Analyzing the potential mechanism of Buyang Huanwu decoction for the treatment of salt-sensitive hypertension based on network pharmacology and in vivo experiments

Background:Buyang Huanwu decoction(BHD)is a traditional Chinese medicine herbal formula used for treating hypertension,particularly in the later stages of hypertension when it is associated with intracerebral hemorrhage.This study aims to investigate the treatment mechanism of BHD to provide a basis for its clinical application in hypertension treatment.Methods:Network pharmacology analysis and cell culture experiments were performed to explore the potential proteins and mechanisms of action of BHD against hypertension.Bioactive compounds related to BHD were screened,and relevant targets associated with hypertension and BHD were retrieved.Molecular docking technology was used to identify the effective signaling pathway based on the Kyoto Encyclopedia of Genes and Genomes and protein-protein interaction network cores.Lastly,the effects and mechanisms of BHD on salt-sensitive hypertensive endothelial cells were investigated.Results:Ninety-three potential therapeutic targets for BHD and salt-sensitive hypertension were found to be closely associated with the PI3K/Akt/eNOS signaling pathway and oxidative stress.Cell experiments further indicated the pivotal role of endothelial cells in hypertension,and validation analysis showed that BHD significantly preserved cell morphology,suppressed oxidative stress reactions,activated the PI3K/Akt/eNOS signaling pathways,preserved normal endothelial cell function,and reduced cell apoptosis.Conclusion:BHD effectively activates the PI3K/Akt/VEGF signaling pathway,attenuates oxidative stress-induced injury in endothelial cells exposed to high salt levels,and mitigates apoptosis,supporting the use of traditional Chinese medicine BHD in the treatment of salt-sensitive hypertension.

Recovery of Fe,V,and Ti in modified Ti-bearing blast furnace slag

A two-stage oxidation—alkali leaching—acid leaching method was proposed to recovery Fe,V,and Ti in modified Ti-bearing blast furnace slag.The optimal experiment conditions of iron extraction were one-stage oxidation time 40 s and holding time 8 min.The recovery rate of iron was 89.93%.The optimum experiment conditions of vanadium extraction were total oxidation time of 126 s,NaOH concentration of 4.0 mol/L,leaching temperature of 95℃,leaching time of 90 min,and the number of cycle was 4.The leaching rate of vanadium was 92.13%.The optimal experiment conditions of titanium extraction were HCl concentration of 4.5 mol/L,leaching temperature of 75℃,and leaching time of 90 min.The TiO_(2)content of synthetic rutile was 98.61%.

Behind-plate overpressure effect of steel-encased reactive material projectile impacting thin aluminum plate

Ballistic impact and sealed chamber tests were performed on the steel-encased reactive material projectile(SERMP)to understand its behind-plate overpressure effect when impacting the thin aluminum plates.The reactive material encased with a 1.5 mm thick 30CrMnSiNi2A steel shell was launched onto the initially sealed test chamber with a 3 mm thick 2024-T3 thin aluminum cover plate.Moreover,the overpressure signals in the test chamber were recorded by pressure sensors.The experimental results indicate an unusual behind-plate overpressure effect:as the density of the projectile increases from 6.43 g/cm^(3) to 7.58 g/cm^(3) by increasing the content of tungsten powder,although its total chemical energy decreases,it produces a higher behind-target overpressure at a lower impact velocity.A theoretical model is proposed to predict the reaction length of reactive material inside the projectile based on one-dimensional shock wave theory to understand this unexpected result.In addition,the deviation between the actual energy release and the theoretical calculation results,also the variation of overpressure rise time are analyzed and discussed.As the analyses show,when the SERMP successfully penetrates the cover plate,an increasing density of the reactive material inside the projectile always means that the delaying rarefaction wave effect,an increase of its internal pressure and strain rate levels.These factors lead to the increase of the overpressure limit velocity and reaction extent of the reactive material,while the overpressure rise time decreases.

Effect of rutile crystal shapes on its settlement

The effect of rutile crystal shapes on its settlement in a modified slag was studied by theoretical analysis,FactSage simulation,X-ray diffraction and scanning electron microscopy.The results show that the settling velocities of spherical rutile crystals are faster than those of other shapes of rutile crystals under the same volume conditions,and the shape transformation of rutile crystals from rod to sphere can be achieved by adding titanium slag to Ti-bearing blast furnace slag.The volume fractions of the rutile crystals in the upper and lower parts of the modified slag are 30%and 71%when the added titanium slag increases to 278 g,indicating that rutile settling is obvious.Due to the rutile settling,half shaker sorting task is saved,and the recovery rate of TiO2 is significantly increased.The TiO2 content of rutile is greater than 93%,and the total content of CaO and MgO is less than 0.4%,meeting the requirements for the raw materials of titanium white in the chloride process.

Point-contact spectroscopy on antiferromagnetic Kondo semiconductors Ce𝑇T2Al10 (T= Ru and Os)

We have carried out point-contact spectroscopy(PCS)measurements on one family of antiferromagnetic Kondo semiconductor CeT2Al10(T=Ru and Os)with a Neel temperature´TN∼27.5 and 28.5 K,respectively.Their PCS conductance curves both exhibit a characteristic coherent double-peak-structure at temperatures below TN,signaling an AFM gap around the Fermi surface.The temperature dependent AFM gap∆1 follows a Bardeen-Cooper-Schrieffer(BCS)-like mean-field behavior with a moderate gap anisotropy for PCS along different crystal axes.Another asymmetric gap-like feature is observed for both compounds at temperatures far below TN,which is consistent with opening of a new hybridization gap∆h inside the long-range ordered AFM state.Our results suggest a common itinerant nature of the anomalous AFM ordering,constraining theoretical models to explain the AFM origin in CeRu2Al10 and CeOs2Al10.

Bidirectional highly-efficient quantum routing in a T-bulge-shaped waveguide

Quantum routing in a T-bulge-shaped waveguide system coupled with a driven cyclic three-level atom and a twolevel atom is investigated theoretically.By employing the discrete-coordinate scattering method,exact expressions of the transport coefficients along three ports of the waveguide channels are derived.Our results show that bidirectional high transfer-rate single-photon routing between two channels can be effectively implemented,with the help of the effective potential generated by two atoms and the external driving.Moreover,multiple band zero-transmission emerges in the scattering spectra,arising from the quantum interferences among photons scattered by the boundary and the bulged resonators.The proposed system may suggest an efficient duplex router with filtering functions.