应用MRI和定量^1H-MRS预测乳腺癌对新辅助化疗的病理反应

目的随访新辅助化疗（NAC）实现病理完全反应（pCR）和无病理反应（non—pCR）的乳腺癌病人,比较胆碱复合物（tCho）浓度与肿瘤大小的改变。方法本研究由伦理审查委员会批准并符合HIPAA。得到病人知情同意。35例乳腺癌病人[平均年龄（48＋11）岁；年龄范围29～75岁]入组。治疗包括阿霉素和环磷酰胺,其次是紫杉类为基础的方案。应用Mann—Whitney非参数检验对病理完全反应和无反应者的胆碱复合物浓度及肿瘤大小的改变进行分析。通过受试者工作特性曲线（ROC）区分两者并比较两者曲线下面积（AUC）。

Methods for a blind analysis of isobar data collected by the STAR collaboration

In 2018,the STAR collaboration collected data from^(96)_(44)Ru+^(96)_(44)Ru and^(96)_(40)Zr+^(96)_(40)Zr at√^(S)NN=200 Ge V to search for the presence of the chiral magnetic effect in collisions of nuclei.The isobar collision species alternated frequently between 9644 Ru+^(96)_(44)Ru and^(96)_(40)Zr+^(96)_(40)Zr.In order to conduct blind analyses of studies related to the chiral magnetic effect in these isobar data,STAR developed a three-step blind analysis procedure.Analysts are initially provided a"reference sample"of data,comprised of a mix of events from the two species,the order of which respects time-dependent changes in run conditions.After tuning analysis codes and performing time-dependent quality assurance on the reference sample,analysts are provided a species-blind sample suitable for calculating efficiencies and corrections for individual≈30-min data-taking runs.For this sample,species-specific information is disguised,but individual output files contain data from a single isobar species.Only run-by-run corrections and code alteration subsequent to these corrections are allowed at this stage.Following these modifications,the"frozen"code is passed over the fully un-blind data,completing the blind analysis.As a check of the feasibility of the blind analysis procedure,analysts completed a"mock data challenge,"analyzing data from Au+Au collisions at√^(S)NN=27 Ge V,collected in 2018.The Au+Au data were prepared in the same manner intended for the isobar blind data.The details of the blind analysis procedure and results from the mock data challenge are presented.

Empirical model for estimating vertical concentration profiles of re-suspended, sediment-associated contaminants

Vertical distribution processes of sediment contaminants in water were studied by flume experiments. Experimental results show that settling velocity of sediment particles and turbulence characteristics are the major hydrodynamic factors impacting distribution of pollutants, especially near the bottom where particle diameter is similar in size to vortex structure. Sediment distribution was uniform along the distance, while contaminant distribution slightly lagged behind the sediment. The smaller the initial sediment concentration was, the more time it took to achieve a uniform concentration distribution for suspended sediment. A contaminants transportation equation was established depending on mass conservation equations. Two mathematical estimation models of pollutant distribution in the overlying water considering adsorption and desorption were devised based on vertical distribution of suspended sediment: equilibrium partition model and dynamic micro-diffusion model. The ratio of time scale between the sediment movement and sorption can be used as the index of the models. When this ratio was large, the equilibrium assumption was reasonable, but when it was small, it might require dynamic micro-diffusion model.

Sample size effect on the dynamic torsional behaviour of the 2A12 aluminium alloy

In order to investigate the effect of sample size on the dynamic torsional behaviour of the 2A12 aluminium alloy. In this paper, torsional split Hopkinson bar tests are conducted on this alloy with different sample dimensions. It is found that with the decreasing gauge length and thickness, the tested yield strength increases. However, the sample innerlouter diameter has little effect on the dynamic torsional behaviour. Based on the finite element method, the stress states in the alloy with different sample sizes are analysed. Due to the effect of stress concentration zone （SCZ）, the shorter sample has a higher yield stress. Furthermore, the stress distributes more uniformly in the thinner sample, which leads to the higher tested yield stress. According to the experimental and simulation analysis, some suggestions on choosing the sample size are given as well.

TEMPERATURE DEPENDENCE OF VISCOSITY OF Al-Si ALLOY MELTS

The relationship between the viscosity and temperature of Al-Si alloy melts was investigated. The viscosity of three different types of Al-Si alloy melts was measured. It was showed that the relationship between the viscosity and temperature of hypoeutectic Al-5%Si and eutectic Al- 12.5%Si alloy melts is approximately exponential except for some special zones, but that of the hypereutectic melt is different. The paper discussed the correlation of the viscosity and atomic density, which is thought that the viscosity corresponds to the atomic density to some extent.

