Non-contact remote sensing techniques,such as terrestrial laser scanning(TLS)and unmanned aerial vehicle(UAV)photogrammetry,have been globally applied for landslide monitoring in high and steep mountainous areas.These...Non-contact remote sensing techniques,such as terrestrial laser scanning(TLS)and unmanned aerial vehicle(UAV)photogrammetry,have been globally applied for landslide monitoring in high and steep mountainous areas.These techniques acquire terrain data and enable ground deformation monitoring.However,practical application of these technologies still faces many difficulties due to complex terrain,limited access and dense vegetation.For instance,monitoring high and steep slopes can obstruct the TLS sightline,and the accuracy of the UAV model may be compromised by absence of ground control points(GCPs).This paper proposes a TLS-and UAV-based method for monitoring landslide deformation in high mountain valleys using traditional real-time kinematics(RTK)-based control points(RCPs),low-precision TLS-based control points(TCPs)and assumed control points(ACPs)to achieve high-precision surface deformation analysis under obstructed vision and impassable conditions.The effects of GCP accuracy,GCP quantity and automatic tie point(ATP)quantity on the accuracy of UAV modeling and surface deformation analysis were comprehensively analyzed.The results show that,the proposed method allows for the monitoring accuracy of landslides to exceed the accuracy of the GCPs themselves by adding additional low-accuracy GCPs.The proposed method was implemented for monitoring the Xinhua landslide in Baoxing County,China,and was validated against data from multiple sources.展开更多
Water-induced landslides in hydropower reservoirs pose a great threat to both project operation and human life.This paper examines three large reservoirs in Sichuan Province,China.Field surveys,site monitoring data an...Water-induced landslides in hydropower reservoirs pose a great threat to both project operation and human life.This paper examines three large reservoirs in Sichuan Province,China.Field surveys,site monitoring data analyses and numerical simulations are used to analyze the spatial distribution and failure mechanisms of water-induced landslides in reservoir areas.First,the general rules of landslide development in the reservoir area are summarized.The first rule is that most of the landslides have rear edge elevations of 100e500 m above the normal water level of the reservoir,with volumes in the range of 106 e107 m 3.When the volume exceeds a certain amount,the number of sites at which the landscape can withstand landslides is greatly reduced.Landslide hazards mainly occur in the middle section of the reservoir and less in the annex of the dam site and the latter half of the reservoir area.The second rule is that sedimentary rocks such as sandstone are more prone to landslide hazards than other lithologies.Then,the failure mechanism of changes in the water level that reduces the stability of the slope composed of different geomaterials is analyzed by a proposed slope stability framework that considers displacement and is discussed with the monitoring results.Permeability is an essential parameter for understanding the diametrically opposed deformation behavior of landslides experiencing filling-drawdown cycles during operation.This study seeks to provide inspiration to subsequent researchers,as well as guidance to technicians,on landslide prevention and control in reservoir areas.展开更多
Local geometric information and discontinuity features are key aspects of the analysis of the evolution and failure mechanisms of unstable rock blocks in rock tunnels.This study demonstrates the integration of terrest...Local geometric information and discontinuity features are key aspects of the analysis of the evolution and failure mechanisms of unstable rock blocks in rock tunnels.This study demonstrates the integration of terrestrial laser scanning(TLS)with distinct element method for rock mass characterization and stability analysis in tunnels.TLS records detailed geometric information of the surrounding rock mass by scanning and collecting the positions of millions of rock surface points without contact.By conducting a fuzzy K-means method,a discontinuity automatic identification algorithm was developed,and a method for obtaining the geometric parameters of discontinuities was proposed.This method permits the user to visually identify each discontinuity and acquire its spatial distribution features(e.g.occurrences,spac-ings,trace lengths)in great detail.Compared with hand mapping in conventional geotechnical surveys,the geometric information of discontinuities obtained by this approach is more accurate and the iden-tification is more efficient.Then,a discrete fracture network with the same statistical characteristics as the actual discontinuities was generated