Analysis and Prediction of Effect of Turning Marks Diffraction on Image Quality of Optical System

Single-point diamond turning (SPDT) is widely used in the machining of infrared materials and metal-based mirrors. Diamond tips can scratch material, replicate the shape of the tip, and create annular turning marks on optical surfaces, which can have unpredictable adverse effects on imaging. In order to predict the effect of turning marks diffraction on the degradation of imaging quality, a model of the influence of SPDT processing parameters on the reduction of system imaging MTF under the influence of ideal grating turning marks diffraction was established. The results show that the depth of the turning mark will lead to the decline of MTF, especially the low frequency information. Finally, a method is proposed to reduce the effect of turning marks diffraction through changing the processing parameters. .

Characteristic Analysis of Off-Axis Meta-Lens

Meta-lens are a new type of planar optical element that can flexibly manipulate the phase, polarization and amplitude of the beam, and are currently receiving a great deal of attention as they are easier to process and manufacture. Off-axis meta-lens are a special type of meta-lens with a certain degree of dispersion that can be used as a beam-splitting element, providing a unique and feasible way to realize micro-miniature instruments. We analyze the effects of different numerical apertures and off-axis angles on the spectral resolution, focusing efficiency and simulation results of off-axis meta-lens to provide ideas for subsequent research and application of off-axis meta-lens. A number of off-axis meta-lens with parameters NA = 0.408 α = 13°, NA = 0.18 α = 13° and NA = 0.408 α = 20° were simulated through Lumerical software. The results show that the off-axis angle is related to the resolution;the larger the angle, the better the spectral resolution but the lower the focusing efficiency;when the numerical aperture is smaller, the smaller the coverage of the phase distribution, which will lead to a larger deviation between simulation and theory. The designer needs to balance the numerical aperture, off-axis angle and other parameters reasonably according to the requirements in order to achieve the desired effect. The findings of this study have important reference values for the theoretical analysis of off-axis meta-lens and the design of parameters in practical applications. .

炫彩咖喱——姜黄素的颜色变幻及应用

以食品调料咖喱的主要成分姜黄素为原料,通过系统优化其酸碱变色、光解、离子识别及溶剂化变色性质等,由浅入深面向社会公众及幼小群体、中学生、本科生设计了一系列科普实验。本项目从身边常见的分子入手,向公众阐述表面现象背后的化学原理,生动阐释化学源于生活、造福生活的理念,提升民众科学素养,激发探索热情。

Apolipoprotein C1 promotes tumor progression in gastric cancer

Background:Gastric cancer(GC)is a malignancy with the worst prognosis that seriously threatens human health,especially in East Asia.Apolipoprotein C1(apoc1)belongs to the apolipoprotein family.In addition,apoc1 has been associated with various tumors.However,its role in GC remains unclear.Methods:Firstly,we quantified its expression in GC and adjacent tumor tissues,using The Cancer Genome Atlas(TCGA).Next,we assessed cell invasion and migration abilities.Finally,we revealed the role of apoc1 in the tumor microenvironment(TME),immune cell infiltration and drug sensitivity.Results:Firstly,in TCGA database,it has been shown that elevated expression of apoc1 was identified in various cancers,including GC,then we found that high expression of apoc1 was significantly correlated with poor prognosis in GC.Histologically,apoc1 expression is proportional to grade,cancer stage,and T stage.The experimental results showed that apoc1 promoted cell invasion and migration.Then GO,KEGG,and GSEA pathway analyses indicated that apoc1 may be involved in the WNT pathway and immune regulation.Furthermore,we found out the tumor-infiltrating immune cells related to apoc1 in the tumor microenvironment(TME)using TIMER.Finally,we investigated the correlation between apoc1 expression and drug sensitivity,PD-1 and CTLA-4 therapy.Conclusions:These results suggest that apoc1 participates in the evolution of GC,and may represent a potential target for detection and immunotherapy in GC.

