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连续变量量子密钥分发系统中动态偏振控制研究 被引量:1
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作者 张光伟 白建东 +3 位作者 颉琦 靳晶晶 张永梅 刘文元 《物理学报》 SCIE EI CAS CSCD 北大核心 2024年第6期119-127,共9页
连续变量量子密钥分发系统中,本地光场和信号光场采用时分复用,偏振复用方式通过长距离单模光纤传输.外界复杂环境会使单模光纤产生双折射效应,导致本地光场和信号光场的偏振态漂移,严重影响接收端平衡零拍探测结果.因此,高效动态偏振... 连续变量量子密钥分发系统中,本地光场和信号光场采用时分复用,偏振复用方式通过长距离单模光纤传输.外界复杂环境会使单模光纤产生双折射效应,导致本地光场和信号光场的偏振态漂移,严重影响接收端平衡零拍探测结果.因此,高效动态偏振控制单元是推动系统外场实用化进程的关键技术.本文理论上证明了系统接收端仅考虑任意偏振消光比输出时,偏振控制单元只需两个控制自由度即可.在此基础上将贝叶斯参数估计方法有效融入混沌-猴群算法,同时在现场可编程逻辑门阵列硬件上实现控制算法,结合积分型光场探测器建立动态偏振控制单元,仿真和实验结果表明单次偏振控制静态消光比达到30 dB以上的平均周期为400μs.为了应对偏振态连续变化情况,将动态偏振控制单元集成到连续变量量子密钥分发系统,实验测试了偏振态扰动速率在0—2 krad/s范围内系统仍然能够正常运转. 展开更多
关键词 连续变量量子密钥分发 贝叶斯参数估计方法 猴群算法 动态偏振控制器
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极化角依赖的铯原子魔术波长光阱理论分析
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作者 白建东 刘硕 +2 位作者 刘文元 颉琦 王军民 《物理学报》 SCIE EI CAS CSCD 北大核心 2023年第6期81-88,共8页
在对经激光预冷却的原子进行俘获的光学偶极阱中,魔术波长光学偶极阱可以消除所关心的两原子态间跃迁的差分光频移,使得光子在原子态间的跃迁频率与自由空间相同,对于提高实验重复率、减弱原子的退相干具有重要意义,使其在冷原子物理、... 在对经激光预冷却的原子进行俘获的光学偶极阱中,魔术波长光学偶极阱可以消除所关心的两原子态间跃迁的差分光频移,使得光子在原子态间的跃迁频率与自由空间相同,对于提高实验重复率、减弱原子的退相干具有重要意义,使其在冷原子物理、量子光学、精密测量等领域已成为越来越重要的技术手段.本文基于多能级模型理论计算了耦合铯原子D2线的6S_(1/2)基态和6P_(3/2)激发态对光阱激光波长(800-1000 nm)依赖的动态电极化率,得到了俘获基态和激发态的光阱激光的魔术波长.由于角动量大于0.5的原子态的极化率对极化角非常敏感,本文以线偏振光阱激光为例,讨论并分析了魔术波长与相应的魔术极化率对极化角的依赖关系,得到了魔术极化角为54.7°以及该角度下的魔术波长分别为886.4315 nm与934.0641 nm,进一步分析了这两种情况下魔术条件的鲁棒性与实验操作的可行性. 展开更多
关键词 铯原子D2线 动态极化率 魔术波长光阱 极化角
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SegNet-based first-break picking via seismic waveform classification directly from shot gathers with sparsely distributed traces 被引量:3
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作者 San-Yi Yuan Yue Zhao +2 位作者 Tao Xie jie qi Shang-Xu Wang 《Petroleum Science》 SCIE CAS CSCD 2022年第1期162-179,共18页
Manually picking regularly and densely distributed first breaks(FBs)are critical for shallow velocitymodel building in seismic data processing.However,it is time consuming.We employ the fullyconvolutional Seg Net to a... Manually picking regularly and densely distributed first breaks(FBs)are critical for shallow velocitymodel building in seismic data processing.However,it is time consuming.We employ the fullyconvolutional Seg Net to address this issue and present a fast automatic seismic waveform classification method to pick densely-sampled FBs directly from common-shot gathers with sparsely distributed traces.Through feeding a large number of representative shot gathers with missing traces and the corresponding binary labels segmented by manually interpreted fully-sampled FBs,we can obtain a welltrained Seg Net model.When any unseen gather including the one with irregular trace spacing is inputted,the Seg Net can output the probability distribution of different categories for waveform classification.Then FBs can be picked by locating the boundaries between one class on post-FBs data and the other on pre-FBs background.Two land datasets with each over 2000 shots are adopted to illustrate that one well-trained 25-layer Seg Net can favorably classify waveform and further pick fully-sampled FBs verified by the manually-derived ones,even when the proportion of randomly missing traces reaches50%,21 traces are missing consecutively,or traces are missing regularly. 展开更多
关键词 First-break picking Deep learning Irregular seismic data Waveform classification
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Inverse spectral decomposition using an I_p-norm constraint for the detection of close geological anomalies 被引量:2
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作者 San-Yi Yuan Shan Yang +2 位作者 Tie-Yi Wang jie qi Shang-Xu Wang 《Petroleum Science》 SCIE CAS CSCD 2020年第6期1463-1477,共15页
