Electrical Characteristics of Tangjiawan Landslide in Lixian, Sichuan

A wide range of terrain features and landforms,which are exemplified by intricate geological formations and diverse rock compositions,are found in the western mountainous regions of China.These areas frequently encounter geological disasters.As one of the natural disasters,landslides lead to considerable loss of human life and property.Considering mitigation of the losses caused by landslide disasters,a necessary measure for disaster prevention and mitigation involves conducting detailed investigations and monitoring of landslides,which is also the cornerstone of landslide warning.This study compares and analyzes the feasibility of the magnetotelluric detection method for landslides using the results of engineering geological surveys and landslide monitoring.The study aims to address the scientific problem of the validity of using magnetotelluric methods to detect landslide development processes.The Tangjiawan landslide signal on the left side of the K94+000~K94+145 section of the Wenma Expressway is analyzed by employing engineering geological survey,magnetotelluric detection,landslide monitoring,landslide analysis,and other methods.Analysis results provide the static electrical characteristics of lithology,structure,and groundwater,as well as the dynamic electrical characteristics of landslide development.This study focuses on analyzing the relationship between the methods of magnetotelluric detection and engineering geological surveys and the results of landslide monitoring.The workflow and methods for data collection,processing,inversion,interpretation,and analysis using the magnetotelluric method to detect the dynamic development process of landslides are presented in the conclusion.Preliminary conclusions indicate a strong correlation between the dynamic changes in magnetotelluric wave impedance with the surface displacement of landslides and the dynamic changes in groundwater.The use of the magnetotelluric method for landslide detection and monitoring is a feasible example.The research results can offer certain technical references for the detection and monitoring of landslides using magnetotelluric methods and also provide references and guidance for the selection of diversified landslide monitoring methods in the future.

小儿肺部感染合并胃食管返流的影响因素及其临床特征分析

目的探讨小儿肺部感染合并胃食管返流(Gastroesophageal reflux, GER)的影响因素并对其临床特征进行分析.方法选取2015-03/2017-08常山县人民医院收治的139例肺部感染患儿作为实验组,选择同期于我院进行体检的98例儿童作为参照组.对所有儿童进行24 h食管pH监测,比较两组GER发生情况,分析肺部感染与GER的关系并通过Logisitic回归分析两者发生的影响因素,观察肺部感染合并GER患儿的临床特征.结果实验组的反流次数、平均每次反流时间、最长反流时间、酸消除时间、酸暴露时间百分率、BoixOchoa计分及GER阳性率均明显高于参照组(均P <0.05).对139例肺部感染患儿各项指标进行单因素分析,结果显示影响肺部感染并发GER的因素为患儿的年龄、病情严重程度、慢性咽炎及镇静药物使用情况(均P<0.05),患儿性别对肺部感染并发GER无影响(P>0.05); Logisitic回归分析结果表明,患儿的年龄、病情严重程度、慢性咽炎及镇静药物使用情况均可以影响肺部感染合并GER的发生(均P<0.05). 56例肺部感染并发GER的患儿中,有29例出现咳嗽, 21例出现溢乳, 11例出现呕吐, 8例出现哭闹拒食, 6例出现呛奶, 5例出现喘鸣, 2例出现喘息;其中有13例同时存在咳嗽及溢乳症状, 7例同时存在咳嗽及呕吐症状,6例同时存在咳嗽及哭闹拒食症状,4例同时存在咳嗽及呛奶症状.有29例(51.79%)患儿合并基础疾病:11例喉软化,牛奶过敏和先天性心脏病各5例,3例运动发育迟缓,漏斗胸和食道裂孔疝各2例,营养不良l例.结论小儿肺部感染并发GER的发病率明显较高,患儿年龄,肺部感染严重程度、慢性咽炎及镇静药物使用情况是影响其发生的危险因素,且患儿多存在基础疾病;肺部感染患儿临床伴有咳嗽、溢乳、呕吐、哭闹拒食、呛奶及喘鸣等表现时可考虑GER.

