Observational Subseasonal Variability of the PM_(2.5) Concentration in the Beijing-Tianjin-Hebei Area during the January 2021 Sudden Stratospheric Warming

It is still not well understood if subseasonal variability of the local PM_(2.5) in the Beijing-Tianjin-Hebei(BTH)region is affected by the stratospheric state.Using PM_(2.5) observations and the ERA5 reanalysis,the evolution of the air quality in BTH during the January 2021 sudden stratospheric warming(SSW)is explored.The subseasonal variability of the PM_(2.5) concentration after the SSW onset is evidently enhanced.Stratospheric circumpolar easterly anomalies lasted for 53 days during the January-February 2021 SSW with two evident stratospheric pulses arriving at the ground.During the tropospheric wave weakening period and the intermittent period of dormant stratospheric pulses,the East Asian winter monsoon weakened,anomalous temperature inversion developed in the lower troposphere,anomalous surface southerlies prevailed,atmospheric moisture increased,and the boundary layer top height lowered,all of which favor the accumulation of pollutant particulates,leading to two periods of pollution processes in the BTH region.In the phase of strengthened East Asian winter monsoon around the very beginning of the SSW and another two periods when stratospheric pulses had reached the near surface,opposite-signed circulation patterns and meteorological conditions were observed,which helped to dilute and diffuse air pollutants in the BTH region.As a result,the air quality was excellent during the two periods when the stratospheric pulse had reached the near surface.The increased subseasonal variation of the regional pollutant particulates after the SSW onset highlights the important role of the stratosphere in the regional environment and provides implications for the environmental prediction.

Increased summer electric power demand in Beijing driven by preceding spring tropical North Atlantic warming

By using electric power data,observational station temperature data in Beijing,CN05.1 temperature data,ERA5 atmospheric reanalysis data,and ERSST.v3 b sea surface temperature(SST) data,it is found that summer(JulyAugust) electric power demand in Beijing is remarkably positively correlated with the previous spring(MarchApril) tropical North Atlantic(TNA) SST anomaly(SSTA).The possible physical mechanism of the TNA SSTA affecting summer electric power in Beijing is also revealed.When a positive SSTA occurs in the TNA during spring,anomalous easterlies prevail over the tropical central Pacific,which can persist to the following summer.Trade winds are thus enhanced over the northern Pacific,which favors a strengthening of upwelling cold water in the tropical central-eastern Pacific.As a result,a negative SSTA appears in the central-eastern Pacific in summer,which means a La Nina event is triggered by the previous TNA SSTA through the Bjerknes feedback.During the La Nina event,an anomalous anticyclonic circulation occupies the northwestern Pacific.The southerly anomalies at the western edge of this anomalous anticyclone strengthen the transportation of warm and humid airflow from the low latitudes to North China,where Beijing is located,causing higher summer temperatures and increased electricity usage for air conditioning,and vice versa.The results of this study might provide a new scientific basis and dues for the seasonal prediction of summer electric power demand in Beijing.

原子精度制造新原理和新方法

目前航空航天、核物理、微电子、光电子和半导体等国家战略领域高性能装备的性能需求日渐严苛,核心零部件的制造精度必须迈进原子级水平,亟需研究原子精度的高性能制造新原理和新方法。本文归纳并提出了目前迫切需求的原子级表面精度、原子级结构精度、原子级损伤控制以及原子级特征尺寸结构创成四大原子精度制造核心能力,从能场辅助原子级切削、多能场辅助原子有序排布、表面能弱化原子精度材料去除以及超光学衍射极限的原子精度制造四大方向进行系统梳理,介绍了面向不同应用场景的原子精度制造新原理和新方法的研究现状,并概述了各类方法的优势和缺点,从中提炼出多能场耦合条件下的能量和原子间相互作用机理这一关键科学问题,并从四大方向上对未来我国原子级制造的基础研究提出了建议。

Effect of different cold air intensities and their lagged effects on outpatient visits for respiratory illnesses in Handan in different seasons

本文利用2016年到2019年邯郸市气象要素和呼吸系统疾病门诊数据,分析了不同季节不同强度的冷空气过程及其对呼吸系统疾病的影响,结果显示:尽管呼吸系统疾病在冬季高发,夏季最低,但冷空气对呼吸系统疾病的影响在夏,春季最大,就诊人数分别在冷空气日后两天和五天增加18.4%和13.3%,而冬季就诊人数在冷空气日后三天仅增加3.2%.冷空气对疾病影响的滞后时间在夏,秋和冬季随冷空气强度的增加而减少,而春季的滞后时间总是很长.这些发现可为科学应对气候异常导致的人群健康风险提供针对性依据.

