Impact of Morphology of Conductive Agent and Anode Material on Lithium Storage Properties

In this study,the impact of morphology of conductive agent and anode material(Fe3O4)on lithium storage properties was throughly investigated.Granular and belt-like Fe3O4active materials were separately blended with two kinds of conductive agents(i.e.,granular acetylene black and multi-walled carbon nanotube)as anodes in lithium-ion batteries(LIBs),respectively.It was found that the morphology of conductive agent is of utmost importance in determining LIBs storage properties.In contrast,not as the way we anticipated,the morphology of anode material merely plays a subordinate role in their electrochemical performances.Further,the morphology-matching principle of electrode materials was discussed so as to render their utilization more rational and effective in LIBs.

k_(eff)uncertainty quantification and analysis due to nuclear data during the full lifetime burnup calculation for a small-sized prismatic high temperature gas-cooled reactor

To benefit from recent advances in modeling and computational algorithms,as well as the availability of new covariance data,sensitivity and uncertainty analyses are needed to quantify the impact of uncertain sources on the design parameters of small prismatic high-temperature gascooled reactors(HTGRs).In particular,the contribution of nuclear data to the k_(eff)uncertainty is an important part of the uncertainty analysis of small-sized HTGR physical calculations.In this study,a small-sized HTGR designed by China Nuclear Power Engineering Co.,Ltd.was selected for k_(eff)uncertainty analysis during full lifetime burnup calculations.Models of the cold zero power(CZP)condition and full lifetime burnup process were constructed using the Reactor Monte Carlo Code RMC for neutron transport calculation,depletion calculation,and sensitivity and uncertainty analysis.For the sensitivity analysis,the Contribution-Linked eigenvalue sensitivity/Uncertainty estimation via Track length importance Characterization(CLUTCH)method was applied to obtain sensitive information,and the "sandwich" method was used to quantify the k_(eff)uncertainty.We also compared the k_(eff)uncertainties to other typical reactors.Our results show that ^(235)U is the largest contributor to k_(eff)uncertainty for both the CZP and depletion conditions,while the contribution of ^(239)Pu is not very significant because of the design of low discharge burnup.It is worth noting that the radioactive capture reaction of ^(28)Si significantly contributes to the k_(eff)uncertainty owing to its specific fuel design.However,the k_(eff)uncertainty during the full lifetime depletion process was relatively stable,only increasing by 1.12%owing to the low discharge burnup design of small-sized HTGRs.These numerical results are beneficial for neutronics design and core parameters optimization in further uncertainty propagation and quantification study for small-sized HTGR.

Dorsal root ganglion progenitors differentiate to gamma-aminobutyric acid-and choline acetyltransferase-positive neurons

This study examined the isolation and differentiation of dorsal root ganglion progenitor cells for therapeutic use in neurodegenerative diseases. Rat embryonic dorsal root ganglia progenitors were isolated and purified using the differential adhesion method combined with cytosine arabinoside treatment. After culture in serum-free medium supplemented with B27, basic fibroblast growth factor and epidermal growth factor, these cells remained viable and survived for more than 18 months in vitro. Most cells differentiated to neurons that were immunoreactive for gamma-aminobutyric acid and choline acetyltransferase as detected by immunohistochemical staining. In addition, nerve growth factor and neurotrophic tyrosine kinase receptor expression were also observed in dorsal root ganglion progenitors and differentiated cells. K252a, an inhibitor that blocks nerve growth factor-induced signaling, inhibited cell survival, suggesting the possible existence of a nerve growth factor autocrine loop in these proliferating cells.