An important application of spectral decomposition(SD)is to identify subsurface geological anomalies such as channels and karst caves,which may be buried in full-band seismic data.However,the classical SD methods incl... An important application of spectral decomposition(SD)is to identify subsurface geological anomalies such as channels and karst caves,which may be buried in full-band seismic data.However,the classical SD methods including the wavelet transform(WT)are often limited by relatively low time-frequency resolution,which is responsible for false high horizonassociated space resolution probably indicating more geological structures,especially when close geological anomalies exist.To address this issue,we impose a constraint of minimizing an lp(0<p<1)norm of time-frequency spectral coefficients on the misfit derived by using the inverse WT and apply the generalized iterated shrinkage algorithm to invert for the optimal coefficients.Compared with the WT and inverse SD(ISD)using a typical l1-norm constraint,the modified ISD(MISD)using an lp-norm constraint can yield a more compact spectrum contributing to detect the distributions of close geological features.We design a 3 D synthetic dataset involving frequency-close thin geological anomalies and the other3 D non-stationary dataset involving time-close anomalies to demonstrate the effectiveness of MISD.The application of 4 D spectrum on a 3 D real dataset with an area of approximately 230 km2 illustrates its potential for detecting deep channels and the karst slope fracture zone. 展开更多
关键词 Spectral decomposition Seismic interpretation Inverse problem High resolution Deep exploration
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The effects of <i>astragalus</i>polysaccharide on zebrafish cell apoptosis and senescence 被引量:3
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作者 Guangqing Xia Xiaojuan Han +4 位作者 jie qi Wei Liu Jinzhi Song Jiamei qin Lihua Liu 《American Journal of Molecular Biology》 2012年第2期103-109,共7页
Astragalus polysaccharide (AP) is the extraction of astragalus, which is a plant used in traditional Chinese herb medicine and may increase an orgainism’s resistance to stress. Several earlier studies in vitro have i... Astragalus polysaccharide (AP) is the extraction of astragalus, which is a plant used in traditional Chinese herb medicine and may increase an orgainism’s resistance to stress. Several earlier studies in vitro have indicated that AP has anti-aging activities, however the mechanism underlyling these activities was unclear and remained to be elucidated. In this study, Using the zebrafish (Danio rerio), we evaluated molecular mechanism of the effect of AP on zebrafish growth, development and apoptosis. 30 zebrafish embryos (24 hours post fertilization (hpf)) were exposed to varying concentrations of AP (from 0.125 mg/ml to 0. 5 mg/ml) continuously for 3 days. The results of β-galactosidase (SA-β-gal) and acridine orange fluorescence showed that AP can delay zebrafish embryos apoptosis under the concentration of 0.125 mg/ml. In addition, the differential gene expression of AP treated zebrafish embryos was examined by RT-PCR analysis. We found that the gene expression of mdm2 and tert were up-regulated while bax, p21 and p53 gene expression were down-regulated during early apoptosis of the zebrafish embryos mediated by AP. These results demonstrated that AP may play a role during the induction of senescence and this function might by p53-mediated pathway. 展开更多
关键词 ASTRAGALUS POLYSACCHARIDE ZEBRAFISH Cell Proliferation SENESCENCE
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Ni-Doped BiVO4 with V4+ Species and Oxygen Vacancies for Efficient Photoelectrochemical Water Splitting
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作者 Dechao Kong jie qi +3 位作者 Danyang Liu Xiangwen Zhang Lun Pan Jijun Zou 《Transactions of Tianjin University》 EI CAS 2019年第4期340-347,共8页
Bismuth vanadate is a promising photoanode material for photoelectrochemical (PEC) water splitting, but its activity and stability need to be further improved. In this work, we synthesized Ni-doped BiVO 4 abundant wit... Bismuth vanadate is a promising photoanode material for photoelectrochemical (PEC) water splitting, but its activity and stability need to be further improved. In this work, we synthesized Ni-doped BiVO 4 abundant with V 4+ species and oxygen defects through an in situ electrodeposition method. The eff ective doping can decrease the particle size of BiVO 4 and lead to the formation of V 4+ species/oxygen defects. Accordingly, the doped and defective BiVO 4 showed high optical absorption and rapid charge transfer, and further showed much higher PEC activity than pure BiVO 4 . Specifi cally, 5-Ni-BiVO 4 exhibits the highest activity in PEC water splitting, with a photocurrent of 2.39 mA/cm 2 at 1.23 V versus RHE (the reversible hydrogen electrode), which is 2.5 times higher than pure BiVO 4 (0.94 mA/cm 2 ), and much higher incident photon-to-current effi ciency (IPCE) value of 45%(while only 25% for BiVO 4 at ca. 400 nm). This work provides an in situ method for the development of a high-performance photoanode. 展开更多
