Obesity is associated with gut dysbiosis and metabolic endotoxin.Junshanyinzhen tea extract(JSTE)reduced fat accumulation and body weight in obese mice.However,the effects and mechanism of JSTE in preventing obesity w...Obesity is associated with gut dysbiosis and metabolic endotoxin.Junshanyinzhen tea extract(JSTE)reduced fat accumulation and body weight in obese mice.However,the effects and mechanism of JSTE in preventing obesity were unclear.Therefore,we used different doses of JSTE(75,150 and 300 mg/(kg·day))to evaluate the effect on high-fat diet(HFD)-induced rats under 8 weeks of intervention.Here,our results showed that JSTE could significantly reduce body weight gain,blood lipid levels and fat accumulation,improve fatty damage in liver tissue(P<0.05).In addition,JSTE increased the expression of intestinal tight junction proteins(P<0.05),relieved metabolic endotoxemia(P<0.05)and chronic low-grade inflammation in HFD rats.Sequencing of fecal samples showed that JSTE could effectively reverse the microbial diversity and the ratio of Firmicutes to Bacteroidetes to normal levels in HFD-fed rats.Desulfovibrioceae and Erysipelotrichaceae,which are positively related to obesity,were decreased by JSTE intervention(P<0.05).while Bifidobacteriaceae,Bacteroidaceae,Akkermansia,and Clostridium,which are negatively related to obesity,were increased.Together,these results suggested that JSTE might effectively prevent obesity by modulating gut microbiota dysbiosis,intestinal barrier dysfunction,metabolic endotoxemia and chronic low-grade infl ammation in HFD-induced rats.展开更多
Most ground faults in distribution network are caused by insulation deterioration of power equipment.It is difficult to find the insulation deterioration of the distribution network in time,and the development trend o...Most ground faults in distribution network are caused by insulation deterioration of power equipment.It is difficult to find the insulation deterioration of the distribution network in time,and the development trend of the initial insulation fault is unknown,which brings difficulties to the distribution inspection.In order to solve the above problems,a situational awareness method of the initial insulation fault of the distribution network based on a multi-feature index comprehensive evaluation is proposed.Firstly,the insulation situation evaluation index is selected by analyzing the insulation fault mechanism of the distribution network,and the relational database of the distribution network is designed based on the data and numerical characteristics of the existing distribution management system.Secondly,considering all kinds of fault factors of the distribution network and the influence of the power supply region,the evaluation method of the initial insulation fault situation of the distribution network is proposed,and the development situation of the distribution network insulation fault is classified according to the evaluation method.Then,principal component analysis was used to reduce the dimension of the training samples and test samples of the distribution network data,and the support vector machine(SVM)was trained.The optimal parameter combination of the SVM model was found by the grid search method,and a multi-class SVM model based on 1-v-1 method was constructed.Finally,the trained multi-class SVM was used to predict 6 kinds of situation level prediction samples.The results of simulation examples show that the average prediction accuracy of 6 situation levels is above 95%,and the perception accuracy of 4 situation levels is above 96%.In addition,the insulation maintenance decision scheme under different situation levels is able to be given when no fault occurs or the insulation fault is in the early stage,which can meet the needs of power distribution and inspection for accurately sensing the insulation fault situation.The correctness and effectiveness of this method are verified.展开更多
Objective： To study the mechanisms in gambogic acid （GA） -induced JeKo-1 human Mantle Cell Lymphoma cell apoptosis in vitro. Methods： The proliferation of GA-treated JeKo-1 cells was measured by CCK-8 assay and Ki...Objective： To study the mechanisms in gambogic acid （GA） -induced JeKo-1 human Mantle Cell Lymphoma cell apoptosis in vitro. Methods： The proliferation of GA-treated JeKo-1 cells was measured by CCK-8 assay and Ki-67 immunocytochemical detection. Apopt0sis, cell cycle and mitochondrial membrane potential were measured by flow cytometric analysis. Caspase-3, -8 and -9 were detected by colorimetric assay. Bcl-2 and Bax were analyzed by Western blotting. Results： GA inhibited cell growth in a time- and dose- dependent manner. GA induces apoptosis in JeKo- 1 cells but not in normal bone marrow cells, which was involved in reducing the membrane potential of mitochondria, activating caspases-3, -8 and -9 and decreasing the ratio of Bd-2 and Bax without cell cycle arresting. Conclusions： GA induced apoptosis in human MCL JeKo-1 cells by regulating Bcl-2/Bax and activating caspase-3, -8 and -9 via mitochondrial pathway without affecting cell cycle.展开更多
A clear understanding of the evolution characteristics of leaching solution’s damage to the basement rock of ion-adsorbed rare earth deposits is essential in the in situ leaching mining.In this study,some laboratory ...A clear understanding of the evolution characteristics of leaching solution’s damage to the basement rock of ion-adsorbed rare earth deposits is essential in the in situ leaching mining.In this study,some laboratory tests were carried out to investigate the deterioration behavior and failure mechanism of rock under the erosion of leaching solution.For this purpose,granite specimens were soaked in the leaching solution for different periods and then some physical and mechanical parameters were measured.The experimental results show that the strength of the rock without any soaking is the maximum.After 60 d,the rock strength,mass(dry)and P-wave velocity(dry)decrease to the minimum,while the porosity of the specimens reaches the maximum.Moreover,the failure pattern of the specimens in the uniaxial compression tests is affected as the soaking time increases.The scanning electron microscopy(SEM)image results indicate that the erosion of quartz crystals inside the rock specimens gets more intense with the increase of soaking time.Also,the internal crystal failure mode gradually changes from the trans-granular to the inter-granular.The insights gained from this study are helpful for better understanding the evolution characteristics of leaching solution’s damage to the basement rock of ionadsorbed rare earth deposits.展开更多