Smad2 mediates Activin/Nodal signaling in mesendoderm differentiation of mouse embryonic stem cells

Although Activin/Nodal signaling regulates pluripotency of human embryonic stem （ES） cells, how this signaling acts in mouse ES cells remains largely unclear. To investigate this, we confirmed that mouse ES cells possess active Smad2-mediated Activin/Nodal signaling and found that Smad2-mediated Activin/Nodal signaling is dispensable for self-renewal maintenance but is required for proper differentiation toward the mesendoderm lineage. To gain insights into the underlying mechanisms, Smad2-associated genes were identified by genome-wide chromatin immu- noprecipitation-chip analysis. The results showed that there is a transcriptional correlation between Smad2 binding and Activin/Nodal signaling modulation, and that the development-related genes were enriched among the Smad2- bound targets. We further identified Tapbp as a key player in mesendoderm differentiation of mouse ES cells acting downstream of the Activin/Nodal-Smad2 pathway. Taken together, our findings suggest that Smad2-mediated Activin/Nodal signaling orchestrates mesendoderm lineage commitment of mouse ES cells through direct modulation of corresponding developmental regulator expression.

An Improved Graphics Processing Unit Acceleration Approach for Three-Dimensional Structural Topology Optimization Using the Element-Free Galerkin Method

We proposed an improved graphics processing unit(GPU)acceleration approach for three-dimensional structural topology optimization using the element-free Galerkin(EFG)method.This method can effectively eliminate the race condition under parallelization.We established a structural topology optimization model by combining the EFG method and the solid isotropic microstructures with penalization model.We explored the GPU parallel algorithm of assembling stiffness matrix,solving discrete equation,analyzing sensitivity,and updating design variables in detail.We also proposed a node pair-wise method for assembling the stiffnessmatrix and a node-wise method for sensitivity analysis to eliminate race conditions during the parallelization.Furthermore,we investigated the effects of the thread block size,the number of degrees of freedom,and the convergence error of preconditioned conjugate gradient(PCG)on GPU computing performance.Finally,the results of the three numerical examples demonstrated the validity of the proposed approach and showed the significant acceleration of structural topology optimization.To save the cost of optimization calculation,we proposed the appropriate thread block size and the convergence error of the PCG method.

Using SELDI-TOF-MS technology for screening serum markers of hepatic carcinoma in rats

Objective： To identify potential serum markers of hepatic carcinoma in rats through Surface-Enhanced Laser Desorption Ionization-Time of Flight-Mass Spectrometry（SELDI-TOF-MS） Technology. Methods： A rat model of hepatic carcinoma was established. The serum samples of hepatic carcinoma and normal rats were analyzed via SELDI-TOF-MS Technology. The changes of the serum protein fingerprint patterns were observed between the experimental group of hepatic carcinoma and the controls. The analysis was conducted by statistical software-Biomarker Wizard. Results： Fifty-six protein peaks in the serums were found. Within m/z 0-20 000, the protein peaks of rrdz 1158, 8 835 and 15 302 of hepatic carcinoma serums were obviously higher in the rat models compared with those in the controls（P 〈 0.01）. Conclusion： Three peaks were considered as potential biomarkers according to the serum protein fingerprint patterns of the hepatic carcinoma group and the control group.

Mathematical model of solidification for round CC billets

A coupled mathematical model was established to simulate the whole solidification process of round billet continuous casting for wheel steel using piecewise linear functions of heat flux density in the mold, the secondary cooling zone and the with- drawing-straightening zone. The calculated results were consistent with the measured data showing that the model accords with the practice. The surface temperature and the solidified shell thickness of round billets are more strongly influenced by casting speed than by casting temperature. The holding zones have effect on surface temperature, which is more obvious for the 450 mm round billet. The relation between casting temperature/speed and solidification end is expressed as a linear function. The solidification end is located after straightening machine.

