With the development of Industry 4.0 and big data technology,the Industrial Internet of Things(IIoT)is hampered by inherent issues such as privacy,security,and fault tolerance,which pose certain challenges to the rapi...With the development of Industry 4.0 and big data technology,the Industrial Internet of Things(IIoT)is hampered by inherent issues such as privacy,security,and fault tolerance,which pose certain challenges to the rapid development of IIoT.Blockchain technology has immutability,decentralization,and autonomy,which can greatly improve the inherent defects of the IIoT.In the traditional blockchain,data is stored in a Merkle tree.As data continues to grow,the scale of proofs used to validate it grows,threatening the efficiency,security,and reliability of blockchain-based IIoT.Accordingly,this paper first analyzes the inefficiency of the traditional blockchain structure in verifying the integrity and correctness of data.To solve this problem,a new Vector Commitment(VC)structure,Partition Vector Commitment(PVC),is proposed by improving the traditional VC structure.Secondly,this paper uses PVC instead of the Merkle tree to store big data generated by IIoT.PVC can improve the efficiency of traditional VC in the process of commitment and opening.Finally,this paper uses PVC to build a blockchain-based IIoT data security storage mechanism and carries out a comparative analysis of experiments.This mechanism can greatly reduce communication loss and maximize the rational use of storage space,which is of great significance for maintaining the security and stability of blockchain-based IIoT.展开更多
A three-dimensional(3D)multiple phase field model,which takes into account the grain boundary(GB)energy anisotropy caused by texture,is established based on real grain orientations and Read-Shockley model.The model is...A three-dimensional(3D)multiple phase field model,which takes into account the grain boundary(GB)energy anisotropy caused by texture,is established based on real grain orientations and Read-Shockley model.The model is applied to the grain growth process of polycrystalline Mg(ZK60)alloy to investigate the evolution characteristics in different systems with varying proportions of low-angle grain boundary(LAGB)caused by different texture levels.It is found that the GB energy anisotropy can cause the grain growth kinetics to change,namely,higher texture levels(also means higher LAGB proportion)result in lower kinetics,and vice versa.The simulation results also show that the topological characteristics,such as LAGB proportion and distribution of grain size,undergo different evolution characteristics in different systems,and a more serious grain size fluctuation can be caused by a higher texture level.The mechanism is mainly the slower evolution of textured grains in their accumulation area and the faster coarsening rate of non-textured grains.Therefore,weakening the texture level is an effective way for implementing a desired homogenized microstructure in ZK60 Mg alloy.The rules revealed by the simulation results should be of great significance for revealing how the GB anisotropy affects the evolution of polycrystalline during the grain growth after recrystallization and offer the ideas for processing the alloy and optimizing the microstructure.展开更多
