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古萤叶甲属Furusawaia二新种记述(鞘翅目:叶甲科)
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作者 丁昌萍 申健 杨美霞 《Entomotaxonomia》 CSCD 2024年第1期27-32,共6页
Furusawaia Chûjô属全世界已知7种,仅分布于中国云南、四川、台湾地区,是中国特有属。本文描记采自云南的古萤叶甲属2新种:F. yangi sp.nov.和F. gaoligongensis sp. nov.,文中还提供了该属的名录,编制了该属的分种检索表。
关键词 萤叶甲亚科 分类 检索表
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SHT-based public auditing protocol with error tolerance in FDL-empowered IoVs
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作者 Kui Zhu Yongjun Ren +2 位作者 jian shen Pandi Vijayakumar Pradip Kumar Sharma 《Digital Communications and Networks》 SCIE CSCD 2024年第1期142-149,共8页
With the intelligentization of the Internet of Vehicles(lovs),Artificial Intelligence(Al)technology is becoming more and more essential,especially deep learning.Federated Deep Learning(FDL)is a novel distributed machi... With the intelligentization of the Internet of Vehicles(lovs),Artificial Intelligence(Al)technology is becoming more and more essential,especially deep learning.Federated Deep Learning(FDL)is a novel distributed machine learning technology and is able to address the challenges like data security,privacy risks,and huge communication overheads from big raw data sets.However,FDL can only guarantee data security and privacy among multiple clients during data training.If the data sets stored locally in clients are corrupted,including being tampered with and lost,the training results of the FDL in intelligent IoVs must be negatively affected.In this paper,we are the first to design a secure data auditing protocol to guarantee the integrity and availability of data sets in FDL-empowered IoVs.Specifically,the cuckoo filter and Reed-Solomon codes are utilized to guarantee error tolerance,including efficient corrupted data locating and recovery.In addition,a novel data structure,Skip Hash Table(SHT)is designed to optimize data dynamics.Finally,we illustrate the security of the scheme with the Computational Diffie-Hellman(CDH)assumption on bilinear groups.Sufficient theoretical analyses and performance evaluations demonstrate the security and efficiency of our scheme for data sets in FDL-empowered IoVs. 展开更多
关键词 Internet of vehicles Federated deep learning Data security Data auditing Data locating and recovery
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Fluid property identification of the Lower Cretaceous reservoirs with complex oil-water contacts in Deseo Basin,Chad
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作者 Xinxin Zhang Lianfeng Zhu +4 位作者 Tianjiao Wang Xiaokang Shi Bo Han jian shen Hailei Gao 《Energy Geoscience》 EI 2024年第1期89-98,共10页
Recently,exploration breakthroughs have been made in the Lower Cretaceous sandstone reservoirs in the Doseo Basin,but the identification of reservoir fluid property is difficult due to variable reservoir lithology,com... Recently,exploration breakthroughs have been made in the Lower Cretaceous sandstone reservoirs in the Doseo Basin,but the identification of reservoir fluid property is difficult due to variable reservoir lithology,complex oil-water contact within and faint responses of the oil zone,which causes the lower accuracy of reservoir fluid property identification with conventional mudlogging and wirelogging techniques.Applying the geochemical logging,fluorescent logging,mud logging and cutting logging technology,in combination with formation test data,this paper distinguishes the crude oil types,analyzes the logging response characteristics of oil zone after water washing,and establishes the interpretation charts and parameter standards for reservoir fluid properties.The crude oil can be divided into two types,namely viscous-heavy and thin-light,based on total hydrocarbon content and component concentration tested by mud logging,features of pyrolysis gas chromatogram and fluorescence spectroscopy.The general characteristics of oil layers experienced water washing include the decrease of total hydrocarbon content and component concentration from mud logging,the decrease of S1 and PS values from geochemical logging,the decrease of hydrocarbon abundance and absence of some light components in pyrolysis gas chromatogram,and the decrease of fluorescence area and intensity from fluorescence logging.According to crude oil types,the cross plots of S1 versus peak-baseline ratio,and the cross plots of rock wettability versus fluorescence area ratio are drawn and used to interpret reservoir fluid property.Meanwhile,the standards of reservoir fluid parameter are established combining with the parameters of PS and the parameters in above charts,and comprehensive multiparameter correlation in both vertical and horizontal ways is also performed to interpret reservoir fluid property.The application in the Doseo Basin achieved great success,improving interpretation ability of fluid property in the reservoir with complex oil-water contact,and also provided technical reference for the efficient exploration and development of similar reservoirs. 展开更多
