Clinicopathologic significance of BAG1 and TIMP3 expression in colon carcinoma

AIM: To explore the expression of BAG1 and tissue inhibitor of metalloproteinase 3 (TIMP3) in colon carcinoma and their correlation and clinicopathologic significance. METHODS: SABC immunohistochemistry was used to detect the expression of BAG1 and TIMP3 in 80 colon carcinoma tissues and 20 normal colonic mucosa. RESULTS: Positive rate of BAG1 in colon carcinoma tissue (80%) was notably higher compared to normal colonic mucosa (10%) (P < 0.05). However, no significant difference was observed in positive rate of TIMP3 in colon carcinoma tissue (43.75%) as compared with normal colonic mucosa (60%) (P > 0.05). Expression of BAG1 and TIMP3 was strongly associated with colon carcinoma differentiation, Duke's staging, lymph node metastasis and survival rate (P < 0.05), but not associated with gender and age. Moreover, BAG1 expression was not correlated with TIMP3. CONCLUSION: Our results suggest that over-expression of BAG1 or attenuated expression of TIMP3 may play an important role in genesis and development of colon carcinoma. The protein expression levels of BAG1 and TIMP3 are related to the malignant degree, infiltration and metastasis of colon carcinoma. BAG1 and TIMP3 might be new biological parameters in predicting invasion and metastasis of colon carcinoma.

Radiation Vulcanization of Magnetorheological Elastomers Based on Silicone Rubber

The fabrication of magnetorheological （MR） elastomers was studied by two vulcanization methods, including heat vulcanization （HV） and radiation vulcanization （RV）, were employed to fabricate MRE samples. The dynamical mechanical properties were characterized by using a dynamic mechanic analyzer. In particular, both the MR effect and its durability were investigated. The experimental results showed that RV samples have large magnetoinduced modulus, large zero-field modulus, and good durability property of MR effect. To explain these results, cubic deformation and plasticizer migration were analyzed. Large magneto-induced modulus of RV sample results from cubic deformation during vulcanization process. And the plasticizer migration results in better durability of MR effect.

Adjuvant chemotherapy after liver transplantation for hepatocellular carcinoma: a systematic review and a meta-analysis

BACKGROUND： Hepatocellular carcinoma （HCC） is one of the most common tumors worldwide and liver transplanta- tion （LT） is considered as the best therapeutic option for patients with HCC combined with cirrhosis. However, tumor recurrence after LT for HCC remains the major obstacle for long-term survival. The present study was to evaluate the effi- cacy and necessity of adjuvant chemotherapy in patients with HCC who had undergone LT.

Direct Z-scheme WO_(3-x) nanowire-bridged TiO_(2) nanorod arrays for highly efficient photoelectrochemical overall water splitting

All-solid-state Z-scheme photocatalysts for overall water splitting to evolve H_(2) is a promising strategy for efficient conversion of solar energy.However,most of these strategies require redox mediators.Herein,a direct Z-scheme photoelectrocatalytic electrode based on a WO_(3-x)nanowire-bridged TiO_(2)nanorod array heterojunction is constructed for overall water splitting,producing H_(2).The as-prepared WO_(3-x)/TiO_(2)nanorod array heterojunction shows photoelectrochemical(PEC)overall water splitting activity evolving both H_(2) and O_(2)under UV-vis light irradiation.An optimum PEC activity was achieved over a 1.67-WO_(3-x)/TiO_(2)photoelectrode yielding maximum H_(2) and O_(2)evolution rates roughly 11 times higher than that of pure TiO_(2)nanorods without any sacrificial agent or redox mediator.The role of oxygen vacancy in WO_(3-x)in affecting the H_(2) production rate was also comprehensively studied.The superior PEC activity of the WO_(3-x)/TiO_(2)electrode for overall water splitting can be ascribed to an efficient Z-scheme charge transfer pathway between the WO_(3-x)nanowires and TiO_(2)nanorods,the presence of oxygen vacancies in WO_(3-x),and a bias potential applied on the photoelectrode,resulting in effective spatial charge separation.This study provides a novel strategy for developing highly efficient PECs for overall water splitting.