关键词 BiVO 4 Doping PHOTOELECTROCHEMISTRY V 4+ SPECIES Oxygen VACANCIES
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Profiling seed soluble sugar compositions in 1164 Chinese soybean accessions from major growing ecoregions
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作者 jie qi Shengrui Zhang +13 位作者 Muhammad AzamAbdul wahab S.Shaibu Ahmed M.Abdelghany Yue Feng Yuanyuan HuaiHuoyi Feng Yitian Liu Caiyou Ma Berhane S.Gebregziabher Suprio Ghosh Jing Li Deyue Yu Bin Li Lijuan qiu Junming Sun 《The Crop Journal》 SCIE CSCD 2022年第6期1825-1831,共7页
Soluble sugar is a key quality trait of soybean seeds.We developed rapid and economic extraction and quantification methods for seed soluble sugars using an ultra-high performance liquid chromatography system with a r... Soluble sugar is a key quality trait of soybean seeds.We developed rapid and economic extraction and quantification methods for seed soluble sugars using an ultra-high performance liquid chromatography system with a refractive index detector.We evaluated the soluble sugar compositions of 1164 soybean accessions collected from diverse ecoregions and grown in multiple locations and years.Total soluble sugar(TSS)content was influenced by accession type,year of cultivation,and ecoregion.The mean contents of fructose,glucose,sucrose,raffinose,stachyose and TSS were 3.31,5.21,55.60,6.60,35.47,and 106.19 mg g^(-1),respectively.The highest mean TSS content(108.71 mg g^(-1)) was observed in accessions from Northern Region of China.Cultivars contained higher contents of sucrose,raffinose,and TSS,whereas landraces had a higher content of stachyose.Fourteen accessions with mean TSS contents>130 mg g^(-1) were identified as elite soybean resources.TSS was correlated with sucrose,raffinose,stachyose,protein,oil and total tocopherol.The main soluble sugar components were correlated with latitude and longitude,indicating that the geographical origin of the accessions affected their seed soluble sugar compositions.The developed methods and elite identified accessions can be used in the food and feed industry and in soybean breeding programs aimed at improving soybean seed nutrition. 展开更多
关键词 Soluble sugars Soybean[Glycine max(L.)Merrill] UPLC-RID Natural variation Geographical distribution
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Interventional Therapy for Cerebral Aneurysms Under the Guidance of 3D Printing Technology
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作者 Xiangkong Song Xinguo Sun +2 位作者 Hualong Wang jie qi Guoqing Wang 《Proceedings of Anticancer Research》 2020年第4期42-46,共5页
Objective:To explore the clinical method and effect of 3D printing in the treatment of cerebral aneurysms.Methods:The authors research work on the hospital,work time in February 2019-February 2020,this study selected ... Objective:To explore the clinical method and effect of 3D printing in the treatment of cerebral aneurysms.Methods:The authors research work on the hospital,work time in February 2019-February 2020,this study selected patients of cerebral aneurysms,this period are selected for treatment of 100 cases of patients,randomly divided into two groups,a group to give simple intervention,named as the control group,another group for the interventional therapy under the guidance of 3 D printing,named as experimental group,analyze the effect of two groups of patients with clinical intervention.Results:The length of hospital stay in the experimental group was shorter than that in the control group.Meanwhile,the incidence of complications and adverse reactions in the experimental group and the control group were 6.00%and 18.00%,the experimental group was better(P<0.05).Conclusion:3D printing technology can be applied in the treatment of patients with cerebral aneurysms to provide guidance for interventional surgical treatment.It has significant effect,can reduce the incidence complications in patients,has significant clinical effect,and can be popularized. 展开更多