关键词 Doseo Basin Reservoir interpretation Oil-water contact Fluid property Crude oil type
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Recent progress in ternary mixed matrix membranes for CO_(2) separation
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作者 Zikang Qin Yulei Ma +13 位作者 Jing Wei Hongfang Guo Bangda Wang Jing Deng Chunhai Yi Nanwen Li Shouliang Yi Yi Deng Wentao Du jian shen Wenju jiang Lu Yao Lin Yang Zhongde Dai 《Green Energy & Environment》 SCIE EI CAS CSCD 2024年第5期831-858,共28页
Mixed matrix membranes(MMMs)could combine the advantages of both polymeric membranes and porousfillers,making them an effective alternative to conventional polymer membranes.However,interfacial incompatibility issues,s... Mixed matrix membranes(MMMs)could combine the advantages of both polymeric membranes and porousfillers,making them an effective alternative to conventional polymer membranes.However,interfacial incompatibility issues,such as the presence of interfacial voids,hardening of polymer chains,and blockage of micropores by polymers between common MMMsfillers and the polymer matrix,currently limit the gas sep-aration performance of MMMs.Ternary phase MMMs(consisting of afiller,an additive,and a matrix)made by adding a third compound,usually functionalized additives,can overcome the structural problems of binary phase MMMs and positively impact membrane separation performance.This review introduces the structure and fabrication processes for ternary MMMs,categorizes various nanofillers and the third component,and summarizes and analyzes in detail the CO_(2) separation performance of newly developed ternary MMMs based on both rubbery and glassy polymers.Based on this separation data,the challenges of ternary MMMs are also discussed.Finally,future directions for ternary MMMs are proposed. 展开更多
关键词 CO_(2) separation Mixed matrix membranes Ternary phase
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Effectiveness of fecal DNA syndecan-2 methylation testing for detection of colorectal cancer in a high-risk Chinese population
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作者 Wen-Feng Luo Yu-Ting Jiao +9 位作者 Xiao-Ling Lin Ying Zhao sheng-Bo Wang jian shen Jie Deng Yu-Feng Ye Ze-Ping Han Fang-Mei Xie Jin-Hua He Yu Wan 《World Journal of Gastrointestinal Oncology》 SCIE 2024年第4期1361-1373,共13页
BACKGROUND Colorectal cancer(CRC)is among the most prevalent and life-threatening malignancies worldwide.Syndecan-2 methylation(mSDC2)testing has emerged as a widely used biomarker for early detection of CRC in stool ... BACKGROUND Colorectal cancer(CRC)is among the most prevalent and life-threatening malignancies worldwide.Syndecan-2 methylation(mSDC2)testing has emerged as a widely used biomarker for early detection of CRC in stool and serum samples.Cancer(CRC)is among the most prevalent and life-threatening malignancies worldwide.mSDC2 testing has emerged as a widely used biomarker for early detection of CRC in stool and serum samples.AIM To validate the effectiveness of fecal DNA mSDC2 testing in the detection of CRC among a high-risk Chinese population to provide evidence-based data for the development of diagnostic and/or screening guidelines for CRC in China.METHODS A high-risk Chinese cohort consisting of 1130 individuals aged 40-79 years was selected for evaluation via fecal mSDC2 testing.Sensitivity and specificity for CRC,advanced adenoma(AA)and advanced colorectal neoplasia(ACN)were determined.High-risk factors for the incidence of colorectal lesions were determined and a logistic regression model was constructed to reflect the efficacy of the test.RESULTS A total of 1035 high-risk individuals were included in this study according to established criteria.Among them,16 suffered from CRC(1.55%),65 from AA(6.28%)and 189 from non-AAs(18.26%);150 patients were diagnosed with polyps(14.49%).Diagnoses were established based upon colonoscopic and pathological examinations.Sensitivities of the mSDC2 test for CRC and AA were 87.50%and 40.00%,respectively;specificities were 95.61%for other groups.Positive predictive values of the mSDC2 test for CRC,AA and ACN were 16.09%,29.89%and 45.98%,respectively;the negative predictive value for CRC was 99.79%.After adjusting for other high-risk covariates,mSDC2 test positivity was found to be a significant risk factor for the occurrence of ACN(P<0.001).CONCLUSION Our findings confirmed that offering fecal mSDC2 testing and colonoscopy in combination for CRC screening is effective for earlier detection of malignant colorectal lesions in a high-risk Chinese population. 展开更多