Treatment with sorafenib plus camrelizumab after splenectomy for primary splenic angiosarcoma with liver metastasis:A case report and literature review

BACKGROUND Primary splenic angiosarcoma(PSA)is an extremely rare and aggressive mesenchymal malignancy with high metastatic potential and a poor prognosis.There are no established treatment guidelines for PSA,even for adjuvant therapy.This rare case may provide a reliable therapeutic regime for a better prognosis.CASE SUMMARY A 49-year-old female who complained of right-upper quadrant abdominal pain was diagnosed as having PSA with splenic rupture and liver metastasis.After splenectomy and liver tumor resection,she received sorafenib and camrelizumab therapy.After 15 mo of follow-up,she is in good condition,without recurrence or any identified metastasis.CONCLUSION Immunotherapy combined with targeted therapy could be a potential option for the adjuvant therapy of PSA.

Guest Editorial Special Issue on Mid-Infrared Lasers and Applications

Mid-infrared （mid-IR） lasers, generally defined as having an operation wavelength in the spectral region of 2μm to 20μm, have attracted great scientific and technological interests owing to their widespread applications. This wavelength range not only contains some strong vibration transitions of many important molecules, thus, exhibiting enormous potential in medical, spectroscopy.

锌-空气电池隔膜的关键作用及其最新研究进展

在化石能源日益短缺、资源消耗急剧增加的背景下,开发可再生的清洁能源,如太阳能和风能,变得尤为重要。然而,这些清洁能源供应不稳定,因此需要大规模能源转换和储存装置的发展。在这方面,锌-空气电池能量密度高、安全性好、成本低、易组装、对环境友好并且金属锌储量丰富,作为能源储存与转换器件有良好的发展前景,但在应用的过程中仍存在一些问题。其中,隔膜在锌-空气电池中起着隔离正负极,防止短路的重要作用,但关于锌-空气电池隔膜及其改性的研究较少。本文简要介绍了锌-空气电池的发展,以水系碱性锌-空气电池为例,阐述了其工作原理。文中通过理解电池各个组件可能导致电池失效的机制,重点分析了隔膜性能对整体电池性能的影响。其中包括隔膜的离子选择性、离子导电性、稳定性以及保水性等因素。这些因素在锌-空气电池中起到至关重要的作用,直接影响电池的效率、寿命和稳定性。此外,本文还对锌-空气电池隔膜未来发展方向进行了展望。随着科技的进步,锌-空气电池的隔膜材料可能会进行更多的改良和创新,以提高电池的性能和稳定性。对于清洁能源的推动,锌-空气电池在能源储存和转换领域有望发挥更大的作用。

完全机器人腹腔镜腹膜后入路活体供肾切取术的临床应用

目的探讨机器人腹腔镜腹膜后入路活体供肾切取的手术技术及安全性,总结临床经验。方法分析该院2017年1月所实施的3例机器人活体供肾切取术,供受体均为母子关系,供体年龄47~49岁,受体年龄23~29岁,其中取左肾2例,右肾1例,术前供体各项检查及伦理审批完全符合捐献条件,术前血管成像未发现血管变异,1例术中发现一支副肾动脉。结果 3例患者顺利完成供肾切取术,未行中转开放。术后未发生手术相关并发症,手术时间分别为115.0、120.0和140.0 min;术中出血量50、85及110 ml;热缺血时间2.0~4.0 min;3例患者均在术后第3天拨除引流管,术后第5天出院。移植肾均在血流开放后2.0 min内泌尿,术后1周内移植肾功能均恢复正常。结论采用经腹膜后入路行机器人活体供肾切取术是安全有效的,供体术后恢复快,对供肾也无不利影响,但高昂的手术费用制约了其广泛的临床应用。

Continuous Positive Airway Pressure Effectively Alleviates Arrhythmias in Patients with Obstructive Sleep Apnea:Possible Relationship with Counteracting Oxidative Stress