There are many population-based stochastic search algorithms for solving optimization problems. However, the universality and robustness of these algorithms are still unsatisfactory. This paper proposes an enhanced se...There are many population-based stochastic search algorithms for solving optimization problems. However, the universality and robustness of these algorithms are still unsatisfactory. This paper proposes an enhanced self-adaptiveevolutionary algorithm （ESEA） to overcome the demerits above. In the ESEA, four evolutionary operators are designed to enhance the evolutionary structure. Besides, the ESEA employs four effective search strategies under the framework of the self-adaptive learning. Four groups of the experiments are done to find out the most suitable parameter values for the ESEA. In order to verify the performance of the proposed algorithm, 26 state-of-the-art test functions are solved by the ESEA and its competitors. The experimental results demonstrate that the universality and robustness of the ESEA out-perform its competitors.展开更多
Micro/meso scale modification can bring big changes in macroscale property.The addition of nanofillers makes materials strong,durable and multifunctional/smart.This paper aims at studying mechanical property,durabilit...Micro/meso scale modification can bring big changes in macroscale property.The addition of nanofillers makes materials strong,durable and multifunctional/smart.This paper aims at studying mechanical property,durability,electrical property,electromagnetic property and piezoresistivity of concrete with nano silica(NS),carbon nanotube(CNT),botryoid hybrid carbon material(BHCBM),nano graphite展开更多
The temperature and moisture of the pavement structure can be greatly influenced by the wind speed above pavement surface.The wind speed above pavement surface not only is dominated by the wind speed of atmosphere,but...The temperature and moisture of the pavement structure can be greatly influenced by the wind speed above pavement surface.The wind speed above pavement surface not only is dominated by the wind speed of atmosphere,but also it is highly related to the landform and buildings around road.However,currently there are no studies about the wind field above pavement surface in consideration of the effect of the landform and buildings.A simulation method,which is combined with geographic information system(GIS),wind data from meteorological observatory and computational fluid dynamics(CFD)software,is employed to study the effect of the landform and the wind speed of atmosphere on the wind field above pavement surface.Three cases are studied,including an urban road,a coastal road and a mountainous road.Furthermore,the wind field distribution above road surface in different wind directions was studied in our work.Results indicate that the wind field above pavement surface can be greatly affected by the landforms,buildings and wind direction.This simulation method can provide reliable results for the wind field above pavement surface.The maximum relative errors between simulated and measured wind speed can be less than 20%in the analysis of the three cases.It is recommended that the CFD simulation method is a good tool to accurately know the wind field above pavement surface.展开更多
Sustainable and resilient pavement infrastructure is critical for current economic and environmental challenges.In the past 10 years,the pavement infrastructure strongly supports the rapid development of the global so...Sustainable and resilient pavement infrastructure is critical for current economic and environmental challenges.In the past 10 years,the pavement infrastructure strongly supports the rapid development of the global social economy.New theories,new methods,new technologies and new materials related to pavement engineering are emerging.Deterioration of pavement infrastructure is a typical multi-physics problem.Because of actual coupled behaviors of traffic and environmental conditions,predictions of pavement service life become more and more complicated and require a deep knowledge of pavement material analysis.In order to summarize the current and determine the future research of pavement engineering,Journal of Traffic and Transportation Engineering(English Edition)has launched a review paper on the topic of"New innovations in pavement materials and engineering:A review on pavement engineering research 2021".Based on the joint-effort of 43 scholars from 24 well-known universities in highway engineering,this review paper systematically analyzes the research status and future development direction of 5 major fields of pavement engineering in the world.The content includes asphalt binder performance and modeling,mixture performance and modeling of pavement materials,multi-scale mechanics,green and sustainable pavement,and intelligent pavement.Overall,this review paper is able to provide references and insights for researchers and engineers in the field of pavement engineering.展开更多