关键词 Colorectal cancer Syndecan-2 DNA methylation Chinese population
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Effects of Supplemented Shengmai San (SMS) on Blood Biochemistry and HSP72 Expression in Peripheral Blood of Flying-saucer Athletes before and after High Temperature Training
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作者 jian shen Feng Xu +1 位作者 Bin Jin Rongquan Zhang 《Journal of Integrative Medicine(双语)》 2020年第2期17-21,共5页
Objective:The purpose of this paper is to study the effects of supplemented Shengmai San on the expression of heat shock protein 72(HSP72)and blood biochemistry in peripheral blood of flying-saucer athletes before and... Objective:The purpose of this paper is to study the effects of supplemented Shengmai San on the expression of heat shock protein 72(HSP72)and blood biochemistry in peripheral blood of flying-saucer athletes before and after high temperature training,so as to provide experimental basis for enhancing thermal endurance and preventing heat disease of flying-saucer athletes with anti-heat disease drugs.Methods:24 flying-saucer athletes from Zhejiang province were selected and divided into two groups,including control group and traditional Chinese medicine group with 12 people in each group.Among them,those who did not drink supplemented Shengmai San were in the control group,while those who drank it were in the traditional Chinese medicine group.During summer training,high temperature training task was carried out for 2 weeks.Flying-saucer athletes in traditional Chinese medicine group were given supplemented Shengmai San before training every morning and afternoon.Peripheral venous blood of each group was extracted before experiment and 2 weeks later and lymphocyte HSP72 content,blood routine and biochemical indexes were determined respectively.Results:Before the experiment,there were no abnormal phenomenon blood routine,biochemical test value and HSP72 expression in the control group and the traditional Chinese medicine group.After comparison,there was no significant difference(P>0.05).After the high temperature training,the expression of HSP72 in the Chinese medicine group was significantly higher than that before the training and control group(P<0.05).There were significant differences in white blood cell count before and after the experiment(P<0.05).Conclusion:Taking supplemented Shengmai San can significantly increase expression of HSP72 in up-regulation of flying saucer athletes after thermal stimulation,thus enhancing thermal tolerance and preventing thermal diseases. 展开更多
关键词 Supplemented Shengmai San Flying saucer athletes Training of high temperature HSP72
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数据治理下的区域教育质量监测数据分析系统探究 被引量:4
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作者 沈健 罗强 《中国教育信息化》 2023年第4期77-85,共9页
教育质量监测数据分析涉及海量的数据,迫切需要开展数据治理相关理论在教育质量监测数据分析领域的研究和运用。研究者采用文献研究和案例分析等方法,明确了教育质量监测数据分析阶段中数据治理的概念,剖析了区域教育质量监测数据分析... 教育质量监测数据分析涉及海量的数据,迫切需要开展数据治理相关理论在教育质量监测数据分析领域的研究和运用。研究者采用文献研究和案例分析等方法,明确了教育质量监测数据分析阶段中数据治理的概念,剖析了区域教育质量监测数据分析系统的构建原则和框架:由功能模块、算法支撑和保障体系三个层级构成,包括12个功能模块、4个算法库以及贯穿全过程的数据质量保障体系;并以苏州市教育质量监测数据分析系统为例,阐述了数据治理理念在区域教育质量监测数据分析系统构建中的具体应用和实践:实现数据深度挖掘、监测工具质量分析、增值评价等功能的运用。最后,展望了区域教育质量监测数据分析系统的未来拓展方向。 展开更多
关键词 教育质量监测 数据治理 数据标准化 数据分析系统 区域教育
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Progress in research on tumor microenvironment-based spatial omics technologies
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作者 FANGMEI XIE NAITE XI +12 位作者 ZEPING HAN WENFENG LUO jian shen JINGGENG LUO XINGKUI TANG TING PANG YUBING LV JIABING LIANG LIYIN LIAO HAOYU ZHANG YONG jianG YUGUANG LI JINHUA HE 《Oncology Research》 SCIE 2023年第6期877-885,共9页
Spatial omics technology integrates the concept of space into omics research and retains the spatial information of tissues or organs while obtaining molecular information.It is characterized by the ability to visuali... Spatial omics technology integrates the concept of space into omics research and retains the spatial information of tissues or organs while obtaining molecular information.It is characterized by the ability to visualize changes in molecular information and yields intuitive and vivid visual results.Spatial omics technologies include spatial transcriptomics,spatial proteomics,spatial metabolomics,and other technologies,the most widely used of which are spatial transcriptomics and spatial proteomics.The tumor microenvironment refers to the surrounding microenvironment in which tumor cells exist,including the surrounding blood vessels,immune cells,fibroblasts,bone marrow-derived inflammatory cells,various signaling molecules,and extracellular matrix.A key issue in modern tumor biology is the application of spatial omics to the study of the tumor microenvironment,which can reveal problems that conventional research techniques cannot,potentially leading to the development of novel therapeutic agents for cancer.This paper summarizes the progress of research on spatial transcriptomics and spatial proteomics technologies for characterizing the tumor immune microenvironment. 展开更多