QTL mapping by whole genome re-sequencing and analysis of candidate genes for salt tolerance in linseed(Linum usitatissmum L.)

Soil salinization is detrimental to the growth and development of flax and ultimately leads to a decrease in yield.However,the molecular mechanism of linseed response to salt stress is still unclear.In this study,a salt-tolerant(ST)linseed variety STS and a salt-sensitive(SS)variety DYM were selected as experiment materials.Bulk segregation analysis and whole-genome resequencing technologies were performed to map salt tolerance quantitative trait loci(QTL).A total of 38,625 QTL loci were identified.Fifteen genes(which were not annotated in the reference genome)were identified within a 2.597 Mb region in chromosome 1.Two salt tolerance candidate genes Lus.o.m.scaffold91.141 and Lus.o.m.Scaffold1.14 encoding WD40 and cytochrome P450 were identified by predicting protein functions.Previous studies showed that WD40 and cytochrome P450 could significantly improve plant salt stress tolerance.In this paper,results showed that Lus.o.m.scaffold91.141 and Lus.o.m.Scaffold1.14 might be involved in response to salt stress in lineseed.The fine mapping and functional analysis of these genes provide a molecular breeding basis for the genetic improvement of high salt-tolerant linseed varieties.

Seed filling dynamic traits of oil flax in response to nitrogen and phosphorus

Crop yield is primarily seed-filling-limited in production system under field conditions.This study was aimed to determine whether seed filling traits of oil flax(Linum usitatissimum L.)could be controlled by phosphorus(P),nitrogen(N),and phosphorus and nitrogen(NP)supply.Effects on seed filling traits were investigated in 2 years including capsule diameter,capsule height,capsule dry matter(DM),seed DM per capsule,pericarp DM per capsule,protein content and oil content.DM translocation from pericarps to seed,translocation efficiency,and contribution of photoassimilates during seed filling period were also detected.In a randomized complete block design,cultivar'Longyaza 1'was grown under P(33 kg P/ha),N(75 kg N/ha),and NP(33 kg P/ha and 75 kg N/ha)along with a zerofertilizer(CK)treatment in 2013 and 2014.Results suggested that DM translocation efficiency and contribution efficiency increased to different extent due to P,N or NP application.At 42 DAA(days after anthesis),seed DM per capsule reached the greatest,while protein content and pericarp DM obtained the least level.However,the highest oil content was detected at 35 DAA.A significant positive linear relationship was observed between seed DM,capsule DM and DM translocation in both years.Protein content showed inconsistent relation with oil content.The results indicated that appropriate N and P management could be an effective approach to increase oil flax production.

中国畜产品半年度报告

2008年1月下旬和2月上旬之间，中国出现了50年不遇的大雪，中国的畜牧生产因此遭受打击。同时，猪肉的投入成本和产品价格均处高位。谷物和油料作物价格走高以及肉品供应短缺的情况看来在整个2008年当中都不会改变。

Cognitive malingering assessed using event-related potential P300 evoked by the old-new task in the oddball paradigm

The P300, an endogenous subcomponent of the event-related potential, is thought to reflect cognitive processes. The event-related potential evoked by the old-new memory recognition task in the oddball paradigm is suitable for examining the neural processes involved in malingered neurocognitive deficits. Forty-four undergraduates were randomly assigned to a simulated malingering group and a truth-telling group, Another 22 patients with head injudes were enrolled as a control group. All participants completed the old-new memory recognition task in the oddball paradigm. The mean P300 amplitude of the simulated malingering group was significantly reduced compared with the truth-telling group （P 〈 0.01）, but was increased compared with the control group （P〈 0.01）. These results revealed that the P300, evoked by the old-new memory recognition task of the oddball paradigm, may be a helpful indicator for determining cognitive malingering.

