In the process of constructing domain-specific knowledge graphs,the task of relational triple extraction plays a critical role in transforming unstructured text into structured information.Existing relational triple e...In the process of constructing domain-specific knowledge graphs,the task of relational triple extraction plays a critical role in transforming unstructured text into structured information.Existing relational triple extraction models facemultiple challenges when processing domain-specific data,including insufficient utilization of semantic interaction information between entities and relations,difficulties in handling challenging samples,and the scarcity of domain-specific datasets.To address these issues,our study introduces three innovative components:Relation semantic enhancement,data augmentation,and a voting strategy,all designed to significantly improve the model’s performance in tackling domain-specific relational triple extraction tasks.We first propose an innovative attention interaction module.This method significantly enhances the semantic interaction capabilities between entities and relations by integrating semantic information fromrelation labels.Second,we propose a voting strategy that effectively combines the strengths of large languagemodels(LLMs)and fine-tuned small pre-trained language models(SLMs)to reevaluate challenging samples,thereby improving the model’s adaptability in specific domains.Additionally,we explore the use of LLMs for data augmentation,aiming to generate domain-specific datasets to alleviate the scarcity of domain data.Experiments conducted on three domain-specific datasets demonstrate that our model outperforms existing comparative models in several aspects,with F1 scores exceeding the State of the Art models by 2%,1.6%,and 0.6%,respectively,validating the effectiveness and generalizability of our approach.展开更多
With the advancement of new engineering construction,it is urgent to explore the teaching reform of professional courses in the cultivation of landscape architecture professionals in combination with industry needs.In...With the advancement of new engineering construction,it is urgent to explore the teaching reform of professional courses in the cultivation of landscape architecture professionals in combination with industry needs.In order to solve the problems existing in the current Landscape Engineering course,such as traditional teaching methods,insufficient student interest,lack of practical links,and the disconnection between teaching content and industry demand.This study discusses the teaching reform of the Landscape Engineering course based on the CDIO(Conceive-Design-Implement-Operate)concept,aiming at solving the problems mentioned.Through the integration of CDIO mode,the core competencies that students should have are defined,including environmental landscape design and planning,innovative thinking,project management,and so on.The research emphasizes project-driven learning,interdisciplinary knowledge integration,and practical skill training,and puts forward strategies such as teacher training and professional development support to ensure the implementation of the reform.The purpose of the reform was to improve students’professional ability and employment competitiveness,promote the improvement of education quality and the sustainable development of the industry,and exert a positive impact on landscape engineering education and industry progress.展开更多
BACKGROUND: How to induce endogenous neural stem cells (NSCs) to differentiate into needed neural cell types is a hot spot of current researches. OBJECTIVE: To compare differences between fetal bovine serum and Ch...BACKGROUND: How to induce endogenous neural stem cells (NSCs) to differentiate into needed neural cell types is a hot spot of current researches. OBJECTIVE: To compare differences between fetal bovine serum and Chinese herbal formula Naoluoxintong serum supplementation for inducing proliferation and differentiation in rat embryonic NSCs. DESIGN, TIME AND SETTING: An in vitro, serum pharmacology, comparative, observation study was performed from March to September in 2008 at the Laboratory of Neurodegenerative Diseases, College of Life Science in University of Science and Technology of China, the Key Laboratory Breeding Base of Acupuncture Foundation and Technology in Anhui University of Traditional Chinese Medicine, the Anhui Province Key Laboratory of R & D of Chinese Medicine, and at the Level 3 Laboratory of Molecular Biology of the State Administration of Traditional Chinese Medicine. MATERIALS: The Chinese herbal formula Naoluoxintong was produced by Radix Astragali, Radix Notoginseng, Rhizoma Chuanxiong, Scolopendra at Anhui University of Traditional Chinese Medicine. Mouse anti-rat nestin, gliat fibrillary acidic protein, and galactocerebroside monoclonal antibodies, as well as rabbit anti-neuron-specific enolase polyclonal antibody were produced by Chemicon, Billerica, MA, USA. METHODS: Wistar rats aged 3 months were intragastrically infused with Naoluoxintong. Wistar rat embryonic NSCs (passage 8) were induced to proliferate and differentiate using 10% fetal bovine serum, 10% Naoluoxintong serum, and 10% rat serum. MAIN OUTCOME MEASURES: Phenotypic changes in cultured cells were detected using phase contrast microscopy, and cell proliferation and differentiation were observed using immunofluorescence staining. RESULTS: Proliferation and differentiation of embryonic NSCs was induced by three different types of blood serum. Although the differentiation time course with Nao/uoxintongserum was later than with the other two methods, the differentiated cells were morphologically similar to mature neurons to a greater extent. CONCLUSION: Nao/uoxintong serum supplementation induced differentiation of NSCs into neuronal-like cells and stimulated neuronal maturation.展开更多