with the distinct element method,and a representative nu-merical model of the jointed surrounding rock mass was established.By means of numerical simulation,potential unstable rock blocks were assessed,and failure mechanisms were analyzed.This method was applied to detection and assessment of unstable rock blocks in the spillway and sand flushing tunnel of the Hongshiyan hydropower project after a collapse.The results show that the noncontact detection of blocks was more labor-saving with lower safety risks compared with manual surveys,and the stability assessment was more reliable since the numerical model built by this method was more consistent with the distribution characteristics of actual joints.This study can provide a reference for geological survey and unstable rock block hazard mitigation in tunnels subjected to complex geology and active rockfalls.展开更多
As a traditional herbal medicine,the major alkaloids in Uncaria rhynchophylla have been proven to have blood pressure-lowering and sedative effects.It is essential to develop an effective method for the determination ...As a traditional herbal medicine,the major alkaloids in Uncaria rhynchophylla have been proven to have blood pressure-lowering and sedative effects.It is essential to develop an effective method for the determination of the major alkaloids in U.rhynchophylla.In this research,a rapid quantitative analysis involving multi-components analysis by a single marker strategy coupled with core-shell column HPLC was adopted to analyse four alkaloids(corynoxeine,isocorynoxeine,isorhynchophylline,rhynchophylline)in U.rhynchophylla.Isorhynchophylline was selected as the internal reference substance,the content of which was determined by the traditional external standard method.Relative correction factors(RCF)between isorhynchophylline and the other three alkaloids were calculated respectively.The results showed that the QAMS method had good robustness under different HPLC instruments.Nineteen batches of U.rhynchophylla were tested.No significant difference was observed between the results by QAMS and EMS(Correlation coefficient>0.99,p>0.05).The QAMS method could be employed as a rapid,effective technique for the quality control of U.rhynchophylla.展开更多
Prohibited pesticide residues have become one of the main factors affecting the quality and safety of Lycii Fructus,However,rarely studies focus on the rapid determination of these residues.Here,a total of 30 kinds of...Prohibited pesticide residues have become one of the main factors affecting the quality and safety of Lycii Fructus,However,rarely studies focus on the rapid determination of these residues.Here,a total of 30 kinds of prohibited pesticide residues were determined by ultra-performance liquid chromatography tandem triple quadrupole mass spectrometry(UPLC-MS/MS)in five different process ways.Pretreatment methods,chromatographic separation and detection conditions in mass spectrometry were all optimized accordingly.Among the five different pretreatment methods,the first and third solid phase extraction failed to provide high recoveries of sulfosulfuron compounds(both lower than 60%).Recovery of chlorphenamidine by the Quick Easy Cheap Effective Rugged and Safe multiresidue method(QuEChERS)was lower than 60%,which did not meet the requirements of trace determination.The concentrations of 30 prohibited pesticides residues treated by straightforward and solid phase extraction showed good linearity in their corresponding ranges,with correlation coefficients over 0.99.The average recoveries of straightforward ranged from 78.13%to 110.9%,while RSD ranged from 1.3%to 16.9%,albeit poor purification was observed.The recovery yield from solid phase extraction was between 67.75%and 103.08%with RSD value from 0.8%to 14.0%,which met the requirements of trace determination,this method has good precision and stability.These results could be employed to other Traditional Chinese Medicines(TCMs)in detecting prohibited pesticide residues.展开更多
The stability of the surrounding rocks of large underground powerhouses is always emphasized during the construction process,especially in large-scale underground projects under construction,such as the Baihetan hydro...The stability of the surrounding rocks of large underground powerhouses is always emphasized during the construction process,especially in large-scale underground projects under construction,such as the Baihetan hydropower station in China.According to field investigations,numerical simulations and monitoring data analysis,we present a comparative analysis of the deformation and failure characteristics of the surrounding rocks of underground powerhouses on the left and right banks of the Baihetan hydropower station.The failure characteristics and deformation magnitude of the underground powerhouses on the left and right banks are quite different.Under the