LIC color texture enhancement algorithm for ocean vector field data based on HSV color mapping and cumulative distribution function

Texture-based visualization method is a common method in the visualization of vector field data.Aiming at adding color mapping to the texture of ocean vector field and solving the ambiguity of vector direction in texture image,a new color texture enhancement algorithm based on the Line Integral Convolution(LIC)for the vector field data is proposed,which combines the HSV color mapping and cumulative distribution function calculation of vector field data.This algorithm can be summarized as follows:firstly,the vector field data is convoluted twice by line integration to get the gray texture image.Secondly,the method of mapping vector data to each component of the HSV color space is established.And then,the vector field data is mapped into HSV color space and converted from HSV to RGB values to get the color image.Thirdly,the cumulative distribution function of the RGB color components of the gray texture image and the color image is constructed to enhance the gray texture and RGB color values.Finally,both the gray texture image and the color image are fused to get the color texture.The experimental results show that the proposed LIC color texture enhancement algorithm is capable of generating a better display of vector field data.Furthermore,the ambiguity of vector direction in the texture images is solved and the direction information of the vector field is expressed more accurately.

Evaluation of the Acute Toxicity of Prochloraz-manganese Chloride Complex to Environmental Species

[Objectives] This study was conducted to evaluate the toxicity risk of prochloraz-manganese chloride complex to environmental organisms. [Methods] The acute toxicity tests of prochloraz-manganese chloride complex on 8 common environmental organisms, such as Coturnix coturnix japonica, Apis mellifera L., Eisenia foetida, Bombyx mori, Trichogramma japonicum, Brachydanio rerio, Daphnia magna Straus and Scenedesmus obliquus were carried out. [Results] Prochloraz-manganese chloride complex to D. magna EC50(48 h): 1.11 mg a.i./L, with a 95% confidence limit of 1.00-1.26 mg a.i./L;B. rerio LC50(96 h): 2.84 mg a.i./L, with a 95 % Confidence limit of 2.43-3.48 mg a.i./L;S. obliquus ErC50(72 h): 1.88×10^-2 mg a.i./L, with a 95% confidence limit of 1.70×10^-2-2.16×10^-2 mg a.i./L;C. coturnix LD50(168 h): 1.01×10^3 mg a.i./kg body weight, with a 95% confidence limit of 7.87×10^2-1.27×10^3 mg a.i./kg body weight;T. japonicum LR50(24 h): 2.53×10^-3 mg a.i./cm^2, with a 95% confidence limit of 2.14×10^-3-2.99×10^-3 mg a.i./cm^2;B. mori LC50(96 h): 2.03×10^2 mg a.i./L, with a 95% confidence limit of 1.79×10^2-2.30×10^2 mg a.i./L;A. mellifera(peroral) LD50(48 h)>100 μg a.i./bee;A. mellifera(contact) LD50(48 h)>100 μg a.i./bee;E. foetida LC50(14 d)>1.00×10^2 mg a.i./kg dry soil. According to the Guidance for Evaluating and Calculating Degradation Kinetics in Environmental Media for Pesticide Registration, prochloraz-manganese chloride complex had low toxicity to A. mellifera, C. coturnix, B. mori and E. foetida, medium toxicity to D. magna and B. rerio, and high toxicity and low risk to S. obliquus and T. japonicum. [Conclusions] This study provides a data basis for the toxicity and environmental safety evaluation of the agent.

Multispectral Imaging for Authenticity Identification and Quality Evaluation of <i>Flos carthami</i>

The identification and quality evaluation of Flos carthami were studied using tunable liquid spectral imaging instrument, to discuss the application range and advantages of spectral imaging technology in Chinese medicine identification and quality control field. The Flos carthami was indentified by extracting the normalized characteristic spectral curves of Flos carthami, Crocus sativus and Dendranthema morifolium, which were standard samples supplied by National Institute for Drug Control. The qualities of Flos carthamies collecting from different pharmacies were evaluated by extracting their normalized characteristic spectral curves. The imaging spectrum testing system was designed independently. The spectral resolution was 5 nm, and the spectral range was from 400 nm to 680 nm. The results showed that the normalized characteristic spectral curve of Flos carthami was significantly different from those of Crocus sativus’ and Dendranthema morifolium’s, and the fluorescence intensity of Flos carthami from different commercial sources were different. Spectral imaging technology could be used to identify and evaluate Flos carthami, and operation method was rapid, convenient and non-destructive.