A robust viscoelastic surfactant tolerating 20% HCl up to 150℃ for oil well stimulation

Viscoelastic surfactants(VES)are often used as viscous diverters in acidizing stimulation to prolong the acid consumption time and maximize zonal coverage of the acid for improving well productivity.However,the ceiling temperature of commercial VES cannot exceed 120℃in practical use because of the poor thermal stability and fragile molecular structure,hindering their implementation in hightemperature oil reservoirs,i.e.,≥150℃.Here we synthesized a novel C22-tailed diamine,N-erucaminopropyl-N,N-dimethylamine(EDPA),and examined comparatively its rheological behavior,assemblies morphology and molecular stability in 20 wt%HCl with a commercial VES,erucyl dimethyl amidopropyl betaine(EDAB).The feasibility of EDPA for acidizing stimulation was assessed by acid etching of carbonate rock with its HCl solution at 150℃.Rheological results showed that the 2.5 wt%EDPA—20 wt%HCl solution maintains stable viscosity of 90 m Pa s at 150℃for 60 min,while that of 2.0 wt%EDAB HCl solution is just 1 m Pa s under identical conditions.1H NMR spectra and cryo-TEM observations revealed that the chemical structure and self-assembled architectures of EDPA remained intact in such context,but the EDAB suffered from degradation due to the hydrolysis of the amide group,accounting for the poor heat-resistance and acid-tolerance.The reaction rate of 2.5 wt%EDPA HCl solution with carbonate rock was one order of magnitude lower than that of 20 wt%HCl solution at 150℃,underpinning the potential of EDPA to be used in the high-temperature reservoirs acidizing.This work improved the thermal tolerance of VES in highly concentrated HCl solution,paving a feasible way for the acidization of high-temperature reservoir environments(~150℃).

Microstructural evolution and hot tensile behavior of Mg−3Zn−0.5Zr alloy subjected to multi-pass friction stir processing

The microstructures and hot tensile behaviors of ZK30 alloys subjected to single-and multi-pass friction stir processing(FSP)were systematically investigated.Following single-pass FSP(S-FSP),coarse grains underwent refinement to 1−2μm,with a distinct basal texture emerging in the stir zone(SZ).Additionally,second-phase particles were fragmented,dispersed,and partially dissolved.Multi-pass FSP(M-FSP)further enhanced the homogeneity of the microstructure,reduced texture intensity differences,and decreased the fraction of second-phase particles by 50%.Both S-FSP and M-FSP SZs demonstrated superplasticity at strain rates below 1×10^(−3)s^(−1)and at temperatures of 250−350℃.The S-FSP SZ exhibited an elongation of 390%at 250℃and 1×10^(−4)s^(−1),while the M-FSP SZ achieved an elongation of 406%at 350℃and 1×10^(−3)s^(−1).The superplastic deformation of SZ was co-dominated by grain boundary sliding(GBS)and the solute-drag mechanism in S-FSP and mainly by GBS in M-FSP.

Rapid fabrication of modular 3D paper-basedmicrofluidic chips using projection-based 3D printing

Paper-based microchips have different advantages,such as better biocompatibility,simple production,and easy handling,making them promising candidates for clinical diagnosis and other fields.This study describes amethod developed to fabricate modular three-dimensional(3D)paper-based microfluidic chips based on projection-based 3D printing(PBP)technology.A series of two-dimensional(2D)paper-based microfluidic modules was designed and fabricated.After evaluating the effect of exposure time on the accuracy of the flow channel,the resolution of this channel was experimentally analyzed.Furthermore,several 3D paper-based microfluidic chips were assembled based on the 2D ones using different methods,with good channel connectivity.Scaffold-based 2D and hydrogel-based 3D cell culture systems based on 3D paper-based microfluidic chips were verified to be feasible.Furthermore,by combining extrusion 3D bioprinting technology and the proposed 3D paper-based microfluidic chips,multiorgan microfluidic chips were established by directly printing 3D hydrogel structures on 3D paperbased microfluidic chips,confirming that the prepared modular 3D paper-based microfluidic chip is potentially applicable in various biomedical applications.

