Modularized and Parametric Modeling Technology for Finite Element Simulations of Underground Engineering under Complicated Geological Conditions

The surrounding geological conditions and supporting structures of underground engineering are often updated during construction,and these updates require repeated numerical modeling.To improve the numerical modeling efficiency of underground engineering,a modularized and parametric modeling cloud server is developed by using Python codes.The basic framework of the cloud server is as follows:input the modeling parameters into the web platform,implement Rhino software and FLAC3D software to model and run simulations in the cloud server,and return the simulation results to the web platform.The modeling program can automatically generate instructions that can run the modeling process in Rhino based on the input modeling parameters.The main modules of the modeling program include modeling the 3D geological structures,the underground engineering structures,and the supporting structures as well as meshing the geometric models.In particular,various cross-sections of underground caverns are crafted as parametricmodules in themodeling program.Themodularized and parametric modeling program is used for a finite element simulation of the underground powerhouse of the Shuangjiangkou Hydropower Station.This complicatedmodel is rapidly generated for the simulation,and the simulation results are reasonable.Thus,this modularized and parametric modeling program is applicable for three-dimensional finite element simulations and analyses.

R3-MYB proteins OsTCL1 and OsTCL2 modulate seed germination via dual pathways in rice

Salt and drought stress are common abiotic factors that exert a detrimental influence on seed germination,potentially leading to significantly impaired growth and production in rice.Gaining a comprehensive understanding of the molecular response of seeds to abiotic stress during the germination is of paramount importance.In the present study,we identified two R3-MYB genes in rice,namely OsTCL1 and OsTCL2,and characterized their roles in regulating seed germination under salt and drought stress.Plants with tcl1 and tcl2 mutant alleles exhibited delayed seed germination,particularly under stress conditions.The tcl1 tcl2 double mutant showed an even more pronounced reduction in germination during initial stages of germination,thereby indicating a redundant regulatory function of OsTCL1 and OsTCL2 in seed germination under abiotic stresses.Furthermore,we demonstrated that the transcript levels of several phospholipase D(PLD)genes were downregulated in the tcl1 tcl2 mutant,resulting in a decreased level of the phosphatidic acid(PA)product.Application of 1-butanol,a competitive substrate inhibitor of PLD-dependent production of PA,attenuated the stress response of the tcl1 tcl2 mutant.This suggests that OsTCL1 and OsTCL2 partially modulate seed germination through the PLD-PA signaling pathway.Moreover,there were alterations in the expression of genes involved in abscisic acid(ABA)biosynthesis,metabolism and signaling transduction in the double mutant.These changes affected the endogenous ABA level and ABA response,thereby influencing seed germination.Application of both 1-butanol and ABA synthesis inhibitor sodium tungstate(Na2WO4)nearly eliminated the differences in stress response between wild type and the tcl1 tcl2 mutant.This indicates that OsTCL1 and OsTCL2 synergistically coordinate seed germination under abiotic stresses through both the PLD-PA signaling and ABA-mediated pathways.

Z型2D/2D ZnIn_(2)S_(4)/Ti-BPDC异质结增强可见光激发光催化析氢反应

二维层状材料由于其超薄的厚度和大量的暴露反应位点,在光催化领域显示出诱人的前景,且其对光生载流子转移的有效调节更有利于进一步提高催化性能.在此,我们通过简单的静电自组装工艺合成了直接Z型2D/2D异质结,ZnIn_(2)S_(4)/Ti-BPDC.超薄层状形貌使催化剂具有更多的暴露活性位点和较短的电荷转移距离.两种半导体间较大的接触界面和紧密相互作用保障了平滑的相间电子传输通道.交错且匹配的能带结构为构造内部电场和能带弯曲以实现Z型电荷转移提供了基础.得益于上述各方面的协同作用,ZnIn_(2)S_(4)/Ti-BPDC异质结显示出显著增强的界面光生载流子转移效率和光催化析氢性能.此外,该2D/2D ZnIn_(2)S_(4)/Ti-BPDC异质结具有优异的稳定性和可回收性,在可持续能源转换领域表现出一定的应用潜能.

