Car-following strategy of intelligent connected vehicle using extended disturbance observer adjusted by reinforcement learning

Disturbance observer-based control method has achieved good results in the carfollowing scenario of intelligent and connected vehicle(ICV).However,the gain of conventional extended disturbance observer(EDO)-based control method is usually set manually rather than adjusted adaptively according to real time traffic conditions,thus declining the car-following performance.To solve this problem,a car-following strategy of ICV using EDO adjusted by reinforcement learning is proposed.Different from the conventional method,the gain of proposed strategy can be adjusted by reinforcement learning to improve its estimation accuracy.Since the“equivalent disturbance”can be compensated by EDO to a great extent,the disturbance rejection ability of the carfollowing method will be improved significantly.Both Lyapunov approach and numerical simulations are carried out to verify the effectiveness of the proposed method.

Demyelinating neuropathy in patients with hepatitis B virus: A case report

BACKGROUND Hepatitis B rarely leads to demyelinating neuropathy,despite peripheral neuropathy being the first symptom of hepatitis B infection.CASE SUMMARY A 64-year-old man presented with sensorimotor symptoms in multiple peripheral nerves.Serological testing showed that these symptoms were due to hepatitis B.After undergoing treatment involving intravenous immunoglobulin and an antiviral agent,there was a notable improvement in his symptoms.CONCLUSION Although hepatitis B virus(HBV)infection is known to affect hepatocytes,it is crucial to recognize the range of additional manifestations linked to this infection.The connection between long-term HBV infection and demyelinating neuropathy has seldom been documented;hence,prompt diagnostic and treatment are essential.The patient's positive reaction to immunoglobulin seems to be associated with production of the antigen-antibody immune complex.

Pre-training transformer with dual-branch context content module for table detection in document images

Background Document images such as statistical reports and scientific journals are widely used in information technology.Accurate detection of table areas in document images is an essential prerequisite for tasks such as information extraction.However,because of the diversity in the shapes and sizes of tables,existing table detection methods adapted from general object detection algorithms,have not yet achieved satisfactory results.Incorrect detection results might lead to the loss of critical information.Methods Therefore,we propose a novel end-to-end trainable deep network combined with a self-supervised pretraining transformer for feature extraction to minimize incorrect detections.To better deal with table areas of different shapes and sizes,we added a dualbranch context content attention module(DCCAM)to high-dimensional features to extract context content information,thereby enhancing the network's ability to learn shape features.For feature fusion at different scales,we replaced the original 3×3 convolution with a multilayer residual module,which contains enhanced gradient flow information to improve the feature representation and extraction capability.Results We evaluated our method on public document datasets and compared it with previous methods,which achieved state-of-the-art results in terms of evaluation metrics such as recall and F1-score.https://github.com/Yong Z-Lee/TD-DCCAM.

Rare primary colonic T cell lymphoma with curative resection by endoscopic submucosal dissection:A case report

BACKGROUND The gastrointestinal tract is a well-known extranodal site of lymphoma.B-cell lymph-oma is the most common type,while T-cell lymphoma is uncommon.Primary gastrointestinal lymphoma mainly occurs in the stomach and small intestine,and the colon is less frequently involved,especially in females.CASE SUMMARY A 45-year-old woman was admitted to our hospital for physical examination.Gastroenteroscopy revealed a visible pedunculated polyp in the transverse colon,for which endoscopic submucosal dissection(ESD)was performed.Pathology suggested highly active proliferation of T lymphocytes with atypical hyperplasia.CONCLUSION A middle-aged female patient was found to have colonic T-cell lymphoma by endoscopy.The lesion was successfully removed by ESD,and the surgical margin was negative.It is essential to raise awareness of colonic T-cell lymphoma and choose the appropriate treatment.