Background： For Chinese patients with hepatocellular carcinoma （HCC）, surgical resection is the most important treatment to achieve long-term survival for patients with an early-stage tumor, and yet the prognosis a...Background： For Chinese patients with hepatocellular carcinoma （HCC）, surgical resection is the most important treatment to achieve long-term survival for patients with an early-stage tumor, and yet the prognosis after surgery is diverse. We aimed to construct a scoring system （Shanghai Score） for individualized prognosis estimation and adjuvant treatment evaluation. Methods： A multivariate Cox proportional hazards model was constructed based on 4166 HCC patients undergoing resection during 2001-2008 at Zhongshan Hospital. Age, hepatitis B surface antigen, hepatitis B e antigen, partial thromboplastin time, total bilirubin, alkaline phosphatase, y-glutamyltransferase, a-fetoprotein, tumor size, cirrhosis, vascular invasion, differentiation, encapsulation, and tumor number were finally retained by a backward step-down selection process with the Akaike information criterion. The Harrell＇s concordance index （C-index） was used to measure model performance. Shanghai Score is calculated by summing the products of the 14 variable values times each variable＇s corresponding regression coefficient. Totally 1978 patients from Zhongshan Hospital undergoing resection during 2009-2012, 808 patients from Eastern Hepatobiliary Surgery Hospital during 2008-2010, and 244 patients from Tianjin Medical University Cancer Hospital during 2010-2011 were enrolled as external validation cohorts. Shanghai Score was also implied in evaluating adjuvant treatment choices based on propensity score matching analysis.Results： Shanghai Score showed good calibration and discrimination in postsurgical HCC patients. The bootstrap-corrected C-index （confidence interval [CI]） was 0.74 for overall survival （OS） and 0.68 for recurrence-free survival （RFS） in derivation cohort （4166 patients）, and in the three independent validation cohorts, the CIs for OS ranged 0.70 0.72 and that for RFS ranged 0.63 0.68. Furthermore, Shanghai Score provided evaluation for adjuvant treatment choices （transcatheter arterial chemoembolization or interferon-a）. The identified subset of patients at low risk could be ideal candidates for curative surgery, and subsets of patients at moderate or high risk could be recommended with possible adjuvant therapies after surgery. Finally, a web server with individualized outcome prediction and treatment recommendation was constructed. Conclusions： Based on the largest cohort up to date, we established Shanghai Score - an individualized outcome prediction system specifically designed for Chinese HCC patients after surgery. The Shanghai Score web server provides an easily accessible tool to stratify the prognosis of patients undergoing liver resection for HCC.展开更多
The application of Non-Orthogonal Multiple Access(NOMA) technology into satelliteaerial-ground integrated networks can meet the requirements of ultra-high rate and massive connectivity for the Sixth-Generation(6G) com...The application of Non-Orthogonal Multiple Access(NOMA) technology into satelliteaerial-ground integrated networks can meet the requirements of ultra-high rate and massive connectivity for the Sixth-Generation(6G) communication systems. We consider an uplink NOMA scenario for such a satellite-aerial-ground integrated network where multiple users communicate with satellite under the help of an Unmanned Aerial Vehicle(UAV) as an aerial relay equipped with a phased array. Supposing that buffer-aided decode-and-forward protocol is adopted at the UAV relay, we first formulate an optimization problem to maximize Ergodic Sum Rate(ESR) of the considered system subject to individual power constraint and quality-of-service constraint of each user.Then, with known imperfect channel state information of each user, we propose a joint power allocation and robust Beam Forming(BF) iterative algorithm to maximize ESR for the user-to-UAV link. Besides, to take the advantages of Free-Space Optical(FSO) and millimeter Wave(mmWave)communications, we present a switch-based hybrid FSO/mmWave scheme and a robust BF algorithm for the UAV-to-satellite link to achieve higher rate. Moreover, a closed-form ESR expression is derived. Finally, the effectiveness and correctness of the proposed solutions are verified by numerical simulations, and the performance evaluation results show that the proposed solutions not only achieve performance enhancement and robustness, but also outperform the orthogonal multiple access significantly.展开更多
The plant tryptophan （Trp） biosynthetic pathway produces many secondary metabolites with diverse functions. Indole- 3-acetic acid （IAA）, proposed as a derivative from Trp or its precursors, plays an essential role...The plant tryptophan （Trp） biosynthetic pathway produces many secondary metabolites with diverse functions. Indole- 3-acetic acid （IAA）, proposed as a derivative from Trp or its precursors, plays an essential role in plant growth and development. Although the Trp-dependant and Trp-independent IAA biosynthetic pathways have been proposed, the enzymes, reactions and regulatory mechanisms are largely unknown. In Arabidopsis, indole-3-glycerol phosphate （IGP） is suggested to serve as a branchpoint component in the Trp-independent IAA biosynthesis. To address whether other enzymes in addition to Trp synthase ~ （TSA1） catalyze IGP cleavage, we identified and characterized an indole synthase （INS） gene, a homolog of TSA1 in Arabidopsis. INS exhibits different subcellular localization from TSA1 owing to the lack of chloroplast transit pepUde （cTP）. In si//co data show that the expression levels of INS and TSA1 in all examined organs are quite different. Histochemical staining of INS promoter-GUS transgenic lines indicates that INS is expressed in vascular tissue of cotyledons, hypocotyls, roots and rosette leaves as well as in flowers and siliques. INS is capable of complementing the Trp auxotrophy of Escherichia co// AtrpA strain, which is defective in Trp synthesis due to the deletion of TSA. This implies that INS catalyzes the conversion of IGP to indole and may be involved in the biosynthesis of Trp-independent IAA or other secondary metabolites in Arabidopsis.展开更多
