In this work,we achieve high count-rate single-photon output in single-mode(SM)optical fiber.Epitaxial and dilute InAs/GaAs quantum dots(QDs)are embedded in a GaAs/AlGaAs distributed Bragg reflector(DBR)with a micro-p...In this work,we achieve high count-rate single-photon output in single-mode(SM)optical fiber.Epitaxial and dilute InAs/GaAs quantum dots(QDs)are embedded in a GaAs/AlGaAs distributed Bragg reflector(DBR)with a micro-pillar cavity,so as to improve their light emission extraction in the vertical direction,thereby enhancing the optical SM fiber’s collection capabil-ity(numerical aperture:0.13).By tuning the temperature precisely to make the quantum dot exciton emission resonant to the micro-pillar cavity mode(Q~1800),we achieve a fiber-output single-photon count rate as high as 4.73×10^(6) counts per second,with the second-order auto-correlation g2(0)remaining at 0.08.展开更多
By constructing a research framework of theoretical concepts such as leisure involvement, authenticity experience, place attachment, and willingness to revisit, the aim is to explore the authenticity experience and it...By constructing a research framework of theoretical concepts such as leisure involvement, authenticity experience, place attachment, and willingness to revisit, the aim is to explore the authenticity experience and its influencing mechanisms in shared accommodation consumption. Research data are collected by using questionnaire survey method, and statistical analysis of data is conducted using SPSS 21.0. Research has found that leisure involvement has a significant positive impact on authenticity experience, place attachment, and willingness to revisit;authenticity experience has a significant positive impact on place attachment and willingness to revisit;place attachment has a significant positive impact on willingness to revisit. Therefore, shared accommodation owners need to strengthen the editing and publishing of leisure strategies on we media to enhance customers sense of leisure involvement;pay attention to enhancing the local authentic cultural experience of tenants, in order to increase their sense of attachment to the place and thereby enhance their willingness to stay.展开更多
Soil salinity has a major impact on rice seed germination,severely limiting rice production.Herein,a rice germination defective mutant under salt stress(gdss)was identified by using chemical mutagenesis.The GDSS gene ...Soil salinity has a major impact on rice seed germination,severely limiting rice production.Herein,a rice germination defective mutant under salt stress(gdss)was identified by using chemical mutagenesis.The GDSS gene was detected via MutMap and shown to encode potassium transporter OsHAK9.Phenotypic analysis of complementation and mutant lines demonstrated that OsHAK9 was an essential regulator responsible for seed germination under salt stress.OsHAK9 is highly expressed in germinating seed embryos.Ion contents and non-invasive micro-test technology results showed that OsHAK9 restricted K^(+)efflux in salt-exposed germinating seeds for the balance of K^(+)/Na^(+).Disruption of OsHAK9 significantly reduced gibberellin 4(GA4)levels,and the germination defective phenotype of oshak9a was partly rescued by exogenous GA_(3)treatment under salt stress.RNA sequencing(RNA-seq)and real-time quantitative polymerase chain reaction analysis demonstrated that the disruption of OsHAK9 improved the GA-deactivated gene OsGA2ox7 expression in germinating seeds under salt stress,and the expression of OsGA2ox7 was significantly inhibited by salt stress.Null mutants of OsGA2ox7 created using clustered,regularly interspaced,short palindromic repeat(CRISPR)/CRISPR-associated nuclease 9 approach displayed a dramatically increased seed germination ability under salt stress.Overall,our results highlight that OsHAK9 regulates seed germination performance under salt stress involving preventing GA degradation by mediating OsGA2ox7,which provides a novel clue about the relationship between GA and OsHAKs in rice.展开更多
Maintaining low modulus while endowing the wide-range linear stretchability to wearable or implantable devices is crucial for these devices to reduce the mechanical mismatch between the devices and human skin/tissue i...Maintaining low modulus while endowing the wide-range linear stretchability to wearable or implantable devices is crucial for these devices to reduce the mechanical mismatch between the devices and human skin/tissue interfaces.However,improving linear stretchability often results in an increased modulus of stretchable electronic materials,which hinders their conformability in long-term quantifiable monitoring of organs.Herein,we develop a hybrid structure involving interlocking low-modulus porous elastomers(Ecoflex-0030)and MXene-based hydrogels with crosslinking networks of polyvinyl alcohol,sodium alginate,and MXene.This hydrogel–elastomer structure exhibits superior performance compared with previous reports,with a wide linear stretchability strain range from 0 to 1000%and maintaining a low modulus of 6.4 kPa.Moreover,the hydrogel–elastomer hybrids can be utilized as highly sensitive strain sensors with remarkable characteristics,including high sensitivity(gauge factor~3.52),a linear correlation between the resistance and strain(0–200%),rapid response(0.18 s)and recovery times(0.21 s),and excellent electrical reproducibility(1000 loading–unloading cycles).Those electrical and mechanical properties allow the sensor to act as a suitable quantifiable equipment in organ monitoring,human activities detecting,and human–machine interactions.展开更多