New rabbit model for benign biliary stricture formation with repeatable administration

BACKGROUND The treatment of benign biliary strictures(BBS)is a challenging clinical problem.At present,there is a lack of ideal models for the study of BBS treatment.AIM To develop a novel animal model of BBS to simulate studies on the processes and mechanisms in the human condition.METHODS A rabbit model of benign bile duct stricture was established by surgical injury of the bile duct.After removal of the gallbladder,a drainage tube was placed th-rough the cystic duct at the stump,and a BBS model was induced by surgical injury at the lower end of the common bile duct.RESULTS Compared with the control group,the model rabbits showed gross jaundice,increased serum bilirubin,and decreased liver function.Cholangiography showed segmental bile duct stenosis in the model rabbits.Pathological staining showed inflammatory cell infiltration and fibrosis in the biliary tract of rabbits in the model group.This was consistent with the clinical manifestations of BBS.This model provided serology,imaging,pathology,and other aspects of BBS.CONCLUSION We have successfully established an animal model of benign stricture of the lower bile duct with repeatable administration,which is consistent with the clinical manifestations of BBS.

The Impact of Seasonal Variation on Clinical Pregnancy and Live Birth Rates in Assisted Reproductive Technology: A Retrospective Cohort Study in Hainan

Objective:To investigate the influence of season on live birth and clinical pregnancy rates,as well as assisted reproductive technology(ART)outcomes,in the Hainan region.Methods:Patients were categorized into four groups based on the dates of artificial insemination and transplantation:spring,summer,autumn,or winter.The main outcome measures were clinical pregnancy rates and live birth rates.Secondary outcomes included body mass index(BMI),oocyte number,two pronuclei(2PN)cleavage rate,total gonadotropin(Gn)dosage and days,age,2PN fertilization rate,sperm concentration,sperm PR rate,anti-Müllerian hormone(AMH),and endometrial thickness.Outpatient semen quality indicators included sperm PR rate,total sperm count,sperm concentration,and total sperm motility.Results:This retrospective cohort study analyzed 2,016 artificial insemination cycles and 1,783 ovarian retrieval cycles from January 2017 to October 2022,and assessed the semen quality of 6,651 outpatients from May 2017 to October 2022.In artificial insemination cycles,sperm PR rate and clinical pregnancy rate were highest in winter,with a statistically significant difference between groups(P<0.05).Clinical pregnancy rate was influenced by both age and sperm PR rate(P<0.05).In ovarian retrieval cycles,the winter group had significantly higher clinical pregnancy,2PN fertilization,and 2PN cleavage rates than the other groups.The autumn group had higher live birth rates,though not significantly different.Additionally,winter months showed higher total sperm concentration and total sperm number compared to other seasons.Conclusion:Seasonality affected clinical pregnancy and live birth rates in artificial insemination cycles but not in ovarian retrieval cycles in the Hainan region.These findings suggest that while there is no need to choose a specific season for ovarian retrieval cycles,artificial insemination in winter may be preferable for patients.

流空间视域下城市内部物流联系及其网络结构——以深圳市为例

以深圳市为例,基于“流空间”视域研究城市内部物流网络,将货车GPS数据作为物流“流动数据”,结合社区发现模型,识别城市内部重要物流节点及其空间联系特征,并采用社会网络分析法刻画城市内部物流网络结构。结果表明:深圳市内部物流联系整体偏弱,呈现“西密东疏”的空间联系特征,具有显著极化发展态势,形成物流活动西进西出而物流设施居中分布的错位布局;物流联系“异质相吸”特征明显,不同类型节点的物流活动更趋向于朝特定区域流动;城市内部物流网络依赖于“机场-工业区-港口-物流园”廊道的联系纽带作用,形成以廊道为轴心线向周边扩散的物流廊道网络模式。由此,从重塑物流空间、调整规划编制、培育新增长级等方面提出促进城市内部物流协调高质量发展的建议,支撑打造城市物流发展的“深圳样本”,并助力其融入粤港澳大湾区的世界级物流枢纽建设。