Prophylactic/preemptive donor lymphocyte infusion(p/pDLI)and intensified conditioning have shown promising results in experimental studies of refractory/relapsed acute leukemia(RRAL),but real-world data remain scarce....Prophylactic/preemptive donor lymphocyte infusion(p/pDLI)and intensified conditioning have shown promising results in experimental studies of refractory/relapsed acute leukemia(RRAL),but real-world data remain scarce.We conducted a multicenter,population-based analysis of 932 consecutive patients.The three-year leukemia-free survival(LFS)rates were 56%for patients receiving both p/pDLI and intensified myeloablative conditioning(MAC)(intenseMAC)and 30%for those who received neither therapy per landmark analysis.Multivariable analyses were run separately for acute myeloid leukemia(AML)and acute lymphoblastic leukemia(ALL),and p/pDLI treatment was linked to significantly higher LFS than non-DLI for both AML and ALL patients without increasing the nonrelapse mortality.IntenseMAC was associated with significantly lower relapse and higher LFS than nonintensified MAC despite higher nonrelapse mortality rates in ALL,while there was no impact of intenseMAC observed in AML.p/pDLI achieved superior outcomes in both matched-sibling donor(MSD)and haploidentical donor transplantation,while intenseMAC only influenced MSD outcomes.Data suggest that RRAL patients receiving“total therapy”by way of p/pDLI and intensified conditioning treatment have an improved chance for LFS,with p/pDLI being safer with a more extensive impact relative to intenseMAC.Patients with RRAL can tolerate both interventions and achieve a reasonable outcome.展开更多
High-throughput satellites(HTSs) play an important role in future millimeter-wave(mm Wave) aeronautical communication to meet high speed and broad bandwidth requirements. This paper investigates the outage performance...High-throughput satellites(HTSs) play an important role in future millimeter-wave(mm Wave) aeronautical communication to meet high speed and broad bandwidth requirements. This paper investigates the outage performance of an aeronautical broadband satellite communication system’s forward link, where the feeder link from the gateway to the HTS uses free-space optical(FSO) transmission and the user link from the HTS to aircraft operates at the mm Wave band. In the user link, spot beam technology is exploited at the HTS and a massive antenna array is deployed at the aircraft. We first present a location-based beamforming(BF) scheme to maximize the expected output signal-to-noise ratio(SNR) of the forward link with the amplify-and-forward(AF) protocol,which turns out to be a phased array. Then, by supposing that the FSO feeder link follows Gamma-Gamma fading whereas the mm Wave user link experiences shadowed Rician fading, we take the influence of the phase error into account, and derive the closed-form expression of the outage probability(OP) for the considered system. To gain further insight, a simple asymptotic OP expression at a high SNR is provided to show the diversity order and coding gain. Finally, numerical simulations are conducted to confirm the validity of the theoretical analysis and reveal the effects of phase errors on the system outage performance.展开更多
Repair of DNA double-strand breaks(DSBs) via the homologous recombination(HR) pathway is a highly regulated process. A number of proteins that participate in HR are intricately modulated by the cell cycle and chromati...Repair of DNA double-strand breaks(DSBs) via the homologous recombination(HR) pathway is a highly regulated process. A number of proteins that participate in HR are intricately modulated by the cell cycle and chromatin environments of DSBs. Recent studies have revealed a clear impact of transcription on HR in transcribed regions of the genome. Several models have been put forth to explain how the process of transcription and/or its RNA products may influence HR. Here we discuss the results and models from these studies, presenting an emerging view of transcription-coupled DSB repair.展开更多
To the Editor： Mantle cell lymphoma （MCL） is a non-Hodgkin＇s lymphoma （NHL） subtype and considered one of the most aggressive lyrnphomas with worse prognosis than other subtypes ofN H L. Despite the great progre...To the Editor： Mantle cell lymphoma （MCL） is a non-Hodgkin＇s lymphoma （NHL） subtype and considered one of the most aggressive lyrnphomas with worse prognosis than other subtypes ofN H L. Despite the great progress over the last several decades, treatment of MCL still has troubles in survival, relapse, and drug resistance.展开更多
基金supported by National Modern Agricultural Industry Technology System(CARS-23)Yueyang Yellow Tea Product Innovation Research Project(2018xny-js053).
文摘Obesity is associated with gut dysbiosis and metabolic endotoxin.Junshanyinzhen tea extract(JSTE)reduced fat accumulation and body weight in obese mice.However,the effects and mechanism of JSTE in preventing obesity were unclear.Therefore,we used different doses of JSTE(75,150 and 300 mg/(kg·day))to evaluate the effect on high-fat diet(HFD)-induced rats under 8 weeks of intervention.Here,our results showed that JSTE could significantly reduce body weight gain,blood lipid levels and fat accumulation,improve fatty damage in liver tissue(P<0.05).In addition,JSTE increased the expression of intestinal tight junction proteins(P<0.05),relieved metabolic endotoxemia(P<0.05)and chronic low-grade inflammation in HFD rats.Sequencing of fecal samples showed that JSTE could effectively reverse the microbial diversity and the ratio of Firmicutes to Bacteroidetes to normal levels in HFD-fed rats.Desulfovibrioceae and Erysipelotrichaceae,which are positively related to obesity,were decreased by JSTE intervention(P<0.05).while Bifidobacteriaceae,Bacteroidaceae,Akkermansia,and Clostridium,which are negatively related to obesity,were increased.Together,these results suggested that JSTE might effectively prevent obesity by modulating gut microbiota dysbiosis,intestinal barrier dysfunction,metabolic endotoxemia and chronic low-grade infl ammation in HFD-induced rats.