关键词 Spatial omics Spatial transcriptomics Spatial proteomics Tumor microenvironment
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玻璃体切除联合玻璃体腔注射康柏西普治疗PCV并发玻璃体积血 被引量:9
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作者 沈健 胥利平 +1 位作者 孟祥俊 周明 《国际眼科杂志》 CAS 北大核心 2018年第9期1660-1664,共5页
目的:研究玻璃体切除联合玻璃体腔注射康柏西普治疗息肉状脉络膜血管病变(polypoidal choroidal vasculopathy,PCV)并发玻璃体积血的临床效果。方法:回顾性分析我院2013-05/2016-08收治入院行玻璃体切除术治疗患者59例59眼的病例资料,其... 目的:研究玻璃体切除联合玻璃体腔注射康柏西普治疗息肉状脉络膜血管病变(polypoidal choroidal vasculopathy,PCV)并发玻璃体积血的临床效果。方法:回顾性分析我院2013-05/2016-08收治入院行玻璃体切除术治疗患者59例59眼的病例资料,其中21眼仅予以玻璃体切除设为对照组;38眼玻璃体切除联合康柏西普玻璃体腔注射设为观察组。观察两组患者治疗效果和安全性。结果:随访12mo结束时,观察组眼底彩色照相可见38眼患者视网膜深层、浅层出血和渗出均完全吸收,且B超检查可见所有患者视网膜下积血完全吸收;对照组经玻璃体切除后12mo眼底检查可见玻璃体腔积血完全吸收,但有18眼患者视网膜下伴不同程度出血、渗出,B超检查可见视网膜下仍有少量积血。两组患者治疗前后最佳矫正视力变化差异有统计学意义(P<0.01)。治疗后1、3、6、12mo观察组最佳矫正视力均明显优于对照组,组间差异有统计学意义(P<0.05)。两组患者治疗前后黄斑中心凹视网膜厚度变化差异有统计学意义(P<0.01)。观察组术后1wk,1、3、6、12mo黄斑中心凹视网膜厚度均明显低于对照组,组间差异有统计学意义(P<0.05)。观察组康柏西普玻璃体腔注射后1wk,37眼患者前房和虹膜新生血管完全消退,仅1眼残留少量明显萎缩的新生血管,消退率为97%;对照组玻璃体切除术后1wk,16眼新生血管明显消退,消退率为76%,组间差异有统计学意义(χ~2=35.680,P<0.001)。两组患者随访均未见严重并发症,且组间不良反应发生率差异无统计学意义(P>0.05)。结论:玻璃体切除联合玻璃体腔注射康柏西普治疗PCV并发玻璃体积血疗效确切,且安全性较高。 展开更多
关键词 息肉状脉络膜血管病变 玻璃体积血 玻璃体切除术 康柏西普
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Effect Analysis of WeChat Platform Combined with PBL Teaching Method for Standardized Training of Residents in Anesthesiology Department
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作者 Xiaoyan Sun jian shen 《Journal of Clinical and Nursing Research》 2023年第4期45-50,共6页
Objective: To explore and analyze the effect of the WeChat platform combined with the PBL teaching method in the standardized training of anesthesia residents. Methods: 120 anesthesiology residents from January 2018 t... Objective: To explore and analyze the effect of the WeChat platform combined with the PBL teaching method in the standardized training of anesthesia residents. Methods: 120 anesthesiology residents from January 2018 to the end of December 2019 were selected, and divided into a control group and an observation group of 60 each according to the time sequence of admission. The control group adopted the conventional teaching mode, and the observation group adopted the WeChat platform combined PBL teaching method. The scores of theoretical knowledge and anesthesia skills operation after training, the scores of the teaching interest survey, and the satisfaction with the teaching mode between the two groups were compared. Results: The scores of theoretical knowledge and anesthesia skills operation in the observation group were significantly higher than those in the control group, and the indicators of teaching interest in the observation group were also higher than those in the control group. The differences were statistically significant (P < 0.05). The satisfaction degree of the observation group was significantly higher than that of the control group, and the difference was also statistically significant (P < 0.05). Conclusion: The WeChat platform combined with the PBL teaching method is beneficial to improve the training effect of anesthesiology residents, stimulating autonomous learning ability, ensuring the effective practice of theoretical knowledge, and promoting them to move towards a higher standard of anesthesia skills. 展开更多
关键词 WeChat platform PBL teaching method Anesthesiology department Resident physician Traditional teaching
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Application Research of Fragmented Case Teaching in Standardized Training of Residents in Anesthesiology Department
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作者 Xiaokai Zhou jian shen 《Journal of Clinical and Nursing Research》 2023年第5期1-6,共6页
