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有序还是无序:陈列秩序与产品属性的匹配效应
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作者 李斌 金来 +3 位作者 陈晓曦 俞炜楠 李爱梅 戴先炽 《心理学报》 CSSCI CSCD 北大核心 2024年第10期1448-1461,共14页
本研究探讨了产品属性和陈列秩序之间的匹配效应及其对消费者产品偏好的影响。基于联想学习理论,通过4个系列研究,发现产品属性和陈列秩序之间存在匹配关系,即产品的自然属性与无序陈列的关系更紧密,而产品的人工属性与有序陈列的关系... 本研究探讨了产品属性和陈列秩序之间的匹配效应及其对消费者产品偏好的影响。基于联想学习理论,通过4个系列研究,发现产品属性和陈列秩序之间存在匹配关系,即产品的自然属性与无序陈列的关系更紧密,而产品的人工属性与有序陈列的关系更紧密。基于此,提出了“自然=无序”与“人工=有序”的消费者朴素信念。这两种朴素信念进一步影响了消费者的产品偏好,即当产品呈现自然属性(vs.人工属性)时,消费者对无序陈列(vs.有序陈列)下的产品产生更高的偏好,反之亦然。同时,流畅性感知在其中起中介作用。进一步研究发现效价(积极vs.消极)线索会在其中起到调节作用,即效价线索的出现显著提高了消费者对“自然-有序”和“人工-无序”的产品偏好及流畅性感知。这些结果说明了产品属性与陈列秩序之间存在密切联系,研究结论可为商家在商品陈列和广告营销的策略制定提供重要的实践启示。 展开更多
关键词 产品属性 陈列秩序 流畅性感知 消费者朴素信念 效价线索
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Paleoenvironmental reconstruction and organic matter accumulation of the paleogene shahejie oil shale in the Zhanhua Sag, Bohai Bay Basin, Eastern China
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作者 Xiao-Lin Wang Xiao-Min Zhu +5 位作者 jin lai Xing-Yue Lin Xiang Wang Yu-Shan Du Chao Huang Yu-Rui Zhu 《Petroleum Science》 SCIE EI CAS CSCD 2024年第3期1552-1568,共17页
The controlling factors of organic-rich shale accumulation is essential for the exploration and development of shale oil and gas resources.The sedimentary environment plays a vital role in the formation of organic-ric... The controlling factors of organic-rich shale accumulation is essential for the exploration and development of shale oil and gas resources.The sedimentary environment plays a vital role in the formation of organic-rich sediments in lacustrine facies.This article unravels the mineralogy,geochemistry,and paleoenvironmental evolution during the deposition of the Paleogene Shahejie Formation(Es_(3)^(L)).It discusses the effects of paleoclimate,paleosalinity,paleoredox conditions,paleowater depth,and paleoproductivity on organic matter(OM)enrichment.Finally,the OM enrichment model was established.The results show that the mineralogical compositions are mainly composed of calcite(avg.40.13%),quartz(avg.21.64%)and clay minerals(avg.24.07%),accompanied by dolomite(avg.7.07%),feldspar(avg.6.36%)and pyrite(avg.2.95%).The Es_(3)^(L) shale has a high abundance of OM,with total organic carbon(TOC)ranging from 1.07%to 5.12%.The organic matter type is mainly composed of type I-II_(1) kerogen,which is generally considered a good-quality source rock.The source of OM is a mixture of lower bacteria,algae,and plants.During the early sedimentary period,the paleoclimate was dry and cold,with high salinity,intense reducibility,and relatively low productivity.During the late sedimentary period,the climate became warmer and more humid.As a result,the salinity decreased to a level that was suitable for biological reproduction,and productivity increased gradually due to the input of terrigenous plants.Paleosalinity and paleoclimate determined the environment of the sedimentary period,in addition,paleoproductivity and paleoredox condition indicated the formation and preservation conditions of OM.The warm and humid climate,brackish water,suitable reduction conditions and high productivity are the favorable conditions for the generation and preservation of organic matter.The research results may have implications for the genetic mechanisms of organic matter accumulation.They will provide theoretical and technical insights into the exploration and development of shale oil. 展开更多
关键词 Elemental geochemical PALEOENVIRONMENT Organic matter accumulation Paleogene shahejie formation Zhanhua Sag Bohai Bay Basin
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新媒体环境下的大学生日常生活信息获取行为 被引量:4
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作者 杨利军 巫宇清 金来 《图书馆论坛》 CSSCI 北大核心 2021年第2期123-132,共10页