disadvantageous condition where the maximum principal stress intersects the axis of the powerhouse at a large angle,the left bank underground powerhouse shows prominent stress-controlled failure characteristics such as spalling,slack collapse and concrete cracking.Although the maximum principal stress is in the favorable condition which intersects the right bank powerhouse at a small angle,the relatively high intermediate principal stress with an angle subvertical to the right bank powerhouse plays an essential role in its deformation and failure,indicating that the influence of high intermediate principal stress cannot be ignored.In addition,structural plane-controlled failure and large deformation are also more evident on the right bank due to the extensive distribution of weak structural planes and complex surrounding rock properties.展开更多
Haynaldia villosa is a wild relative of wheat and a valuable gene resource for wheat improvement.Owing to the limited number of probes available for fluorescence in situ hybridization(FISH),the resolution at which the...Haynaldia villosa is a wild relative of wheat and a valuable gene resource for wheat improvement.Owing to the limited number of probes available for fluorescence in situ hybridization(FISH),the resolution at which the karyotype of H.villosa can be characterized is poor,hampering accurate characterization of small segmental alien introgressions.We designed ten oligonucleotide probes using tandem repeats in DNA sequences derived from the short arm of H.villosa chromosome 6 V(6 VS).FISH with seven of them resulted in clear signals on H.villosa chromosomes.Using these,we constructed FISH karyotypes for H.villosa using oligo-6 VS-1 and oligo-6 VS-35 oligonucleotides and characterized the distribution of the two probes in five different H.villosa accessions.The new FISH probes can efficiently characterize H.villosa introgressions into wheat.展开更多
Liver regeneration following injury aids the restoration of liver mass and the recovery of liver function.In the present study we investigated the contribution of megakaryocytic leukemia 1(MKL1),a transcriptional modu...Liver regeneration following injury aids the restoration of liver mass and the recovery of liver function.In the present study we investigated the contribution of megakaryocytic leukemia 1(MKL1),a transcriptional modulator,to liver regeneration.We report that both MKL1 expression and its nuclear translocation correlated with hepatocyte proliferation in cell and animal models of liver regeneration and in liver failure patients.Mice with MKL1 deletion exhibited defective regenerative response in the liver.Transcriptomic analysis revealed that MKL1 interacted with E2F1 to program pro-regenerative transcription.MAPKAPK2 mediated phosphorylation primed MKL1 for its interaction with E2F1.Of interest,phospholipase d2 promoted MKL1 nuclear accumulation and liver regeneration by catalyzing production of phosphatidic acid(PA).PA administration stimulated hepatocyte proliferation and enhanced survival in a MKL1-dependent manner in a pre-clinical model of liver failure.Finally,PA levels was detected to be positively correlated with expression of pro-regenerative genes and inversely correlated with liver injury in liver failure patients.In conclusion,our data reveal a novel mechanism whereby MKL1 contributes to liver regeneration.Screening for small-molecule compounds boosting MKL1 activity may be considered as a reasonable approach to treat acute liver failure.展开更多
Landslides are one of the geological disasters with wide distribution,high impact and serious damage around the world.Landslide risk assessment can help us know the risk of landslides occurring,which is an effective w...Landslides are one of the geological disasters with wide distribution,high impact and serious damage around the world.Landslide risk assessment can help us know the risk of landslides occurring,which is an effective way to prevent landslide disasters in advance.In recent decades,artificial intelligence(AI)has developed rapidly and has been used in a wide range of applications,especially for natural hazards.Based on the published literatures,this paper presents a detailed review of AI applications in landslide risk assessment.Three key areas where the application of AI is prominent are identified,including landslide detection,landslide susceptibility assessment,and prediction of landslide displacement.Machine learning(ML)containing deep learning(DL)has emerged as the primary technology which has been considered successfully due to its ability to quantify complex nonlinear relationships of soil structures and landslide predisposing factors.Among the algorithms,convolutional neural networks(CNNs)and recurrent neural networks(RNNs)are two models that are most widely used with satisfactory results in landslide risk assessment.The generalization ability,sampling training strategies,and hyperparameters optimization of these models are crucial and should be carefully considered.The challenges and opportunities of AI applications are also fully discussed to provide suggestions for future research in landslide risk assessment.展开更多