The Xin'an Medical School began in the Jin Dynasty(266-420),developed in the Song Dynasty(960-1279),prospered in theMing and Qing dynasties(1368-1911),and has been passed down to the modern era.As a school of medi...The Xin'an Medical School began in the Jin Dynasty(266-420),developed in the Song Dynasty(960-1279),prospered in theMing and Qing dynasties(1368-1911),and has been passed down to the modern era.As a school of medicine with distinct regional characteristics,it has contributed to the development of traditional Chinese medicine and exerted farreaching influence,mainly in literature resources,medical theory,clinical application,and spiritual culture.This paper intends to discuss its academic characteristics and contribution to the development of traditional Chinese medicine,focusing on its formation,academic inheritance and innovation,overseas popularization,and integration of Confucianism,Taoism,and Buddhism in medicine.展开更多
Objective:To explore the recent 20 years' herbal administration rules in TCM treatments of ovarian cysts (OCs) based on data mining.Methods:A prescription database for ovarian cysts was established by ACCESS 2007....Objective:To explore the recent 20 years' herbal administration rules in TCM treatments of ovarian cysts (OCs) based on data mining.Methods:A prescription database for ovarian cysts was established by ACCESS 2007.Importing the database into SPSS17.0 and SPSS Modeler14.1.SPSS17.0 was used for descriptive and cluster analyses,while SPSS Modeler14.1 was used for association rules analysis.Results:After screening,363 prescriptions were obtained.The 10 most frequently-used Chinese herbal medicines are Zedoaria (Rhizoma Curcumae),Poria cocos (Poria),Common buried rubber (Rhizoma Sparganii),Red peony root (Radix Paeoniae Rubra),Peach seed (Semen Persicae),Danggui (Radix Angelicae Sinensis),Chinese angelica (Ramulus Cinnamomi),Liquorice root (Radix Glycyrrhizae),Pangolin scales (Squama Manis) and Moutan cortex (Cortex Moutan Radicis);the 5 most common syndromes of OCs are qi stagnation and blood stasis,phlegm and blood stasis,uterine blood stasis,stagnation of liver qi and retention of phlegm and dampness,nearly to 54.26%;In association rules analysis,5 sets of two-herbs association rules were obtained,17 sets of three-herbs association rules were obtained,22 sets of four-herbs association rules were obtained and 4 sets of five-herbs association rules were obtained;By clustering,13 sets of core couplet medicinals were obtained.Conclusion:Medicinal herbs for promoting blood circulation to remove blood stasis,resolve hard lumps,for strengthening the spleen,eliminating phlegm,and relieving liver qi stagnation were highly used in the treatment of OCs;Herbs attributed to the Liver Meridian,the Spleen Meridian and the Heart Meridian were highly used in OCs;The compatibility of herbs for promoting blood circulation to remove blood stasis and resolve hard lumps were highly used;Guizhi Fuling Wan (GFW) was often used and combined with other herbs in the treatment of OCs.展开更多
A great concern has been raised regarding the issue of fluoroquinolones(FQs)in the environment.In this work,the transformation of FQs by commonly used oxidant permanganate(Mn(VII))in the absence and presence of humic ...A great concern has been raised regarding the issue of fluoroquinolones(FQs)in the environment.In this work,the transformation of FQs by commonly used oxidant permanganate(Mn(VII))in the absence and presence of humic acid(HA),ubiquitously existing in aquatic environments,was systematically investigated.Here,the catalytic role of in-situ formed MnO;on Mn(VII)oxidation of FQs depending on solution pH and co-existing substrates was firstly reported.It was interestingly found that HA could appreciably accelerate FQs degradation by Mn(VII)at environmentally relevant pH.HA as a reductant in accelerating FQs by Mn(VII)oxidation was distinctly elucidated for the first time,where MnO;in situ formed from the reduction of Mn(VII)by HA served as a catalyst.Similar products were observed in the presence versus absence of HA.Considering that the accelerating role of HA was related to its reducing ability,an activation method based on Mn(VII)and reductant(i.e.,Fe(II),Mn(II)and(bi)sulfite)was proposed,which exhibited considerable potential for application in the treatment of FQs contaminated water.展开更多
