Association between triglyceride-glucose index and colorectal polyps:A retrospective cross-sectional study

BACKGROUND Colorectal polyps(CPs)are frequently occurring abnormal growths in the colorectum,and are a primary precursor of colorectal cancer(CRC).The triglyceride-glucose(TyG)index is a novel marker that assesses metabolic health and insulin resistance,and has been linked to gastrointestinal cancers.AIM To investigate the potential association between the TyG index and CPs,as the relation between them has not been documented.METHODS A total of 2537 persons undergoing a routine health physical examination and colonoscopy at The First People's Hospital of Kunshan,Jiangsu Province,China,between January 2020 and December 2022 were included in this retrospective cross-sectional study.After excluding individuals who did not meet the eligibility criteria,descriptive statistics were used to compare characteristics between patients with and without CPs.Logistic regression analyses were conducted to determine the associations between the TyG index and the prevalence of CPs.The TyG index was calculated using the following formula:Ln[triglyceride(mg/dL)×glucose(mg/dL)/2].The presence and types of CPs was determined based on data from colonoscopy reports and pathology reports.RESULTS A nonlinear relation between the TyG index and the prevalence of CPs was identified,and exhibited a curvilinear pattern with a cut-off point of 2.31.A significant association was observed before the turning point,with an odds ratio(95% confidence interval)of 1.70(1.40,2.06),P<0.0001.However,the association between the TyG index and CPs was not significant after the cut-off point,with an odds ratio(95% confidence interval)of 0.57(0.27,1.23),P=0.1521.CONCLUSION Our study revealed a curvilinear association between the TyG index and CPs in Chinese individuals,suggesting its potential utility in developing colonoscopy screening strategies for preventing CRC.

Retraction note to:Association between triglyceride-glucose index and colorectal polyps:A retrospective cross-sectional study

We have decided to retract the above article because we have concluded that the limitations in our data sample may potentially lead to misinterpretation of the findings.

Molecular mechanism prediction analysis of Xiaozheng decoction in the treatment of bladder cancer based on network pharmacology

Background:To investigate the mechanism of Xiaozheng decoction in treatment of bladder cancer based on network pharmacology.Methods:Based on the Tradictional Chinese Medicine Systems Pharmacology Database(TCMSP),the active compositions of Xiaozheng decoction were screened.The targets of active components were obtained from TCMSP,Swiss Target Prediction,and STITCH database.By mapping the disease targets of bladder cancer obtained from the DisGeNET and Genecards databases,the potential targets of Xiaozheng decoction for bladder cancer were obtained.The active components of Xiaozheng decoction-targets network was constructed using the Cytoscape software.The target protein interaction(PPI)network was constructed by using the String online platform,which was visualized by Cytoscape software and analyzed by network topology to obtain the key targets of Xiaozheng decoction.GO bioprocess enrichment analysis and KEGG pathway enrichment analysis were performed on key targets of the Xiaozheng decoction by DAVID database.Results:A total of 68 active components and 255 potential targets of Xiaozheng decoction in the treatment of bladder cancer were retrieved and screened out.The key targets were enriched and analyzed by the GO biological pathway,and 135 pathways were obtained,which involved transcriptional process,platelet activation,cell proliferation,and apoptosis.KEGG pathway enrichment analysis revealed 95 pathways,mainly involving cancer pathway,bladder cancer pathway,MAPK signaling pathway,PI3K-Akt signaling pathway,and VEGF signaling pathway.Conclusion:The result of this study showed that Xiaozheng decoction may play its therapeutic role through multiple components,multiple targets and multiple pathways,and preliminarily explored the mechanism of Xiaozheng decoction in the treatment of bladder cancer,laying a foundation for subsequent experimental studies.