Measurements of dihadron correlations relative to the event plane in Au+Au collisions at√^(S)NN=200 GeV

Dihadron azimuthal correlations containing a high transverse momentum(pr)trigger particle are sensit-ive to the properties of the nuclear medium created at RHIC through the strong interactions occurring between the traversing parton and the medium,ie.jet-quenching.Previous measurements revealed a strong modification to di-hadron azimuthal correlations in Au+Au collisions with respect to ptp and d+Au collisions.The modification in-creases with the collision centrality,suggesting a path-length or energy density dependence to the je-quenching ef-fect.This paper reports STAR measurements of dihadron azimuthal correlations in mid-central(20%-60%)Au+Au collisions at√^(S)NN=200 GeV as a function of the trigger particle's azimuthal angle relative to the event plane,Ф_(s)=|Ф_(t)-ψ_(Ep)|.The azimuthal correlation is studied as a function of both the trigger and associated particle pr.The subtractions of the combinatorial background and anisotropic flow,assuming Zero Yield At Minimum(ZYAM),are described.The correlation results are first discussed with subtraction of the even harmonic(elliptic and quadrangu-lar)flow backgrounds.The away-side correlation is strongly modifed,and the modification varies withФ_(s),with a double-peak structure for out-of-plane trigger particles.The near-side ridge(long range pseudo-rapidity△_(η)correla-tion)appears to drop with increasingФ_(s)while the jet-like component remains approximately constant.The correla-tion functions are further studied with the subtraction of odd harmonic triangular flow background arising from fluc-tuations.It is found that the triangular flow,while responsible for the majority of the amplitudes,is not sufficient to explain theφs-dependence of the ridge or the away-side double-peak structure.The dropping ridge withФ_(s)could be attributed to aФ_(s)-dependent lliptie anisotropy;however,the physics mechanism of the ridge remains an open ques-tion.Even with aФ_(s)-dependent elliptic flow,the away-side correlation structure is robust.These results,with extens-ive systematic studies of the dihadron correlations as a function ofФ_(s),trigger and associated particle pT,and the pseudo-rapidity range△_(η),should provide stringent inputs to help understand the underlying physics mechanisms of jet-medium interactions in high energy nuclear collisions.

Structures and formation mechanisms of dislocation-induced precipitates in relation to the age-hardening responses of Al-Mg-Si alloys

In the slightly deformed Al-Mg-Si alloys,dislocation-induced precipitates are frequently observed,and they usually line up,forming sophisticated precipitation microstructures.Using atomic-resolution electron microscopy in association with hardness measurements,we systematically investigated these precipitates in relation to the age-hardening responses of the alloys.Our study reveals that the majority of dislocation-induced complex precipitates are actually short-range ordered while long-range disordered polycrystalline precipitates and multiphase composite precipitates,including polycrystalline U2 precipitates,B’/U2,B’-2/U2,B’/B’-2/U2 and’/U2 composite precipitates.It is suggested that the formation of these complex precipitates is mainly owing to a high nucleation rate and rapid growth of different precipitate phases parallel to the associated dislocation lines.Since dislocation-induced precipitates consume more Mg than Si from the matrix and have a high formation kinetics,they will have different impacts on the matrix precipitation in different types of Al-Mg-Si alloys.Our results further demonstrate that for the"normally-β"-hardened"alloy,their formation leads to a coarser precipitate microstructure in the matrix,whereas for the"normally-β’-hardened"alloy,their formation reverses the precipitation pathway in the matrix,resulting in a reduced age-hardening potential of the former alloy and an improved age-hardening potential of the latter alloy.

A hidden precipitation scenario of theθ’-phase in Al-Cu alloys

Al-Cu binary alloys are important and interesting industry materials.Up to date,the formation mechanisms of the key strengthening precipitates,namedθ’-phase,in the alloys are still controversial.Here,we report that for non-deformed bulk Al-Cu alloys theθ’-phase actually has its own direct precursors that can form only at elevated aging temperature(>ca.200℃).These high-temperature precursors have the same plate-like morphology as theθ’-phase precipitates but rather different structures.Atomicresolution imaging reveals that they have a tetragonal structure with a=0.405 nm and c=1.213 nm,and an average composition of Al_(5-x)Cu_(1+x)(0≤x<1),being fully coherent with the Al-lattice.This precursor phase may initiate with a composition of Al5 Cu and evolve locally towards Al_(4)Cu_(2)in composition,eventually leading to a consequent structural transformation into theθ’-phase(Al4 Cu2=Al2 Cu).There are evidences that because of their genetic links in structure,such a high-temperature precursor may transform to theθ’-phase without having to change their morphology and interface structure.Our study reveals a well-defined and previously hidden precipitation scenario for theθ’-phase to form in Al-Cu alloys at an elevated aging temperature.