Background:Chronic kidney disease(CKD)has a high global prevalence and large unmet need.Central to developing new CKD therapies are in vivo models in CKD.However,next-generation antibody,protein,and gene therapies are...Background:Chronic kidney disease(CKD)has a high global prevalence and large unmet need.Central to developing new CKD therapies are in vivo models in CKD.However,next-generation antibody,protein,and gene therapies are highly specific,meaning some do not cross-react with rodent targets.This complicates preclinical development,as established in vivo rodent models cannot be utilized unless tool therapeutics are also developed.Tool compounds can be difficult to develop and,if available,typically have different epitopes,sequences,and/or altered affinity,making it unclear how efficacious the lead therapeutic may be,or what dosing regimen to investigate.To address this,we aimed to develop a nonhuman primate model of CKD.Methods:In vivo rodent unilateral ureteral obstruction(UUO)models kidney fibrosis and is commonly used due to its rapidity,consistency,and ease.We describe translation of this model to the cynomolgus monkey,specifically optimizing the model duration to allow adequate time for assessment of novel therapeutics prior to the fibrotic plateau.Results:We demonstrated that disease developed more slowly in cynomolgus monkeys than in rodents post-UUO,with advanced fibrosis developing by 6 weeks.The tubulointerstitial fibrosis in cynomolgus monkeys was more consistent with human obstructive disease than in rodents,having a more aggressive tubular basement expansion and a higher fibroblast infiltration.The fibrosis was also associated with increased transglutaminase activity,consistent with that seen in patients with CKD.Conclusion:This cynomolgus monkey UUO model can be used to test potential human-specific therapeutics in kidney fibrosis.展开更多
目的:对比高嵌体与全冠在修复牙体缺损中的美学效果及预后。方法:选取2020年6月-2022年1月笔者医院收治的牙体缺损患者120例(共229颗患牙),采用随机数字法分为对照组(60例,113颗患牙)和观察组(60例,116颗患牙),对照组采用常规全瓷冠修...目的:对比高嵌体与全冠在修复牙体缺损中的美学效果及预后。方法:选取2020年6月-2022年1月笔者医院收治的牙体缺损患者120例(共229颗患牙),采用随机数字法分为对照组(60例,113颗患牙)和观察组(60例,116颗患牙),对照组采用常规全瓷冠修复治疗,观察组采用CAD/CAM全瓷高嵌体修复治疗,观察两组的修复时间(备牙时间、取模时间和总体操作时间),治疗后第6个月、12个月及18个月的修复效果,以及治疗前、治疗后第3个月牙周指标及龈沟液生化指标[C反应蛋白(C-reactive protein,CRP)、人CXC趋化因子配体16(CXC chemokine ligand 16,CXCL16)、白细胞介素1β(Interleukin-1β,IL-1β)]变化,对比两组牙齿美观满意度。结果:观察组备牙时间、取模时间和总体操作时间均显著低于对照组(P<0.05);观察组、对照组治疗后第6个月、12个月、18个月修复优良率分别为100% vs 100%、97.41% vs 85.84%、96.55% vs 83.19%,两组治疗后12、18个月比较差异有统计学意义(P<0.05);治疗后第3个月,两组出血指数(Bleeding index,BI)、菌斑指数(Plaque index,PLI)、牙龈指数(Gingival index,GI)及龈沟液CRP、CXCL16、IL-1β水平均显著降低(P<0.05),且观察组显著低于对照组(P<0.05),两组咀嚼能力显著升高,且观察组显著高于对照组(均P<0.05);观察组患者对修复体满意度(98.34%)显著高于对照组(81.67%)(P<0.05)。结论:CAD/CAM全瓷高嵌体技术应用于修复牙体缺损临床效果显著,可明显改善牙周情况及炎症反应,远期修复效果好,美观度高,患者满意度高,值得临床推广应用。展开更多
基金supported by China’s National Natural Science Foundation(Nos.62072249,62072056)This work is also funded by the National Science Foundation of Hunan Province(2020JJ2029).
文摘With the development of Industry 4.0 and big data technology,the Industrial Internet of Things(IIoT)is hampered by inherent issues such as privacy,security,and fault tolerance,which pose certain challenges to the rapid development of IIoT.Blockchain technology has immutability,decentralization,and autonomy,which can greatly improve the inherent defects of the IIoT.In the traditional blockchain,data is stored in a Merkle tree.As data continues to grow,the scale of proofs used to validate it grows,threatening the efficiency,security,and reliability of blockchain-based IIoT.Accordingly,this paper first analyzes the inefficiency of the traditional blockchain structure in verifying the integrity and correctness of data.To solve this problem,a new Vector Commitment(VC)structure,Partition Vector Commitment(PVC),is proposed by improving the traditional VC structure.Secondly,this paper uses PVC instead of the Merkle tree to store big data generated by IIoT.PVC can improve the efficiency of traditional VC in the process of commitment and opening.Finally,this paper uses PVC to build a blockchain-based IIoT data security storage mechanism and carries out a comparative analysis of experiments.This mechanism can greatly reduce communication loss and maximize the rational use of storage space,which is of great significance for maintaining the security and stability of blockchain-based IIoT.