Caveolin1在乳腺癌中的作用及其表观遗传调控机制

乳腺癌是女性最常见的恶性肿瘤,严重威胁女性的生命和健康。其发病机制尚未完全明确,尽管临床治疗疗效显著但依然困难重重。质膜微囊Caveolea是一种存在于细胞表面,由Caveolin蛋白覆盖的质膜内陷,其在细胞中发挥着物质转运和信号转导等一系列重要功能。作为Caveolea的重要组成部分,Caveolin1参与调控内吞、信号转导、脂质运输和储存、细胞运动侵袭等各种生理活动。本文重点阐述Caveolin1在乳腺癌发生发展中的作用及其表观遗传调控机制。

Application of Fingerprint Combined with QAMS in Quality Evaluation of Zhenrongdan Mixture

[Objectives] The research aimed to evaluate the quality of Zhenrongdan mixture by fingerprint combining QAMS. [Methods] The quality evaluation method was established and validated with echinacoside as internal reference to determine the contents of other components(ferulic acid, salvianolic acid B, and icariin) according to the relative correction factor. The accuracy and feasibility of QAMS were evaluated by comparison on the results between the measured value and calculation value by external standard method and QAMS. [Results] A common pattern of characteristic fingerprint of Zhenrongdan mixture by HPLC was established. Thirteen common peaks were identified, and they account for 91% of the total peak area, and four components were verified in five batches of Zhenrongdan mixture. Good similarities with correlation coefficients higher than 0.99 were found in the fingerprints. There was no significant difference between the quantitative results of the four ingredients in the five batches by external standard method and QAMS. [Conclusions] The method of fingerprint combined with QAMS could be used for the quality control of multiple components determination and fingerprint chromatography for Zhenrongdan mixture.

Secoisolariciresinol diglycoside(SDG)lignan content of oil flax:Genotypic and environmental variations and association with other traits

The secoisolariciresinol diglycoside(SDG)lignan of oil flax(Linum usitatissimum L.)is influenced by genotype,environment and the interaction of genotype×environment.This field study was conducted to investigate the effects of genotype and environment on the SDG lignan content,six genotypes(Longya 8,Zhangya 2,Linxiabai,Shandanbai,Gaolanbai,and DYMS)were sown under eight locations(Hohhot,Datong,Minle,Yili,Shuangta,Jingtai,Guyuan,and Zhangjiakou)in 2014 and 2015 in China.The experimental design was a randomized complete block with three replications.Results showed that Longya 8 had the highest SDG lignan content(7.27mg/g)and Shandanbai had the lowest(4.71 mg/g)across 16 environments.The SDG lignan content ranged from 4.70 mg/g at Datong to 7.74 mg/g at Minle Research Station.In the present study,the results indicated that differences among genotypes in SDG lignan content accounted for 51.38%variation of the total variation and environments accounted for 44.40%variation of the total variation.Moreover,we found that the altitude had a positive effect on SDG lignan content of flaxseed,presumably owing to differences in temperature,humidity,sunshine time,etc.These results indicated that the SDG lignan content was genetically controlled,and was also to be influenced by environmental conditions,especially altitude.

Agricultural Traceable and Marketing System Based on iOS-Platform and Wireless Sensor Network

With the rapid development of Things of Internet and its related technologies such as Wireless Sensor Network and remote access system development, its application on agricultural and farming domain has become a new research direction. This paper discusses a practical and efficient system by applying mobile software development technologies and ZigBee communication network. To achieve a compact and flexible iOS-based client, this study takes advantage of Model-View-ViewModel pattern as well as Client/Server style. Several encryption technologies such as Message Digest algorithm and Rivest Shamir Adleman algorithm are combined to ensure information security. Compared to the common portable marketing system, the proposed system also provides accurate growth information which is collected by wireless sensor network, and proposes a more flexible design pattern for mobile client hence obtaining a better performance on iOS devices.