基金funded by the Science and Technology Project of China Southern Power Grid(YNKJXM20210175)the National Natural Science Foundation of China(52177070).
文摘Most ground faults in distribution network are caused by insulation deterioration of power equipment.It is difficult to find the insulation deterioration of the distribution network in time,and the development trend of the initial insulation fault is unknown,which brings difficulties to the distribution inspection.In order to solve the above problems,a situational awareness method of the initial insulation fault of the distribution network based on a multi-feature index comprehensive evaluation is proposed.Firstly,the insulation situation evaluation index is selected by analyzing the insulation fault mechanism of the distribution network,and the relational database of the distribution network is designed based on the data and numerical characteristics of the existing distribution management system.Secondly,considering all kinds of fault factors of the distribution network and the influence of the power supply region,the evaluation method of the initial insulation fault situation of the distribution network is proposed,and the development situation of the distribution network insulation fault is classified according to the evaluation method.Then,principal component analysis was used to reduce the dimension of the training samples and test samples of the distribution network data,and the support vector machine(SVM)was trained.The optimal parameter combination of the SVM model was found by the grid search method,and a multi-class SVM model based on 1-v-1 method was constructed.Finally,the trained multi-class SVM was used to predict 6 kinds of situation level prediction samples.The results of simulation examples show that the average prediction accuracy of 6 situation levels is above 95%,and the perception accuracy of 4 situation levels is above 96%.In addition,the insulation maintenance decision scheme under different situation levels is able to be given when no fault occurs or the insulation fault is in the early stage,which can meet the needs of power distribution and inspection for accurately sensing the insulation fault situation.The correctness and effectiveness of this method are verified.
基金supported by a grant from the Key Project supported by medical science and technology development Foundation of Nanjing Department of Health (No. ZKX09016)
文摘Objective： To study the mechanisms in gambogic acid （GA） -induced JeKo-1 human Mantle Cell Lymphoma cell apoptosis in vitro. Methods： The proliferation of GA-treated JeKo-1 cells was measured by CCK-8 assay and Ki-67 immunocytochemical detection. Apopt0sis, cell cycle and mitochondrial membrane potential were measured by flow cytometric analysis. Caspase-3, -8 and -9 were detected by colorimetric assay. Bcl-2 and Bax were analyzed by Western blotting. Results： GA inhibited cell growth in a time- and dose- dependent manner. GA induces apoptosis in JeKo- 1 cells but not in normal bone marrow cells, which was involved in reducing the membrane potential of mitochondria, activating caspases-3, -8 and -9 and decreasing the ratio of Bd-2 and Bax without cell cycle arresting. Conclusions： GA induced apoptosis in human MCL JeKo-1 cells by regulating Bcl-2/Bax and activating caspase-3, -8 and -9 via mitochondrial pathway without affecting cell cycle.
基金funded by the National Natural Science Foundation of China (Grant No. 51764014)the Natural Science Foundation of Jiangxi Province of China (Grant No. 20192BAB206018)+2 种基金the Education Commission of Jiangxi Province of China (GJJ160674)the Youth Jinggang Scholars Program in Jiangxi Provincethe Innovative Leading Talents Program in Ganzhou and Chongyi Zhangyuan Tungsten Co. Ltd., China, for the kind supports
文摘A clear understanding of the evolution characteristics of leaching solution’s damage to the basement rock of ion-adsorbed rare earth deposits is essential in the in situ leaching mining.In this study,some laboratory tests were carried out to investigate the deterioration behavior and failure mechanism of rock under the erosion of leaching solution.For this purpose,granite specimens were soaked in the leaching solution for different periods and then some physical and mechanical parameters were measured.The experimental results show that the strength of the rock without any soaking is the maximum.After 60 d,the rock strength,mass(dry)and P-wave velocity(dry)decrease to the minimum,while the porosity of the specimens reaches the maximum.Moreover,the failure pattern of the specimens in the uniaxial compression tests is affected as the soaking time increases.The scanning electron microscopy(SEM)image results indicate that the erosion of quartz crystals inside the rock specimens gets more intense with the increase of soaking time.Also,the internal crystal failure mode gradually changes from the trans-granular to the inter-granular.The insights gained from this study are helpful for better understanding the evolution characteristics of leaching solution’s damage to the basement rock of ionadsorbed rare earth deposits.
