Photodynamic therapy(PDT)has been emerged as a promising modality for cancer treatment.However,the development of drug delivery system enabling continuous release of photosensitizers(PSs)for long-term PDT treatment st...Photodynamic therapy(PDT)has been emerged as a promising modality for cancer treatment.However,the development of drug delivery system enabling continuous release of photosensitizers(PSs)for long-term PDT treatment still remains challenges.Herein,a H_(2)O_(2)-responsive injectable hydrogel,covalently crosslinked by N^(1)-(4-boronobenzyl)-N^(3)-(4-boronophenyl)-N^(1),N^(1),N^(3),N^(3)-tetramethylpropane-1,3-diaminium(TSPBA)with PVA containing polythiophene quaternary ammonium salt(PT2)polymer dots(PDots)as a photosensitizer was fabricated.Under the stimulation of H_(2)O_(2),the obtained injectable hydrogel gradually degrades and releases PDots.In vitro experiments suggested that the released PDots could realize efficient tumor cells inhibition through its robust singlet oxygen generation capability upon 577 nm laser irradiation.In vivo studies demonstrated a sustained retention of PDots for at least 7 days following single-dose administration,facilitating efficient tumor inhibition with light treatments for 3 times without apparent biotoxicity.This work presents an innovative polymer dots-based composite local drug delivery system for long-term PDT in cancer treatment.展开更多
A water-soluble, polythiophene-based colorimetric sensor was designed for selective and sensitive detection of carbenicillin in HEPES buffer solution. Quaternized quinine was linked to thiophene through bis-functional...A water-soluble, polythiophene-based colorimetric sensor was designed for selective and sensitive detection of carbenicillin in HEPES buffer solution. Quaternized quinine was linked to thiophene through bis-functionality benzyl group, which can interact with carbenicillin via electrostatic interaction and geometric match effect. The sensor exhibited a colorimetric signal change upon the addition of carbenicillin because of the formation of more nonplanar structures. However, the addition of other beta-lactarn antibiotics or dicarboxylic acids into the sensor solution caused no obvious changes in absorbance intensity ratio. This result may be attributed to the cavity formed by the semi-rigid framework of PTQ2, which is suitable for the special binding with carbenicillin. This novel sensor can effectively distinguish carbenicillin from other beta-lactam antibiotics and has a wide linear range response in HEPES buffer solution. Linear calibration curves are obtained with 0 to 18 μmol/L of HEPES buffer solution, with a limit of detection of 0.54μmol/L.展开更多
基金financially supported by the National Natural Science Foundation of China(Nos.52272052 and 51972315)。
文摘Photodynamic therapy(PDT)has been emerged as a promising modality for cancer treatment.However,the development of drug delivery system enabling continuous release of photosensitizers(PSs)for long-term PDT treatment still remains challenges.Herein,a H_(2)O_(2)-responsive injectable hydrogel,covalently crosslinked by N^(1)-(4-boronobenzyl)-N^(3)-(4-boronophenyl)-N^(1),N^(1),N^(3),N^(3)-tetramethylpropane-1,3-diaminium(TSPBA)with PVA containing polythiophene quaternary ammonium salt(PT2)polymer dots(PDots)as a photosensitizer was fabricated.Under the stimulation of H_(2)O_(2),the obtained injectable hydrogel gradually degrades and releases PDots.In vitro experiments suggested that the released PDots could realize efficient tumor cells inhibition through its robust singlet oxygen generation capability upon 577 nm laser irradiation.In vivo studies demonstrated a sustained retention of PDots for at least 7 days following single-dose administration,facilitating efficient tumor inhibition with light treatments for 3 times without apparent biotoxicity.This work presents an innovative polymer dots-based composite local drug delivery system for long-term PDT in cancer treatment.
基金financially supported by the National Natural Science Foundation of China(Nos.20903110 and 21173244)
文摘A water-soluble, polythiophene-based colorimetric sensor was designed for selective and sensitive detection of carbenicillin in HEPES buffer solution. Quaternized quinine was linked to thiophene through bis-functionality benzyl group, which can interact with carbenicillin via electrostatic interaction and geometric match effect. The sensor exhibited a colorimetric signal change upon the addition of carbenicillin because of the formation of more nonplanar structures. However, the addition of other beta-lactarn antibiotics or dicarboxylic acids into the sensor solution caused no obvious changes in absorbance intensity ratio. This result may be attributed to the cavity formed by the semi-rigid framework of PTQ2, which is suitable for the special binding with carbenicillin. This novel sensor can effectively distinguish carbenicillin from other beta-lactam antibiotics and has a wide linear range response in HEPES buffer solution. Linear calibration curves are obtained with 0 to 18 μmol/L of HEPES buffer solution, with a limit of detection of 0.54μmol/L.