This work is aimed at exploring the clinical efficacy of continuous positive airway pressuie(CPAP)in treatment of patients with arrhythmias combined with obstructive sleep apnea(OSA).Through evaluating serum native thiol,malonaldehyde(MDA)and nicotinamide adenine dinucleotide phosphate oxidase(NADPH oxidase)in these patients and describing the effects on oxidative parameters of CPAP therapy for 3 months,we confirmed the impact of oxidative stress on arrhythmias.A total of 64 patients with OSA combined with arrhythmias were collected from April 2014 to April 2017 with full clinical information.Patients were divided into two groups(paired experiment design):32 patients in group A(control group),who received unchanged anti-arrhythmia treatment and 32 patients in group B,who were subjected to unchanged pharmacological anti-arrhythmia therapy combined with CPAP.OSA related parameters were compared between the two groups after 3-month therapy.And the levels of parameters of oxidative stress in patients were measured before and after CPAP therapy.After 3 months of CPAP therapy,compared with the control group,the percentage of sage N3(NREM 3)and stage R(REM)in total sleep time was significantly increased,while apnea-hypopnea index(AHI)and the Epworth Sleepiness Scale(ESS)score were evidently decreased.Meanwhile,the lowest oxygen saturation(LSpCh)was also elevated after CPAP treatment for 3 months.The CPAP therapy significantly prevented the occurrence of arrhythmias(P<0.05).Both the MDA level and NADPH oxidase levels were significantly lower in the group B than in the group A(P<0.05).But serum native thiol was improved by CPAP treatment(P<0.05).In conclusion,proper use of CPAP therapy provides significant benefits for the treatment of arrhythmia in patients with OSA.

Photocatalysts of Cr Doped TiO2 Film Prepared by Micro Arc Oxidation

A series of Cr doped TiO2 films were prepared by micro arc oxidation （MAO） using an electrolyte of Na3PO4＋K2Cr2O7. X-ray diffraction and scanning electron microscopy revealed that the films mainly consisted of anatase phase with a porous surface morphology. The films have an excellent photocatalytic effect for degradation of methylene blue and decomposition of water under visible light illumination. This arises from the formation of Cr3＋/Cr4＋ and oxygen vacancy energy levels owing to Cr doping. The former reduces the electron-hole recombination chance, while the latter generates a new gap between the conduction band （CB） and valence band （VB） of TiO2, which lowers the photo energy of the excited electron in the VB to the oxygen vacancy states. The mechanisms for film synthesis during the MAO process are also presented.

In situ characterizations of advanced electrode materials for sodium-ion batteries toward high electrochemical performances

Energy storage is an ever-growing global concern due to increased energy needs and resource exhaustion.Sodium-ion batteries(SIBs)have called increasing attention and achieved substantial progress in recent years owing to the abundance and even distribution of Na resources in the crust,and the predicted low cost of the technique.Nevertheless,SIBs still face challenges like lower energy density and inferior cycling stability compared to mature lithium-ion batteries(LIBs).Enhancing the electrochemical performance of SIBs requires an in-deep and comprehensive understanding of the improvement strategies and the underlying reaction mechanism elucidated by in situ techniques.In this review,commonly applied in situ techniques,for instance,transmission electron microscopy(TEM),Raman spectroscopy,X-ray diffraction(XRD),and X-ray absorption near-edge structure(XANES),and their applications on the representative cathode and anode materials with selected samples are summarized.We discuss the merits and demerits of each type of material,strategies to enhance their electrochemical performance,and the applications of in situ characterizations of them during the de/sodiation process to reveal the underlying reaction mechanism for performance improvement.We aim to elucidate the composition/structure-per formance relationship to provide guidelines for rational design and preparation of electrode materials toward high electrochemical performance.

In situ Raman spectroscopy reveals the mechanism of titanium substitution in P2–Na_(2/3)Ni_(1/3)Mn_(2/3)O_(2): Cathode materials for sodium batteries

Layered P2–Na_(2/3)Ni_(1/3)Mn_(2/3)O_2 is a promising cathode material. It exhibits a high capacity and suitable operating voltage and undergoes a phase transition from P2 to O2 during charge/discharge.Researchers have used Ti substitution to improve the cathode, yet the chemical principles that underpin elemental substitution and functional improvement remain unclear. To clarify these principles, we used in situ Raman spectroscopy to monitor chemical changes in P2–Na2/3 Ni1/3 Mn1/3 Ti1/3 O2 and P2–Na_(2/3)Ni_(1/3)Mn_(2/3)O_2 during charge/discharge. Based on the change in the A_(1g) and E_g peaks during charge/discharge, we concluded that Ti substitution compressed the transition metal layer and expanded the planar oxygen layer in the unit cell. Titanium stabilized the P2 phase structure, which improved the cycling stability of P2–NaNMT. Our results provide clear theoretical support for future research on modifying electrodes by elemental substitution.