Objective:To explore the effect of fragmented case teaching in the standardized training of residents in anesthesiology department.Methods:80 doctors who participated in the standardized training of residents in anest... Objective:To explore the effect of fragmented case teaching in the standardized training of residents in anesthesiology department.Methods:80 doctors who participated in the standardized training of residents in anesthesiology department from January 2021 to January 2022 were selected as the research objects,and the 80 doctors were divided into experimental groups according to the clinical teaching mode(n=40,implemented case fragmented teaching method)and the control group(n=40,traditional teaching method).The training lasted for 2 months,and the medical history collection,medical record analysis,practical operation ability,theoretical assessment results,and the degree of satisfaction towards the training of the two groups of doctors were compared.Results:After 2 months of training,the theoretical knowledge and operational ability of the doctors in the two groups have improved to a certain extent,but the medical history collection,medical record analysis,practical operation ability,theoretical assessment results and satisfaction of the doctors in the experimental group were significantly better than those in the control group(P<0.05).Conclusion:The effect of the fragmented case teaching method in the standardized training of anesthesiology residents is significantly better than the traditional teaching mode.The abilities of doctors have significantly improved after the training.Hence,the fragmented case teaching method is worthy of promotion in clinical practice. 展开更多
关键词 Case fragmentation teaching Anesthesiology department Resident physician Standardized training Application
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Ability of human umbilical cord mesenchymal stem cells to repair chemotherapy-induced premature ovarian failure 被引量:26
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作者 jian shen Dai Cao Jing-Li Sun 《World Journal of Stem Cells》 SCIE CAS 2020年第4期277-287,共11页
BACKGROUND Premature ovarian insufficiency(POI)and premature ovarian failure(POF)have become one of the major problems threatening women of childbearing age.Studies have shown that stem cells transplanted from bone ma... BACKGROUND Premature ovarian insufficiency(POI)and premature ovarian failure(POF)have become one of the major problems threatening women of childbearing age.Studies have shown that stem cells transplanted from bone marrow,umbilical cord,peripheral blood and amniotic fluid can migrate and proliferate to the ovary,promote ovarian function repair,increase the number of follicles and granulosa cells at all levels of ovary,improve endocrine function,and can differentiate into oocytes in specific ovarian environment to restore fertility to some extent.AIM To study the ability of human umbilical cord mesenchymal stem cells(hUCMSCs)to repair ovarian injury after chemotherapy.METHODS A total of 110 female BALB/c mice(aged 7-8 wk old)with body masses of 16.0-20.0 g were selected.The mice were fed until 12 wk of age,and cyclophosphamide was administered by intraperitoneal injection for 14 consecutive days to induce premature ovarian failure in mice.Seventy-five mice with estrous cycle disorder were screened and randomly divided into 3 groups according to their body weight:model group,positive control group and hUCMSC group,and each group had 25 mice.Another 25 mice were used as negative controls.The mice in the hUCMSC group were injected with hUCMSCs in the tail vein,and the mice in the positive control group were given an oestradiol valerate solution and a medroxyprogesterone acetate solution in the tail vein.On the 1^st,15^th,30^th,45^th,and 60^th days after intravenous administration,vaginal smears were made to monitor the estrous cycles of the mice.The ovaries were weighed,and pathological sections were made to observe the morphology of the follicles;blood samples were collected to monitor the concentration of sex hormones(oestradiol and follicle-stimulating hormone).RESULTS The estrous cycles of the model group mice were disrupted throughout the experiment.Mice in the hUCMSC group and the positive control group resumed normal estrous cycles.The ovarian weight of the model group mice continued to decline.The ovarian weight of the hUCMSC group mice and the positive control group mice decreased first and then gradually increased,and the ovarian weight of the hUCMSC group mice was heavier than that of the positive control group mice.The difference was statistically significant(P<0.05).Compared with the negative control group,the model group experienced a decrease in oestradiol and an increase in follicle-stimulating hormone,and the difference was statistically significant(P<0.05).Compared with the model group,the hUCMSC and positive control groups experienced a slight increase in oestradiol and a decrease in follicle-stimulating hormone;the difference was statistically significant(P<0.05).The pathological examination revealed that the mouse ovaries from the model group were atrophied,the volume was reduced,the cortical and medullary structures were disordered,the number of follicles at all stages was significantly reduced,the number of atretic follicles increased,the number of primordial follicles and corpus luteum significantly decreased,and the corpus luteum had an irregular shape.Compared with those of the model group,the lesions of the hUCMSC and positive control groups significantly improved.CONCLUSION hUCMSCs can repair ovarian tissue damaged by chemotherapy to a certain extent,can improve the degree of apoptosis in ovarian tissue,and can improve the endocrine function of mouse ovaries. 展开更多