关键词 3D printing technology Interventional therapy Cerebral aneurysms Intervention effect
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Endovascular Application of Magnetic Resonance Double Mismatch Technique for Acute Anterior Circulation Large Vessel Occlusion with Cerebral Infarction in an Unknown Time Window
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作者 Xiangkong Song qing Zhang +2 位作者 Lilin Gao jie qi Guoqing Wang 《Journal of Clinical and Nursing Research》 2020年第5期43-46,共4页
Objective:To investigate the clinical effects of applying the magnetic resonance double mismatch technique to endovascular treatment of acute anterior circulation,large vessel occlusion with cerebral infarction in an ... Objective:To investigate the clinical effects of applying the magnetic resonance double mismatch technique to endovascular treatment of acute anterior circulation,large vessel occlusion with cerebral infarction in an unknown time window.Methods:The research work was carried out in our hospital,the work was carried out from November 2018 to November 2019,the patients with acute anterior circulation large vessel occlusion with cerebral infarction who were treated in our hospital during this period,100 patients,50 patients with an unknown time window and 50 patients with definite time window were selected,and they were named as the experimental and control groups,given different examination methods,were given to investigate the clinical treatment effect.Results:Patients’data on HIHSS score before treatment,the incidence of intracranial hemorrhage and rate of Mrs≤2 rating after 90 days of treatment were not significantly different(P>0.05),which was not meaningful.The differences in data between the two groups concerning HIHSS scores were relatively significant before,and after treatment(P<0.05).Conclusion:The magnetic resonance double mismatch technique will be applied in the endovascular treatment of acute anterior circulation large vessel occlusion with cerebral infarction of unknown time window. 展开更多
关键词 Magnetic resonance double mismatch technique Unknown time window Acute anterior circulation large vessel occlusion with cerebral infarction Therapeutic effect
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Ablation of drivers in patients with persistent atrial fibrillation refractory to pulmonary vein antral isolation:Target characteristics and 3-year outcomes
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作者 Liang Shi jie qi +6 位作者 Yanjiang Wang Wenkai Liao Xuexun Li Shunan He Lihong Huang Ying Tian Xingpeng Liu 《Chinese Medical Journal》 SCIE CAS CSCD 2024年第14期1747-1749,共3页
To the Editor:Pulmonary vein antral isolation(PVAI)is the cornerstone of catheter ablation techniques used in the treatment of patients with atrial fibrillation(AF).However,the outcomes of a PVAI-only strategy for per... To the Editor:Pulmonary vein antral isolation(PVAI)is the cornerstone of catheter ablation techniques used in the treatment of patients with atrial fibrillation(AF).However,the outcomes of a PVAI-only strategy for persistent AF have proven suboptimal.The majority of patients with persistent AF may require further atrial ablation beyond PVAI.Ablation of AF drivers,a patient-tailored ablation strategy for persistent AF with a procedural endpoint of AF termination,has garnered increasing attention in recent years.[1]We aimed to determine the electrogram(EGM)characteristics of AF drivers that can predict AF termination. 展开更多
关键词 ATRIAL PATIENTS FIBRILLATION
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基于压缩态的一维连续变量测量设备无关方案
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作者 刘文元 白建东 +2 位作者 颉琦 靳晶晶 刘泽慧 《量子光学学报》 北大核心 2024年第2期45-57,共13页
测量设备无关协议有效消除了系统中关于探测端的侧信道攻击。一维调制相干态的连续变量量子密钥分发协议具有调制过程简单,成本低和消耗随机数少等特点,其实现条件相比于二维高斯调制更加简单。为了简化实验系统,同时保证较高的安全密... 测量设备无关协议有效消除了系统中关于探测端的侧信道攻击。一维调制相干态的连续变量量子密钥分发协议具有调制过程简单,成本低和消耗随机数少等特点,其实现条件相比于二维高斯调制更加简单。为了简化实验系统,同时保证较高的安全密钥速率和传输距离,本文在连续变量量子密钥分发基础上,结合测量设备无关和一维调制相干态协议,提出了基于压缩态的一维调制连续变量测量设备无关协议,详细分析了此方案的实际安全性能,包括传输距离对称和非对称情况。数值仿真结果表明,通过调整调制方差Vm和压缩参数r获得较高安全密钥速率和传输距离,同时分析了加入光源噪声和探测噪声对该方案安全性能的影响机制。这些结果为该方案实验实现提供了理论依据,为进一步简化连续变量量子密钥分发系统实验实现,降低成本,推动系统实用化进程提供了有效途径。 展开更多