Graphitic carbon nitride (g-C3N4) has become an attractive visible-light-responsive photocatalyst because of its semiconductor polymer compositions and easy-modulated band structure. However, the bulk g-C3N4 photocata...Graphitic carbon nitride (g-C3N4) has become an attractive visible-light-responsive photocatalyst because of its semiconductor polymer compositions and easy-modulated band structure. However, the bulk g-C3N4 photocatalyst has the low separation efficiency of photogenerated carriers and unsatisfied surface catalytic performance, which leads to poor photocatalytic performance. As for this, MgTi2O5 with high chemical stability, wide band gap and negative conduction band was used as a suitable platform for coupling with g-C3N4 to enhance charge separation and promoted the photoactivity. Different from common approaches, here, we propose an innovative method to construct g-C3N4/MgTi2O5 nanocomposites featuring “0 + 1 >1" magnification effect to improve g-C3N4 photocatalytic performance under visible light irradiation. Additionally, compositing metal oxides of MgTi2O5 with g-C3N4 has proven to be a proper strategy to accelerate surface catalytic reactions in g-C3N4, and the photoinduced carriers were modulated to maintain thermodynamic equilibrium, which convincingly promotes the photocatalytic activity. The photocatalytic performance of the nanocomposites was measured by hydrogen production and CO2 reduction under visible light. The developed g-C3N4/MgTi2O5 nanocomposites with a 5 wt.% MgTi2O5 exhibits the highest H2 and CO yield under visible light and excellent stability compare to the other MgTi2O5 contents in composites. According to surface photo-voltage spectra, electrochemical CO2 reduction, photoluminescence, etc. The superior performance can be related to an enhanced electron lifetime, the promoted charge transfer and the increased electronic separation property of g-C3N4. Our work provides an approach to overcome the defect of pure g-C3N4, which accesses to composite with the second component matched well.展开更多
We state that the flag-transitive automorphism group of a 2-(v,5,λ)design D is primitive of affine type or almost simple type.W e also find that there are up to isomorphism 202-(v,5,λ)designs admitting flag-transiti...We state that the flag-transitive automorphism group of a 2-(v,5,λ)design D is primitive of affine type or almost simple type.W e also find that there are up to isomorphism 202-(v,5,λ)designs admitting flag-transitive automorphism groups with socle of a sporadic simple group.展开更多
With increasing incidence and geography,cancer is one of the leading causes of death,reduced quality of life and disability worldwide.Principal progress in the development of new anticancer therapies,in improving the ...With increasing incidence and geography,cancer is one of the leading causes of death,reduced quality of life and disability worldwide.Principal progress in the development of new anticancer therapies,in improving the efficiency of immunotherapeutic tools,and in the personification of conventional therapies needs to consider cancer-specific and patient-specific programming of innate immunity.Intratumoral TAMs and their precursors,resident macrophages and monocytes,are principal regulators of tumor progression and therapy resistance.Our review summarizes the accumulated evidence for the subpopulations of TAMs and their increasing number of biomarkers,indicating their predictive value for the clinical parameters of carcinogenesis and therapy resistance,with a focus on solid cancers of non-infectious etiology.We present the state-of-the-art knowledge about the tumorsupporting functions of TAMs at all stages of tumor progression and highlight biomarkers,recently identified by single-cell and spatial analytical methods,that discriminate between tumor-promoting and tumor-inhibiting TAMs,where both subtypes express a combination of prototype M1 and M2 genes.Our review focuses on novel mechanisms involved in the crosstalk among epigenetic,signaling,transcriptional and metabolic pathways in TAMs.Particular attention has been given to the recently identified link between cancer cell metabolism and the epigenetic programming of TAMs by histone lactylation,which can be responsible for the unlimited protumoral programming of TAMs.Finally,we explain how TAMs interfere with currently used anticancer therapeutics and summarize the most advanced data from clinical trials,which we divide into four categories:inhibition of TAM survival and differentiation,inhibition of monocyte/TAM recruitment into tumors,functional reprogramming of TAMs,and genetic enhancement of macrophages.展开更多
基金supported by the Key-Area Research and Development Program of Guangdong Province(Grant No.2018B030329001)the National Key Technologies R&D Program of China(2018YFA0306101)+2 种基金The Scientific Instrument Developing Project of the Chinese Academy of Science(YJKYYQ20170032)the National Natural Science Foundation of China(61505196)the Program of Beijing Academy of Quantum Information Sciences(Grant No.Y18G01).