关键词 UMBILICAL cord mesenchymal stem cells PREMATURE OVARIAN failure CHEMOTHERAPY REPAIR OVARIAN injury ENDOCRINE function
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联合手术治疗合并白内障的急性闭角型青光眼疗效观察 被引量:25
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作者 陈星 于建春 +3 位作者 沈健 周丹英 吴雁冰 孙庆祝 《国际眼科杂志》 CAS 北大核心 2019年第7期1158-1161,共4页
目的:分析白内障超声乳化人工晶状体植入联合房角分离术治疗合并白内障的急性闭角型青光眼的临床应用效果。方法:选取2010-06/2018-09期间我院收治的合并白内障的急性闭角型房角粘连<180°患者40例40眼,根据手术方法不同分为观... 目的:分析白内障超声乳化人工晶状体植入联合房角分离术治疗合并白内障的急性闭角型青光眼的临床应用效果。方法:选取2010-06/2018-09期间我院收治的合并白内障的急性闭角型房角粘连<180°患者40例40眼,根据手术方法不同分为观察组和对照组。观察组采用白内障超声乳化人工晶状体植入联合前房角分离术治疗,对照组采用白内障超声乳化人工晶状体植入术治疗,将两组患者治疗结果进行对比。结果:术后3、6mo,观察组视力、眼压、前房深度均优于对照组( P <0.05)。随访期间两组均无严重并发症发生。结论:白内障超声乳化人工晶状体植入联合房角分离术治疗合并白内障的急性闭角型房角粘连<180°的患者临床效果显著。 展开更多
关键词 白内障 急性闭角型青光眼 超声乳化 房角分离术
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D-dimer level and long-term outcome in patients with end-stage heart failure secondary to idiopathic dilated cardiomyopathy 被引量:10
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作者 Bi HUANG Yuan-Jing LI +3 位作者 jian shen Yuan YANG Gang LIU Su-Xin LUO 《Journal of Geriatric Cardiology》 SCIE CAS CSCD 2019年第8期621-629,共9页
Background Previous studies had demonstrated hemostatic abnormalities in patients with heart failure (HF) and several studies have shown that abnormal coagulation indices, represented by elevated D-dimer, had prognost... Background Previous studies had demonstrated hemostatic abnormalities in patients with heart failure (HF) and several studies have shown that abnormal coagulation indices, represented by elevated D-dimer, had prognostic significance in patients with compatible or acute decompensated HF. However, the impact of D-dimer on the outcome in patients with end-stage HF remains unclear. Methods A total of 244 consecutive patients with end-stage HF due to idiopathic dilated cardiomyopathy (DCM) were prospectively enrolled from February 2011 to September 2014. D-dimer levels were measured and its prognostic value was assessed. Primary endpoint was all-cause mortality during the follow-up period. Secondary endpoints were stroke, bleeding, occurrence of sustained ventricular tachycardia or ventricular fibrillation, and major adverse cardiovascular events (MACE). Results D-dimer was significantly elevated in the non-survivors (median: 0.8 vs. 1.1 mg/L, P < 0.001). Traditional markers including B-type natriuretic peptide, troponin I, left ventricular ejection fraction, and left ventricular end-diastolic dimension provided limited prognostic value;but the addition of D-dimer refined the risk stratification. The optimal cut-off value of D-dimer to predict all-cause mortality was 0.84 mg/L by receiver operator characteristic analysis. Elevated D-dimer level was independently associated with increased risk of long-term all-cause mortality (HR = 2.315, 95% CI: 1.570–3.414, P < 0.001) and MACE (HR = 1.256, 95% CI: 1.058–1.490, P = 0.009), and the predictive value was independent of age, sex, atrial fibrillation and anticoagulation status. Conclusions Elevated D-dimer level was independently associated with poor long-term outcome in patients with end-stage HF secondary to idiopathic DCM, and the predictive value was superior to that of traditional prognostic markers. 展开更多
关键词 D-DIMER END-STAGE heart failure IDIOPATHIC DILATED CARDIOMYOPATHY Long-term OUTCOME
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Risk scores,prevention,and treatment of maternal venous thromboembolism 被引量:11
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作者 Wei Zhang jian shen Jing-Li Sun 《World Journal of Clinical Cases》 SCIE 2020年第11期2210-2218,共9页
BACKGROUND At present,the preventive treatment for pregnancy-related venous thromboembolism(VTE)in China is in its infancy,and there is no uniform or standardized industry guide.Drug prevention and treatment of pregna... BACKGROUND At present,the preventive treatment for pregnancy-related venous thromboembolism(VTE)in China is in its infancy,and there is no uniform or standardized industry guide.Drug prevention and treatment of pregnancyrelated VTE rely highly on foreign guidelines;however,due to the differences in ethnicity and national conditions,there are many controversies over the indications for drug treatment,drug selection,and dose selection for anticoagulant therapy.AIM To investigate the risk scores,prevention,and treatment of maternal VTE to promote the prevention and standardized treatment of