Resource planning is becoming an increasingly important and timely problem for cloud users.As more Web services are moved to the cloud,minimizing network usage is often a key driver of cost control.Most existing appro...Resource planning is becoming an increasingly important and timely problem for cloud users.As more Web services are moved to the cloud,minimizing network usage is often a key driver of cost control.Most existing approaches focus on resources such as CPU,memory,and disk I/O.In particular,CPU receives the most attention from researchers,but the bandwidth is somehow neglected.It is challenging to predict the network throughput of modem Web services,due to the factors of diverse and complex response,evolving Web services,and complex network transportation.In this paper,we propose a methodology of what-if analysis,named Log2Sim,to plan the bandwidth resource of Web services.Log2Sim uses a lightweight workload model to describe user behavior,an automated mining approach to obtain characteristics of workloads and responses from massive Web logs,and traffic-aware simulations to predict the impact on the bandwidth consumption and the response time in changing contexts.We use a real-life Web system and a classic benchmark to evaluate Log2Sim in multiple scenarios.The evaluation result shows that Log2Sim has good performance in the prediction of bandwidth consumption.The average relative error is 2%for the benchmark and 8% for the real-life system.As for the response time,Log2Sim cannot produce accurate predictions for every single service request,but the simulation results always show similar trends on average response time with the increase of workloads in different changing contexts.It can provide sufficient information for the system administrator in proactive bandwidth planning.展开更多
基金Science and Technology Innovation 2030-Major Project of“New Generation Artificial Intelligence”granted by Ministry of Science and Technology,Grant Number 2020AAA0109300.
文摘In the process of constructing domain-specific knowledge graphs,the task of relational triple extraction plays a critical role in transforming unstructured text into structured information.Existing relational triple extraction models facemultiple challenges when processing domain-specific data,including insufficient utilization of semantic interaction information between entities and relations,difficulties in handling challenging samples,and the scarcity of domain-specific datasets.To address these issues,our study introduces three innovative components:Relation semantic enhancement,data augmentation,and a voting strategy,all designed to significantly improve the model’s performance in tackling domain-specific relational triple extraction tasks.We first propose an innovative attention interaction module.This method significantly enhances the semantic interaction capabilities between entities and relations by integrating semantic information fromrelation labels.Second,we propose a voting strategy that effectively combines the strengths of large languagemodels(LLMs)and fine-tuned small pre-trained language models(SLMs)to reevaluate challenging samples,thereby improving the model’s adaptability in specific domains.Additionally,we explore the use of LLMs for data augmentation,aiming to generate domain-specific datasets to alleviate the scarcity of domain data.Experiments conducted on three domain-specific datasets demonstrate that our model outperforms existing comparative models in several aspects,with F1 scores exceeding the State of the Art models by 2%,1.6%,and 0.6%,respectively,validating the effectiveness and generalizability of our approach.
基金The 2023 Inner Mongolia Agricultural University Offline First-Class Undergraduate Courses Project(Inner Agricultural University Education No.[2023]13,RC2400001250)。
文摘With the advancement of new engineering construction,it is urgent to explore the teaching reform of professional courses in the cultivation of landscape architecture professionals in combination with industry needs.In order to solve the problems existing in the current Landscape Engineering course,such as traditional teaching methods,insufficient student interest,lack of practical links,and the disconnection between teaching content and industry demand.This study discusses the teaching reform of the Landscape Engineering course based on the CDIO(Conceive-Design-Implement-Operate)concept,aiming at solving the problems mentioned.Through the integration of CDIO mode,the core competencies that students should have are defined,including environmental landscape design and planning,innovative thinking,project management,and so on.The research emphasizes project-driven learning,interdisciplinary knowledge integration,and practical skill training,and puts forward strategies such as teacher training and professional development support to ensure the implementation of the reform.The purpose of the reform was to improve students’professional ability and employment competitiveness,promote the improvement of education quality and the sustainable development of the industry,and exert a positive impact on landscape engineering education and industry progress.