Massive bleeding in small intestinal mucosa-associated lymphoid tissue lymphoma associated with COVID-19 infection:a case report

The increased risk of mucosa-associated lymphoid tissue(MALT)lymphoma is closely associated with chronic antigenic stimulation,with infection being the most common cause of recurrence.Lesions are usually associated with the gastrointestinal tract,and the involvement of small intestinal is rare.Recent studies have established a close relationship between novel coronavirus 2019(COVID-19)and the occurrence and progression of various diseases.This article presents a rare case of a small intestinal MALT lymphoma.The patient was initially admitted with COVID-19 pneumonia and subsequently developed gastrointestinal bleeding during hospitalization.Medical and endoscopic treatments were ineffective,and an emergency exploratory laparotomy was performed.The affected segment of the small intestine was excised,and a pathological biopsy confirmed the diagnosis of MALT lymphoma.This case underscores the significance of raising clinical awareness of this condition among health care professionals.

1961-2019年黑龙江省冬季气温季节内变化及环流异常特征

利用1961—2019年黑龙江省冬季气温、NCEP再分析资料和环流指数资料,采用多变量经验正交函数分解、合成分析、相关分析等方法,分析黑龙江省冬季气温季节内变化及其环流异常特征,并进一步对比了主要环流因子在冬季气温季节内演变不同模态中的相对贡献。结果表明:季节内变化是黑龙江省冬季气温变化的基本特征。黑龙江省冬季气温存在季节内一致变化、12月和翌年1—2月反位相变化、12月至翌年1月和2月反位相变化三个主要模态。当冬季气温处于第一模态分布一致偏暖(冷)时,环流呈现北极涛动(AO)正(负)位相的分布特征,东亚冬季风(EAWM)偏弱(强)。当冬季气温发生季节内冷暖转换时,季内极涡、高空急流、西伯利亚高压(SH)和EAWM强度、中高纬环流经向度等均有明显调整。第二模态1月和第三模态2月环流场分别呈现类似极地欧亚型(PEA)和东大西洋型(EA)遥相关的分布特征。AO、SH、EAWM、PEA和EA是冬季气温季节内演变的重要影响因子。

The 2020/21 Extremely Cold Winter in China Influenced by the Synergistic Effect of La Niña and Warm Arctic

In the first half of winter 2020/21,China has experienced an extremely cold period across both northern and southern regions,with record-breaking low temperatures set in many stations of China.Meanwhile,a moderate La Niña event which exceeded both oceanic and atmospheric thresholds began in August 2020 and in a few months developed into its mature phase,just prior to the 2020/21 winter.In this report,the mid−high-latitude large-scale atmospheric circulation anomalies in the Northern Hemisphere,which were forced by the negative phase of Arctic Oscillation,a strengthened Siberian High,an intensified Ural High and a deepened East Asian Trough,are considered to be the direct reason for the frequent cold surges in winter 2020/21.At the same time,the synergistic effect of the warm Arctic and the cold tropical Pacific(La Niña)provided an indispensable background,at a hemispheric scale,to intensify the atmospheric circulation anomalies in middle-to-high latitudes.In the end,a most recent La Niña prediction is provided and the on-coming evolution of climate is discussed for the remaining part of the 2020/21 winter for the purpose of future decision-making and early warning.