maternal thrombosis.METHODS A retrospective analysis was performed on 7759 patients who gave birth at our hospital from June 2018 to June 2019.Risk factors for pregnancy-related VTE,prenatal and postpartum VTE risk scores,prophylactic anticoagulant therapy,side effects after medication,and morbidity were analysed.RESULTS The risk factors for VTE were mainly caesarean delivery,obesity,and advanced maternal age.Regarding pregnancy-related VTE risk scores,there were 7520 patients in the low-risk group with a prenatal score<3 points and 239 in the high-risk group with a score≥3,and 44 patients received drug prevention and treatment during pregnancy.There were 4223 patients in the low-risk group with a postpartum score<2 points and 3536 in the high-risk group with a score≥2 points,and 824 patients received drug prevention and treatment for 10 d.Among the patients who did not present with VTE before delivery,we found one case each of pulmonary embolism secondary to lower extremity venous thrombosis,intracranial venous sinus thrombosis,and asymptomatic lower extremity venous thrombosis during the postpartum follow-up.CONCLUSION VTE poses a serious threat to maternal safety,and the society should increase its vigilance against pregnancy-related VTE. 展开更多
关键词 PREGNANCY PUERPERIUM Venous thromboembolism Risk factors PREVENTION ANTICOAGULATION
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Characterisation of the bacterial community in expressed prostatic secretions from patients with chronic prostatitis/chronic pelvic pain syndrome and infertile men: a preliminary investigation 被引量:8
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作者 Dong-sheng Hou Wen-Min Long +3 位作者 jian shen Li-Ping Zhao Xiao-Yan Pang Chen Xu 《Asian Journal of Andrology》 SCIE CAS CSCD 2012年第4期566-573,共8页
The expressed prostatic secretions (EPSs) of men with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS), infertile men and normal men were subjected to microbiological study. EPSs were collected from the ... The expressed prostatic secretions (EPSs) of men with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS), infertile men and normal men were subjected to microbiological study. EPSs were collected from the subjects, which included 26 normal men, 11 infertile patients and 51 CP/CPPS patients. DNA was extracted from each specimen, and the V3 regions of the 16S rRNA genes were amplified using universal bacterial primers. The results showed that the EPS 16S rRNA gene-positive rate in the CP/CPPS and infertile patients was much higher than in the normal men, but without any difference among the three patient groups. The denaturing gradient gel electrophoresis (DGGE) method was used to characterize the EPS bacterial community structure of the prostate fluid from patients with CP/CPPS or infertility issues. Principal component analysis (PCA) and partial least squares (PLS) analyses of PCR-DGGE profiles revealed that the EPS bacterial community structure differed among the three groups. Three bands were identified as the key factors responsible for the discrepancy between CP/CPPS patients and infertile patients (P〈O.05). Two bands were identified as priority factors in the discrepancy of category IliA and category IIIB prostatitis patients (P〈O.05). According to this research, the ecological balance of the prostate and low urethra tract, when considered as a microenvironment, might play an important role in the maintenance of a healthy male reproductive tract. 展开更多
关键词 BACTERIA chronic prostatitis/chronic pelvic pain syndrome denaturing gradient gel electrophoresis PROSTATITIS
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Histone methyltransferase SETDB1 is required for prostate cancer cell proliferation, migration and invasion 被引量:7
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作者 Yi Sun Min Wei +10 位作者 Shan-Cheng Ren Rui Chen Wei-Dong Xu Fu-Bo Wang Ji Lu jian shen Yong-Wei Yu jian-Guo Hou Chuan-Liang Xu Jiao-Ti Huang Ying-Hao Sun 《Asian Journal of Andrology》 SCIE CAS CSCD 2014年第2期319-324,I0012,共7页
SETDB1 has been established as an oncogene in a number of human carcinomas. The present study was to evaluate the expression of SETDB1 in prostate cancer (PCa) tissues and cells and to preliminarily investigate the ... SETDB1 has been established as an oncogene in a number of human carcinomas. The present study was to evaluate the expression of SETDB1 in prostate cancer (PCa) tissues and cells and to preliminarily investigate the role of SETDB1 in prostate tumorigenesis in vitro. Quantitative reverse transcription polymerase chain reaction (qRT-PCR) and immunohistochemistry (IHC) were used to detect the expression of SETDB1 in PCa tissues, adjacent normal tissues, benign prostatic hyperplasia (BPH) tissues, PCa cell lines and normal prostate epithelial cells. The results suggested that SETDB1 was upregulated in human PCa tissues compared with normal tissues at the mRNA and protein levels. The role of SETDB1 in proliferation was analyzed with cell counting kit-8, colony-forming efficiency and flow cytometry assays. The results indicated that downregulation of SETDB1 by siRNA inhibited PCa cell growth, and induced GO/G1 cell cycle arrest. The PCa cell migration and invasion decreased by silcencing SETDBt which were assessed by using in vitro scratch and transwell invasion assay respectively. Our data suggested that SETDB1 is overexpressed in human PCa. Silencing SETDB1 inhibited PCa cell proliferation, migration and invasion. 