Based on the data of hail disaster in Qujing City and the detection data of the new generation of Doppler weather radar, the spatial and temporal distribution characteristics of hail disaster and hail suppression oper...Based on the data of hail disaster in Qujing City and the detection data of the new generation of Doppler weather radar, the spatial and temporal distribution characteristics of hail disaster and hail suppression operations in Qujing City were analyzed statistically, and the hail suppression operations of a typical cell case was analyzed. The results showed that the number of hail days and hail frequency showed an increasing trend in Qujing City from 2017 to 2022, and the number of artificial hail suppression operations increased accordingly. Hail disaster occurred most frequently in Xuanwei City. Through the analysis of hail suppression operations of a typical cell case, it is found that the operations were timely, and the location was reasonable. The ammunition used was sufficient, and the overall effect of the hail suppression operations was good.展开更多
目的旨在引入政策一致性(Policy Modeling Consistency,PMC)指数模型量化评估医防融合政策,以期为优化我国医防融合政策提供参考。方法以“医防融合”为关键词,在中央政府及相关部门的官方网站进行检索获取政策文本30份,基于ROST CM 6....目的旨在引入政策一致性(Policy Modeling Consistency,PMC)指数模型量化评估医防融合政策,以期为优化我国医防融合政策提供参考。方法以“医防融合”为关键词,在中央政府及相关部门的官方网站进行检索获取政策文本30份,基于ROST CM 6.0软件与PMC指数模型对我国医防融合政策文本进行量化评价。结果医防融合政策文本的PMC指数均值为4.552,其中8项政策为可接受等级。结论应加强医防融合政策的顶层设计,优化政策工具的组合应用,有效利用中医、中西医结合在医防融合服务中的优势。展开更多
Bitterness,one of the 5“basic tastes”,is usually undesired by humans.However,abundant literature reported that bitter fruits and vegetables have beneficial health effects due to their bitter contributors.This review...Bitterness,one of the 5“basic tastes”,is usually undesired by humans.However,abundant literature reported that bitter fruits and vegetables have beneficial health effects due to their bitter contributors.This review provided an updated overview of the main bitter contributors of typical bitter fruits and vegetables and their health benefits.The main bitter contributors,including phenolics,terpenoids,alkaloids,amino acids,nucleosides and purines,were summarized.The bioactivities and wide range of beneficial effects of them on anti-cancers,anti-inflammations,anti-microbes,neuroprotection,inhibiting chronic and acute injury in organs,as well as regulating behavior performance and metabolism were reported.Furthermore,not only did the bitter taste receptors(taste receptor type 2 family,T2Rs)show taste effects,but extra-oral T2Rs could also be activated by binding with bitter components,regulating physiological activities via modulating hormone secretion,immunity,metabolism,and cell proliferation.This review provided a new perspective on exploring and explaining the nutrition of bitter foods,revealing the relationship between the functions of bitter contributors from food and T2Rs.Future trends may focus on revealing the possibility of T2Rs being targets for the treatment of diseases,exploring the mechanism of T2Rs mediating the bioactivities,and making bitter foods more acceptable without getting rid of bitter contributors.展开更多
Background:In the 21st century,as globalization accelerates and global public health crises occur,the One Health approach,guided by the holistic thinking of human-animal-environment and emphasizing interdisciplinary c...Background:In the 21st century,as globalization accelerates and global public health crises occur,the One Health approach,guided by the holistic thinking of human-animal-environment and emphasizing interdisciplinary collaboration to address global health issues,has been strongly advocated by the international community.An immediate requirement exists for the creation of an assessment tool to foster One Health initiatives on both global and national scales.Methods:Built upon extensive expert consultations and dialogues,this follow-up study enhances the 2022 global One Health index(GOHI)indicator system.The GOHI framework is enriched by covering three indices,e.g.external drivers index(EDI),intrinsic drivers index(IDI),and core drivers index(CDI).The comprehensive indicator system incorporates 13 key indicators,50 indicators,and 170 sub I-indicators,utilizing a fuzzy analytic hierarchy process to ascertain the weight for each indicator.Weighted and summed,the EDI,IDI,and CDI scores contribute to the computation of the overall GOHI 2022 score.By comparing the ranking and the overall scores among the seven regions and across 160 countries/territories,we have not only derived an overall profile of the GOHI 2022 scores,but also assessed the GOHI framework.We also compared rankings of indicators and sub Iindicators to provide greater clarity on the strengths and weaknesses of each region within the One Health domains.Results:The GOHI 2022 performance reveals significant disparities between countries/territories ranged from 39.03 to 70.61.The global average score of the GOHI 2022 is 54.82.The average score for EDI,IDI,and CDI are 46.57,58.01,and 57.25,respectively.In terms of global rankings,countries from North America,Europe and Central Asia,East Asia and Pacific present higher scores.In terms of One Health domains of CDI,the lowest scores are observed in antimicrobial resistance(median:43.09),followed by food security(median:53.78),governance(median:54.77),climate change(median:64.12)and zoonotic diseases(median:69.23).Globally,the scores of GOHI vary spatially,with the highest score in North America while lowest in sub-Saharan Africa.In addition,evidence shows associations between the socio-demographic profile of countries/territories and their GOHI performance in certain One Health scenarios.Conclusion:The objective of GOHI is to guide impactful strategies for enhancing capacity building in One Health.With advanced technology and an annually updated database,intensifying efforts to refine GOHI's data-mining methodologies become imperative.The goal is to offer profound insights into disparities and progressions in practical One Health implementation,particularly in anticipation of future pandemics.展开更多
文摘Based on the data of hail disaster in Qujing City and the detection data of the new generation of Doppler weather radar, the spatial and temporal distribution characteristics of hail disaster and hail suppression operations in Qujing City were analyzed statistically, and the hail suppression operations of a typical cell case was analyzed. The results showed that the number of hail days and hail frequency showed an increasing trend in Qujing City from 2017 to 2022, and the number of artificial hail suppression operations increased accordingly. Hail disaster occurred most frequently in Xuanwei City. Through the analysis of hail suppression operations of a typical cell case, it is found that the operations were timely, and the location was reasonable. The ammunition used was sufficient, and the overall effect of the hail suppression operations was good.