关键词 连续变量量子密钥分发 测量设备无关 一维高斯调制 压缩态
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TRIB3 promotes pulmonary fibrosis through inhibiting SLUG degradation by physically interacting with MDM2 被引量:1
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作者 Xiaoxi Lv Shanshan Liu +14 位作者 Chang Liu Yunxuan Li Tingting Zhang jie qi Ke Li Fang Hua Bing Cui Xiaowei Zhang Yuxin Liu Jiaojiao Yu Jinmei Yu Li Li Xia Li Zhigang Yao Bo Huang 《Acta Pharmaceutica Sinica B》 SCIE CAS CSCD 2023年第4期1631-1647,共17页
Pulmonary fibrosis(PF)is the pathological structure of incurable fibroproliferative lung diseases that are attributed to the repeated lung injury-caused failure of lung alveolar regeneration(LAR).Here,we report that r... Pulmonary fibrosis(PF)is the pathological structure of incurable fibroproliferative lung diseases that are attributed to the repeated lung injury-caused failure of lung alveolar regeneration(LAR).Here,we report that repetitive lung damage results in a progressive accumulation of the transcriptional repressor SLUG in alveolar epithelial type II cells(AEC2s).The abnormal increased SLUG inhibits AEC2s from self-renewal and differentiation into alveolar epithelial type I cells(AEC1s).We found that the elevated SLUG represses the expression of the phosphate transporter SLC34A2 in AEC2s,which reduces intracellular phosphate and represses the phosphorylation of JNK and P38 MAPK,two critical kinases supporting LAR,leading to LAR failure.TRIB3,a stress sensor,interacts with the E3 ligase MDM2 to suppress SLUG degradation in AEC2s by impeding MDM2-catalyzed SLUG ubiquitination.Targeting SLUG degradation by disturbing the TRIB3/MDM2 interaction using a new synthetic staple peptide restores LAR capacity and exhibits potent therapeutic efficacy against experimental PF.Our study reveals a mechanism of the TRIB3—MDM2—SLUG—SLC34A2 axis causing the LAR failure in PF,which confers a potential strategy for treating patients with fibroproliferative lung diseases. 展开更多
关键词 E3 ligase Lung injury MDM2 Protein—protein interaction PROTEOLYSIS UBIQUITINATION UPS
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Treating oily solids using a CO_(2)-responsive surfactant-free microemulsion:An enhanced approach for oil removal from solid surfaces 被引量:1
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作者 Xiaojiang Li Xu Liu +4 位作者 jie qi Yang Yang Jinyu Wang Shanshan Dai Hongsheng Lu 《ChemPhysMater》 2023年第3期217-224,共8页
Because switchable water is difficult to apply directly for oil removal,an enhanced approach to improve oil removal is proposed using a surfactant-free microemulsion(SFME)containing switchable water.The SFME is formed... Because switchable water is difficult to apply directly for oil removal,an enhanced approach to improve oil removal is proposed using a surfactant-free microemulsion(SFME)containing switchable water.The SFME is formed using switchable water(aqueous N,N-dimethylethanolamine(DMEA)or N,N-dimethylbutylamine(BDEA))and a hydrophobic amine(N-butyldiethanolamine(DMBA)).The single-phase region for preparing the SFME is determined using a ternary phase diagram,and the microstructure types are distinguished using the con-ductivity method.The pH changes and dynamic laser scattering test results demonstrate that the SFME exhibits irreversible transformation behavior regulated by CO_(2).Moreover,the recovered SFME containing BDEA has a microstructure with a smaller particle size after removing the CO_(2) by bubbling N 2 at 65°C,which is attributed to the higher proportion of DMEA than that of BDEA.In addition,dodecane and diesel oil are shown to dissolve in the SFME,and the oil solubility of the SFME increases with increasing oil phase(DMBA)content.The interface free energy theory reveals that the oil is more easily detached with the addition of SFME than with switchable water only owing to the reduced interface free energy of oil on the solid surface.Thus,an enhanced approach for removing oil is proposed to wash oil sands,where the oil removal efficiency of switchable water can be improved by using SFMEs containing switchable water. 展开更多