Unveiling anneal hardening in dilute Al-doped Al_(x)CoCrFeMnNi(x = 0,0.1) high-entropy alloys

Anneal hardening has been one of the approaches to improve mechanical properties of solid solution alloys with the face-centered cubic(FCC) structure,whereby a considerable strengthening can be attained by annealing of cold-worked alloys below the recrystallization temperature(T_(rx)).Microscopically,this hardening effect has been ascribed to several mechanisms,i.e.solute segregation to defects(dislocation and stacking fault) and short-range chemical ordering,etc.However,none of these mechanisms can well explain the anneal hardening recently observed in phase-pure and coarse-grained FCC-structured high-entropy alloys(HEAs).Here we report the observations,using high-resolution electron channeling contrast imaging and transmission electron microscopy,of profuse and stable dislocation substructures in a cold-rolled CoCrFeMnNi HEA subject to an annealing below T_(rx).The dislocation substructures are observed to be thermally stable up to T_(rx),which could arise from the chemical complexity of the high-entropy system where certain elemental diffusion retardation occurs.The microstructure feature is markedly different from that of conventional dilute solid solution alloys,in which dislocation substructures gradually vanish by recovery during annealing,leading to a strength drop.Furthermore,dilute addition of 2 at.% Al leads to a reduction in both microhardness and yield strength of the cold-rolled and subsequently annealed(≤500℃) HEA.This Al induced softening effect,could be associated with the anisotropic formation of dislocation substructure,resulting from enhanced dislocation planar slip due to glide plane softening effect.These findings suggest that the strength of HEAs can be tailored through the anneal hardening effect from dislocation substructure strengthening.

Nano-phase transformation of composite precipitates in multicomponent Al-Mg-Si(-Sc)alloys

Sc-addition can significantly enhance the performance of the micro-alloyed Al-Mg-Si-Sc alloys.However,the mechanisms by which the Sc element modifies the microstructure of the alloys are still unknown in many cases.Here,using atomic-scale transmission electron microscopy and atomic-resolution spectroscopy,we have revealed the microstructural differences between two age-hardened Al-0.5Mg-0.4Si(wt.%)alloys with and without Sc-addition.The first significant effect of Sc-addition on the precipitation microstructure of the Al-Mg-Si-Sc alloy is that Sc-atoms may distribute at theβ"-precipitate/Al-matrix interface and therefore accelerate aging kinetics at the initial stage of hardening.The second significant effect of Sc-addition is that in the transition from theβ"-hardened peak-age stage to theβ′-hardened late stage,Sc-atoms can greatly improve the stability of transitionalβ"/B'/β′composite precipitates by entering the B'-substructures and/or locating at the precipitate/Al interfaces.As such Sc-atoms effectively suppressβ"toβ'transformation and cross-sectional coarsening of bothβ"and composite precipitates,leading to much finer precipitate needles with smaller diameter but much larger length,as compared with those precipitate needles formed in the alloy without Sc-addition.Hence,the alloy with Sc-addition exhibits a much better thermal stability than that without Sc.

Development of a 750-mm-long stripline kicker for HEPS

Purpose The superfast kickers are required for the HEPS storage ring on-axis injection system due to its very small dynamic aperture.A 750-mm-long stripline pair type of kicker prototype was researched and developed to demonstrate achieved performance of bandwidth,impedance,kicker strength,field uniformity and beam power loss.Methods The cross sections of the kicker main body and the end of taper part are optimized for a good impedance matching and field uniformity.3D simulation further optimizes the taper part to minimize the beam power loss and maintain a lower reflection.The high-voltage feedthrough is also designed and optimized by 3D CST.RF and high-voltage measurements are taken to verify the design of kicker assembly.Results The testing transmission odd-mode impedance is 50±0.5Ω,the even-mode impedance is 60±0.5Ω,and return loss is less than−13 dB.The peak voltage and the rise time of pulse width inserting kicker assembly just decrease 3%of 20 kV and slow down 80 ps,respectively.Conclusions RF testing results agree well with the simulation ones,which meet the design specification.The kicker assembly works well at±20 kV pulse.