Intersection control with connected and automated vehicles:a review

Purpose–This paper aims to review the studies on intersection control with connected and automated vehicles(CAVs).Design/methodology/approach–The most seminal and recent research in this area is reviewed.This study specifically focuses on two categories:CAV trajectory planning and joint intersection and CAV control.Findings–It is found that there is a lack of widely recognized benchmarks in this area,which hinders the validation and demonstration of new studies.Originality/value–In this review,the authors focus on the methodological approaches taken to empower intersection control with CAVs.The authors hope the present review could shed light on the state-of-the-art methods,research gaps and future research directions.

Termination of Transcription of LAT Increases the Amounts of ICP0 mRNA but Does Not Alter the Course of HSV-1 Infection in Latently Infected Murine Ganglia

On entering sensory ganglia,herpes simplex viruses 1(HSV-1)establishes a latent infection with the synthesis of a latency associated transcript(LAT)or initiates productive infection with expression of a set of immediate early viral proteins.The precise mechanisms how expression of a genes is suppressed during the latency are unknown.One mechanism that has been proposed is illustrated in the case of ICP0,a key immediate early viral regulatory protein.Specifically,the 2 kb LAT intron is complementary to the 30 terminal portion of ICP0 m RNA.To test the hypothesis that accumulation of LAT negatively affects the accumulation of ICP0 m RNA,we inserted a DNA fragment encoding two poly(A)sequences into LAT to early terminate LAT transcript without interrupting the complementary sequence of ICP0 transcript(named as SR1603).Comparisons of the parent(SR1601)and mutant(SR1603)HSV-1 viruses showed the following:Neurons harboring latent SR1603 virus accumulated equivalent amounts of viral DNA but higher amounts of ICP0 m RNA and lower amounts of LAT,when compared to neurons harboring the SR1601 virus.One notable difference between the two viruses is that viral RNA accumulation in explanted ganglia harboring SR1603 virus initiated significantly sooner than that in neurons harboring SR1601 virus,suggesting that ICP0 may act as an activator of viral gene expression in permissive cells.Collectively,these data suggest that increased ICP0 m RNA by suppressed LAT did not affect the establishment of latency in latently infected murine ganglia.

Future connected vehicles:Communications demands,privacy and cyber-security

1.Introduction With the advance of data collection,data processing,telecommunication and vehicular technologies,connected vehicles(CVs)have been emerging as a crucial branch of smart mobility(Olia et al.,2015;Li et al.,2021).Its basic idea is to realize real-time exchanges and processing of essential information,such as positions and destinations,among surrounding vehicles and infrastructures.

床旁超声介入联合抗生素治疗急重症细菌性肝脓肿的临床分析

目的探讨床旁超声引导下经皮穿刺置管引流术(percutaneous catheter drainage,PCD)联合抗生素治疗急重症细菌性肝脓肿的临床效果。方法选取90例因细菌性肝脓肿并急性感染性休克行床旁超声引导下PCD的患者为研究对象,记录置管前和置管术后1、3、7 d患者的脓肿最大直径、白细胞计数、中性粒细胞百分比、C-反应蛋白、血清乳酸等,根据细菌培养结果、药敏结果调整抗生素使用,分析比较治疗前后各参数的差异性,另外记录患者置管引流时间、住院时间及并发症等情况,评估治疗效果。结果90例患者均顺利完成PCD,操作时间为(53.43±7.77)min。置管术后1、3和7 d患者脓肿最大直径、白细胞、中性粒细胞百分比、C-反应蛋白、血清乳酸均较置管前有好转,差异均有统计学意义(P<0.05)。术后患者置管引流时间为(7.77±1.46)d,住院时间为(14.71±1.52)d,术后2例出现胆汁漏,其他88例未出现并发症。根据患者是否存在糖尿病分组,结果显示糖尿病组气腔形成的比例更高(26.23%vs 6.90%,χ^(2)=4.592,P=0.032)。结论床旁超声引导下PCD方便快速,联合针对性抗生素治疗急重症细菌性肝脓肿效果好、并发症少,合并糖尿病时易形成气腔,临床操作中需更加谨慎。