文摘目的旨在引入政策一致性(Policy Modeling Consistency,PMC)指数模型量化评估医防融合政策,以期为优化我国医防融合政策提供参考。方法以“医防融合”为关键词,在中央政府及相关部门的官方网站进行检索获取政策文本30份,基于ROST CM 6.0软件与PMC指数模型对我国医防融合政策文本进行量化评价。结果医防融合政策文本的PMC指数均值为4.552,其中8项政策为可接受等级。结论应加强医防融合政策的顶层设计,优化政策工具的组合应用,有效利用中医、中西医结合在医防融合服务中的优势。
基金National Natural Science Foundation of China(No.52161040)Major Science and Technology Research and Development Project of Jiangxi Province(No.20203ABC28W006)+1 种基金Natural Science Foundation of Jiangxi Province,China,(No.20202ACBL214011)Key Project of"Science and Technology to Promote Mongolian Development",China(No.XM2021BT03)。
基金the financial support provided by“Pioneer”and“Leading Goose”R&D Program of Zhejiang(2022C020122022C02078)。
文摘Bitterness,one of the 5“basic tastes”,is usually undesired by humans.However,abundant literature reported that bitter fruits and vegetables have beneficial health effects due to their bitter contributors.This review provided an updated overview of the main bitter contributors of typical bitter fruits and vegetables and their health benefits.The main bitter contributors,including phenolics,terpenoids,alkaloids,amino acids,nucleosides and purines,were summarized.The bioactivities and wide range of beneficial effects of them on anti-cancers,anti-inflammations,anti-microbes,neuroprotection,inhibiting chronic and acute injury in organs,as well as regulating behavior performance and metabolism were reported.Furthermore,not only did the bitter taste receptors(taste receptor type 2 family,T2Rs)show taste effects,but extra-oral T2Rs could also be activated by binding with bitter components,regulating physiological activities via modulating hormone secretion,immunity,metabolism,and cell proliferation.This review provided a new perspective on exploring and explaining the nutrition of bitter foods,revealing the relationship between the functions of bitter contributors from food and T2Rs.Future trends may focus on revealing the possibility of T2Rs being targets for the treatment of diseases,exploring the mechanism of T2Rs mediating the bioactivities,and making bitter foods more acceptable without getting rid of bitter contributors.
基金supported by China Medical Board[No.20–365]Bill&Melinda Gates Foundation[No.INV-046218]the National Natural Science Foundation of China[No.72204160].
文摘Background:In the 21st century,as globalization accelerates and global public health crises occur,the One Health approach,guided by the holistic thinking of human-animal-environment and emphasizing interdisciplinary collaboration to address global health issues,has been strongly advocated by the international community.An immediate requirement exists for the creation of an assessment tool to foster One Health initiatives on both global and national scales.Methods:Built upon extensive expert consultations and dialogues,this follow-up study enhances the 2022 global One Health index(GOHI)indicator system.The GOHI framework is enriched by covering three indices,e.g.external drivers index(EDI),intrinsic drivers index(IDI),and core drivers index(CDI).The comprehensive indicator system incorporates 13 key indicators,50 indicators,and 170 sub I-indicators,utilizing a fuzzy analytic hierarchy process to ascertain the weight for each indicator.Weighted and summed,the EDI,IDI,and CDI scores contribute to the computation of the overall GOHI 2022 score.By comparing the ranking and the overall scores among the seven regions and across 160 countries/territories,we have not only derived an overall profile of the GOHI 2022 scores,but also assessed the GOHI framework.We also compared rankings of indicators and sub Iindicators to provide greater clarity on the strengths and weaknesses of each region within the One Health domains.Results:The GOHI 2022 performance reveals significant disparities between countries/territories ranged from 39.03 to 70.61.The global average score of the GOHI 2022 is 54.82.The average score for EDI,IDI,and CDI are 46.57,58.01,and 57.25,respectively.In terms of global rankings,countries from North America,Europe and Central Asia,East Asia and Pacific present higher scores.In terms of One Health domains of CDI,the lowest scores are observed in antimicrobial resistance(median:43.09),followed by food security(median:53.78),governance(median:54.77),climate change(median:64.12)and zoonotic diseases(median:69.23).Globally,the scores of GOHI vary spatially,with the highest score in North America while lowest in sub-Saharan Africa.In addition,evidence shows associations between the socio-demographic profile of countries/territories and their GOHI performance in certain One Health scenarios.Conclusion:The objective of GOHI is to guide impactful strategies for enhancing capacity building in One Health.With advanced technology and an annually updated database,intensifying efforts to refine GOHI's data-mining methodologies become imperative.The goal is to offer profound insights into disparities and progressions in practical One Health implementation,particularly in anticipation of future pandemics.