A huge adenosquamous carcinoma of the pancreas with sarcomatoid change:An unusual case report

Adenosquamous carcinoma rarely occurs in the pancreas,and is characterized by the presence of cellular components from both duct adenocarcinoma and squamous carcinoma.Here,we describe a rare case of pancreatic adenosquamous carcinoma with sarcomatous change.Immunohistochemistry showed that the sarcomatous lesion lost the epithelial marker and aberrantly expressed of acquired mesenchymal markers,which indicated that this special histological phenotype may be attributed to epithelial-mesenchymal transition.This case also indicated that a routine radical surgery without aggressive treatment strategies was still appropriate for adenosquamous carcinoma of the pancreas with sarcomatoid change.

Individualized leukemia cell-population profiles in common B-cell acute lymphoblastic leukemia patients

Immunophenotype is critical for diagnosing common B-cell acute lymphoblastic leukemia (common ALL) and detecting minimal residual disease. We developed a protocol to explore the immunophenotypic profiles of common ALL based on the expression levels of the antigens associated with B lymphoid development, including IL-7Rα (CD127), cytoplasmic CD79a (cCD79a), CD19, VpreB (CD179a), and sIgM, which are successive and essential for progression of B cells along their developmental pathway. Analysis of the immunophenotypes of 48 common ALL cases showed that the immunophenotypic patterns were highly heterogeneous, with the leukemic cell population differing from case to case. Through the comprehensive analysis of immunophenotypic patterns, the profiles of patient-specific composite leukemia cell populations could provide detailed information helpful for the diagnosis, therapeutic monitoring, and individualized therapies for common ALL.

Management of bile duct injuries combined with accessory hepatic duct during laparoscopic cholecystectomy

Bile duct injuries(BDIs)are difficult to avoid absolutely when the biliary tract has a malformation,such as accessory hepatic duct.Here,we investigated the management strategies for BDI combined with accessory hepatic duct during laparoscopic cholecystectomy.

Catheterization of the gallbladder: A novel mouse model of severe acute cholangitis

AIM To establish a severe acute cholangitis(SAC) model in mice.METHODS Cholecystic catheterization was performed under the condition of bile duct ligation(BDL). Trans-cholecystic injection of lipopolysaccharide(LPS) was defined as the SAC animal model. Sham operation group, intraperitoneal injection of LPS without BDL group, intraperitoneal injection of LPS with BDL group and trans-cholecystic injection of normal saline with BDL group were defined as control groups. The survival rates and tissue injuries in liver, lungs and kidney were evaluated.RESULTS Mice in the SAC group showed a time-dependent mortality and much more severe tissue injuries in liver, lungs and kidney, compared with other groups. However, relieving biliary obstruction could effectively reduce mortality and attenuate liver injury in the SAC mouse model.CONCLUSION Trans-cholecystic injection of LPS under the condition of biliary obstruction could establish a repeatable and reversible mouse model of SAC.

Complete duodenal obstruction induced by groove pancreatitis: A case report

BACKGROUND Groove pancreatitis(GP)is a type of chronic pancreatitis occurring in an anatomic area between the duodenum,head of the pancreas,and common bile duct.Duodenal obstruction is always caused by malignant pancreatic diseases,such as pancreatic head carcinoma,while is rarely induced by benign pancreatic diseases,such as pancreatitis.CASE SUMMARY A 39-year-old man presented with a 1-mo history of upper abdominal discomfort.His concomitant symptoms were abdominal distension,postprandial nausea,and vomiting.Contrast-enhanced computed tomography of the abdomen showed thickening of the intestinal wall with enhancement of the descending segment of the duodenum,which could not be clearly differentiated from the head of the pancreas.Upper gastrointestinal radiographs and gastrointestinal endoscopy showed a complete obstruction of the descending duodenum.An operation found that a 3-cm mass was located in the“groove part”of the pancreas and oppressing the descending duodenum.Pancreaticoduodenectomy was performed to relieve the obstruction and thoroughly remove the pancreatic lesions.The pathologic diagnosis was pancreatitis.The patient had an uneventful recovery with no complications.CONCLUSION Because of the special location and the contracture induced by long-term chronic inflammation,our case reminds surgeons that some benign pancreatic diseases,such as GP,can also present with symptoms similar to those of pancreatic cancer.This knowledge can help to avoid an unnecessary radical operation.