关键词 Oil removal CO_(2)-responsive Switchable water MICROEMULSION
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Suspected malignant hyperthermia in a young Chinese patient undergoing a micro varicocelectomy surgery
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作者 Hongjiao Xu Zhaomin Wang +5 位作者 Zhongmei Peng Jianhai Zhang Xiang Li Di Liu jie qi Jinbao Li 《Chinese Medical Journal》 SCIE CAS CSCD 2023年第17期2116-2118,共3页
To the Editor:Malignant hyperthermia(MH)is a pharmacogenetic disorder of skeletal muscles that presents as an acute hypermetabolic state triggered by depolarizing muscle relaxants and volatile anesthetics in susceptib... To the Editor:Malignant hyperthermia(MH)is a pharmacogenetic disorder of skeletal muscles that presents as an acute hypermetabolic state triggered by depolarizing muscle relaxants and volatile anesthetics in susceptible individuals.[1]The reported incidence of MH reaction ranged from 1:250,000 to 1:10,000.[1]However,the exact incidence in the Asian population remains unknown.A recent report suggested that the incidence of MH in Japan was 1 to 2 per 100,000 anesthetics,[2]which was similar to that in Western countries.In China,there are only a few reported cases,which may be attributed to incomplete records,and the actual incidence might be higher.[3,4]In China,between January 1978 and March 2004,only 34 cases of MH were recorded.[5]Due to the lack of the effective drug dantrolene,the mortality rate at that time was 73.5%.[5]Here,we reported the onset and treatment of a patient with suspected MH. 展开更多
关键词 HYPERTHERMIA PATIENT MORTALITY
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纳米颗粒表面活性剂对T型微通道中液滴分裂的影响 被引量:1
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作者 齐杰 彭佳庆 +2 位作者 杨圣贤 骆政园 白博峰 《科学通报》 EI CAS CSCD 北大核心 2022年第8期795-804,共10页
液滴分裂是微通道中获得单分散小尺寸液滴的重要方法,纳米颗粒表面活性剂能够包裹液滴,是制备功能胶囊的潜在技术手段,研究纳米颗粒表面活性剂作用下的液滴分裂行为对于获得尺寸更小、分散性更好的功能液滴具有重要意义.本文通过微流体... 液滴分裂是微通道中获得单分散小尺寸液滴的重要方法,纳米颗粒表面活性剂能够包裹液滴,是制备功能胶囊的潜在技术手段,研究纳米颗粒表面活性剂作用下的液滴分裂行为对于获得尺寸更小、分散性更好的功能液滴具有重要意义.本文通过微流体可视化实验和理论分析方法,研究纳米颗粒表面活性剂对液滴分裂的影响规律.在纳米颗粒表面活性剂作用下,液滴分裂存在阻塞分裂、过渡态分裂、非阻塞分裂、不分裂4种状态;通过分析液滴颈部宽度随时间的变化关系,得出纳米颗粒表面活性剂对液滴分裂的影响机理,即通过降低界面张力影响挤压颈缩速率;通过分析基于液滴尺寸与毛细数的液滴分裂状态分布相图,建立了液滴阻塞分裂与非阻塞分裂的临界转化理论模型. 展开更多
关键词 液滴分裂 纳米颗粒 表面活性剂 微通道
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Relationships of Inflammatory Factors and Risk Factors with Different Target Organ Damage in Essential Hypertension Patients 被引量:24
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作者 Chun-Lin Lai Jin-Ping Xing +7 位作者 Xiao-Hong Liu jie qi Jian-qiang Zhao You-Rui Ji Wu-Xiao Yang Pu-Juan Yan Chun-Yan Luo Lu-Fang Ruan 《Chinese Medical Journal》 SCIE CAS CSCD 2017年第11期1296-1302,共7页
Background: Atherosclerosis (AS) is an inflammatory disease. Inflammation was considered to play a role in the whole process of AS. This study aimed to analyze the relationships of inflammatory factors and risk fac... Background: Atherosclerosis (AS) is an inflammatory disease. Inflammation was considered to play a role in the whole process of AS. This study aimed to analyze the relationships of inflammatory factors and risk factors with different target organ damages (TOD) in essential hypertension (EH) patients and to explore its clinical significance. Methods: A total of 294 EH patients were selected and divided into four groups according to their conditions of TOD. Forty-eight healthy subjects were selected as control. The clinical biochemical parameters, serum amyloid A, serum tryptase, and lipoprotein-associated phospholipase A2 (Lp-PLA2) in each group were detected, and the related risk factors were also statistically analyzed. Results: Fihrinogen (Fbg) was the most significant independent risk factor in acute coronary syndrome (ACS) group (odds ratio [OR]: 22.242, 95% confidence interval [CI]: 6.458-76.609, P 〈 0.001) with the largest absolute value of the standardized partial regression coefficient B' (b': 1.079). Lp-PLA2 was the most significant independent risk factor in stroke group (OR: 13.699, 95% CI: 5.236-35.837, P 〈 0.001) with b" 0.708. Uric acid (UA) was the most significant independent risk factor in renal damage group (OR: 15.307, 95% CI:4.022 58.250, P〈0.001)with b'= 1.026. Conclusions: Fbg, Lp-PLA2, and UA are the strongest independent risk factors toward the occurrence of ACS, ischemic stroke, and renal damage in EH patients, thus exhibiting the greatest impacts on the occurrence ofACS, ischemic stroke, and renal damage in EH patients, respectively. 展开更多