面向德才兼备拔尖创新人才培养的分析化学(2)教学思考与实践

在科学和技术日益精进的年代,探索如何培养德才兼备的拔尖创新人才是分析化学(2)教学实践的一项重要任务。基于对现有分析化学(2)经典教学内容中中国元素显示度不明显、理论知识与实践结合不够紧密、教学内容缺乏时代性和前沿性的思考等问题,我们不断完善教学内容和教学方法,在教学内容中融入思政案例、社会热点案例、科学前沿进展,推进分析化学(2)科学育人和思政育人双重育人功能的有机融合,对培养德才兼备拔尖创新人才进行了教学探究和实践。

Large-Scale Vehicle Platooning:Advances and Challenges in Scheduling and Planning Techniques

Through vehicle-to-vehicle(V2V)communication,autonomizing a vehicle platoon can significantly reduce the distance between vehicles,thereby reducing air resistance and improving road traffic efficiency.The gradual maturation of platoon control technology is enabling vehicle platoons to achieve basic driving functions,thereby permitting large-scale vehicle platoon scheduling and planning,which is essential for industrialized platoon applications and generates significant economic benefits.Scheduling and planning are required in many aspects of vehicle platoon operation;here,we outline the advantages and challenges of a number of the most important applications,including platoon formation scheduling,lane-change planning,passing traffic light scheduling,and vehicle resource allocation.This paper’s primary objective is to integrate current independent platoon scheduling and planning techniques into an integrated architecture to meet the demands of large-scale platoon applications.To this end,we first summarize the general techniques of vehicle platoon scheduling and planning,then list the primary scenarios for scheduling and planning technique application,and finally discuss current challenges and future development trends in platoon scheduling and planning.We hope that this paper can encourage related platoon researchers to conduct more systematic research and integrate multiple platoon scheduling and planning technologies and applications.

Point cloud upsampling generative adversarial network based on residual multi-scale off-set attention

Background Owing to the limitations of the working principle of three-dimensional(3D) scanning equipment, the point clouds obtained by 3D scanning are usually sparse and unevenly distributed. Method In this paper, we propose a new generative adversarial network(GAN) that extends PU-GAN for upsampling of point clouds. Its core architecture aims to replace the traditional self-attention(SA) module with an implicit Laplacian offset attention(OA) module and to aggregate the adjacency features using a multiscale offset attention(MSOA)module, which adaptively adjusts the receptive field to learn various structural features. Finally, residual links are added to create our residual multiscale offset attention(RMSOA) module, which utilizes multiscale structural relationships to generate finer details. Result The results of several experiments show that our method outperforms existing methods and is highly robust.

Green Hydrothermal Synthesis and Applications of Sorbus pohuashanensis/Aronia melanocarpa Extracts Functionalized-Au/Ag/AuAg Nanoparticles

Nanoparticles(NPs)have already been widely used in catalysis,antibacterial and coating fields.Compared with the traditional toxic and harmful reducing reagents,green synthesis of NPs by using plant extracts is not only environmental-friendly and cost-effective but also conducive to the multi-level and efficient utilization of wild plant resources.In this study,the aqueous extracts from Sorbus pohuashanensis(SP)and Aronia melanocarpa(AM)fruits were used as the reducing and protective reagents for synthesizing Au/AgNPs,with the characteristics of originality operation and high repeatability.The SP/AM fruit extracts functionalized Au/AgNPs were characterized by UV-vis spectroscopy(UV-vis),transmission electron microscopy(TEM),energy dispersive spectroscopy(EDS),scanning electron microscope(SEM),X-ray diffraction(XRD)and Fourier transform infrared spectroscopy(FTIR).UV-vis spectrums showed the NPs peaks verified by the presence between 400–550 nm;TEM and SEM demonstrated NPs displayed approximately spherical structures;EDS confirmed the existence of Au/Ag elements;XRD measurements confirmed that the obtained NPs showed highly crystalline structures;FTIR demonstrated the fruits extracts were adsorbed on the surface of NPs.Primary experiments indicated that SP/AM fruit extracts functionalized-NPs could be used as the reagents for removing the organic dyes efficiently;Zone of inhibition tests(ZOI)explained that NPs have slow-release antibacterial activity.