Application of Multispectral Imaging Method in Rapid Identification and Analysis of Chinese Herbal Medicine Powders

Five kinds of traditional flower Chinese medicine powders (TFCMD) were identified using tuneable liquid spectral imaging instrument, to discuss the application range and advantages of spectral imaging technology in Chinese medicine identification and analysis field. The testing system is the liquid crystal multispectral imaging system designed by ourselves. All the tests are standard samples supplied by National Institute for Drug Control. The spectral cubes of Campsis grandiflora, Carthamus tinctorius, Albizzia julibrissin, Dendranthema morifolium, and Dendranthema indicum were captured, and then the normalized characteristic spectral curves of them were picked up. The spectral resolution is 5 nm, and the spectral range is 400 nm - 650 nm. The result shows that different TFCMD has different normalized characteristic fluorescence spectral curve. Spectral imaging technology can be used to identify TFCMD, and the testing course is convenient, quick, noninvasive and without pre-treatment.

丁基橡胶的结构对硫化胶疲劳性能的影响

橡胶的机械疲劳过程复杂,影响因素众多。文中对不同微观结构的丁基橡胶进行室温屈挠龟裂实验,应用红外光谱仪和场发射扫描电子显微镜,分析了硫化胶屈挠疲劳前后分子链结构和微观形貌的变化。实验结果表明,不饱和度高的丁基橡胶硫化速度较快,屈挠过程中硫化胶表面热氧老化程度较高;相对分子质量相近的2种丁基橡胶不饱和度高的硫化胶的抗机械疲劳性能较好;屈挠龟裂过程中异相颗粒处的应力集中是导致形成龟裂裂纹的主要原因。

结直肠癌患者血清IL-37水平及与临床病理特征的关系

目的观察结直肠癌患者血浆白细胞介素-37(IL-37)水平及与临床病理特点及预后的关系,探讨血清IL-37在结直肠癌诊疗中的临床价值。方法选取2017年1月—2019年1月在丽水市中心医院胃肠外科就诊的结直肠癌患者200例作为结直肠癌组,另取该院同期健康体检者200例作为对照组。采用酶联免疫吸附试验测定血清IL-37水平。结果结直肠癌组血清IL-37水平低于对照组(P<0.05)。结直肠癌不同临床分期患者血清IL-37水平比较,差异有统计学意义(P<0.05),随着临床分期升高血清IL-37水平降低。临床分期高、有淋巴结转移、有远处转移、生存时间短的患者血清IL-37水平低于临床分期低、无淋巴结转移、无远处转移、生存时间长的患者(P<0.05)。不同年龄、性别、肿瘤位置、肿瘤类型、浸润深度及分化程度患者血清IL-37水平比较,差异无统计学意义(P>0.05)。Cox回归单因素分析显示,不同临床分期、淋巴结转移、远处转移及IL-37水平结直肠癌患者生存期比较,差异有统计学意义(P<0.05)。多因素分析显示,临床分期[RR=0.043(95%CI:0.014,0.102)]、淋巴结转移[RR=0.038(95%CI:0.016,0.097)]、远处转移[RR=0.049(95%CI:0.013,0.120)]和IL-37水平[RR=0.067(95%CI:0.028,0.168)]是结直肠癌患者生存的影响因素。结论结直肠癌患者血清IL-37水平降低,血清IL-37水平与结直肠癌患者的临床分期、淋巴结转移、远处转移和预后关系密切。

Prognostic factors and therapeutic effects of different treatment modalities for colorectal cancer liver metastases