Analysis on the situation and countermeasures of water resources supply and demand in the cities of small and medium-sized river basins along southeast coast of China-taking Xiamen City as an example

The small and medium-sized river basins along southeast coast of China hold comparatively abundant water resources.However,the rapid resources urbanization in recent years has produced a series of water problems such as deterioration of river water quality,water shortage and exacerbated floods,which have constrained urban economic development.By applying the principle of triple supply-demand equilibrium,this paper focuses on the estimation of levels of water supply and demand in 2030 at different guarantee probabilities,with a case study of Xiamen city.The results show that water shortage and inefficient utilization are main problems in the city,as the future water supply looks daunting,and a water shortage may hit nearly 2×10^(8)m^(3)in an extraordinarily dry year.Based on current water supply-demand gap and its trend,this paper proposes countermeasures and suggestions for developing and utilizing groundwater resources and improving the utilization rate of water resources,which can supply as a reference for other southeast middle-to-small-sized basin cities in terms of sustainable water resources and water environment protection.

Influence of Precursor Powder Fabrication Methods on the Superconducting Properties of Bi-2223 Tapes

Bi-2223 precursor powders are prepared by both oxalate co-precipitation(CP) and spray pyrolysis(SP) methods.The influence of fabrication methods on the superconducting properties of Bi-2223 tapes are systematically studied. Compared to the CP method, SP powder exhibits spherical particle before calcination and smaller particle size after calcinations with more uniform chemical composition, which leads to a lower reaction temperature during calcination process for Bi-2223 tapes. Meanwhile, the non-superconducting phases in SP powder are more uniformly distributed with smaller particle sizes. These features result in finer homogeneity of critical current in large-length of Bi-2223 tape, higher density of filaments and better texture after heat treatment. Therefore,the SP method could be considered as a better route to prepare precursor powder for large-length Bi-2223 tape fabrication.

Heat treatment on phase evolution of Bi-2223 precursor powder prepared by spray pyrolysis method

The phase evolution of Bi-2223 precursor powder prepared by spray pyrolysis method is studied with different heat treatment parameters. The results show that the reaction temperature and phase composition of precursor powder depend on heat treatment atmosphere. Phase assemblage of(Bi,Pb)-2212, AEC, CuO, and small Bi-2201 can be obtained by heat-treated in N2-0.1%O_2 atmosphere. For precursor powder, there is sufficient reaction process at 770℃, and the dimension of Bi-2212 phase increases rapidly with the increase of heat treatment temperature and time. The dimension of AEC phase also increases by extending heat treatment time. As a balance among phase assemblage, dimension of particle and adequate reaction, a reasonable precursor powder can be obtained by heat-treated at 770℃ for 12 h–16 h in N2-0.1%O_2 atmosphere. Critical current of 37-filament Bi-2223 tape is about 120 A, which confirms that these heat treatment parameters are reasonable.

Generation of Gaussian-Shape Single Photons for High Efficiency Quantum Storage

We report the generation of heralded single photons with Gaussian-shape temporal waveforms through the spatial light modulation technique in an atomic ensemble. Both the full width at half maximum and the peak position of the Gaussian waveform can be controlled while the single photon nature holds well. We also analyze the bandwidth of the generated single photons in frequency domain and show how the sidebands of the frequency spectrum are modified by the shape of the temporal waveform. The generated single photons are especially suited for the realization of high efficiency quantum storage based on electromagnetically induced transparency.