Use of infrared thermal imaging to diagnose health of Ammopiptanthus mongolicus in northwestern China

Population of the rare and endangered species Ammopiptanthus mongolicus （Maxim.） Cheng f. declined rapidly in China＇s add region and Central Asia. There is an urgent need to protect this species, which is particularly important in maintaining biodiversity throughout the arid region of northwestern China. By analyzing the infrared thermal images based on plant-transpiration transfer coef- ficient （hat） and photosynthetic parameters, we made quantitative and accurate diagnoses of the plant growth and health status of A. mongolicus. Using an LI-COR6400 photosynthesis system, we measured the net photosynthetic rate （Pn）, stomatal conductance （Gs）, and transpiration rate （Tr）. Infrared thermal images obtained in the field were processed by ENVI4.8 software to calculate surface tem- peratures of the plant subjects. We found that the plant transpiration transfer coefficient of A. mongolicus was inthe order of old plants 〉young plants 〉intermediate-aged plants. Declining health levels of young, intermediate, and old plants were divided into three categories： 〈0.4, 0.4-0.7, and 〉0.7. The coefficient showed a significant negative correlation with Tr, Gs, and Pn, indicating that they can simultaneously reflect the state of plant growth. By estab- lishing hat and photosynthetic parameters in regression model Y = a-blnx, we can accurately diagnose plant growth and decline of plant health conditions.

PROPAGATION OF LOVE WAVES IN PRESTRESSED PIEZOELECTRIC LAYERED STRUCTURES LOADED WITH VISCOUS LIQUID

We investigate analytically the effect of initial stress in piezoelectric layered structures loaded with viscous liquid on the dispersive and attenuated characteristics of Love waves, which involves a thin piezoelectric layer bonded perfectly to an unbounded elastic substrate. The effects of initial stress in the piezoelectric layer and the viscous coefficient of the liquid on the phase velocity of Love waves are analyzed. Numerical results are presented and discussed. The analytical method and the results can be useful for the design of chemical and biosensing liquid sensors.

DYNAMIC ANTI-PLANE PROBLEMS OF PIEZOCERAMICS AND APPLICATIONS IN ULTRASONICS—A REVIEW

We review theoretical results on anti-plane motions of polarized ceramics based on the linear theory of piezoelectricity. Solutions to dynamic problems of the propagation of bulk acoustic waves （BAW） and surface acoustic waves （SAW）, vibrations of finite bodies, and applications to various piezoelectric devices including piezoelectric waveguides, resonators, mass sensors, fluid sensors, actuators, nondestructive evaluation, power harvesters （generators）, transformers, and power transmission through an elastic wall by acoustic waves are discussed. Complications due to material inhomogeneity, initial stress, electromagnetic coupling, electric field gradient and semiconduction are also discussed. The paper cites 82 references.

The Predictability of Ocean Environments that Contributed to the 2020/21 Extreme Cold Events in China:2020/21 La Niña and 2020 Arctic Sea Ice Loss

Several consecutive extreme cold events impacted China during the first half of winter 2020/21,breaking the low-temperature records in many cities.How to make accurate climate predictions of extreme cold events is still an urgent issue.The synergistic effect of the warm Arctic and cold tropical Pacific has been demonstrated to intensify the intrusions of cold air from polar regions into middle-high latitudes,further influencing the cold conditions in China.However,climate models failed to predict these two ocean environments at expected lead times.Most seasonal climate forecasts only predicted the 2020/21 La Niña after the signal had already become apparent and significantly underestimated the observed Arctic sea ice loss in autumn 2020 with a 1-2 month advancement.In this work,the corresponding physical factors that may help improve the accuracy of seasonal climate predictions are further explored.For the 2020/21 La Niña prediction,through sensitivity experiments involving different atmospheric-oceanic initial conditions,the predominant southeasterly wind anomalies over the equatorial Pacific in spring of 2020 are diagnosed to play an irreplaceable role in triggering this cold event.A reasonable inclusion of atmospheric surface winds into the initialization will help the model predict La Niña development from the early spring of 2020.For predicting the Arctic sea ice loss in autumn 2020,an anomalously cyclonic circulation from the central Arctic Ocean predicted by the model,which swept abnormally hot air over Siberia into the Arctic Ocean,is recognized as an important contributor to successfully predicting the minimum Arctic sea ice extent.