BACKGROUND Colorectal cancer(CRC)is one of the most common malignant tumors in China,and the liver is the most common metastatic site in patients with advanced CRC.Hepatectomy is the gold standard treatment for colorectal liver metastases.For patients who cannot undergo radical resection of liver metastases for various reasons,ablation therapy,interventional therapy,and systemic chemotherapy can be used to improve their quality of life and prolong their survival time.AIM To explore the prognostic factors and treatments of liver metastases of CRC.METHODS A retrospective analysis was conducted on 87 patients with liver metastases from CRC treated at the Liaoning Cancer Hospital and Institute between January 2005 and March 2011.According to different treatments,the patients were divided into the following four groups:Surgical resection group(36 patients);ablation group(23 patients);intervention group(15 patients);and drug group(13 patients).The clinicopathological data and postoperative survival of the four groups were analyzed.The Kaplan-Meier method was used for survival analysis,and the Cox proportional hazards regression model was used for multivariate analysis.RESULTS The median survival time of the 87 patients was 38.747±3.062 mo,and the 1-and 3-year survival rates were 87.5%and 53.1%,respectively.The Cox proportional hazards model showed that the following factors were independent factors affecting prognosis:The degree of tumor differentiation,the number of metastases,the size of metastases,and whether the metastases are close to great vessels.The results of treatment factor analysis showed that the effect of surgical treatment was better than that of drugs,intervention,or ablation alone,and the median survival time was 48.83±4.36 mo.The drug group had the worst prognosis,with a median survival time of only 13.5±0.7 mo(P<0.05).For patients with liver metastases of CRC near the great vessels,the median survival time(27.3 mo)of patients undergoing surgical resection was better than that of patients using other treatments(20.6 mo)(P<0.05).CONCLUSION Patients with a low degree of primary tumor differentiation,multiple liver metastases(number of tumors>4),and maximum diameter of liver metastases>5 cm have a poor prognosis.Among drug therapy,intervention,ablation,and surgical treatment options,surgical treatment is the first choice for liver metastases.When liver metastases are close to great vessels,surgical treatment is significantly better than drug therapy,intervention,and ablation alone.

Study on the role of Cathepsin B and JNK signaling pathway in the development of cerebral aneurysm

Objective: To investigate the correlation between JNK signal and the apoptosis of VSMC as well as the expression of Cathepsin B and to explore the role of JNK signal in the development of cerebral aneurysm. Methods: Rat models of cerebral aneurysm were established and histopathologic changes of cerebral aneurysm and the apoptosis of VSMC were analyzed. Rat models were respectively subject to subcutaneous injection of Cathepsin B si RNA and JNK inhibitor SP600125. Western blot technique was used to detect the expression of proteins like Cathepsin B, Caspase-3, and p-JNK. Spearman's rho was used to examine the correlation between p-JNK and Cathepsin B, as well as the expression of relevant proteins. Results:The success rate of modeling rats with cerebral aneurysm was 88.75%. After the respective injection of Cathepsin B si RNA, SP600125 and their combination, the cell densities of VSMC of rats with cerebral aneurysm all increased significantly(P<0.05 or P<0.01), but the apoptosis rate of VSMC decreased significantly(P<0.01). Compared with normal rats, the expression of Cathepsin B, Caspase-3 and p-JNK in cerebral aneurysm models increased significantly. Effectively intervening Cathepsin B genes with Cathepsin B si RNA could significantly inhibit the expression of Cathepsin B and Caspase-3, but hardly influence the expression of p-JNK. JNK inhibitor SP600125 had no influence on the expression of Cathepsin B and Caspase-3, but effectively inhibited the expression of p-JNK. In cerebral aneurysm tissues, positive correlation was observed between the expression of p-JNK and Cathepsin B, the correlation coefficient was r=0.640. Conclusion: After the attack of cerebral aneurysm, proteins like Cathepsin B, Caspase-3 and p-JNK are all involved in the apoptosis of VSMCs. This process may be realized by Cathepsin B which activates the apoptosis mechanism of Caspase-3 and mediate the apoptosis of VSMC through the JNK signaling pathway. Therefore, silencing Cathepsin B gene or inhibiting the conduction through JNK signaling pathway can mitigate the apoptosis of vascular smooth muscle cells in cerebral aneurysm.