关键词 HYPERTENSION Inflammatory Cytokines Target Organ Damage
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Antiferromagnetic element Mn modified PtCo truncated octahedral nanoparticles with enhanced activity and durability for direct methanol fuel cells 被引量:7
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作者 qiqi Zhang Jialong Liu +7 位作者 Tianyu Xia jie qi Haochang Lyu Baoyuan Luo Rongming Wang Yizhong Guo Lihua Wang and Shouguo Wang 《Nano Research》 SCIE EI CAS CSCD 2019年第10期2520-2527,共8页
Pt-based magnetic nano catalysts are one of the most suitable cand idates for electrocatalytic materials due to their high electrochemistry activity and retrievability.Unfortunately,the inferior durability prevents th... Pt-based magnetic nano catalysts are one of the most suitable cand idates for electrocatalytic materials due to their high electrochemistry activity and retrievability.Unfortunately,the inferior durability prevents them from being scaled-up,limiting their commercial applications.Herein,an antiferromagnetic element Mn was introduced into PtCo nanostructured alloy to synthesize uniform Mn-PtCo truncated octahedral nanoparticles(TONPs)by one-pot method.Our results show that Mn can tune the blocking temperature of Mn-PtCo TONPs due to its an tiferromag netism.At low temperatures,Mn-PtCo TONPs are ferromag netic,and the coercivity in creases gradually with in creasi ng Mn contents.At room temperature,the Mn-PtCo TONPs display superparamag netic behavior,which is greatly helpful for in dustrial recycling.Mn doping can not only modify the electronic structure of PtCo TONPs but also enhanee electrocatalytic performance for methanol oxidation reaction.The maximum specific activity of Mn-PtCo-3 reaches 8.1 A`m^-2,3.6 times of commercial Pt/C(2.2 A·m^-2)and 1.4 times of PtCo TONPs(5.6 A`m^-2),respectively.The mass activity decreases by only 30%after 2,000 cycles,while it is 45%and 99%(nearly inactive)for PtCo TONPs and commercial Pt/C catalysts,respectively. 展开更多
关键词 Mn-PtCo trun cated OCTAHEDRAL nano particles an tiferromag netic eleme nt magnetic properties ELECTROCATALYTIC performa NEE
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Blockade of c-Src Within the Paraventricular Nucleus Attenuates Inflammatory Cytokines and Oxidative Stress in the Mechanism of the TLR4 Signal Pathway in Salt-Induced Hypertension 被引量:6
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作者 qing Yang Xiao-Jing Yu +7 位作者 qing Su qiu-Yue Yi Xin-Ai Song Xiao-Lian Shi Hong-Bao Li jie qi Guo-qing Zhu Yu-Ming Kang 《Neuroscience Bulletin》 SCIE CAS CSCD 2020年第4期385-395,共11页
Toll-like receptor 4 (TLR4) and cellular Src (cSrc) are closely associated with inflammatory cytokines and oxidative stress in hypertension, so we designed this study to explore the exact role of c-Src in the mechanis... Toll-like receptor 4 (TLR4) and cellular Src (cSrc) are closely associated with inflammatory cytokines and oxidative stress in hypertension, so we designed this study to explore the exact role of c-Src in the mechanism of action of the TLR4 signaling pathway in salt-induced hypertension. Salt-sensitive rats were given a high salt diet for 10 weeks to induce hypertension. This resulted in higher levels of TLR4, activated c-Src, pro-inflammatory cytokines, oxidative stress, and arterial pressure. Infusion of a TLR4 blocker into the hypothalamic paraventricular nucleus (PVN) decreased the activated c-Src, while microinjection of a c-Src inhibitor attenuated the PVN levels of nuclear factor-kappa B, pro-inflammatory cytokines, and oxidative stress. Our findings suggest that a longterm high-salt diet increases TLR4 expression in the PVN and this promotes the activation of c-Src, which upregulates the expression of pro-inflammatory cytokines and results in the overproduction of reactive oxygen species.Therefore, inhibiting central c-Src activity may be a new target for treating hypertension. 展开更多