Trabecular Plate Loss and Deteriorating Elastic Modulus of Femoral Trabecular Bone in Intertrochanteric Hip Fractures

Osteoporotic hip fracture is associated with significant trabecular bone loss, which is typically characterized as low bone density by dual-energy X-ray absorptiometry （DXA） and altered microstructure by micro-computed tomography （pCT）. Emerging morphological analysis techniques, e.g. individual trabecula segmentation （ITS）, can provide additional insights into changes in plate-like and rod-like trabeculae, two major micro- structural types serving different roles in determining bone strength. Using ITS, we evaluated trabecular microstructure of intertrochanteric bone cores obtained from 23 patients undergoing hip replacement surgery for intertrochanteric fracture and 22 cadaveric controls. Micro-finite element （~FE） analyses were performed to further understand how the abnormalities seen by ITS might translate into effects on bone strength. ITS analyses revealed that, near fracture site, plate-like trabeculae were seriously depleted in fracture patients, but trabecular rod volume was maintained. Besides, decreased plate area and rod length were observed in fracture patients. Fracture patients also showed decreased elastic moduli and shear moduli of trabecular bone. These results provided evidence that in intertrochanteric hip fracture, preferential loss of plate-like trabeculae led to more rod-like microstructure and deteriorated mechanical competence adjacent to the fracture site, which increased our understanding of the biomechanical pathogenesis of hip fracture in osteoporosis.

PARALLEL FINITE ELEMENT ANALYSIS OF HIGH FREQUENCY VIBRATIONS OF QUARTZ CRYSTAL RESONATORS ON LINUX CLUSTER

Quartz crystal resonators are typical piezoelectric acoustic wave devices for frequency control applications with mechanical vibration frequency at the radio-frequency （RF） range. Precise analyses of the vibration and deformation are generally required in the resonator design and improvement process. The considerations include the presence of electrodes, mountings, bias fields such as temperature, initial stresses, and acceleration. Naturally, the finite element method is the only effective tool for such a coupled problem with multi-physics nature. The main challenge is the extremely large size of resulted linear equations. For this reason, we have been employing the Mindlin plate equations to reduce the computational difficulty. In addition, we have to utilize the parallel computing techniques on Linux clusters, which are widely available for academic and industrial applications nowadays, to improve the computing efficiency. The general principle of our research is to use open source software components and public domain technology to reduce cost for developers and users on a Linux cluster. We start with a mesh generator specifically for quartz crystal resonators of rectangular and circular types, and the Mindlin plate equations are implemented for the finite element analysis. Computing techniques like parallel processing, sparse matrix handling, and the latest eigenvalue extraction package are integrated into the program. It is clear from our computation that the combination of these algorithms and methods on a cluster can meet the memory requirement and reduce computing time significantly.

京津冀地区天然气峰谷差成因及影响分析

2013年国家出台《大气污染防治行动计划》,2017年底发布《北方地区冬季清洁取暖规划(2017-2021)》,促使京津冀地区天然气消费量倍增。在清洁采暖、“煤改气”的推动下,地区天然气峰谷差绝对量逐年拉大。2019年,高低月峰谷比为2.5∶1,高月高日和低月低日峰谷比维持在4∶1,天然气采暖高峰月用气占比接近60%。导致京津冀地区天然气需求峰谷差拉大的主要原因是城市采暖“煤改气”项目投产集中、低气温以及价格因素等。巨大峰谷差加大了基础设施投入和供气成本。在中国北方采暖区域,天然气峰谷差大的现象将长期存在,除了从需求侧进行优化管理,还应从供应侧降低供气成本,同时需要政府在行政性措施和市场化手段之间做好平衡。

卵圆孔的解剖学研究及其临床意义

目的观察卵圆孔(FO)的形态及变异,为三叉神经痛、海绵窦区肿瘤的诊治提供参考依据。方法选取83例结构完整的颅骨标本,采用游标卡尺测量卵圆孔长度、宽度。分别测量FO与同侧颞骨岩尖(APP)、后床突(PCP)之间的距离,分别记为FO-APP,FO-PCP;记录FO形态特点。结果①FO具有如下形态:椭圆形98例;“D”字型60例;三角形3例;圆形2例;不规则形2例;缝1例。FO内具有骨棘3例,骨结节3例,骨刺2例。②左侧FO长度、宽度分别为(7.37±1.21)和(4.28±0.99)mm;FO与颞骨岩尖、后床突距离分别为(9.88±3.54)和(15.68±3.49)mm;右侧FO长度、宽度分别为(7.84±1.18)和(4.06±0.99)mm;FO与颞骨岩尖、后床突距离分别为(9.44±3.20)和(16.74±4.57)mm。③右侧FO长度高于左侧(P<0.05);左侧FO宽度与FO-APP呈负相关(r=-0.526,P=0.043);右侧FO宽度与FO-APP呈负相关(r=-0.341,P=0.039);右侧FO宽度与FO-PCP呈负相关(r=-0.369,P=0.047)。结论分析FO与颞骨岩尖、后床突等重要结构解剖学参数不仅提高脑外科医生对颅中窝解剖特征的认识,而且对三叉神经减压、海绵窦肿瘤的诊疗具有重要意义。