Galectin-14 promotes hepatocellular carcinoma tumor growth via enhancing heparan sulfate proteoglycan modification

Hepatocellular carcinoma(HCC)is a highly heterogeneous malignancy and lacks effective treatment.Bulk-sequencing of different gene transcripts by comparing HCC tissues and adjacent normal tissues provides some clues for investigating the mechanisms or identifying potential targets for tumor progression.However,genes that are exclusively expressed in a subpopulation of HCC may not be enriched or detected through such a screening.In the current study,we performed a single cell-clone-based screening and identified galectin-14 as an essential molecule in the regulation of tumor growth.The aberrant expression of galectin-14 was significantly associated with a poor overall survival of liver cancer patients with database analysis.Knocking down galectin-14 inhibited the proliferation of tumor growth,whereas overexpressing galectin-14 promoted tumor growth in vivo.Non-targeted metabolomics analysis indicated that knocking down galectin-14 decreased glycometabolism;specifically that glycoside synthesis was significantly changed.Further study found that galectin-14 promoted the expression of cell surface heparan sulfate proteoglycans(HSPGs)that functioned as co-receptors,thereby increasing the responsiveness of HCC cells to growth factors,such as epidermal growth factor and transforming growth factor-alpha.In conclusion,the current study identifies a novel HCC-specific molecule galectin-14,which increases the expression of cell surface HSPGs and the uptake of growth factors to promote HCC cell proliferation.

Bone marrow mesenchymal stem cell-induced autophagy ameliorates TNBS-induced experimental colitis by downregulating the NLRP3 inflammasome

This study aimed to elucidate the potential mechanisms through which bone marrow-derived mesenchymal stem cells(BM-MSCs)may be effective in alleviating experimental colitis induced by treatment with 2,4,6-trinitrobenzene-sulfonate acid(TNBS),specifically through autophagy modulation.Methods:BM-MSCs were collected from BALB/c mice for subsequent experiments.The study employed cell counting kits(CCK-8)to investigate the impact of the MSC-conditioned medium(M medium)on the proliferation of RAW264.7 macrophages.The GFP-mRFP-LC3 adenovirus was transfected into RAW264.7 to detect autophagic flux.The gene expression of cytokines was assessed through quantitative reverse transcription polymerase chain reaction(qRT-PCR).Western blot analysis was employed to determine the presence of a binding interaction between NOD-like receptor protein 3(NLRP3)and autophagy.Furthermore,a colitis mouse model was established by TNBS induction.Clinical disease activity score was assessed regularly,and histological and morphometric analyses were performed on colonic tissues.Inflammatory serum cytokines were identified using an enzyme-linked immunosorbent assay.Results:BM-MSCs significantly promoted the proliferation of RAW264.7.In vitro lipopolysaccharide(LPS)-stimulated RAW264.7 cells,treated with BM-MSCs,triggered autophagy and inhibited cytokine mRNA expression.Additionally,in LPS-induced RAW264.7,BM-MSCs enhanced the Beclin1 protein expression and the microtubule-associated protein 1 light chain 3(LC3)-II to LC3-I ratio while suppressing the protein levels of NLRP3 and apoptosis-associated speck-like protein(ASC).Nevertheless,3-methyladenine(3-MA),an inhibitor of autophagy,prevented the impact of BM-MSCs by reducing the levels of NLRP3 and ASC proteins,suggesting that autophagy triggered the inhibition of the NLRP3 inflammasome.In comparison to the mice in the TNBS group,the mice in the TNBS+MSC group displayed a more acute form of colitis,and the IL1βand IL18 cytokines in their serum were lowered as well.In the meantime,3-MA raised IL1βand IL18 cytokine levels and worsened TNBS-induced experimental colitis.Conclusions:BM-MSCs can suppress inflammation in TNBS-induced experimental mice by inhibiting the NLRP3 inflammasome,thereby enhancing autophagy.