文摘In this work,we achieve high count-rate single-photon output in single-mode(SM)optical fiber.Epitaxial and dilute InAs/GaAs quantum dots(QDs)are embedded in a GaAs/AlGaAs distributed Bragg reflector(DBR)with a micro-pillar cavity,so as to improve their light emission extraction in the vertical direction,thereby enhancing the optical SM fiber’s collection capabil-ity(numerical aperture:0.13).By tuning the temperature precisely to make the quantum dot exciton emission resonant to the micro-pillar cavity mode(Q~1800),we achieve a fiber-output single-photon count rate as high as 4.73×10^(6) counts per second,with the second-order auto-correlation g2(0)remaining at 0.08.
基金Supported by 2022 Students Entrepreneurship Training Program Project of Zhaoqing University(X202210580160X).
文摘By constructing a research framework of theoretical concepts such as leisure involvement, authenticity experience, place attachment, and willingness to revisit, the aim is to explore the authenticity experience and its influencing mechanisms in shared accommodation consumption. Research data are collected by using questionnaire survey method, and statistical analysis of data is conducted using SPSS 21.0. Research has found that leisure involvement has a significant positive impact on authenticity experience, place attachment, and willingness to revisit;authenticity experience has a significant positive impact on place attachment and willingness to revisit;place attachment has a significant positive impact on willingness to revisit. Therefore, shared accommodation owners need to strengthen the editing and publishing of leisure strategies on we media to enhance customers sense of leisure involvement;pay attention to enhancing the local authentic cultural experience of tenants, in order to increase their sense of attachment to the place and thereby enhance their willingness to stay.
基金supported by the National Natural Science Foundation of China(Grant Nos.32272169,32000377,32172037,and 31601387)the Natural Science Foundation of Guangdong Province(Grant No.2022A1515110449)the Hainan Yazhou Bay Seed Laboratory(project of B21HJ1002)。
文摘Soil salinity has a major impact on rice seed germination,severely limiting rice production.Herein,a rice germination defective mutant under salt stress(gdss)was identified by using chemical mutagenesis.The GDSS gene was detected via MutMap and shown to encode potassium transporter OsHAK9.Phenotypic analysis of complementation and mutant lines demonstrated that OsHAK9 was an essential regulator responsible for seed germination under salt stress.OsHAK9 is highly expressed in germinating seed embryos.Ion contents and non-invasive micro-test technology results showed that OsHAK9 restricted K^(+)efflux in salt-exposed germinating seeds for the balance of K^(+)/Na^(+).Disruption of OsHAK9 significantly reduced gibberellin 4(GA4)levels,and the germination defective phenotype of oshak9a was partly rescued by exogenous GA_(3)treatment under salt stress.RNA sequencing(RNA-seq)and real-time quantitative polymerase chain reaction analysis demonstrated that the disruption of OsHAK9 improved the GA-deactivated gene OsGA2ox7 expression in germinating seeds under salt stress,and the expression of OsGA2ox7 was significantly inhibited by salt stress.Null mutants of OsGA2ox7 created using clustered,regularly interspaced,short palindromic repeat(CRISPR)/CRISPR-associated nuclease 9 approach displayed a dramatically increased seed germination ability under salt stress.Overall,our results highlight that OsHAK9 regulates seed germination performance under salt stress involving preventing GA degradation by mediating OsGA2ox7,which provides a novel clue about the relationship between GA and OsHAKs in rice.
基金supported by the National Natural Science Foundation of China(62001066,62104022,and 61971074)the Natural Science Foundation of Chongqing(2022NSCQ-MSX2366)+11 种基金the Fundamental Research Funds for the Central Universities(2020CDJ-LHZZ069 and 2020CDJYGGD004)the open research fund of Key Laboratory of MEMS of Ministry of Education,Southeast Universitythe Science and Technology Research Program of Chongqing Municipal Education Commission(kjzd-k202000105)the Start-up Foundation of Nanjing Vocational University of Industry Technology(YK21-03-02201012321DXS79HK2351-10:205050623HK097)the Natural Science Foundation of Jiangsu Province(BK20160702)the High-level Training Project for Professional-leader Teachers of Higher Vocational Colleges in Jiangsu Province(2023TDFX007)the Ministry of Science and Technology of China(2017YFA0204800)the National Natural Science Foundation of China(51420105003,11525415,11327901,61274114,61601116,11674052,and 11204034)the Fundamental Research Funds for the Central Universities(2242017K40066,2242017K40067,2242016K41039,2242020K40023,and 2242019R10)funded by the Administration Office of Jiangsu Talent resources。
文摘Maintaining low modulus while endowing the wide-range linear stretchability to wearable or implantable devices is crucial for these devices to reduce the mechanical mismatch between the devices and human skin/tissue interfaces.However,improving linear stretchability often results in an increased modulus of stretchable electronic materials,which hinders their conformability in long-term quantifiable monitoring of organs.Herein,we develop a hybrid structure involving interlocking low-modulus porous elastomers(Ecoflex-0030)and MXene-based hydrogels with crosslinking networks of polyvinyl alcohol,sodium alginate,and MXene.This hydrogel–elastomer structure exhibits superior performance compared with previous reports,with a wide linear stretchability strain range from 0 to 1000%and maintaining a low modulus of 6.4 kPa.Moreover,the hydrogel–elastomer hybrids can be utilized as highly sensitive strain sensors with remarkable characteristics,including high sensitivity(gauge factor~3.52),a linear correlation between the resistance and strain(0–200%),rapid response(0.18 s)and recovery times(0.21 s),and excellent electrical reproducibility(1000 loading–unloading cycles).Those electrical and mechanical properties allow the sensor to act as a suitable quantifiable equipment in organ monitoring,human activities detecting,and human–machine interactions.
