Clinical research progress on acupuncture for the treatment of otogenic vertigo

Otogenic vertigo is a common disorder that affects the vestibular system,which often results in considerable discomfort and impaired daily functioning.Traditional Chinese medicine(TCM),including acupuncture and moxibustion,has been historically utilized to manage the symptoms of vertigo.However,the effectiveness and methodology of these treatments have rarely been investigated in the medical literature.This study reviews the existing literature on the point selection,method,and therapeutic effect of acupuncture and moxibustion to provide a reference for the TCM treatment of otogenic vertigo.A literature search was performed using the PubMed search engine.The terms used included otogenic vertigo,acupuncture treatment,and acupuncture point selection.A total of 34 relevant articles were retrieved from PubMed.These suggest that the clinical treatment of otogenic vertigo should consider the functions of zang-fu organs and meridians and select different acupuncture treatment methods according to syndrome differentiation based on the difference between deficiency and excess.Acupuncture and moxibustion therapy should be based on acupoint selection,considering the syndrome differentiation,supplemented with experience.The treatment of otogenic vertigo with acupuncture and moxibustion refers to the selection of appropriate acupuncture methods under the guidance of TCM theory and following the principles of syndrome,disease,and meridian differentiation.Common acupuncture methods include body acupuncture,auricular acupuncture,scalp acupuncture,acupoint injection,electroacupuncture,and moxibustion.There are many acupuncture and moxibustion acupoints selected for the treatment of otogenic vertigo.Individualized treatment according to the patient’s specific condition is effective and safe,which can help to improve the patient’s vertigo symptoms and cerebral blood perfusion.

Preparing high-purity iron by direct reduction?smelting separation of ultra-high-grade iron concentrate

A new process for preparing high-purity iron(HPI)was proposed,and it was investigated by laboratory experiments and pilot tests.The results show that under conditions of a reduced temperature of 1075°C,reduced time of 5 h,and CaO content of 2.5wt%,a DRI with a metallization rate of 96.5%was obtained through coal-based direct reduction of ultra-high-grade iron concentrate.Then,an HPI with a Fe purity of 99.95%and C,Si,Mn,and P contents as low as 0.0008wt%,0.0006wt%,0.0014wt%,and 0.0015wt%,respectively,was prepared by smelting separation of the DRI using a smelting temperature of 1625°C,smelting time of 45 min,and CaO content of 9.3wt%.The product of the pilot test with a scale of 0.01 Mt/a had a lower impurity content than the Chinese industry standard.An HPI with a Fe purity of 99.98wt%can be produced through the direct reduction?smelting separation of ultra-high-grade iron concentrate at relatively low cost.The proposed process shows a promising prospect for application in the future.

(D-Ser2) oxyntomodulin recovers hippocampal synaptic structure and theta rhythm in Alzheimer’s disease transgenic mice

In our previous studies,we have shown that(D-Ser2)oxyntomodulin(Oxm),a glucagon-like peptide 1(GLP-1)receptor(GLP1R)/glucagon receptor(GCGR)dual agonist peptide,protects hippocampal neurons against Aβ1-42-induced cytotoxicity,and stabilizes the calcium homeostasis and mitochondrial membrane potential of hippocampal neurons.Additionally,we have demonstrated that(D-Ser2)Oxm improves cognitive decline and reduces the deposition of amyloid-beta in Alzheimer’s disease model mice.However,the protective mechanism remains unclear.In this study,we showed that 2 weeks of intraperitoneal administration of(D-Ser2)Oxm ameliorated the working memory and fear memory impairments of 9-month-old 3×Tg Alzheimer’s disease model mice.In addition,electrophysiological data recorded by a wireless multichannel neural recording system implanted in the hippocampal CA1 region showed that(D-Ser2)Oxm increased the power of the theta rhythm.In addition,(D-Ser2)Oxm treatment greatly increased the expression level of synaptic-associated proteins SYP and PSD-95 and increased the number of dendritic spines in 3×Tg Alzheimer’s disease model mice.These findings suggest that(D-Ser2)Oxm improves the cognitive function of Alzheimer’s disease transgenic mice by recovering hippocampal synaptic function and theta rhythm.

Radial velocity measurements from LAMOST medium-resolution spectroscopic observations: a pointing towards the Kepler field

Radial velocity is one of the key measurements in understanding the fundamental properties of stars, stellar clusters and the Galaxy. A plate of stars in the Kepler field was observed in May of 2018 with the medium-resolution spectrographs of LAMOST, aiming to test the performance of this new system which is the upgraded equipment of LAMOST after the first five-year regular survey. We present our analysis on the radial velocity measurements(RVs) derived from these data. The results show that slight and significant systematic errors exist among the RVs obtained from the spectra collected by different spectrographs and exposures, respectively. After correcting the systematic errors with different techniques, the precision of RVs reaches ～1.3,～1.0,～0.5 and ～0.3 km s^(-1) at S/Nr = 10, 20, 50 and 100, respectively. Comparing with the RVs of standard stars from the APOGEE survey, our RVs are calibrated with a zero-point shift of～7 km s^(-1). The results indicate that the LAMOST medium-resolution spectroscopic system may provide RVs with a reasonable accuracy and precision for the selected targets.