Mycobacterium tuberculosis bacteremia in a human immunodeficiency virus-negative patient with liver cirrhosis:A case report

BACKGROUND With the increasing prevalence of human immunodeficiency virus(HIV),the incidence of Mycobacterium tuberculosis(M.tuberculosis)bacteremia has also increased.As a common affliction of acquired immunodeficiency syndrome patients,M.tuberculosis infection is associated in these patients with severe sepsis and high mortality.In contrast,M.tuberculosis bacteremia is rarely seen in HIVnegative patients,and M.tuberculosis has never been reported from the blood of patients with liver cirrhosis.CASE SUMMARY We evaluated a 55-year-old Chinese male patient who had been admitted to the hospital with abdominal distension of unknown cause of one-week duration,accompanied by diarrhea,shortness of breath,and occasional fever.Based on these indicators of abnormal inflammation and fever,we suspected the presence of an infection.Although evidence of microbial infection was not found in routine clinical tests and the patient did not show typical clinical symptoms of infection with M.tuberculosis,next-generation sequencing of blood samples nevertheless demonstrated the presence of M.tuberculosis,which was subsequently isolated from blood samples grown in conventional Bac T/ALERT FA blood culture bottles.CONCLUSION Our findings demonstrate that HIV-negative liver cirrhosis patients can also be infected with M.tuberculosis.

Efficacy and safety of the long-acting fusion inhibitor albuvirtide in antiretroviral-experienced adults with human immunodeficiency virus-1:interim analysis of the randomized,controlled,phase 3,non-inferiority TALENT study

Background:Albuvirtide is a once-weekly injectable human immunodeficiency virus(HIV)-1 fusion inhibitor.We present interim data for a phase 3 trial assessing the safety and efficacy of albuvirtide plus lopinavir-ritonavir in HIV-1-infected adults already treated with antiretroviral drugs.Methods:We carried out a 48-week,randomized,controlled,open-label non-inferiority trial at 12 sites in China.Adults on the World Health Organization(WHO)-recommended first-line treatment for>6 months with a plasma viral load>1000 copies/mL were enrolled and randomly assigned(1:1)to receive albuvirtide(once weekly)plus ritonavir-boosted lopinavir(ABT group)or the WHO-recommended second-line treatment(NRTI group).The primary endpoint was the proportion of patients with a plasma viral load below 50 copies/mL at 48 weeks.Non-inferiority was prespecified with a margin of 12%.Results:At the time of analysis,week 24 data were available for 83 and 92 patients,and week 48 data were available for 46 and 50 patients in the albuvirtide and NRTI groups,respectively.At 48 weeks,80.4%of patients in the ABT group and 66.0%of those in the NRTI group had HIV-1 RNA levels below 50 copies/mL,meeting the criteria for non-inferiority.For the per-protocol population,the superiority of albuvirtide over NRTI was demonstrated.The frequency of grade 3 to 4 adverse events was similar in the two groups;the most common adverse events were diarrhea,upper respiratory tract infections,and grade 3 to 4 increases in triglyceride concentration.Renal function was significantly more impaired at 12 weeks in the patients of the NRTI group who received tenofovir disoproxil fumarate than in those of the ABT group.Conclusions:The TALENT study is the first phase 3 trial of an injectable long-acting HIV drug.This interim analysis indicates that once-weekly albuvirtide in combination with ritonavir-boosted lopinavir is well tolerated and non-inferior to the WHO-recommended second-line regimen in patients with first-line treatment failure.Trial registration:ClinicalTrials.gov Identifier:NCT02369965;https://www.clinicaltrials.gov.Chinese Clinical Trial Registry No.ChiCTR-TRC-14004276;http://www.chictr.org.cn/enindex.aspx.

Synthesis and biological evaluation of novel 1,2,4-triazole containing 1,2,3-thiadiazole derivatives

A series of novel 1,2,4-triazoles containing 1,2,3-thiadiazole derivatives were designed and synthesized. Their structures were confirmed by melting points, IR, 1H NMR, and elemental analysis and ESI-MS or HRMS. Preliminary bioassays indicated that these compounds exhibited very good insecticidal activity against Aphis laburni at 100 μg/mL, with mortality no less than 95%. Compounds 6a, 6c, 6f, 61 showed higher curative activity against TMV and compound 6h showed a higher induction effects against TMV in vivo at 100 μg/mL. Collectively, our data demonstrate a new strategy for control of insects and viruses.