基金National Natural Science Foundation of China,No.30873293,30672592Natural Science Foundation of Anhui Province,No.070413125,050430904+1 种基金Dr.Yafang Lü Graduate Research Foundation of Beijing University of Chinese Medicine,No.2004Natural Science Research Fund of Education Department of Anhui Province,No.2006KJ382B
文摘BACKGROUND: How to induce endogenous neural stem cells (NSCs) to differentiate into needed neural cell types is a hot spot of current researches. OBJECTIVE: To compare differences between fetal bovine serum and Chinese herbal formula Naoluoxintong serum supplementation for inducing proliferation and differentiation in rat embryonic NSCs. DESIGN, TIME AND SETTING: An in vitro, serum pharmacology, comparative, observation study was performed from March to September in 2008 at the Laboratory of Neurodegenerative Diseases, College of Life Science in University of Science and Technology of China, the Key Laboratory Breeding Base of Acupuncture Foundation and Technology in Anhui University of Traditional Chinese Medicine, the Anhui Province Key Laboratory of R & D of Chinese Medicine, and at the Level 3 Laboratory of Molecular Biology of the State Administration of Traditional Chinese Medicine. MATERIALS: The Chinese herbal formula Naoluoxintong was produced by Radix Astragali, Radix Notoginseng, Rhizoma Chuanxiong, Scolopendra at Anhui University of Traditional Chinese Medicine. Mouse anti-rat nestin, gliat fibrillary acidic protein, and galactocerebroside monoclonal antibodies, as well as rabbit anti-neuron-specific enolase polyclonal antibody were produced by Chemicon, Billerica, MA, USA. METHODS: Wistar rats aged 3 months were intragastrically infused with Naoluoxintong. Wistar rat embryonic NSCs (passage 8) were induced to proliferate and differentiate using 10% fetal bovine serum, 10% Naoluoxintong serum, and 10% rat serum. MAIN OUTCOME MEASURES: Phenotypic changes in cultured cells were detected using phase contrast microscopy, and cell proliferation and differentiation were observed using immunofluorescence staining. RESULTS: Proliferation and differentiation of embryonic NSCs was induced by three different types of blood serum. Although the differentiation time course with Nao/uoxintongserum was later than with the other two methods, the differentiated cells were morphologically similar to mature neurons to a greater extent. CONCLUSION: Nao/uoxintong serum supplementation induced differentiation of NSCs into neuronal-like cells and stimulated neuronal maturation.
文摘The Xin'an Medical School began in the Jin Dynasty(266-420),developed in the Song Dynasty(960-1279),prospered in theMing and Qing dynasties(1368-1911),and has been passed down to the modern era.As a school of medicine with distinct regional characteristics,it has contributed to the development of traditional Chinese medicine and exerted farreaching influence,mainly in literature resources,medical theory,clinical application,and spiritual culture.This paper intends to discuss its academic characteristics and contribution to the development of traditional Chinese medicine,focusing on its formation,academic inheritance and innovation,overseas popularization,and integration of Confucianism,Taoism,and Buddhism in medicine.