基金Project supported by the National Key Research and Development Program of China(Grant No.2016YFB0701204)the 111 Project,China(Grant No.B20029)+2 种基金the Fundamental Research Funds for the Central Universities,China(Grant Nos.N2002017 and N2007011)the National Natural Science Foundation of China(Grant No.51571055)the Science Fund from the Science and Technology Bureau of Jiangyin High-Tech Industrial Development Zone,China(Grant No.ZX20200062)。
文摘A three-dimensional(3D)multiple phase field model,which takes into account the grain boundary(GB)energy anisotropy caused by texture,is established based on real grain orientations and Read-Shockley model.The model is applied to the grain growth process of polycrystalline Mg(ZK60)alloy to investigate the evolution characteristics in different systems with varying proportions of low-angle grain boundary(LAGB)caused by different texture levels.It is found that the GB energy anisotropy can cause the grain growth kinetics to change,namely,higher texture levels(also means higher LAGB proportion)result in lower kinetics,and vice versa.The simulation results also show that the topological characteristics,such as LAGB proportion and distribution of grain size,undergo different evolution characteristics in different systems,and a more serious grain size fluctuation can be caused by a higher texture level.The mechanism is mainly the slower evolution of textured grains in their accumulation area and the faster coarsening rate of non-textured grains.Therefore,weakening the texture level is an effective way for implementing a desired homogenized microstructure in ZK60 Mg alloy.The rules revealed by the simulation results should be of great significance for revealing how the GB anisotropy affects the evolution of polycrystalline during the grain growth after recrystallization and offer the ideas for processing the alloy and optimizing the microstructure.
基金This study was funded by UCB PharmaAnimal work was approved by Prisys Institutional Animal Care and Use Committee under study number 2015-PS11-002(license code SYXK-2014-007).
文摘Background:Chronic kidney disease(CKD)has a high global prevalence and large unmet need.Central to developing new CKD therapies are in vivo models in CKD.However,next-generation antibody,protein,and gene therapies are highly specific,meaning some do not cross-react with rodent targets.This complicates preclinical development,as established in vivo rodent models cannot be utilized unless tool therapeutics are also developed.Tool compounds can be difficult to develop and,if available,typically have different epitopes,sequences,and/or altered affinity,making it unclear how efficacious the lead therapeutic may be,or what dosing regimen to investigate.To address this,we aimed to develop a nonhuman primate model of CKD.Methods:In vivo rodent unilateral ureteral obstruction(UUO)models kidney fibrosis and is commonly used due to its rapidity,consistency,and ease.We describe translation of this model to the cynomolgus monkey,specifically optimizing the model duration to allow adequate time for assessment of novel therapeutics prior to the fibrotic plateau.Results:We demonstrated that disease developed more slowly in cynomolgus monkeys than in rodents post-UUO,with advanced fibrosis developing by 6 weeks.The tubulointerstitial fibrosis in cynomolgus monkeys was more consistent with human obstructive disease than in rodents,having a more aggressive tubular basement expansion and a higher fibroblast infiltration.The fibrosis was also associated with increased transglutaminase activity,consistent with that seen in patients with CKD.Conclusion:This cynomolgus monkey UUO model can be used to test potential human-specific therapeutics in kidney fibrosis.
文摘目的:对比高嵌体与全冠在修复牙体缺损中的美学效果及预后。方法:选取2020年6月-2022年1月笔者医院收治的牙体缺损患者120例(共229颗患牙),采用随机数字法分为对照组(60例,113颗患牙)和观察组(60例,116颗患牙),对照组采用常规全瓷冠修复治疗,观察组采用CAD/CAM全瓷高嵌体修复治疗,观察两组的修复时间(备牙时间、取模时间和总体操作时间),治疗后第6个月、12个月及18个月的修复效果,以及治疗前、治疗后第3个月牙周指标及龈沟液生化指标[C反应蛋白(C-reactive protein,CRP)、人CXC趋化因子配体16(CXC chemokine ligand 16,CXCL16)、白细胞介素1β(Interleukin-1β,IL-1β)]变化,对比两组牙齿美观满意度。结果:观察组备牙时间、取模时间和总体操作时间均显著低于对照组(P<0.05);观察组、对照组治疗后第6个月、12个月、18个月修复优良率分别为100% vs 100%、97.41% vs 85.84%、96.55% vs 83.19%,两组治疗后12、18个月比较差异有统计学意义(P<0.05);治疗后第3个月,两组出血指数(Bleeding index,BI)、菌斑指数(Plaque index,PLI)、牙龈指数(Gingival index,GI)及龈沟液CRP、CXCL16、IL-1β水平均显著降低(P<0.05),且观察组显著低于对照组(P<0.05),两组咀嚼能力显著升高,且观察组显著高于对照组(均P<0.05);观察组患者对修复体满意度(98.34%)显著高于对照组(81.67%)(P<0.05)。结论:CAD/CAM全瓷高嵌体技术应用于修复牙体缺损临床效果显著,可明显改善牙周情况及炎症反应,远期修复效果好,美观度高,患者满意度高,值得临床推广应用。