The sessile nature of plants confines their responsiveness to changing environmental conditions.Gene expression regulation becomes a paramount mechanism for plants to adjust their physiological and morphological behav...The sessile nature of plants confines their responsiveness to changing environmental conditions.Gene expression regulation becomes a paramount mechanism for plants to adjust their physiological and morphological behaviors.Alternative polyadenylation(APA)is known for its capacity to augment transcriptome diversity and plasticity,thereby furnishing an additional set of tools for modulating gene expression.APA has also been demonstrated to exhibit intimate associations with plant stress responses.In this study,we review APA dynamic features and consequences in plants subjected to both biotic and abiotic stresses.These stresses include adverse environmental stresses,and pathogenic attacks,such as cadmium toxicity,high salt,hypoxia,oxidative stress,cold,heat shock,along with bacterial,fungal,and viral infections.We analyzed the overarching research framework employed to elucidate plant APA response and the alignment of polyadenylation site transitions with the modulation of gene expression levels within the ambit of each stress condition.We also proposed a general APA model where transacting factors,including poly(A)factors,epigenetic regulators,RNA m6A modification factors,and phase separation proteins,assume pivotal roles in APA related transcriptome plasticity during stress response in plants.展开更多
Stable radicals are challenging to prepare due to their intrinsic high reactivity.Herein,three trisphenolamine radicals were readily synthesized and exhibited unexpected thermal/electrochemical stability and semicondu...Stable radicals are challenging to prepare due to their intrinsic high reactivity.Herein,three trisphenolamine radicals were readily synthesized and exhibited unexpected thermal/electrochemical stability and semiconductor property.These three nitroxide radicals could be considered as a class of aromatized nitro groups or HNO3 derivatives.The closed-shell nitro-like and open-shell nitroxide resonance structure contribute to their outstanding stability.Furthermore,the tunable ground states,extremely low band gap and p-type charge transport properties were systematically investigated.More importantly,the work presents the concept of aromatic inorganic acid radical(AIAR)and aggregation-induced radical(AIR)mechanism to understand the intrinsic structureproperty relationship of these radicals.In addition,we provide a novel strategy for the design of stable and low bandgap radicals for organic electronics,magnetics,spintronics,etc.展开更多
基金support of the National Natural Science Foundation of China(Grant Nos.U2240221 and 41977229)the Sichuan Youth Science and Technology Innovation Research Team Project(Grant No.2020JDTD0006).
文摘Non-contact remote sensing techniques,such as terrestrial laser scanning(TLS)and unmanned aerial vehicle(UAV)photogrammetry,have been globally applied for landslide monitoring in high and steep mountainous areas.These techniques acquire terrain data and enable ground deformation monitoring.However,practical application of these technologies still faces many difficulties due to complex terrain,limited access and dense vegetation.For instance,monitoring high and steep slopes can obstruct the TLS sightline,and the accuracy of the UAV model may be compromised by absence of ground control points(GCPs).This paper proposes a TLS-and UAV-based method for monitoring landslide deformation in high mountain valleys using traditional real-time kinematics(RTK)-based control points(RCPs),low-precision TLS-based control points(TCPs)and assumed control points(ACPs)to achieve high-precision surface deformation analysis under obstructed vision and impassable conditions.The effects of GCP accuracy,GCP quantity and automatic tie point(ATP)quantity on the accuracy of UAV modeling and surface deformation analysis were comprehensively analyzed.The results show that,the proposed method allows for the monitoring accuracy of landslides to exceed the accuracy of the GCPs themselves by adding additional low-accuracy GCPs.The proposed method was implemented for monitoring the Xinhua landslide in Baoxing County,China,and was validated against data from multiple sources.
基金We gratefully acknowledge the support of the National Key R&D Program of China(Grant No.2017YFC1501102)the National Nat-ural Science Foundation of China(Grant No.41977229)the Sichuan Youth Science and Technology Innovation Research Team Project(Grant No.2020JDTD0006).