Content Determination of Cistanches Herba in Zhenrongdan Mixture by HPLC

[Objectives]To establish a HPLC-UV method for the determination of Cistanches Herba in Zhenrongdan mixture.[Methods]According to the content determination method of Cistanches Herba in the 2020 edition of Chinese Pharmacopoeia,using HPLC-UV method,the content determination method of Cistanches Herba in Zhenrongdan mixture was established,and the content of echinacoside was determined.The related chromatographic conditions were explored,and the methodological investigation was carried out.[Results]The chromatographic conditions were determined as follows:octadecylsilane bonded silica gel as filler(C_(18));80%acetonitrile solution(containing 0.2%phosphoric acid)-0.2%phosphoric acid aqueous solution(15∶85)as mobile phase;detection wavelength was 330 nm.The number of theoretical plates should not be less than 3000 according to the peak of echinacoside.The methodological investigation showed that the method had better precision,accuracy and repeatability.Under the conditions of this study,echinacoside had better linear relationship in the range of 74.9-1498 ng,and the average recovery was 99.1%,RSD=0.5%(n=6).[Conclusions]A method for the determination of Cistanches Herba in Zhenrongdan mixture by HPLC-UV was established.The method is sensitive,rapid,accurate and suitable for the determination of Cistanches Herba in Zhenrongdan mixture.

Quality Standard of Haleniae Herba

[Objectives]The research aimed to establish qualitative and quantitative detection methods of Haleniae Herba,and provide basis for improving its quality standard.[Methods]Using thin-layer chromatography(TLC),qualitative identification of Haleniae Herba was conducted.Using high-performance liquid chromatography,luteolin content of Haleniae Herba was determined.[Results]TLC identification method had good specificity,with clear spots and good degree of separation,and reference medicinal material of Haleniae Herba was prepared.Content determination results displayed that luteolin had good linear relationship in the range of 0.088-1.760μg.The RSD values of precision,repeatability,stability and sample recovery of the instrument met the requirements.[Conclusions]The established method is simple and reproducible,and can be used for the quality control of Haleniae Herba.

Application of Digital Technology in Color Test of Compound Lonicera Granules

[Objectives]The research aimed to study application of digital technique in color test of Compound Lonicera Granules.[Methods]A method of color identification of Compound Lonicera Granules based on digital technology was proposed,and the"four-point collection method of color data"was summarized through experiments.[Results]The method was used to test color of 168 batches of Compound Lonicera Granules,and it was found that the method had the advantages of fast speed,high accuracy and good repeatability.[Conclusions]The method was used to test color of 168 batches of Compound Lonicera Granules,and it was found that the method had the advantages of fast speed,high accuracy and good repeatability.

The underappreciated role of fugitive VOCs in ozone formation and health risk assessment emitted from seven typical industries in China

Fugitive emission from industrial sources may result in ozone formation and health risk,while the exact contribution of this source remains incompletely understood.In this study,emission characteristics,ozone formation potential(OFP)and health risk of fugitive VOCs in7 representative industries were investigated.Chemical material industry was the dominant contributor to VOCs of fugitive emission in comparison with other industries.The OFP of VOCs from fugitive emission was in the range of 1.45×10^(3)-3.98×10^(5)μg/m^(3),with a higher value than that of organized emission in seven industries except for the coking industry and the chemical material industry,suggesting that fugitive VOCs should be taken into account while developing control strategies.Acetaldehyde,m,p-xylene,n-nonane,ethylene,vinyl chloridethe and other high OFP-contributing species were the major reactive species that should be targeted.Health risk assessment investigated non-cancer and cancer risks of fugitive VOCs in 7 industries were all above safe level(HR>1 and LCR>1×10^(-4)),posing remarkable health threats to human health.OVOCs were the main contributor to non-cancer risk,while halohydrocarbons and aromatics contributed most to cancer risks,posing remarkable health threat on human health.Our findings highlighted the contribution of fugitive VOCs on ozone formation and health risk was underestimated,indicating which should be considered in emission control strategies of industrial sources.