基金supported by the Aviation Science Funds of China(2010ZC13012)the Fund of Jiangsu Innovation Program for Graduate Education (CXLX11 0203)
文摘There are many population-based stochastic search algorithms for solving optimization problems. However, the universality and robustness of these algorithms are still unsatisfactory. This paper proposes an enhanced self-adaptiveevolutionary algorithm （ESEA） to overcome the demerits above. In the ESEA, four evolutionary operators are designed to enhance the evolutionary structure. Besides, the ESEA employs four effective search strategies under the framework of the self-adaptive learning. Four groups of the experiments are done to find out the most suitable parameter values for the ESEA. In order to verify the performance of the proposed algorithm, 26 state-of-the-art test functions are solved by the ESEA and its competitors. The experimental results demonstrate that the universality and robustness of the ESEA out-perform its competitors.
文摘Micro/meso scale modification can bring big changes in macroscale property.The addition of nanofillers makes materials strong,durable and multifunctional/smart.This paper aims at studying mechanical property,durability,electrical property,electromagnetic property and piezoresistivity of concrete with nano silica(NS),carbon nanotube(CNT),botryoid hybrid carbon material(BHCBM),nano graphite
基金funds from the National Key R&D Program of China(2018YFB1600100)the National Natural Science Foundation of China(52178417)。
文摘The temperature and moisture of the pavement structure can be greatly influenced by the wind speed above pavement surface.The wind speed above pavement surface not only is dominated by the wind speed of atmosphere,but also it is highly related to the landform and buildings around road.However,currently there are no studies about the wind field above pavement surface in consideration of the effect of the landform and buildings.A simulation method,which is combined with geographic information system(GIS),wind data from meteorological observatory and computational fluid dynamics(CFD)software,is employed to study the effect of the landform and the wind speed of atmosphere on the wind field above pavement surface.Three cases are studied,including an urban road,a coastal road and a mountainous road.Furthermore,the wind field distribution above road surface in different wind directions was studied in our work.Results indicate that the wind field above pavement surface can be greatly affected by the landforms,buildings and wind direction.This simulation method can provide reliable results for the wind field above pavement surface.The maximum relative errors between simulated and measured wind speed can be less than 20%in the analysis of the three cases.It is recommended that the CFD simulation method is a good tool to accurately know the wind field above pavement surface.
基金National Key R&D Program of China(No.2018YFB1600200,2021YFB1600200)National Natural Science Foundation of China(No.51608457,51778038,51808016,51808403,51908057,51908072,51908165,51908331,52008029,52008069,52078018,52078025,52078049,52078209,52108403,52122809,52178417)+9 种基金Marie Sk?odowska-Curie Individual Fellowships of the European Commission’s Horizon 2020 programme(No.101024139)Natural Science Foundation of Heilongjiang Province(No.JJ2020ZD0015)China Postdoctoral Science Foundation funded project(No.BX20180088)Research Capability Enhancement Program for Young Professors of Beijing University of Civil Engineering and Architecture(No.02080921021)Young Scholars of Beijing Talent Program(No.02082721009)Beijing Municipal Natural Science Foundation and Beijing Municipal Education Commission(No.KZ201910016017)German Research Foundation(No.OE 514/15-1(459436571))Fundamental Research Funds for the Central Universities(No.2020kfyXJJS127)Marie Sk?odowska-Curie Individual Fellowships of the European Commission’s Horizon 2020 Programme(No.101030767)Research Fund for High Level Talent Program(No.22120210108)。
文摘Sustainable and resilient pavement infrastructure is critical for current economic and environmental challenges.In the past 10 years,the pavement infrastructure strongly supports the rapid development of the global social economy.New theories,new methods,new technologies and new materials related to pavement engineering are emerging.Deterioration of pavement infrastructure is a typical multi-physics problem.Because of actual coupled behaviors of traffic and environmental conditions,predictions of pavement service life become more and more complicated and require a deep knowledge of pavement material analysis.In order to summarize the current and determine the future research of pavement engineering,Journal of Traffic and Transportation Engineering(English Edition)has launched a review paper on the topic of"New innovations in pavement materials and engineering:A review on pavement engineering research 2021".Based on the joint-effort of 43 scholars from 24 well-known universities in highway engineering,this review paper systematically analyzes the research status and future development direction of 5 major fields of pavement engineering in the world.The content includes asphalt binder performance and modeling,mixture performance and modeling of pavement materials,multi-scale mechanics,green and sustainable pavement,and intelligent pavement.Overall,this review paper is able to provide references and insights for researchers and engineers in the field of pavement engineering.
基金This study was supported by grants from the National High Technology Research and Development Program （863 Program） of China （No. 2015AA020401）, National Key Research and Development Program of China （No. 2016YFC0904101）, State Key Program of National Natural Science Foundation of China （No. 81530077）, National Natural Science Foundation of China （No. 81372317, 81472676, and 81572823）, Projects from the Shanghai Science and Technology Commission （No. 14DZ1940300, 14411970200, 134119a1201, and 14140902301）, and Specialized Research Fund for the Doctoral Program of Higher Education and Research Grants Council Earmarked Research Grants Joint Research Scheme （No. 20130071140008）.