文摘Water-induced landslides in hydropower reservoirs pose a great threat to both project operation and human life.This paper examines three large reservoirs in Sichuan Province,China.Field surveys,site monitoring data analyses and numerical simulations are used to analyze the spatial distribution and failure mechanisms of water-induced landslides in reservoir areas.First,the general rules of landslide development in the reservoir area are summarized.The first rule is that most of the landslides have rear edge elevations of 100e500 m above the normal water level of the reservoir,with volumes in the range of 106 e107 m 3.When the volume exceeds a certain amount,the number of sites at which the landscape can withstand landslides is greatly reduced.Landslide hazards mainly occur in the middle section of the reservoir and less in the annex of the dam site and the latter half of the reservoir area.The second rule is that sedimentary rocks such as sandstone are more prone to landslide hazards than other lithologies.Then,the failure mechanism of changes in the water level that reduces the stability of the slope composed of different geomaterials is analyzed by a proposed slope stability framework that considers displacement and is discussed with the monitoring results.Permeability is an essential parameter for understanding the diametrically opposed deformation behavior of landslides experiencing filling-drawdown cycles during operation.This study seeks to provide inspiration to subsequent researchers,as well as guidance to technicians,on landslide prevention and control in reservoir areas.
基金support of the National Natural Science Foundation of China(Grant No.42102316)the Open Project of the Technology Innovation Center for Geological Environment Monitoring of Ministry of Natural Resources of China(Grant No.2022KFK1212005).
文摘Local geometric information and discontinuity features are key aspects of the analysis of the evolution and failure mechanisms of unstable rock blocks in rock tunnels.This study demonstrates the integration of terrestrial laser scanning(TLS)with distinct element method for rock mass characterization and stability analysis in tunnels.TLS records detailed geometric information of the surrounding rock mass by scanning and collecting the positions of millions of rock surface points without contact.By conducting a fuzzy K-means method,a discontinuity automatic identification algorithm was developed,and a method for obtaining the geometric parameters of discontinuities was proposed.This method permits the user to visually identify each discontinuity and acquire its spatial distribution features(e.g.occurrences,spac-ings,trace lengths)in great detail.Compared with hand mapping in conventional geotechnical surveys,the geometric information of discontinuities obtained by this approach is more accurate and the iden-tification is more efficient.Then,a discrete fracture network with the same statistical characteristics as the actual discontinuities was generated with the distinct element method,and a representative nu-merical model of the jointed surrounding rock mass was established.By means of numerical simulation,potential unstable rock blocks were assessed,and failure mechanisms were analyzed.This method was applied to detection and assessment of unstable rock blocks in the spillway and sand flushing tunnel of the Hongshiyan hydropower project after a collapse.The results show that the noncontact detection of blocks was more labor-saving with lower safety risks compared with manual surveys,and the stability assessment was more reliable since the numerical model built by this method was more consistent with the distribution characteristics of actual joints.This study can provide a reference for geological survey and unstable rock block hazard mitigation in tunnels subjected to complex geology and active rockfalls.
文摘As a traditional herbal medicine,the major alkaloids in Uncaria rhynchophylla have been proven to have blood pressure-lowering and sedative effects.It is essential to develop an effective method for the determination of the major alkaloids in U.rhynchophylla.In this research,a rapid quantitative analysis involving multi-components analysis by a single marker strategy coupled with core-shell column HPLC was adopted to analyse four alkaloids(corynoxeine,isocorynoxeine,isorhynchophylline,rhynchophylline)in U.rhynchophylla.Isorhynchophylline was selected as the internal reference substance,the content of which was determined by the traditional external standard method.Relative correction factors(RCF)between isorhynchophylline and the other three alkaloids were calculated respectively.The results showed that the QAMS method had good robustness under different HPLC instruments.Nineteen batches of U.rhynchophylla were tested.No significant difference was observed between the results by QAMS and EMS(Correlation coefficient>0.99,p>0.05).The QAMS method could be employed as a rapid,effective technique for the quality control of U.rhynchophylla.
