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A novel mouse model of calcific aortic valve stenosis
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作者 Ningjing Qian Yaping wang +12 位作者 wangxing Hu Naifang Cao Yi Qian Jinyong Chen Juan Fang Dilin Xu Haochang Hu Shuangshuang Yang Dao Zhou Hanyi Dai Dongdong Wei jian'an wang Xianbao Liu 《Animal Models and Experimental Medicine》 CAS CSCD 2024年第4期523-532,共10页
Background:Calcific aortic valve stenosis(CAVS)is one of the most challenging heart diseases in clinical with rapidly increasing prevalence.However,study of the mecha-nism and treatment of CAVS is hampered by the lack... Background:Calcific aortic valve stenosis(CAVS)is one of the most challenging heart diseases in clinical with rapidly increasing prevalence.However,study of the mecha-nism and treatment of CAVS is hampered by the lack of suitable,robust and efficient models that develop hemodynamically significant stenosis and typical calcium deposi-tion.Here,we aim to establish a mouse model to mimic the development and features of CAVS.Methods:The model was established via aortic valve wire injury(AVWI)combined with vitamin D subcutaneous injected in wild type C57/BL6 mice.Serial transthoracic echocardiography was applied to evaluate aortic jet peak velocity and mean gradi-ent.Histopathological specimens were collected and examined in respect of valve thickening,calcium deposition,collagen accumulation,osteogenic differentiation and inflammation.Results:Serial transthoracic echocardiography revealed that aortic jet peak velocity and mean gradient increased from 7 days post model establishment in a time depend-ent manner and tended to be stable at 28 days.Compared with the sham group,sim-ple AVWI or the vitamin D group,the hybrid model group showed typical pathological features of CAVS,including hemodynamic alterations,increased aortic valve thicken-ing,calcium deposition,collagen accumulation at 28 days.In addition,osteogenic dif-ferentiation,fibrosis and inflammation,which play critical roles in the development of CAVS,were observed in the hybrid model.Conclusions:We established a novel mouse model of CAVS that could be induced efficiently,robustly and economically,and without genetic intervention.It provides a fast track to explore the underlying mechanisms of CAVS and to identify more effec-tive pharmacological targets. 展开更多
关键词 animal model calcific aortic valve stenosis valve calcification
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Cerebral ischemic injury after transcatheter aortic valve replacement in patients with pure aortic regurgitation
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作者 Xianbao LIU Hanyi DAI +7 位作者 Jiaqi FAN Dao ZHOU Gangjie ZHU Abuduwufuer YIDILISI Jun CHEN Yeming XU Lihan wang jian'an wang 《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》 SCIE CAS CSCD 2023年第6期530-538,共9页
Considering the surgical risk stratification for patients with severe calcific aortic stenosis(AS),transcatheter aortic valve replacement(TAVR)is a reliable alternative to surgical aortic valve replacement(SAVR)(Fan e... Considering the surgical risk stratification for patients with severe calcific aortic stenosis(AS),transcatheter aortic valve replacement(TAVR)is a reliable alternative to surgical aortic valve replacement(SAVR)(Fan et al.,2020,2021;Lee et al.,2021).Despite the favorable clinical benefits of TAVR,stroke remains a dreaded perioperative