文摘Background： For Chinese patients with hepatocellular carcinoma （HCC）, surgical resection is the most important treatment to achieve long-term survival for patients with an early-stage tumor, and yet the prognosis after surgery is diverse. We aimed to construct a scoring system （Shanghai Score） for individualized prognosis estimation and adjuvant treatment evaluation. Methods： A multivariate Cox proportional hazards model was constructed based on 4166 HCC patients undergoing resection during 2001-2008 at Zhongshan Hospital. Age, hepatitis B surface antigen, hepatitis B e antigen, partial thromboplastin time, total bilirubin, alkaline phosphatase, y-glutamyltransferase, a-fetoprotein, tumor size, cirrhosis, vascular invasion, differentiation, encapsulation, and tumor number were finally retained by a backward step-down selection process with the Akaike information criterion. The Harrell＇s concordance index （C-index） was used to measure model performance. Shanghai Score is calculated by summing the products of the 14 variable values times each variable＇s corresponding regression coefficient. Totally 1978 patients from Zhongshan Hospital undergoing resection during 2009-2012, 808 patients from Eastern Hepatobiliary Surgery Hospital during 2008-2010, and 244 patients from Tianjin Medical University Cancer Hospital during 2010-2011 were enrolled as external validation cohorts. Shanghai Score was also implied in evaluating adjuvant treatment choices based on propensity score matching analysis.Results： Shanghai Score showed good calibration and discrimination in postsurgical HCC patients. The bootstrap-corrected C-index （confidence interval [CI]） was 0.74 for overall survival （OS） and 0.68 for recurrence-free survival （RFS） in derivation cohort （4166 patients）, and in the three independent validation cohorts, the CIs for OS ranged 0.70 0.72 and that for RFS ranged 0.63 0.68. Furthermore, Shanghai Score provided evaluation for adjuvant treatment choices （transcatheter arterial chemoembolization or interferon-a）. The identified subset of patients at low risk could be ideal candidates for curative surgery, and subsets of patients at moderate or high risk could be recommended with possible adjuvant therapies after surgery. Finally, a web server with individualized outcome prediction and treatment recommendation was constructed. Conclusions： Based on the largest cohort up to date, we established Shanghai Score - an individualized outcome prediction system specifically designed for Chinese HCC patients after surgery. The Shanghai Score web server provides an easily accessible tool to stratify the prognosis of patients undergoing liver resection for HCC.
基金co-supported by the Key International Cooperation Research Project,China(No.61720106003)Jiangsu Province Science and Technology Project,China(No.BE2021031)+4 种基金the Shanghai Aerospace Science and Technology Innovation Foundation,China(No.SAST2019-095)NUPTSF(No.NY220111)the Research Project of Science and Technology on Complex Electronic System Simulation Laboratory,China(No.DXZT-JC-ZZ-2019-009)the National Natural Science Foundation of China(No.61801234)the Postgraduate Research and Practice Innovation Program of Jiangsu Province,China(No.KYCX210739)。
文摘The application of Non-Orthogonal Multiple Access(NOMA) technology into satelliteaerial-ground integrated networks can meet the requirements of ultra-high rate and massive connectivity for the Sixth-Generation(6G) communication systems. We consider an uplink NOMA scenario for such a satellite-aerial-ground integrated network where multiple users communicate with satellite under the help of an Unmanned Aerial Vehicle(UAV) as an aerial relay equipped with a phased array. Supposing that buffer-aided decode-and-forward protocol is adopted at the UAV relay, we first formulate an optimization problem to maximize Ergodic Sum Rate(ESR) of the considered system subject to individual power constraint and quality-of-service constraint of each user.Then, with known imperfect channel state information of each user, we propose a joint power allocation and robust Beam Forming(BF) iterative algorithm to maximize ESR for the user-to-UAV link. Besides, to take the advantages of Free-Space Optical(FSO) and millimeter Wave(mmWave)communications, we present a switch-based hybrid FSO/mmWave scheme and a robust BF algorithm for the UAV-to-satellite link to achieve higher rate. Moreover, a closed-form ESR expression is derived. Finally, the effectiveness and correctness of the proposed solutions are verified by numerical simulations, and the performance evaluation results show that the proposed solutions not only achieve performance enhancement and robustness, but also outperform the orthogonal multiple access significantly.
基金the National Natural Science Foundation of China(30330040, 30221002)
文摘The plant tryptophan （Trp） biosynthetic pathway produces many secondary metabolites with diverse functions. Indole- 3-acetic acid （IAA）, proposed as a derivative from Trp or its precursors, plays an essential role in plant growth and development. Although the Trp-dependant and Trp-independent IAA biosynthetic pathways have been proposed, the enzymes, reactions and regulatory mechanisms are largely unknown. In Arabidopsis, indole-3-glycerol phosphate （IGP） is suggested to serve as a branchpoint component in the Trp-independent IAA biosynthesis. To address whether other enzymes in addition to Trp synthase ~ （TSA1） catalyze IGP cleavage, we identified and characterized an indole synthase （INS） gene, a homolog of TSA1 in Arabidopsis. INS exhibits different subcellular localization from TSA1 owing to the lack of chloroplast transit pepUde （cTP）. In si//co data show that the expression levels of INS and TSA1 in all examined organs are quite different. Histochemical staining of INS promoter-GUS transgenic lines indicates that INS is expressed in vascular tissue of cotyledons, hypocotyls, roots and rosette leaves as well as in flowers and siliques. INS is capable of complementing the Trp auxotrophy of Escherichia co// AtrpA strain, which is defective in Trp synthesis due to the deletion of TSA. This implies that INS catalyzes the conversion of IGP to indole and may be involved in the biosynthesis of Trp-independent IAA or other secondary metabolites in Arabidopsis.