Spot and Facula Activity Variations of the Eccentric Detached Eclipsing Binary KIC 8098300 Based on the Time-series Orbital Solutions

The LAMOST spectra and Kepler light curves are combined to investigate the detached eclipsing binary KIC 8098300,which shows the O’Connell effect caused by spot/facula modulation.The radial velocity(RV)measurements are derived by using the tomographic spectra disentangling technology.The mass ratio q=K1/K2=0.812±0.007,and the orbital semimajor axis a sin i=14.984±0.048 R_(⊙)are obtained by fitting the RV curves.We optimize the binary model concerning the spot/facula activity with the code PHOEBE and obtain precise parameters of the orbit including the eccentricity e=0.0217±0.0008,the inclination i=87°.71±0°.04,and the angle of periastronω=284°.1±0°.5.The masses and radii of the primary and secondary star are determined as M_(1)=1.3467±0.0001 M_(⊙),R_(1)=1.569±0.003 R_(⊙),and M_(2)=1.0940±0.0001 M_(⊙),R_(2)=1.078±0.002 R_(⊙),respectively.The ratio of temperatures of the two component stars is r_(teff)=0.924±0.001.We also obtain the periastron precession speed of 0.000024±0.000001 day cycle-l.The residuals of out-of-eclipse are analyzed using the auto-correlation function and the discrete Fourier transform.The spot/facula activity is relatively weaker,but the lifetime is longer than that of most single main sequence stars in the same temperature range.The average rotation period of the spots P_(rot)=4.32 days is slightly longer than the orbital period,which may be caused by either the migration of spots/faculae along the longitude or the latitudinal differential rotation.The activity may be spot-dominated for the secondary star and facula-dominated for the primary star.The method of this work can be used to analyze more eclipsing binaries with the O’Connell effect in the Kepler field to obtain the precise parameters and investigate the difference of spot behavior between binaries and single stars.It is helpful for a deeper understanding of the stellar magnetic activity and dynamo theory.

Trigger mechanism of PDSOI NMOS devices for ESD protection operating under elevated temperatures

Trigger characteristics of electrostatic discharge(ESD)protecting devices operating under various ambient temperatures ranging from 30℃to 195℃are investigated.The studied ESD protecting devices are the H-gate NMOS transistors fabricated with a 0.18-μm partially depleted silicon-on-insulator(PDSOI)technology.The measurements are conducted by using a transmission line pulse(TLP)test system.The different temperature-dependent trigger characteristics of groundedgate(GGNMOS)mode and the gate-triggered(GTNMOS)mode are analyzed in detail.The underlying physical mechanisms related to the effect of temperature on the first breakdown voltage V_(T1)investigated through the assist of technology computer-aided design(TCAD)simulation.

Delocalizedπ_(3)^(6) Bond in OX_(2) (X=Halogen) Molecules

OX_(2)(X=halogen)molecules was studied theoretically.Calculation results show that delocalizedπ_(3)^(6) bonds exist in their electronic structures and O atoms adopt the sp^(2) type of hybridization,which violates the prediction of the valence shell electron pair repulsion theory of sp^(3) type.Delocalization stabilization energy is proposed to measure the contribution of delocalizedπ_(3)^(6) bond to energy decrease and proves to bring extra-stability to the molecule.These phenomena can be summarized as a kind of coordinating effect.

The Physical Properties and Starspot Activity of the Triple System KIC 6525196

We present the results of photometric and spectroscopic analyses for the triple-lined system KIC 6525196,an eclipsing binary accompanied by a third star.By modeling the Kepler light curves and radial velocities from LAMOST and HIDES observations,absolute parameters of the system are determined.Both components of the eclipsing binary are found to be solar-like stars with masses and radii of M= 1.0286 ± 0.0026 M,R= 1.127 ± 0.008 R.and M=0.9667 ± 0.0024 M,R=0.963 ± 0.007 R.The mass of the third star is determined to be M= 0.772 ± 0.010 M.With the out-of-eclipse light residuals,we measure rotation period and decay timescale of an active region by using the autocorrelation function.In comparison to the Sun,the activity level of the system is significantly stronger.In addition,a possible short photometric activity cycle of~244 days is detected.

Photoinduced Dehalocyclization to Access Oxindoles Using Formate as a Reductant

Herein,we report an efficient and practical protocol for the photoinduced dehalocyclization of ortho-halophenylacrylamides with formate by the engagement of a CO_(2) radical anion to access substituted oxindoles.This method proceeds smoothly under mild conditions and exhibits a wide range of substrate as well as remarkable functional group compatibility.

Efficient Decarboxylative/Defluorinative Alkylation for the Synthesis of gem-Difluoroalkenes through an SN2’-Type Route

An efficient decarboxylative/defluorinative alkylation for synthesizing gem-difluoroalkenes is described,providing a general method for installation of the challenging alkyl fragments containing a-electron-withdrawing groups into a-trifluoromethyl alkenes.Mechanistic studies suggest that this process involves an SN2,-type synthetic route in the absence of transition-metal catalysts or photocatalysis.Moreover,this protocol can easily be scaled up,and successfully applied to the modification of biologically active molecules,thus complementing methodologies that give access to structurally versatile gem-difluoroalkenes.

Trio-based genome sequencing identifies candidate causal genes in lifelong premature ejaculation

Dear Editor,Premature ejaculation(PE)is the most common sexual dysfunction with prevalence rates of 20%-30%.1Unfortunately,there are limited treatment options as a result of the lack of knowledge about the pathophysiology of PE.2Although the exact etiology of PE is not clear,it is known that PE is etiologcally heterogeneous,with both genetic and environmental factors playing a role.3Schapiro and Waldinger's study suggested that PE ran in families,with a higher morbidity in the family members of PE patients than that in unafected individuals.4,5.The results of Jern's study indicated that PE is moderately heritable,with an inheritability ratio of 28%in a cohort of 3946 pairs of twins.