To meet the growing demand for antibacterial implants for bone-implant-associated infection therapy and avoid the adverse effects of secondary surgery,a degradable platform with pH responsiveness and ion-associated an...To meet the growing demand for antibacterial implants for bone-implant-associated infection therapy and avoid the adverse effects of secondary surgery,a degradable platform with pH responsiveness and ion-associated antibacterial properties was constructed.A small amount of Sn added to Mg-1Zn alloy reduces the biocorrosion rate,which can be attributed to Sn participation in outer-layer film formation,significantly reducing the biocorrosion rate and hydrogen evolution rate after implantation in vivo.These Mg alloys,which are susceptible to degradation in the acidic bacterial microenvironment,degrade by releasing Mg,Zn and Sn,producing favorably alkaline and antibacterial conditions.Samples with the composition of Mg-1Zn-0.5Sn were found to be beneficial for promoting initial cell adhesion and proliferation,resulting in improved biocompatibility and biosafety.The biocompatibility of this alloy was confirmed by the healthy behavior of animals and the absence of acute or chronic toxicity in the liver,spleen,and kidneys.Our results demonstrate that Mg-1Zn-0.5Sn is safe for biological systems,enabling its efficacious use in biomedical applications.展开更多
Safety risks are essential to the success or failure of the large⁃scale complex projects.In order to assess and evaluate the safety risks of the large⁃scale complex projects scientifically,a risk assessment method of ...Safety risks are essential to the success or failure of the large⁃scale complex projects.In order to assess and evaluate the safety risks of the large⁃scale complex projects scientifically,a risk assessment method of work breakdown structure and risk breakdown structure(WBS⁃RBS)is proposed to identify the project risks.In this paper,interval numbers are used to evaluate the risk levels,weights are assigned automatically based on the complexity and risk degree of WBS to distinguish three types of nodes in WBS,and a risk assessment algorithm is designed to assess safety risk at all layers of the project.A case study is conducted to demonstrate how to apply the method.The results show the practicality,robustness and efficiency of our new method,which can be applied to different kinds of large⁃scale complex projects in reality.展开更多
The level of personnel operation ability determines the expected effectiveness of large-scale complex equipment. Firstly, this paper constructs the personnel operational ability evaluation index system and analyzes th...The level of personnel operation ability determines the expected effectiveness of large-scale complex equipment. Firstly, this paper constructs the personnel operational ability evaluation index system and analyzes the data source of index. Secondly, the weight of index is determined and the fuzzy comprehensive evaluation model is proposed. Finally, results of instance analysis show that the evaluation model is feasible and effective.展开更多
文摘To meet the growing demand for antibacterial implants for bone-implant-associated infection therapy and avoid the adverse effects of secondary surgery,a degradable platform with pH responsiveness and ion-associated antibacterial properties was constructed.A small amount of Sn added to Mg-1Zn alloy reduces the biocorrosion rate,which can be attributed to Sn participation in outer-layer film formation,significantly reducing the biocorrosion rate and hydrogen evolution rate after implantation in vivo.These Mg alloys,which are susceptible to degradation in the acidic bacterial microenvironment,degrade by releasing Mg,Zn and Sn,producing favorably alkaline and antibacterial conditions.Samples with the composition of Mg-1Zn-0.5Sn were found to be beneficial for promoting initial cell adhesion and proliferation,resulting in improved biocompatibility and biosafety.The biocompatibility of this alloy was confirmed by the healthy behavior of animals and the absence of acute or chronic toxicity in the liver,spleen,and kidneys.Our results demonstrate that Mg-1Zn-0.5Sn is safe for biological systems,enabling its efficacious use in biomedical applications.
基金This paper was supported by National Social Science Foundation of China(2019⁃SKJJ⁃035)。
文摘Safety risks are essential to the success or failure of the large⁃scale complex projects.In order to assess and evaluate the safety risks of the large⁃scale complex projects scientifically,a risk assessment method of work breakdown structure and risk breakdown structure(WBS⁃RBS)is proposed to identify the project risks.In this paper,interval numbers are used to evaluate the risk levels,weights are assigned automatically based on the complexity and risk degree of WBS to distinguish three types of nodes in WBS,and a risk assessment algorithm is designed to assess safety risk at all layers of the project.A case study is conducted to demonstrate how to apply the method.The results show the practicality,robustness and efficiency of our new method,which can be applied to different kinds of large⁃scale complex projects in reality.
基金supported by the Natural Science Foundation of China(71704184)Projects of the of the National Social Science Foundation of China(15GJ003-245)Science Foundation of Equipment Research(JJ20172A05095)
文摘The level of personnel operation ability determines the expected effectiveness of large-scale complex equipment. Firstly, this paper constructs the personnel operational ability evaluation index system and analyzes the data source of index. Secondly, the weight of index is determined and the fuzzy comprehensive evaluation model is proposed. Finally, results of instance analysis show that the evaluation model is feasible and effective.