展开更多
关键词 EPIGENOMICS histone methyltransferases prostate cancer (PCa) SETDB1
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Down-regulated γ-catenin expression is associated with tumor aggressiveness in esophageal cancer 被引量:6
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作者 Wang-Kai Fang Lian-Di Liao +6 位作者 Wei Gu Bo Chen Zhi-Yong Wu jian-Yi Wu jian shen Li-Yan Xu En-Min Li 《World Journal of Gastroenterology》 SCIE CAS 2014年第19期5839-5848,共10页
AIM: To evaluate the significance of &#x003b3;-catenin in clinical pathology, cellular function and signaling mechanism in esophageal squamous cell carcinoma (ESCC).
关键词 γ -CATENIN Esophageal squamous cell carcinoma Independent prognostic factor Cell-cell adhesion Cell migration
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Static softening behaviors of 7055 alloy during the interval time of multi-pass hot compression 被引量:6
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作者 Liang-Ming Yan jian shen +1 位作者 Jun-Peng Li Bai-Ping Mao 《Rare Metals》 SCIE EI CAS CSCD 2013年第3期241-246,共6页
Multipass plain strain compression test of 7055 alloy was carried out on Gleeble 1500D thermomechanical simulator to study the effect of interval time on static softening behavior between two passes. Microstructural f... Multipass plain strain compression test of 7055 alloy was carried out on Gleeble 1500D thermomechanical simulator to study the effect of interval time on static softening behavior between two passes. Microstructural features of the alloy deformed with delay times varying from 0 to 180 s after achieving a reduction of ,-~52 % in the 13 stages was investigated through TEM and EBSD observations. The 14th pass of peak stresses after different delay times were gained. The peak stress decreases with the interstage delay time increasing, but the decreasing trend is gradually slower. Static recovery, metadynamic recrystallization, and/or static recrystallization can be found in the alloy during two passes. The recovery and recrystallization degree increases with longer interstage delay time. The static recovery is the main softening mechanism. Subgrain coalescence and subgrain growth together with particle-stimulated nucleation are the main nucleation mechanisms for static recrystallization. 展开更多
关键词 7055 aluminum alloy Hot compression Microstructure Interval time
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Digestive tract reconstruction options after laparoscopic gastrectomy for gastric cancer 被引量:18
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作者 jian shen Xiang Ma +1 位作者 Jing Yang jian-Ping Zhang 《World Journal of Gastrointestinal Oncology》 SCIE CAS 2020年第1期21-36,共16页
In addition to the popularity of laparoscopic gastrectomy(LG),many reconstructive procedures after LG have been reported.Surgical resection and lymphatic dissection determine long-term survival;however,the election of... In addition to the popularity of laparoscopic gastrectomy(LG),many reconstructive procedures after LG have been reported.Surgical resection and lymphatic dissection determine long-term survival;however,the election of a reconstruction procedure determines the postoperative quality of life for patients with gastric cancer(GC).Presently,no consensus exists regarding the optimal reconstructive procedure.In this review,the current state of digestive tract reconstruction after LG is reviewed.According to the determining influence of the tumor site on the procedures of surgical resection and reconstruction,we divide these reconstruction procedures into three categories consistent with the resection procedures.We focus on the technical tips of every reconstruction procedure and examine the surgical outcomes(length of surgery and blood loss)and postoperative complications(anastomotic leakage and stricture)to facilitate gastrointestinal surgeons to understand the merits and demerits of every reconstruction procedure. 展开更多
关键词 Digestive tract reconstruction Laparoscopic gastrectomy Gastric cancer Quality of life
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