Rockburst mechanism and the law of energy accumulation and release in mining roadway: a case study

The rockburst dynamic disasters in the process of deep coal mining become more and more serious.Taking the rockburst occurred in the 23130 working face of Yuejin Coal Mine as the engineering background,we study the characteristics of mining stress feld around roadway,the plastic failure morphological characteristics of surrounding rock and the accumulation/release law of elastic energy before and after burst.An analysis model quantitatively describing the physical process of rockburst in the mining roadway is established,and the calculation method of dynamic release of elastic energy in the physical process of rockburst is educed.The mechanism of rockburst in mining roadway is revealed.The results show that an“L-shaped”stress concentration zone is formed within 100 m of the 23130 working face,and the principal stress ratio of the surrounding rock of the transportation roadway is 2.59–4.26.The change of the direction of the maximum principal stress has a signifcant efect on the burst appearance characteristics.The failure strength of diferent sections of the mining roadway is characterized by the elastic energy release value.With the increase of the working face distance,the elastic energy released by burst failure and the expansion variation of failure boundary radius show a nonlinear variation law that tends to decrease steadily after sharp fuctuation.The closer to the working face,the higher the burst risk.At a distance of 10 m from the working surface,the maximum principal stress reaches its maximum value.The butterfy-shaped failure system generated by the surrounding rock of the roadway has energy self-sustainability,and the elastic energy released by the sudden expansion of the butterfy leaf is enough to cause a burst damage of 1.9 magnitude.This work could provide theoretical support for the prediction and prevention of rockburst.

应急通信中异构无人机中继性能仿真评估

无人机基站能够在复杂地形和环境下快速高效部署,协助地面通信系统,满足应急通信需求。然而,现有的研究并未考虑到UAV基站的回传链路设计。可移动的UAV基站是部署在低空中,UAV基站无法采用传统的光纤链路进行数据回传,必须依靠无线链路。针对现有无人机基站回传链路的问题,提出了异构无人机中继组网系统模型以及关键的隧道技术,并从服务速率以及业务延时两个方面分析了无人机异构中继组网性能。通过仿真异构无人机中继承载数据以及语音业务性能,论证了无人机异构中继能够提升用户的业务体验。

Band gaps structure and semi-Dirac point of two-dimensional function photonic crystals

Two-dimensional function photonic crystals, in which the dielectric constants of medium columns are the functions of space coordinates , are proposed and studied numerically. The band gaps structures of the photonic crystals for TE and TM waves are different from the two-dimensional conventional photonic crystals. Some absolute band gaps and semiDirac points are found. When the medium column radius and the function form of the dielectric constant are modulated, the numbers, width, and position of band gaps are changed, and the semi-Dirac point can either occur or disappear. Therefore,the special band gaps structures and semi-Dirac points can be achieved through the modulation on the two-dimensional function photonic crystals. The results will provide a new design method of optical devices based on the two-dimensional function photonic crystals.

Effect of lithium carbonate combined with131I therapy on thyroid function as well as the Fas/FasL expression in peripheral blood of patients with Graves disease and leukopenia

Objective:To study the effect of lithium carbonate combined with131I therapy on thyroid function as well as the Fas/FasL expression in peripheral blood of patients with Graves disease and leukopenia.Methods:124 patients with Graves disease and leukopenia treated in our hospital between May 2012 and October 2015 were randomly divided into the observation group (n=62) who received lithium carbonate combined with131I therapy and control group (n=62) who received131I therapy, and the outcome, autoantibody content, proportion of T lymphocyte subsets as well as the expression levels of Fas and FasL were compared between two groups of patients.Results: 3 months and 6 months after treatment, serum thyroid hormones free triiodothyronine (FT3) and serum free thyroxine (FT4) levels as well as autoantibodies TSAb, TGAb and TPOAb content of observation group were significantly lower than those of control group (P<0.05) while peripheral blood white blood cell count was significantly higher than that of control group (P<0.05);proportion of Treg cells in peripheral blood of observation group was significantly higher than that of control group (P<0.05) while the proportion of Th1 and Th2 cells as well as the expression levels of Fas and FasL were significantly lower than those of control group (P<0.05).Conclusions: Lithium carbonate combined with131I treatment of Graves disease complicated with leukopenia can reduce the thyroid hormone synthesis, increase white blood cell count and regulate the proportion of T lymphocyte subsets as well as the expression of Fas/FasL.