Direct identification of the carbonate intermediate during water-gas shift reaction at Pt-NiO interfaces using surface-enhanced Raman spectroscopy

Noble metal-reducible oxide interfaces have been regarded as one of the most active sites for water-gas shift reaction.However,the molecular reaction mechanism of water-gas shift reaction at these interfaces still remains unclear.Herein,water-gas shift reaction at Pt-NiO interfaces has been in-situ explored using surface-enhanced Raman spectroscopy by construction of Au@Pt@NiO nanostructures.Direct Raman spectroscopic evidence demonstrates that water-gas shift reaction at Pt-NiO interfaces proceeds via an associative mechanism with the carbonate species as a key intermediate.The carbonate species is generated through the reaction of adsorbed CO with gaseous water,and its decomposition is a slow step in water-gas shift reaction.Moreover,the Pt-NiO interfaces would promote the formation of this carbonate intermediate,thus leading to a higher activity compared with pure Pt.This spectral information deepens the fundamental understanding of the reaction mechanism of water-gas shift reaction,which would promote the design of more efficient catalysts.

Air target recognition method against ISRJ for radio frequency proximity sensors using chaotic stream encryption

The interrupted-sampling repeater jamming(ISRJ)can cause false targets to the radio-frequency proximity sensors(RFPSs),resulting in a serious decline in the target detection capability of the RFPS.This article proposes a recognition method for RFPSs to identify the false targets caused by ISRJ.The proposed method is realized by assigning a unique identity(ID)to each RFPS,and each ID is a periodically and chaotically encrypted in every pulse period.The processing technique of the received signal is divided into ranging and ID decryption.In the ranging part,a high-resolution range profile(HRRP)can be obtained by performing pulse compression with the binary chaotic sequences.To suppress the noise,the singular value decomposition(SVD)is applied in the preprocessing.Regarding ID decryption,targets and ISRJ can be recognized through the encryption and decryption processes,which are controlled by random keys.An adaptability analysis conducted in terms of the peak-to-side lobe ratio(PSLR)and bit error rate(BER)indicates that the proposed method performs well within a 70-k Hz Doppler shift.A simulation and experimental results show that the proposed method achieves extremely stable target and ISRJ recognition accuracies at different signal-to-noise ratios(SNRs)and jamming-to-signal ratios(JSRs).

Excretion and detection of SARS coronavirus and its nucleic acid from digestive system

AIM： To study whether severe acute respiratory syndrome coronavirus （SARS-CoV） could be excreted from digestive system.METHODS： Cell culture and semi-nested RT-PCR were used to detect SARS-CoV and its RNA from 21 stool and urine samples, and a kind of electropositive filter media particles was used to concentrate the virus in 10 sewage samples from two hospitals receiving SAILS patients in Beijing in China. RESULTS： It was demonstrated that there was no live SARS-CoV in all samples collected, but the RNA of SARS-CoV could be detected in seven stool samples from SARS patients with any one of the symptoms of fever, malaise, cough, or dyspnea, in 10 sewage samples before disinfection and 3 samples after disinfection from the two hospitals. The RNA could not be detected in urine and stool samples from patients recovered from SARS.CONCLUSION： Nucleic acid of SARS-CoV can be excreted through the stool of patients into sewage system, and the possibility of SARS-CoV transmitting through digestive system cannot be excluded.

In situ tracking of the lithiation and sodiation process of disodium terephthalate as anodes for rechargeable batteries by Raman spectroscopy

Organic compounds represent an appealing group of electrode materials for rechargeable batteries due to their merits of biomass,sustainability,environmental friendliness,and processability.Disodium terephthalate(Na_(2)C_(8)H_(4)O_(4),Na_(2)TP),an organic salt with a theoretical capacity of 255 mAh·g^(-1),is electroactive towards both lithium and sodium.However,its electrochemical energy storage(EES)process has not been directly observed via in situ characterization techniques and the underlying mechanisms are still under debate.Herein,in situ Raman spectroscopy was employed to track the de/lithiation and de/sodiation processes of Na2TP.The appearance and then disappearance of the–COOLi Raman band at 1625 cm^(-1) during the de/lithiation,and the increase and then decrease of the–COONa Raman band at 1615 cm^(-1) during the de/sodiation processes of Na2TP elucidate the one-step with the 2Li+or 2Na+transfer mechanism.We also found that the inferior cycling stability of Na2TP as an anode for sodium-ion batteries(SIBs)than lithium-ion batteries(LIBs)could be due to the larger ion radium of Na+than Li+,which results in larger steric resistance and polarization during EES.The Na2TP,therefore,shows greater changes in spectra during de/sodiation than de/lithiation.We expect that our findings could provide a reference for the rational design of organic compounds for EES.