文摘Objective:To explore the recent 20 years' herbal administration rules in TCM treatments of ovarian cysts (OCs) based on data mining.Methods:A prescription database for ovarian cysts was established by ACCESS 2007.Importing the database into SPSS17.0 and SPSS Modeler14.1.SPSS17.0 was used for descriptive and cluster analyses,while SPSS Modeler14.1 was used for association rules analysis.Results:After screening,363 prescriptions were obtained.The 10 most frequently-used Chinese herbal medicines are Zedoaria (Rhizoma Curcumae),Poria cocos (Poria),Common buried rubber (Rhizoma Sparganii),Red peony root (Radix Paeoniae Rubra),Peach seed (Semen Persicae),Danggui (Radix Angelicae Sinensis),Chinese angelica (Ramulus Cinnamomi),Liquorice root (Radix Glycyrrhizae),Pangolin scales (Squama Manis) and Moutan cortex (Cortex Moutan Radicis);the 5 most common syndromes of OCs are qi stagnation and blood stasis,phlegm and blood stasis,uterine blood stasis,stagnation of liver qi and retention of phlegm and dampness,nearly to 54.26%;In association rules analysis,5 sets of two-herbs association rules were obtained,17 sets of three-herbs association rules were obtained,22 sets of four-herbs association rules were obtained and 4 sets of five-herbs association rules were obtained;By clustering,13 sets of core couplet medicinals were obtained.Conclusion:Medicinal herbs for promoting blood circulation to remove blood stasis,resolve hard lumps,for strengthening the spleen,eliminating phlegm,and relieving liver qi stagnation were highly used in the treatment of OCs;Herbs attributed to the Liver Meridian,the Spleen Meridian and the Heart Meridian were highly used in OCs;The compatibility of herbs for promoting blood circulation to remove blood stasis and resolve hard lumps were highly used;Guizhi Fuling Wan (GFW) was often used and combined with other herbs in the treatment of OCs.
基金supported by the National Natural Science Foundation of China(No.52000038)the Program for Guangdong Introducing Innovative and Entrepreneurial Teams(No.2019ZT08L213)+3 种基金the Key Special Project for Introduced Talents Team of Southern Marine Science and Engineering Guangdong Laboratory(Guangzhou)(No.GML2019ZD0403)the Guangzhou Science and Technology Project(No.202002030093)the Guangdong Basic and Applied Basic Research Foundation(Nos.2019A1515110321 and 2019A1515011947)the Guangdong Natural Science FoundationOutstanding Youth Program(No.2019B151502023)。
文摘A great concern has been raised regarding the issue of fluoroquinolones(FQs)in the environment.In this work,the transformation of FQs by commonly used oxidant permanganate(Mn(VII))in the absence and presence of humic acid(HA),ubiquitously existing in aquatic environments,was systematically investigated.Here,the catalytic role of in-situ formed MnO;on Mn(VII)oxidation of FQs depending on solution pH and co-existing substrates was firstly reported.It was interestingly found that HA could appreciably accelerate FQs degradation by Mn(VII)at environmentally relevant pH.HA as a reductant in accelerating FQs by Mn(VII)oxidation was distinctly elucidated for the first time,where MnO;in situ formed from the reduction of Mn(VII)by HA served as a catalyst.Similar products were observed in the presence versus absence of HA.Considering that the accelerating role of HA was related to its reducing ability,an activation method based on Mn(VII)and reductant(i.e.,Fe(II),Mn(II)and(bi)sulfite)was proposed,which exhibited considerable potential for application in the treatment of FQs contaminated water.
基金This work was supported by the National Key Research and Development Program of China(2018YFB1003302)the National Natural Science Foundation of China(Grant No.61472241).
文摘Resource planning is becoming an increasingly important and timely problem for cloud users.As more Web services are moved to the cloud,minimizing network usage is often a key driver of cost control.Most existing approaches focus on resources such as CPU,memory,and disk I/O.In particular,CPU receives the most attention from researchers,but the bandwidth is somehow neglected.It is challenging to predict the network throughput of modem Web services,due to the factors of diverse and complex response,evolving Web services,and complex network transportation.In this paper,we propose a methodology of what-if analysis,named Log2Sim,to plan the bandwidth resource of Web services.Log2Sim uses a lightweight workload model to describe user behavior,an automated mining approach to obtain characteristics of workloads and responses from massive Web logs,and traffic-aware simulations to predict the impact on the bandwidth consumption and the response time in changing contexts.We use a real-life Web system and a classic benchmark to evaluate Log2Sim in multiple scenarios.The evaluation result shows that Log2Sim has good performance in the prediction of bandwidth consumption.The average relative error is 2%for the benchmark and 8% for the real-life system.As for the response time,Log2Sim cannot produce accurate predictions for every single service request,but the simulation results always show similar trends on average response time with the increase of workloads in different changing contexts.It can provide sufficient information for the system administrator in proactive bandwidth planning.