Longitudinal control for person-following robots

Purpose–This paper aims to address the longitudinal control problem for person-following robots(PFRs)for the implementation of this technology.Design/methodology/approach–Nine representative car-following models are analyzed from PFRs application and the linear model and optimal velocity model/full velocity difference model are qualified and selected in the PFR control.Findings–A lab PFR with the bar-laser-perception device is developed and tested in the field,and the results indicate that the proposed models perform well in normal person-following scenarios.Originality/value–This study fills a gap in the research on PRFs longitudinal control and provides a useful and practical reference on PFRs longitudinal control for the related research.

Traffic signal coordination control for arterials with dedicated CAV lanes

Purpose–This study aims to make full use of the advantages of connected and autonomous vehicles(CAVs)and dedicated CAV lanes to ensure all CAVs can pass intersections without stopping.Design/methodology/approach–The authors developed a signal coordination model for arteries with dedicated CAV lanes by using mixed integer linear programming.CAV non-stop constraints are proposed to adapt to the characteristics of CAVs.As it is a continuous problem,various situations that CAVs arrive at intersections are analyzed.The rules are discovered to simplify the problem by discretization method.Findings–A case study is conducted via SUMO traffic simulation program.The results show that the efficiency of CAVs can be improved significantly both in high-volume scenario and medium-volume scenario with the plan optimized by the model proposed in this paper.At the same time,the progression efficiency of regular vehicles is not affected significantly.It is indicated that full-scale benefits of dedicated CAV lanes can only be achieved with signal coordination plans considering CAV characteristics.Originality/value–To the best of the authors’knowledge,this is the first research that develops a signal coordination model for arteries with dedicated CAV lanes.

Are shared electric scooters energy efficient?

Shared electric scooters(e-scooter)are booming across the world and widely regarded as a sustainable mobility service.An increasing number of studies have investigated the e-scooter trip patterns,safety risks,and environmental impacts,but few considered the energy efficiency of e-scooters.In this research,we collected the operational data of e-scooters from a major provider in Gothenburg to shed light on the energy efficiency performance of e-scooters in real cases.We first develop a multiple logarithmic regression model to examine the energy consumption of single trips and influencing factors.With the regression model,a Monte Carlo simulation framework is proposed to estimate the fleet energy consumption in various scenarios,taking into account both trip-related energy usage and energy loss in idle status.The results indicate that 40%of e-scooter battery energy was wasted in idle status in the current practice,mainly due to the relatively low usage rate(0.83)of e-scooters.If the average usage rate drops below 0.5,the wasted energy could reach up to 53%.In the end,we present a field example to showcase how to optimally integrate public transport with e-scooters from the perspective of energy efficiency.We hope the findings of this study could help understand and resolve the current and future challenges regarding the ever-growing e-scooter services.

超声引导下聚多卡醇泡沫硬化治疗肾囊肿的临床应用价值

目的探讨超声引导下聚多卡醇泡沫在肾囊肿硬化治疗中的临床应用价值。方法分析我院于2019年1月至2020年6月期间收治的42例肾囊肿患者,均在超声引导下行聚多卡醇泡沫硬化治疗,所有患者在术后1、3、6、12个月定期随访复查超声,根据囊肿的缩小率评价疗效。结果42例患者的42个肾囊肿,术后1、3、6、12个月随访,治愈率分别为11.9%、35.7%、42.9%、59.5%;总有效率分别为59.5%、83.3%、92.9%、100.0%。Cox多因素回归分析显示囊肿容积的大小为影响聚多卡醇治疗效果的主要因素。结论超声引导下聚多卡醇泡沫硬化治疗肾囊肿安全、有效,术后随访时间越长,治疗效果越显著,且囊肿容积越小,疗效越确切,值得在临床推广应用。