A novel dentin bonding scheme based on extrafibrillar demineralization combined with covalent adhesion using a dry-bonding technique

Dentin bonding is a dynamic process that involves the penetration of adhesive resin monomers into the extrafibrillar and intrafibrillar demineralized collagen matrix using a wet-bonding technique.However,adhesive resin monomers lack the capacity to infiltrate the intrafibrillar space,and the excess water that is introduced by the wet-bonding technique remains at the bonding interface.This imperfectly bonded interface is inclined to hydrolytic degradation,severely jeopardizing the longevity of bonded clinical restorations.The present study introduces a dentin bonding scheme based on a dry-bonding technique,combined with the use of extrafibrillar demineralization and a collagen-reactive monomer(CRM)-based adhesive(CBA).Selective extrafibrillar demineralization was achieved using 1-wt%high-molecular weight(MW)carboxymethyl chitosan(CMCS)within a clinically acceptable timeframe to create a less aggressive bonding substance for dentin bonding due to its selectively extrafibrillar demineralization capacity.CMCS demineralization decreased the activation of in situ collagenase,improved the shrinking resistance of demineralized collagen,and thus provided stronger and more durable bonding than traditional phosphoric acid etching.The new dentin bonding scheme that contained CMCS and CBA and used a dry-bonding technique achieved an encouraging dentin bonding strength and durability with low technical sensitivity.This bonding scheme can be used to improve the stability of the resin-dentin interface and foster the longevity of bonded clinical restorations.

Atomic-scale roles of Zn element in age-hardened AlMgSiZn alloys

Adding alloying elements to improve the performances or the manufacturing processes of Al-Mg-Si alloys has long been a serious issue in developing advanced automotive aluminum materials.The Zn element,among those promising ones,has demonstrated positive alloying effects on Al-Mg-Si alloys.However,the atomic-scale roles of Zn in an age-hardened Al-Mg-Si-Zn alloy have not been adequately understood.Using atomic-resolution electron microscopy,here we report the precise locations of Zn elements in all hardening precipitates involved and their alloying mechanism at the atomic scale when alloying the alloy.Our results show that Zn atoms enter all the major hardening phases to occupy specific featured atomic sites of the original elements,e.g.the Si1 and Mg2 sites in theβ’-2 phase,and modify their crystal structures,interfacial structures and morphologies in characteristic manners.It is revealed that for theβ’-phase,Zn atoms occupy unique atomic sites,whereas for other phases,they demonstrate similar behaviors as other additive alloying elements such as Ag and Cu do.

Electron tomography for sintered ceramic materials by a neural network algebraic reconstruction technique

The missing wedge effect in electron tomography introduces various types of artifacts in the tomograms and lowers the reconstruction resolution and quality.The artifacts produced in tomographic reconstruction of bulk materials can be very severe,particularly for sintered bulk ceramic materials in which there are often nano-pores or pore-like microstructure features.Here,we report a neural network algebraic reconstruction algorithm with no prior knowledge to perform electron tomography for a sintered SiC material with nano carbon zones.The results show that the proposed algorithm has a great suppressive effect on the missing wedge artifacts and a high tolerance for noise.The information in the missing wedge can be partly recovered by this technique.Thus,both the shape of the bulk SiC specimen and its irregular inner pore-like features are correctly retrieved in the obtained 3D image.Our study shows the effectiveness of the neural network algorithm for improving the reconstruction accuracy of electron tomography,in order to reveal sophisticated 3D microstructures generally existing in sintered ceramic materials.

Measurement of away-side broadening with self-subtraction of flow in Au+Au collisions at √sNN=200 GeV

High transverse momentum(pT)particle production is suppressed owing to the parton(jet)energy loss in the hot dense medium created in relativistic heavy-ion collisions.Redistribution of energy at low-to-modest pT has been difficult to measure,owing to large anisotropic backgrounds.We report a data-driven method for background evaluation and subtraction,exploiting the away-side pseudorapidity gaps,to measure the jetlike correlation shape in Au+Au collisions at √sNN=200 GeV in the STAR experiment.The correlation shapes,for trigger particles pT>3GeV/c and various associated particle pT ranges within 0.5<pT<10GeV/c,are consistent with Gaussians,and their widths increase with centrality.The results indicate jet broadening in the medium created in central heavy-ion collisions.

Anisotropic Inter-granular Corrosion Behaviors and Microstructures of AlMgSiCu Alloy Sheets Made by Thermal–Mechanical Treatments

This study investigates the microstructure and local corrosion behavior of an Al-Mg-Si-Cu alloy,which has been subjected to cold-rolling with different deformation strain ratios(DSRs)and followed by artificial aging.Accelerated corrosion tests show that peak-aged samples with a small DSR(5-10%)are sensitive to inter-granular corrosion(IGC)along both the normal and rolling directions.When the DSR increases to medium strength(20-40%),IGC sensitivity decreases along both directions and corrosion propagates anisotropically.When the DSR is 60-80%,IGC sensitivity along the normal direction continues to decrease,but increases along the rolling direction,indicating pronounced corrosion anisotropy.Microstructural characterization reveals the decreased IGC sensitivity is mainly attributed to a reduction in element segregation at high-angle grain boundaries and the kinked and discontinuous grain boundary corrosion paths.The increased IGC sensitivity along the rolling direction could be related to the significantly flattened grains.