我国学前儿童数学监测指标体系的构建

对儿童学习和发展结果的评估与监控是教育质量监测的重要内容。学前儿童数学监测指标体系本质上是对3～6岁儿童在与数学学习有关的知识、能力、态度、学习品质等方面的发展的较为系统的期望。在厘清21世纪创新社会对人才数学素养要求的基础上,参考国内外研究文献和国内相关政策文件,本研究构建了学前儿童数学监测指标体系草案,然后采用德尔菲专家访谈方法,结合幼儿园教师在实践中的实际使用情况与反馈,对该指标体系进行了内容效度检验,并根据检验结果对指标体系进行了多次修改,最终确定的监测指标体系包含数学知识技能、过程性能力、态度和学习品质三个方面共20条指标,今后应进一步开发和完善与这一数学监测指标体系相匹配的注重儿童数学问题解决过程的诊断性测评工具和适合教师使用的观察评定表,以更好地发挥监测为改进教学、促进儿童发展服务的功能。

Clinical significance of HBME-1,Galectin-3,and CK19 expression and the status of BRAF mutation in papillary thyroid carcinoma

Objective The aim of this study was to explore the clinical significance of the expression of proteins human bone marrow endothelial cell markers(HBME-1), Galectin-3, and cytokeratin19(CK19), as well as the status of v-raf murine sarcoma viral oncogene homolog B1(BRAF) mutation in papillary thyroid carcinoma(PTC). Methods Immunohistochemical staining was performed in 82 specimens each of PTC and papillary benign lesions to detect the expression of HBME-1, Galectin-3, and CK19. Polymerase chain reaction(PCR) and gene sequencing were performed on 60 specimens each of PTC and papillary benign lesions to detect the status of BRAF mutation. Results The positive expression ratios of HBME-1, Galectin-3, and CK19 in PTC were 98.8%, 97.6% and 100% respectively, which were significantly higher than the expressions in papillary benign lesions(P < 0.05). No significant relationship was observed between the expression of these makers and the clinicopathological features of PTC. The sensitivity of co-expression of HBME-1 and CK19 or HBME-1 and Galectin-3 as diagnostic criteria of PTC was 99.9%, with a specificity of 95.4%. BRAF mutation was detected in 40 of 60 PTC(66.7%) specimens. There was a statistical difference in BRAF mutations between PTC and papillary benign lesions(P < 0.05); there were no associations between BRAF mutation and the clinicopathological features of PTC. Conclusion Combined immunohistochemical staining of HBME-1, Galectin-3, and CK19 can further improve the sensitivity and specificity of differential diagnosis of PTC. BRAF mutation is a significant genetic event, which may have diagnostic value for PTC.

5～6岁儿童数学问题解决的认知诊断评估工具

基于认知诊断评估理论和技术,本研究采用文献分析、专家研讨和口语报告法构建5～6岁儿童"数与运算"领域数学问题解决的认知模型,对627名5～6岁儿童进行认知诊断评估,运用认知诊断模型—数据拟合对认知模型和诊断测验进行质量检验。结果显示,认知属性对题目难度的解释量为0.879,效应量为0.834,平均HCI为0.749;认知诊断测验题目的平均区分度为0.707(标准差为0.299);除两题的题目拟合度S-X^2指标的显著性水平<0.01,其他题目的拟合度都较好;测验的信度为0.95;平均掌握概率与测验总分呈单调递增曲线。以上结果说明,本研究构建的儿童数学问题解决认知模型良好,编制的认知诊断测验具有较理想的测量信度与效度,可以作为评估儿童数学问题解决的有效工具,并可以提供精细丰富的诊断信息,从而为相关教育教学及干预研究提供科学依据。