基金supported by the National Natural Science Foundation of China (Nos.21871079 and 21501052).
文摘Graphitic carbon nitride (g-C3N4) has become an attractive visible-light-responsive photocatalyst because of its semiconductor polymer compositions and easy-modulated band structure. However, the bulk g-C3N4 photocatalyst has the low separation efficiency of photogenerated carriers and unsatisfied surface catalytic performance, which leads to poor photocatalytic performance. As for this, MgTi2O5 with high chemical stability, wide band gap and negative conduction band was used as a suitable platform for coupling with g-C3N4 to enhance charge separation and promoted the photoactivity. Different from common approaches, here, we propose an innovative method to construct g-C3N4/MgTi2O5 nanocomposites featuring “0 + 1 >1" magnification effect to improve g-C3N4 photocatalytic performance under visible light irradiation. Additionally, compositing metal oxides of MgTi2O5 with g-C3N4 has proven to be a proper strategy to accelerate surface catalytic reactions in g-C3N4, and the photoinduced carriers were modulated to maintain thermodynamic equilibrium, which convincingly promotes the photocatalytic activity. The photocatalytic performance of the nanocomposites was measured by hydrogen production and CO2 reduction under visible light. The developed g-C3N4/MgTi2O5 nanocomposites with a 5 wt.% MgTi2O5 exhibits the highest H2 and CO yield under visible light and excellent stability compare to the other MgTi2O5 contents in composites. According to surface photo-voltage spectra, electrochemical CO2 reduction, photoluminescence, etc. The superior performance can be related to an enhanced electron lifetime, the promoted charge transfer and the increased electronic separation property of g-C3N4. Our work provides an approach to overcome the defect of pure g-C3N4, which accesses to composite with the second component matched well.
基金supported by the National Natural Science Foundation of China(Grant No.11871224).
文摘We state that the flag-transitive automorphism group of a 2-(v,5,λ)design D is primitive of affine type or almost simple type.W e also find that there are up to isomorphism 202-(v,5,λ)designs admitting flag-transitive automorphism groups with socle of a sporadic simple group.
基金supported by the China Scholarship Council(No.202306320511)by the BSMU Strategic Academic Leadership Program PRIORITY-2030.
文摘With increasing incidence and geography,cancer is one of the leading causes of death,reduced quality of life and disability worldwide.Principal progress in the development of new anticancer therapies,in improving the efficiency of immunotherapeutic tools,and in the personification of conventional therapies needs to consider cancer-specific and patient-specific programming of innate immunity.Intratumoral TAMs and their precursors,resident macrophages and monocytes,are principal regulators of tumor progression and therapy resistance.Our review summarizes the accumulated evidence for the subpopulations of TAMs and their increasing number of biomarkers,indicating their predictive value for the clinical parameters of carcinogenesis and therapy resistance,with a focus on solid cancers of non-infectious etiology.We present the state-of-the-art knowledge about the tumorsupporting functions of TAMs at all stages of tumor progression and highlight biomarkers,recently identified by single-cell and spatial analytical methods,that discriminate between tumor-promoting and tumor-inhibiting TAMs,where both subtypes express a combination of prototype M1 and M2 genes.Our review focuses on novel mechanisms involved in the crosstalk among epigenetic,signaling,transcriptional and metabolic pathways in TAMs.Particular attention has been given to the recently identified link between cancer cell metabolism and the epigenetic programming of TAMs by histone lactylation,which can be responsible for the unlimited protumoral programming of TAMs.Finally,we explain how TAMs interfere with currently used anticancer therapeutics and summarize the most advanced data from clinical trials,which we divide into four categories:inhibition of TAM survival and differentiation,inhibition of monocyte/TAM recruitment into tumors,functional reprogramming of TAMs,and genetic enhancement of macrophages.