文摘Prohibited pesticide residues have become one of the main factors affecting the quality and safety of Lycii Fructus,However,rarely studies focus on the rapid determination of these residues.Here,a total of 30 kinds of prohibited pesticide residues were determined by ultra-performance liquid chromatography tandem triple quadrupole mass spectrometry(UPLC-MS/MS)in five different process ways.Pretreatment methods,chromatographic separation and detection conditions in mass spectrometry were all optimized accordingly.Among the five different pretreatment methods,the first and third solid phase extraction failed to provide high recoveries of sulfosulfuron compounds(both lower than 60%).Recovery of chlorphenamidine by the Quick Easy Cheap Effective Rugged and Safe multiresidue method(QuEChERS)was lower than 60%,which did not meet the requirements of trace determination.The concentrations of 30 prohibited pesticides residues treated by straightforward and solid phase extraction showed good linearity in their corresponding ranges,with correlation coefficients over 0.99.The average recoveries of straightforward ranged from 78.13%to 110.9%,while RSD ranged from 1.3%to 16.9%,albeit poor purification was observed.The recovery yield from solid phase extraction was between 67.75%and 103.08%with RSD value from 0.8%to 14.0%,which met the requirements of trace determination,this method has good precision and stability.These results could be employed to other Traditional Chinese Medicines(TCMs)in detecting prohibited pesticide residues.
基金the support of the National Natural Science Foundation of China (Grant No. 11902210)the Graduate Student’s Research Innovation Foundation of Sichuan University (Grant No. 2018YJSY076)
文摘The stability of the surrounding rocks of large underground powerhouses is always emphasized during the construction process,especially in large-scale underground projects under construction,such as the Baihetan hydropower station in China.According to field investigations,numerical simulations and monitoring data analysis,we present a comparative analysis of the deformation and failure characteristics of the surrounding rocks of underground powerhouses on the left and right banks of the Baihetan hydropower station.The failure characteristics and deformation magnitude of the underground powerhouses on the left and right banks are quite different.Under the disadvantageous condition where the maximum principal stress intersects the axis of the powerhouse at a large angle,the left bank underground powerhouse shows prominent stress-controlled failure characteristics such as spalling,slack collapse and concrete cracking.Although the maximum principal stress is in the favorable condition which intersects the right bank powerhouse at a small angle,the relatively high intermediate principal stress with an angle subvertical to the right bank powerhouse plays an essential role in its deformation and failure,indicating that the influence of high intermediate principal stress cannot be ignored.In addition,structural plane-controlled failure and large deformation are also more evident on the right bank due to the extensive distribution of weak structural planes and complex surrounding rock properties.
基金supported by the National Key Research and Development Program of China(2016YFD0102001)the National Natural Science Foundation of China(31571653,31771782,31201204,31501305)+3 种基金International Cooperation and Exchange Programme of the National Natural Science Foundation of China(31661143005)Introducing the Technique to Exploring the Genetic Germplasm Based on the Chromosome Sorting and Sequencing(2015-Z41)the Special Fund of Jiangsu Province for the Transformation of Scientific and Technological Achievements(BA2017138)supported by European Regional Development Fund Project“Plants as a Tool for Sustainable Global Development”(CZ.02.1.01/0.0/0.0/16_019/0000827)。
文摘Haynaldia villosa is a wild relative of wheat and a valuable gene resource for wheat improvement.Owing to the limited number of probes available for fluorescence in situ hybridization(FISH),the resolution at which the karyotype of H.villosa can be characterized is poor,hampering accurate characterization of small segmental alien introgressions.We designed ten oligonucleotide probes using tandem repeats in DNA sequences derived from the short arm of H.villosa chromosome 6 V(6 VS).FISH with seven of them resulted in clear signals on H.villosa chromosomes.Using these,we constructed FISH karyotypes for H.villosa using oligo-6 VS-1 and oligo-6 VS-35 oligonucleotides and characterized the distribution of the two probes in five different H.villosa accessions.The new FISH probes can efficiently characterize H.villosa introgressions into wheat.
基金This work was supported by grants from the National Natural Science Foundation of China(82200684,82121001,81725001,and 81700554)the Natural Science Foundation of Jiangsu Province(BK20221032).