complication(Auffret et al.,2016;Kapadia et al.,2016;Kleiman et al.,2016;Huded et al.,2019).Ischemic overt stroke,identified in 1.4%to 4.3%of patients in TAVR clinical practice,has been associated with prolonged disability and increased mortality(Auffret et al.,2016;Kapadia et al.,2016;Levi et al.,2022).The prevalence of hyperintensity cerebral ischemic lesions detected by diffusion-weighted magnetic resonance imaging(DW-MRI)was reported to be about 80%,which is associated with impaired neurocognitive function and vascular dementia(Vermeer et al.,2003;Barber et al.,2008;Kahlert et al.,2010). 展开更多
关键词 AORTIC PATIENTS IMPAIRED
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基于柔性材料的亚波长金属光栅偏振器的关键技术研究 被引量:5
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作者 杨江涛 王健安 +1 位作者 王银 胡啸 《中国激光》 EI CAS CSCD 北大核心 2020年第11期326-332,共7页
亚波长周期结构光栅具有传统光栅所不具有的特殊特性,因此利用纳米压印技术在方形的PC(Polycarbonate,聚碳酸酯)上制作了一种亚波长金属纳米光栅偏振器,其周期为278 nm,深度为110 nm,占空比为0.5,沉积的金属铝层为70 nm。然后采用光谱... 亚波长周期结构光栅具有传统光栅所不具有的特殊特性,因此利用纳米压印技术在方形的PC(Polycarbonate,聚碳酸酯)上制作了一种亚波长金属纳米光栅偏振器,其周期为278 nm,深度为110 nm,占空比为0.5,沉积的金属铝层为70 nm。然后采用光谱测试系统对制作的亚波长金属光栅偏振器进行了简单的性能测试。实验结果表明:当入射光波长在600 nm时,制作的亚波长金属光栅偏振器具有较好的偏振特性,其TM偏振光透射效率高达55%,且消光比高达32 dB。另外,利用实验室前期制作的6通道传感器对制作的偏振器性能进行了测试,测试结果显示制作的偏振器的平均误差为0.2002°,最大误差为1.105°,标准误差为0.7255°。该制作工艺只涉及纳米压印工艺和金属蒸镀工艺两个工艺步骤,制作过程不涉及压印胶的涂覆、剥离和刻蚀工艺,因此在低成本、批量化制作大面积的偏振器方面具有很明显的优势,可普遍用于光探测器件、光电开光等半导体光电子器件的制作。 展开更多
关键词 光学器件 柔性材料 亚波长 光栅偏振器 TM透射效率 消光比
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基于大气偏振模式的三维姿态角解算方法 被引量:2
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作者 杨江涛 王健安 +1 位作者 王银 胡啸 《激光与光电子学进展》 CSCD 北大核心 2020年第22期287-295,共9页
为了满足无人飞行器自主导航对姿态参数的迫切需求,提出一种利用大气偏振信息获取载体三维姿态信息的方法。首先充分解析大气偏振模式;然后采用K-means聚类算法解算太阳在空间中的位置信息;最后利用磁罗盘与载体体轴夹角获取载体的航向... 为了满足无人飞行器自主导航对姿态参数的迫切需求,提出一种利用大气偏振信息获取载体三维姿态信息的方法。首先充分解析大气偏振模式;然后采用K-means聚类算法解算太阳在空间中的位置信息;最后利用磁罗盘与载体体轴夹角获取载体的航向信息。在已知航向角的基础上,对导航坐标进行基准变换。首先将天顶点与太阳位置处于同一轴向,使得天顶点与太阳位置矢量处于同一基准并同时旋转;然后根据天顶点与太阳位置固有的高度夹角,将俯仰角与横滚角的计算进行转换;最后通过一系列的转换和计算得到横滚角和俯仰角的信息。实验结果表明,利用大气偏振模式解算的太阳位置可获得有效的载体姿态信息,模拟仿真的解算精度可达0.01°,外场实验的精度可达0.1°。 展开更多
关键词 成像系统 大气偏振模式 K-MEANS聚类算法 导航 姿态
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Kidney function change after transcatheter aortic valve replacement in patients with diabetes and/or hypertension 被引量:2
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作者 Jiaqi FAN Changjie YU +10 位作者 Kaida REN Wanbing LIN Stella NG Zexin CHEN Xinping LIN Lihan wang Qifeng ZHU Yuxin HE Jubo JIANG Xianbao LIU jian'an wang 《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》 SCIE CAS CSCD 2021年第3期241-247,共7页
Aortic stenosis(AS)is a progressive heart valve disease occurring predominantly in older patients.According to a survey in a western country,the prevalence of AS is nearly 6.4%in patients over 75 years old(Carabello a... Aortic stenosis(AS)is a progressive heart valve disease occurring predominantly in older patients.According to a survey in a western country,the prevalence of AS is nearly 6.4%in patients over 75 years old(Carabello and Paulus,2009).Transcatheter aortic valve replacement(TAVR)is an alternative method for AS patients.Previous studies have described how up to 66%of TAVR patients have concomitant baseline kidney dysfunction(Ferro et al.,2015;Gargiulo et al.,2015).The majority of patients can benefit from the TAVR procedure with the recovery of kidney function. 展开更多
关键词 PATIENTS al. KIDNEY
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