为揭示新媒体环境下大学生日常生活信息获取行为特点及其内部网络结构,文章采用问卷调查法和访谈法调查Z大学某班级同学的各类日常生活信息获取路径及其人际关系,运用UCINET对数据进行可视化和相关性分析。研究发现:以微信为代表的新媒... 为揭示新媒体环境下大学生日常生活信息获取行为特点及其内部网络结构,文章采用问卷调查法和访谈法调查Z大学某班级同学的各类日常生活信息获取路径及其人际关系,运用UCINET对数据进行可视化和相关性分析。研究发现:以微信为代表的新媒体拓宽了大学生对购物、旅游、班级活动和校务等信息的获取渠道;传统社会网络关系对大学生学习信息获取的支撑作用仍然很明显;新媒体弱化了以宿舍为单位的日常生活信息获取途径;不同类型的日常生活信息获取关系网络差异较大。 展开更多
关键词 日常生活信息 信息获取 网络结构 大学生
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利多卡因通过激活AMPK/SOCS3信号通路改善阿霉素引起的急性心肌损伤 被引量:1
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作者 陈建溯 宋雅君 +4 位作者 吴胜兰 周超一 金莱 刘文涛 李庆国 《南京医科大学学报(自然科学版)》 CAS 北大核心 2023年第8期1068-1075,共8页
目的:研究利多卡因(lidocaine,Lido)对阿霉素(doxorubicin,Dox)引起小鼠心脏损伤的治疗效果及作用机制。方法:32只SPF小鼠随机分为Saline组、Dox组、Dox+Lido组、Lido组4组(n=8),观察并检测各组小鼠体重、生存率、多普勒血流成像、心电... 目的:研究利多卡因(lidocaine,Lido)对阿霉素(doxorubicin,Dox)引起小鼠心脏损伤的治疗效果及作用机制。方法:32只SPF小鼠随机分为Saline组、Dox组、Dox+Lido组、Lido组4组(n=8),观察并检测各组小鼠体重、生存率、多普勒血流成像、心电图、心脏超声,以及血浆肌酸激酶同工酶(creatine kinase-MB,CK-MB)、肌钙蛋白I(cardiac troponin I,cTnI),心肌组织中组织因子(tissue factor,TF)、基质金属蛋白酶9(matrix metalloprotein 9,MMP-9)、磷酸化磷酸腺苷活化蛋白激酶(phosphorylated adenosine 5’-monophosphate-activated protein kinase,p-AMPK)、缝隙连接蛋白(connexin43,Cx43)、细胞因子信号转导抑制因子3(recombinant suppressors of cytokine signaling 3,SOCS3)的含量。结果:与Saline组比较,Dox组小鼠体重、生存率明显降低,心率降低、QRS波时限及QT间期延长,血浆CK-MB、cTnI值明显上升,心脏挛缩,心腔变小,TF、MMP-9升高,心脏组织中p-AMPK、SOCS3、Cx43表达减低;与Dox组相比,Dox+Lido组小鼠体重、生存率增加,心率上升,QRS波时限及QT间期正常,血浆CK-MB、cTnI值处于正常区间,心脏大小未见明显改变,TF、MMP-9降低,心脏组织中p-AMPK、SOCS3、Cx43表达增加。结论:利多卡因能通过激活p-AMPK/SOCS3/Cx43信号通路和抑制TF/MMP-9高表达改善阿霉素诱导的急性心肌损伤。 展开更多
关键词 阿霉素 心肌损伤 利多卡因 AMPK CX43 SOCS3
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考虑预期功能安全的智能汽车自动紧急制动系统 被引量:7
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作者 谈东奎 胡港君 +2 位作者 朱波 金来 张捷 《汽车工程》 EI CSCD 北大核心 2022年第6期799-807,830,共10页
预期功能安全的提出,使得传统的自动紧急制动系统的安全性受到了挑战。为此,本文中利用基于系统理论过程分析(systems-theoretic process analysis,STPA)方法得到了自动紧急制动系统的预期功能安全要求,在传统的自动紧急制动系统基础上... 预期功能安全的提出,使得传统的自动紧急制动系统的安全性受到了挑战。为此,本文中利用基于系统理论过程分析(systems-theoretic process analysis,STPA)方法得到了自动紧急制动系统的预期功能安全要求,在传统的自动紧急制动系统基础上增加了感知盲区安全车速规划策略。然后基于盲区场景下车辆与行人相遇运动学模型,构造盲区安全车速公式。接着设计加入非线性干扰观测器的速度滑模控制器,对该速度进行跟踪控制,最后在CarSim与Simulink联合平台上开展仿真试验,比较此系统与没有增加预期功能安全要求的自动紧急制动系统的安全性,并进一步在硬件在环仿真试验台上验证。结果表明,考虑预期功能安全的自动紧急制动系统能有效降低行人碰撞风险,并确保车辆安全通过盲区的行驶效率。 展开更多
关键词 预期功能安全 自动紧急制动系统 STPA 感知盲区 最佳安全车速 干扰观测器 滑模控制
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Prediction of multiscale laminae structure and reservoir quality in fine-grained sedimentary rocks:The Permian Lucaogou Formation in Jimusar Sag,Junggar Basin 被引量:4
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作者 Xiao-Jiao Pang Gui-Wen Wang +8 位作者 Li-Chun Kuang jin lai Yang Gao Yi-Di Zhao Hong-Bin Li Song Wang Meng Bao Shi-Chen Liu Bing-Chang Liu 《Petroleum Science》 SCIE CAS CSCD 2022年第6期2549-2571,共23页
Fine-grained sedimentary rocks have become a research focus as important reservoirs and source rocks for tight and shale oil and gas.Laminae development determines the accumulation and production of tight and shale oi... Fine-grained sedimentary rocks have become a research focus as important reservoirs and source rocks for tight and shale oil and gas.Laminae development determines the accumulation and production of tight and shale oil and gas in fine-grained rocks.However,due to the resolution limit of conventional logs,it is challenging to recognize the features of centimeter-scale laminae.To close this gap,complementary studies,including core observation,thin section,X-ray diffraction(XRD),conventional log analysis,and slabs of image logs,were conducted to unravel the centimeter-scale laminae.The laminae recognition models were built using well logs.The fine-grained rocks can be divided into laminated rocks(lamina thickness of<0.01 m),layered rocks(0.01-0.1 m),and massive rocks(no layer or layer