水杨醛亚胺共价修饰碳纳米管负载镍催化剂的合成及催化乙烯齐聚性能

以1,4-丁二胺为起始剂,4-羟基水杨醛和四水合乙酸镍为原料,经亲核加成和配位反应合成具有配位能力的水杨醛亚胺配体和含有活性羟基的水杨醛亚胺镍催化剂。通过缩合反应将水杨醛亚胺镍催化剂共价接枝到碳纳米管上,合成有机配体共价修饰碳纳米管催化剂。傅里叶变换红外光谱、核磁共振氢谱、X射线衍射等表征结果证实了合成的水杨醛亚胺配体及催化剂结构与理论结构相符。经助催化剂MAO活化后,2种催化剂均表现出良好的催化乙烯齐聚性能。条件优化实验确定了2种催化剂的较佳聚合条件,Ni用量5μmol、Al/Ni为500、反应压力0.7 MPa、反应时间30 min,均相催化剂和负载催化剂最佳反应温度分别为25℃和35℃。此条件下,均相催化剂催化乙烯齐聚活性为1.99×10^(5) g/(mol·Ni·h),齐聚产物C8和C10+选择性分别为30.38%和29.65%。负载催化剂催化乙烯齐聚活性为5.25×10^(5) g/(mol·Ni·h),齐聚产物C8和C10+选择性分别为38.14%和15.28%。与均相催化剂相比,负载催化剂具有更好的催化活性和重复利用性。

“儿童的视角”:历史生成与方法论探寻

从思想史的角度进行考察,"视角"本是指西方文艺复兴时期的一种绘画技法,后由尼采提出"视角主义",认为每个生命都有其认识与体验世界的方式,意义世界是多重视角的存在。"儿童的视角"指的是儿童对自身生活世界丰富而多元化的体验、感知和理解,能够为人类社会贡献生命力、真理以及爱的纽带。理解和珍视"儿童的视角"应该成为成人社会的自觉实践和教育活动的基础。儿童视角研究带有一种行动者意味,需要采用跨学科研究方法。目前兴盛于北欧的现象图析学在儿童视角研究方面做出了有益的探索,值得我们借鉴。

IgG4-Related Pancreatitis: A Case Report and Review of Literature

Background: Immunoglobulin G4-related pancreatitis (IgG4-RAIP) is a relatively rare chronic inflammatory disease of the pancreas. The cause of this disease is still unclear. Due to the lack of specific clinical symptoms and imaging findings, it is often misdiagnosed as pancreatic cancer. Clinicians are paying more and more attention to it. Case report: We are reporting an IgG4-RAIP case, in which the patient had been misdiagnosed as pancreatic cancer and prepared for surgical treatment but finally was diagnosed as IgG4-RAIP after pancreatic biopsy and serum immune test. And the patient was recovered after the treatment of glucocorticoids. Discussion: In order to make more patients get correct diagnosis and reasonable treatment, when we encounter undiagnosed cases of pancreatitis or pancreatic cancer in clinical work, it is very important to conduct pancreatic biopsy and serum immune blood test before operation for these patients. Conclusion: Pancreatic biopsy and serum immune blood test can effectively reduce the occurrence of misdiagnosis of IgG4-RAIP.

甘肃民族歌剧的发展历程及其作品特征——从教学歌剧《文成公主》谈起

教学歌剧《文成公主》是新时期中国民族歌剧舞台艺术发展的阶段性成果,更是中国原创民族歌剧发展道路上的一部里程碑之作,其成功源于甘肃歌剧长期以来坚守的延安精神和中华民族共同体创作理念。甘肃歌剧有着丰富多彩的民族主题创作题材、特色浓郁的民族色彩音乐语言、独树一帜的民族风格表现形式和旗帜鲜明的强烈民族品格,其立足于西部敦煌、丝路、多民族特色的创演实践的丰厚积累,为形成风格独特的甘肃民族歌剧打下了坚实的基础。