文摘Liver regeneration following injury aids the restoration of liver mass and the recovery of liver function.In the present study we investigated the contribution of megakaryocytic leukemia 1(MKL1),a transcriptional modulator,to liver regeneration.We report that both MKL1 expression and its nuclear translocation correlated with hepatocyte proliferation in cell and animal models of liver regeneration and in liver failure patients.Mice with MKL1 deletion exhibited defective regenerative response in the liver.Transcriptomic analysis revealed that MKL1 interacted with E2F1 to program pro-regenerative transcription.MAPKAPK2 mediated phosphorylation primed MKL1 for its interaction with E2F1.Of interest,phospholipase d2 promoted MKL1 nuclear accumulation and liver regeneration by catalyzing production of phosphatidic acid(PA).PA administration stimulated hepatocyte proliferation and enhanced survival in a MKL1-dependent manner in a pre-clinical model of liver failure.Finally,PA levels was detected to be positively correlated with expression of pro-regenerative genes and inversely correlated with liver injury in liver failure patients.In conclusion,our data reveal a novel mechanism whereby MKL1 contributes to liver regeneration.Screening for small-molecule compounds boosting MKL1 activity may be considered as a reasonable approach to treat acute liver failure.
基金supported by the National Natural Science Foundation of China(U2240221 and 52379105)the Sichuan Youth Science and Technology Innovation Research Team Project(2020JDTD0006)。
文摘Landslides are one of the geological disasters with wide distribution,high impact and serious damage around the world.Landslide risk assessment can help us know the risk of landslides occurring,which is an effective way to prevent landslide disasters in advance.In recent decades,artificial intelligence(AI)has developed rapidly and has been used in a wide range of applications,especially for natural hazards.Based on the published literatures,this paper presents a detailed review of AI applications in landslide risk assessment.Three key areas where the application of AI is prominent are identified,including landslide detection,landslide susceptibility assessment,and prediction of landslide displacement.Machine learning(ML)containing deep learning(DL)has emerged as the primary technology which has been considered successfully due to its ability to quantify complex nonlinear relationships of soil structures and landslide predisposing factors.Among the algorithms,convolutional neural networks(CNNs)and recurrent neural networks(RNNs)are two models that are most widely used with satisfactory results in landslide risk assessment.The generalization ability,sampling training strategies,and hyperparameters optimization of these models are crucial and should be carefully considered.The challenges and opportunities of AI applications are also fully discussed to provide suggestions for future research in landslide risk assessment.
基金Open access funding provided by Shanghai Jiao Tong Universityfunded in part by the National Nature Science Foundation of China(grant#32270344).
文摘The sessile nature of plants confines their responsiveness to changing environmental conditions.Gene expression regulation becomes a paramount mechanism for plants to adjust their physiological and morphological behaviors.Alternative polyadenylation(APA)is known for its capacity to augment transcriptome diversity and plasticity,thereby furnishing an additional set of tools for modulating gene expression.APA has also been demonstrated to exhibit intimate associations with plant stress responses.In this study,we review APA dynamic features and consequences in plants subjected to both biotic and abiotic stresses.These stresses include adverse environmental stresses,and pathogenic attacks,such as cadmium toxicity,high salt,hypoxia,oxidative stress,cold,heat shock,along with bacterial,fungal,and viral infections.We analyzed the overarching research framework employed to elucidate plant APA response and the alignment of polyadenylation site transitions with the modulation of gene expression levels within the ambit of each stress condition.We also proposed a general APA model where transacting factors,including poly(A)factors,epigenetic regulators,RNA m6A modification factors,and phase separation proteins,assume pivotal roles in APA related transcriptome plasticity during stress response in plants.
基金supported by the Pearl River S&T Nova Program of Guangzhou (201710010194)the National Natural Science Foundation of China (61574061, 21520102006, 21634004, 51521002, 91633301)the Foundation of Guangzhou Science and Technology Project (201707020019)
文摘Stable radicals are challenging to prepare due to their intrinsic high reactivity.Herein,three trisphenolamine radicals were readily synthesized and exhibited unexpected thermal/electrochemical stability and semiconductor property.These three nitroxide radicals could be considered as a class of aromatized nitro groups or HNO3 derivatives.The closed-shell nitro-like and open-shell nitroxide resonance structure contribute to their outstanding stability.Furthermore,the tunable ground states,extremely low band gap and p-type charge transport properties were systematically investigated.More importantly,the work presents the concept of aromatic inorganic acid radical(AIAR)and aggregation-induced radical(AIR)mechanism to understand the intrinsic structureproperty relationship of these radicals.In addition,we provide a novel strategy for the design of stable and low bandgap radicals for organic electronics,magnetics,spintronics,etc.