Unexpected expression of heat-activated transient receptor potential(TRP)channels in winter torpid bats and cold-activated TRP channels in summer active bats

The ability to sense temperature changes is crucial for mammalian survival.Mammalian thermal sensing is primarily carried out by thermosensitive transient receptor potential channels(Thermo-TRPs).Some mammals hibernate to survive cold winter conditions,during which time their body temperature fluctuates dramatically.However,the underlying mechanisms by which these mammals regulate thermal responses remain unclear.Using quantitative real-time polymerase chain reaction(qRT-PCR)and the Western blotting,we found that Myotis ricketti bats had high levels of heat-activated TRPs(e.g.,TRPV1 and TRPV4)during torpor in winter and cold-activated TRPs(e.g.,TRPM8 and TRPC5)during active states in summer.We also found that laboratory mice had high mRNA levels of cold-activated TRPs(e.g.,Trpm8 and Trpc5)under relatively hot conditions(i.e.,40°C).These data suggest that small mammals up-regulate the expression of cold-activated TRPs even under warm or hot conditions.Binding site analysis showed that some homeobox(HOX)transcription factors(TFs)regulate the expression of hot-and cold-activated TRP genes and that some TFs of the Pit-Oct-Unc(POU)family regulate warm-sensitive and cold-activated TRP genes.The dual-luciferase reporter assay results demonstrated that TFs HOXA9,POU3F1,and POU5F1 regulate TRPC5 expression,suggesting that Thermo-TRP genes are regulated by multiple TFs of the HOX and POU families at different levels.This study provides insights into the adaptive mechanisms underlying thermal sensing used by bats to survive hibernation.

Distributed Nash Equilibrium Seeking Over Random Graphs

Dear Editor,This letter is concerned with the distributed Nash equilibrium(NE)seeking in an N-player game over random graphs. We develop a distributed stochastic forward-backward(DSFB) algorithm based on local information exchange between agents. We prove that the DSFB algorithm can converge to an NE almost surely, and analyze the convergence rate of the proposed algorithm. Compared with the existing works on distributed NE seeking, the communication graph in this letter is supposed to be time-varying and stochastic, which makes the NE seeking algorithm more suitable for practical scenarios, but brings a great challenge in both the design and convergence analysis of the algorithm. Besides, by establishing a variational inequality on NE, we relax the co-coercivity or strong monotonicity assumption on the extended pseudo-gradient.

Vaccariside A, Novel Saponin from Vaccaria segetalis (Neck.) Garcke

A new triterpenoid saponin, vaccariside A 1 was isolated from the seeds of l'accaria segetalis using various chromatographic methods. The structure of compound 1 was elucidated by comprehensive spectroscopic analysis as 3-O-beta-D-galactopyranosyl-(1-2)-[beta-D-quinovpyranosyl-(1-4)-beta-D-xylopyranosyl-(1-3)]-beta-D-glucuronopyranosyl quillaic acid 28-O-beta-D-glucopyranosyl-(1-3)-[beta-D-xylopyranosyl-(1-4)]-alpha-L-rhamnopyranosyl-(1-2)-3-O-acetyl-beta-D-fucopyranoside.

The Gravity Gauge Theory and Gravity Field Equation in Flat Space

In this paper, we have proposed the theory of gravity gauge, and the gravity theory has been introduced into quantum field theory. We have further given the tensor equation of gravity field in the flat space, and found the gravity field equation is the Lorentz covariant and gauge invariant. The gravity theory can be quantized and can be unified with the electroweak and strong interaction at a new gauge group .

Photon and Elementary Particles Theory

At present, the research of single-photon is a hot topic, it has been widely applied in quantum measurement, quantum entanglement and quantum information. In this paper, we have proposed a new single photon theory, which is the vector potential A rotation at the vertical motion direction of photon, it can produce the microscopic electric field and magnetic field, and they satisfy the Maxwell equations. We have calculated photon spin, momentum, energy, and found there are left-handed and right-handed photon. In addition, we study the multi-photon theory and the dynamics theory between photons interaction. On this basis, we have further given the compound structures of electron, proton, neutron, neutrino, π meson, dark matter with the photon structural theory, and calculated their mass, charge and spin.