基金Supported by grants from the National Key Research and Development Program of China(2017YFA0104500)from the Ministry of Science and Technology,National Natural Science Foundation of China(81770189,81621001,and 81530046)CAMS Innovation Fund for Medical Sciences(CIFMS)(2019-I2M-5-034)+2 种基金Collaborative Innovation Center of Hematology China,the Science and Technology Project of Guangdong Province of China(2016B030230003)Peking University Clinical Scientist Program(BMU2019LCKXJ003)the Fundamental Research Funds for the Central Universities,and the Project of Health Collaborative Innovation of Guangzhou City(201704020214).We thank the principal investigators and the skilled teams at each of the participating sites.
文摘Prophylactic/preemptive donor lymphocyte infusion(p/pDLI)and intensified conditioning have shown promising results in experimental studies of refractory/relapsed acute leukemia(RRAL),but real-world data remain scarce.We conducted a multicenter,population-based analysis of 932 consecutive patients.The three-year leukemia-free survival(LFS)rates were 56%for patients receiving both p/pDLI and intensified myeloablative conditioning(MAC)(intenseMAC)and 30%for those who received neither therapy per landmark analysis.Multivariable analyses were run separately for acute myeloid leukemia(AML)and acute lymphoblastic leukemia(ALL),and p/pDLI treatment was linked to significantly higher LFS than non-DLI for both AML and ALL patients without increasing the nonrelapse mortality.IntenseMAC was associated with significantly lower relapse and higher LFS than nonintensified MAC despite higher nonrelapse mortality rates in ALL,while there was no impact of intenseMAC observed in AML.p/pDLI achieved superior outcomes in both matched-sibling donor(MSD)and haploidentical donor transplantation,while intenseMAC only influenced MSD outcomes.Data suggest that RRAL patients receiving“total therapy”by way of p/pDLI and intensified conditioning treatment have an improved chance for LFS,with p/pDLI being safer with a more extensive impact relative to intenseMAC.Patients with RRAL can tolerate both interventions and achieve a reasonable outcome.
基金Project supported by the Key International Cooperation Research Project (No. 61720106003)the National Natural Science Foundation of China (No. 61801234)+2 种基金the Shanghai Aerospace Science and Technology Innovation Foundation (No. SAST2019-095)the Research Project of Science and Technology on Complex Electronic System Simulation Laboratory (No. DXZT-JCZZ-2019-009),NUPTSF (No. NY220111)the Postgraduate Research and Practice Innovation Program of Jiangsu Province,China (Nos. KYCX190950 and KYCX200724)。
文摘High-throughput satellites(HTSs) play an important role in future millimeter-wave(mm Wave) aeronautical communication to meet high speed and broad bandwidth requirements. This paper investigates the outage performance of an aeronautical broadband satellite communication system’s forward link, where the feeder link from the gateway to the HTS uses free-space optical(FSO) transmission and the user link from the HTS to aircraft operates at the mm Wave band. In the user link, spot beam technology is exploited at the HTS and a massive antenna array is deployed at the aircraft. We first present a location-based beamforming(BF) scheme to maximize the expected output signal-to-noise ratio(SNR) of the forward link with the amplify-and-forward(AF) protocol,which turns out to be a phased array. Then, by supposing that the FSO feeder link follows Gamma-Gamma fading whereas the mm Wave user link experiences shadowed Rician fading, we take the influence of the phase error into account, and derive the closed-form expression of the outage probability(OP) for the considered system. To gain further insight, a simple asymptotic OP expression at a high SNR is provided to show the diversity order and coding gain. Finally, numerical simulations are conducted to confirm the validity of the theoretical analysis and reveal the effects of phase errors on the system outage performance.
基金supported by NIH grants (GM076388 and CA197779 to Lee Zou, GM118833 to Li Lan)
文摘Repair of DNA double-strand breaks(DSBs) via the homologous recombination(HR) pathway is a highly regulated process. A number of proteins that participate in HR are intricately modulated by the cell cycle and chromatin environments of DSBs. Recent studies have revealed a clear impact of transcription on HR in transcribed regions of the genome. Several models have been put forth to explain how the process of transcription and/or its RNA products may influence HR. Here we discuss the results and models from these studies, presenting an emerging view of transcription-coupled DSB repair.
文摘To the Editor： Mantle cell lymphoma （MCL） is a non-Hodgkin＇s lymphoma （NHL） subtype and considered one of the most aggressive lyrnphomas with worse prognosis than other subtypes ofN H L. Despite the great progress over the last several decades, treatment of MCL still has troubles in survival, relapse, and drug resistance.