Integrative analysis of indirect calorimetry and metabolomics profiling reveals alterations in energy metabolism between fed and fasted pigs

Background: Fasting is a simple metabolic strategy that is used to estimate the maintenance energy requirement where the energy supply for basic physiological functions is provided by the mobilization of body reserves.However, the underlying metabolic components of maintenance energy expenditure are not clear. This study investigated the differences in heat production(HP), respiratory quotient(RQ) and plasma metabolites in pigs in the fed and fasted state, using the techniques of indirect calorimetry and metabolomics.Methods: Nine barrows(45.2 ± 1.7 kg BW) were fed corn-soybean based meal diets and were kept in metabolism crates for a period of 14 d. After 7 d adaptation, pigs were transferred to respiratory chambers to determine HP and RQ based on indirect calorimetry. Pigs were fed the diet at 2,400 k J ME/(kg BW0.6·d) during d 8 to 12. The last 2 d were divided into 24 h fasting and 48 h fasting treatment, respectively. Plasma samples of each pig were collected from the anterior vena cava during the last 3 d(1 d while pigs were fed and 2 d during which they were fasted).The metabolites of plasma were determined by high-resolution mass spectrometry using a metabolomics approach.Results: Indirect calorimetry analysis revealed that HP and RQ were no significant difference between 24 h fasting and 48 h fasting, which were lower than those of fed state(P < 0.01). The nitrogen concentration of urine tended to decrease with fasting(P = 0.054). Metabolomics analysis between the fed and fasted state revealed differences in15 compounds, most of which were not significantly different between 24 h fasting and 48 h fasting. Identified compounds were enriched in metabolic pathways related to linoleic acid metabolism, amino acid metabolism,sphingolipid metabolism, and pantothenate and Co A biosynthesis.Conclusion: These results suggest that the decreases in HP and RQ of growing pigs under fasting conditions were associated with the alterations of linoleic acid metabolism and amino acid metabolism. The integrative analysis also revealed that growing pigs under a 24-h fasting were more appropriate than a 48-h fasting to investigate the metabolic components of maintenance energy expenditure.

Consistency between traditional Chinese medicine constitution-based classification and genetic classification

Background:We studied the consistency between two classification systems for categorizing patients:traditional Chinese medicine(TCM)constitution-based methods,versus genetic clustering.Genetic classification in constitutional identification was also evaluated.Methods:A TCM physician evaluated the constitution of each patient,according to four examinations(inspection,auscultation-olfaction,interrogation,and palpation).Those who met the criteria for Yang-deficient,Yin-deficient,and balanced constitutions were enrolled in the study.Peripheral blood samples were obtained from the participants,and peripheral blood mononuclear cells were separated from the samples within 2 hours.Total RNA extraction from the white blood cells was performed;and an Affymetrix HG-U133 Plus2.0 array was used to determine the peripheral blood gene expression profiles.The samples were classified using a support vector machine genetic classifier,and the“leave-one-out”method was used for validation.Results:The global gene expression profiles of 32 samples were grouped into three categories,and the samples in each of the gene categories corresponded with the three constitution categories.The three constitution types were distinguished using the genetic classifier with 165 genes.The accuracy of the prediction classification was greater than 95%using mathematical method.Conclusions:Participants with Yin-deficient,Yang-deficient,and balanced constitutions have varying physical characteristics and gene expression patterns.Additionally,the results from TCM constitution classification matched those obtained by genetic classification.Finally,our preliminary gene classifier distinguishes among Yin-deficient,Yang-deficient,and balanced constitutions,and provides a methodological basis for identifying the different constitutions.