关键词 TOLL-LIKE receptor 4 Cellular Src Inflammatory cytokines Oxidative stress HYPOTHALAMIC PARAVENTRICULAR nucleus Salt-induced hypertension
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Identification of differential genes in the ovary relative to the testis and their expression patterns in half-smooth tongue sole (Cynoglossus semilaevis) 被引量:3
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作者 Yeying Sun Quanqi Zhang +3 位作者 jie qi Yanjie Chen qiwang Zhong Chunmei Li 《Journal of Genetics and Genomics》 SCIE CAS CSCD 2010年第2期137-145,共9页
Half-smooth tongue sole (Cynoglossus semilaevis) is a rare marine flatfish whose mature ovary and testis greatly differ in volume and weight. The length and weight of mature females are over twice greater than those... Half-smooth tongue sole (Cynoglossus semilaevis) is a rare marine flatfish whose mature ovary and testis greatly differ in volume and weight. The length and weight of mature females are over twice greater than those of mature males. To obtain sufficient information on gonad differentiation and the relationship between gonad development and growth in the fish, we compared gene expression between the ovary and testis using suppression subtractive hybridization (SSH). Testis cDNAs are subtracted from ovary cDNAs and are used to es- tablish an ovary testis-subtracted cDNA library. A total of 41 nonredundant clones are identified, including 20 known cDNAs, 9 unchar-acterized cDNAs (EST clones), and 12 novel sequences. For selected genes such as ZPC, RacGAP, survivin, aquaporin, CPEB, O5, O15, and O18, gene expression patterns are analyzed by reverse transcriptase-polymerase chain reaction (RT-PCR). The results confirm that these genes are only expressed in the ovary and not in the testis, or at higher levels in the ovary than in the testis. At the same time, expressions of certain genes such as ZPC, survivin, aquaporin, CPEB, and O15 are demonstrated to possess sexual dimorphism in the kidney or muscle, and spleen. The results suggest that these genes could play key roles not only in the ovary but in other female tissues as well. 展开更多
关键词 Cynoglossus semilaevis SSH gene expression sexual dimorphism RT-PCR
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Point-of-Care Immunoassays with Tunable Detection Range for Detecting Infection in Intensive Care Unit 被引量:2
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作者 Lei Mou Zulan Li +1 位作者 jie qi Xingyu Jiang 《CCS Chemistry》 CAS 2021年第5期1562-1572,共11页
One of the difficulties of a multiplexed analytical assay is matching the concentration range of different markers.Here,the authors develop an automatic,multiplexed point-of-care(POC)immunoassay that allows detecting ... One of the difficulties of a multiplexed analytical assay is matching the concentration range of different markers.Here,the authors develop an automatic,multiplexed point-of-care(POC)immunoassay that allows detecting C-reactive protein(CRP),procalcitonin(PCT),and interleukin 6(IL-6)in 50μL serum samples with limits of detection 1.87μg/mL,0.17 ng/mL,and 49.75 pg/mL,respectively.The authors use electrospun fibers and surface chemistry of gold nanoparticles(AuNPs)to adjust the detection range of different biomarkers.The authors have proposed some new diagnostic indicators(mScore and mScorePlus)that combine the results of CRP,PCT,IL-6,and complete blood counts(CBCs).The authors also tracked changes in CRP,PCT,and IL-6 of patients in an intensive care unit(ICU).The authors find that mScore and mScorePlus have advantages in improving the diagnostic accuracy and providing more analytical information.mScore and mScorePlus are effective tools to detect infections,differentiate bacterial and viral infections,and monitor disease.Integrating multiple markers into one straightforward parameter is an effective method for analytical applications.The authors believe that this method provides a general way for chemists to develop increasingly accurate detection methods and indicators. 展开更多
关键词 MICROFLUIDICS IMMUNOASSAY multiplexed assay intensive care unit point-of-care testing
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