNA modifications are discussed.Potential therapeutic strategies,such as gene therapy,are reviewed based on these mechanisms.Herein,some of the CVD(such as stroke and peripheral vascular disease)are not included due to the limited availability of literature.Finally,the prospective applications and challenges of RNA modification in CVD are discussed for the purpose of facilitating clinical translation.Moreover,we look forward to more studies exploring the mechanisms and roles of RNA modification in CVD in the future,as there are substantial uncultivated areas to be explored.展开更多
The effect of aging treatment on the microstructure and corrosion behavior of a Fe-18Cr-15Mn-0.66N high-nitrogen stainless steel(HNSS) in 3.5 wt.% Na Cl solution was investigated using a series of electrochemical test...The effect of aging treatment on the microstructure and corrosion behavior of a Fe-18Cr-15Mn-0.66N high-nitrogen stainless steel(HNSS) in 3.5 wt.% Na Cl solution was investigated using a series of electrochemical tests, scanning electronic microscopy(SEM), X-ray diffraction(XRD) and X-ray photoelectron spectroscopy(XPS). The results showed that the aging treatment led to the precipitation of CrN particles along the grain boundaries and their morphologies changed from dispersive particles to continuous network as the aging time increased up to 60 min. Aging time had minor effects on the corrosion potential and corrosion current density, but resulted in the sharp decrease in the pitting corrosion potential.The passive film behaved as a n-type semiconductor, and the donor density of the passive film increased with the aging time. Meanwhile, the fraction of stable oxide(CrO) in the passive film decreased with the aging time. It demonstrates that the aging treatment deteriorated the protectiveness of the passive film, hence weakened the corrosion resistance of HNSS.展开更多
The effect of hydro gen charging on microstructural evolution and corrosion behavior of a Ti-4Al-2V-1Mo-1Fe alloy in a 3.5 wt.% NaCl solution was investigated.The results showed that the hydrogen charging induced the ...The effect of hydro gen charging on microstructural evolution and corrosion behavior of a Ti-4Al-2V-1Mo-1Fe alloy in a 3.5 wt.% NaCl solution was investigated.The results showed that the hydrogen charging induced the formation and growth of γ-TiH and δ-TiH_(2) phases,leading to the initiation and propagation of hydrogen-induced cracks.It was also found that hydrogen charging can change the passivity of this alloy and increase its pitting corrosion susceptibility.The main reason for these was attributed to the fo rmation of hydrides in α phase in the Ti-4Al-2V-1Mo-1Fe alloy,leading to the preferential dissolution of the α phase and thus the deterioration in the protective ability of passive film.展开更多
基金Supported by National Natural Science Foundation of China(Grant Nos.52001142,52005228,51801218,51911530211,51905110)Young Scientists Sponsorship Program by CAST(Grant No.2022QNRC001).
文摘This study employs advanced electrochemical and surface characterization techniques to investigate the impact of electrochemical hydrogen charging on the corrosion behavior and surface film of the Ti-6Al-4V alloy.The findings revealed the formation ofγ-TiH andδ-TiH_(2) hydrides in the alloy after hydrogen charging.Prolonging hydrogen charging resulted in more significant degradation of the alloy microstructure,leading to deteriorated protectiveness of the surface film.This trend was further confirmed by the electrochemical measurements,which showed that the corrosion resistance of the alloy progressively worsened as the hydrogen charging time was increased.Consequently,this work provides valuable insights into the mechanisms underlying the corrosion of Ti-6Al-4V alloy under hydrogen charging conditions.
基金the National Natural Science Foundation of China(Grant No.82073260,82003203,81972837,81572280)the Natural Science Foundation of Hunan Province(Grant No.2023JJ30766,2023JJ10091,2021JJ41058,2019J40420).
文摘Cardiovascular disease(CVD)is the leading cause of death in the world,with a high incidence and a youth-oriented tendency.RNA modification is ubiquitous and indispensable in cell,maintaining cell homeostasis and function by dynamically regulating gene expression.Accumulating evidence has revealed the role of aberrant gene expression in CVD caused by dysregulated RNA modification.In this review,we focus on nine common RNA modifications:N^(6)-methyladenosine(m^(6)A),N^(1)-methyladenosine(m^(1)A),5-methylcytosine(m^(5)C),N^(7)-methylguanosine(m^(7)G),N^(4)-acetylcytosine(ac^(4)C),pseudouridine(Ψ),uridylation,adenosine-to-inosine(A-to-I)RNA editing,and modifications of U34 on tRNA wobble.We summarize the key regulators of RNA modification and their effects on gene expression,such as RNA splicing,maturation,transport,stability,and translation.Then,based on the classification of CVD,the mechanisms by which the disease occurs and progresses through RNA modifications are discussed.Potential therapeutic strategies,such as gene therapy,are reviewed based on these mechanisms.Herein,some of the CVD(such as stroke and peripheral vascular disease)are not included due to the limited availability of literature.Finally,the prospective applications and challenges of RNA modification in CVD are discussed for the purpose of facilitating clinical translation.Moreover,we look forward to more studies exploring the mechanisms and roles of RNA modification in CVD in the future,as there are substantial uncultivated areas to be explored.
基金financially supported by the National Natural Science Foundation of China (Nos. 52001142, 52005228, 51801218, 51911530211, and 51905110)Science Foundation of Jiangsu Province (No. BK 20180984)。
文摘The effect of aging treatment on the microstructure and corrosion behavior of a Fe-18Cr-15Mn-0.66N high-nitrogen stainless steel(HNSS) in 3.5 wt.% Na Cl solution was investigated using a series of electrochemical tests, scanning electronic microscopy(SEM), X-ray diffraction(XRD) and X-ray photoelectron spectroscopy(XPS). The results showed that the aging treatment led to the precipitation of CrN particles along the grain boundaries and their morphologies changed from dispersive particles to continuous network as the aging time increased up to 60 min. Aging time had minor effects on the corrosion potential and corrosion current density, but resulted in the sharp decrease in the pitting corrosion potential.The passive film behaved as a n-type semiconductor, and the donor density of the passive film increased with the aging time. Meanwhile, the fraction of stable oxide(CrO) in the passive film decreased with the aging time. It demonstrates that the aging treatment deteriorated the protectiveness of the passive film, hence weakened the corrosion resistance of HNSS.
基金financially supported by the National Natural Science Foundation of China(Nos.51871211,51871225 and 51701129)。
文摘The effect of hydro gen charging on microstructural evolution and corrosion behavior of a Ti-4Al-2V-1Mo-1Fe alloy in a 3.5 wt.% NaCl solution was investigated.The results showed that the hydrogen charging induced the formation and growth of γ-TiH and δ-TiH_(2) phases,leading to the initiation and propagation of hydrogen-induced cracks.It was also found that hydrogen charging can change the passivity of this alloy and increase its pitting corrosion susceptibility.The main reason for these was attributed to the fo rmation of hydrides in α phase in the Ti-4Al-2V-1Mo-1Fe alloy,leading to the preferential dissolution of the α phase and thus the deterioration in the protective ability of passive film.