spacing of>0.1 m)according to the laminae scale from core observations.According to the mineral superposition assemblages from thin-section observations,the laminated rocks can be further divided into binary,ternary,and multiple structures.The typical mineral components,slabs,and T2spectrum distributions of various lamina types are unraveled.The core can identify the centimeter-millimeter-scale laminae,and the thin section can identify the millimeter-micrometer-scale laminae.Furthermore,they can detect mineral types and their superposition sequence.Conventional logs can identify the meter-scale layers,whereas image logs and related slabs can identify the laminae variations at millimeter-centimeter scales.Therefore,the slab of image logs combined with thin sections can identify laminae assemblage characteristics,including the thickness and vertical assemblage.The identification and classification of lamina structure of various scales on a single well can be predicted using conventional logs,image logs,and slabs combined with thin sections.The layered rocks have better reservoir quality and oil-bearing potential than the massive and laminated rocks.The laminated rocks’binary lamina is better than the ternary and multiple layers due to the high content of felsic minerals.The abovementioned results build the prediction model for multiscale laminae structure using well logs,helping sweet spots prediction in the Permian Lucaogou Formation in the Jimusar Sag and fine-grained sedimentary rocks worldwide. 展开更多
关键词 Fine-grained sedimentary rocks Mineral composition Multiscale laminae structure Reservoir quality Image logs Lucaogou formation
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Bedding parallel fractures in fine-grained sedimentary rocks:Recognition,formation mechanisms,and prediction using well log 被引量:5
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作者 jin lai Bing-Chang Liu +4 位作者 Hong-Bin Li Xiao-Jiao Pang Shi-Chen Liu Meng Bao Gui-Wen Wang 《Petroleum Science》 SCIE CAS CSCD 2022年第2期554-569,共16页
Core,thin section,conventional and image logs are used to provide insights into distribution of fractures in fine grained sedimentary rocks of Permian Lucaogou Formation in Jimusar Sag.Bedding parallel fractures are c... Core,thin section,conventional and image logs are used to provide insights into distribution of fractures in fine grained sedimentary rocks of Permian Lucaogou Formation in Jimusar Sag.Bedding parallel fractures are common in fine grained sedimentary rocks which are characterized by layered structures.Core and thin section analysis reveal that fractures in Lucaogou Formation include tectonic inclined fracture,bedding parallel fracture,and abnormal high pressure fracture.Bedding parallel fractures are abundant,but only minor amounts of them remain open,and most of them are partly to fully sealed by carbonate minerals(calcite)and bitumen.Bedding parallel fractures result in a rapid decrease in resistivity,and they are recognized on image logs to extend along bedding planes and have discontinuous surfaces due to partly-fully filled resistive carbonate minerals as well as late stage dissolution.A comprehensive interpretation of distribution of bedding parallel fractures is performed with green line,red line,yellow line and blue line representing bedding planes,induced fractures,resistive fractures,and open(bedding and inclined)fractures,respectively.The strike of bedding parallel fractures is coinciding with bedding planes.Bedding parallel fractures are closely associated with the amounts of bedding planes,and high density of bedding planes favor the formation of bedding parallel fractures.Alternating dark and bright layers have the most abundant bedding parallel fractures on the image logs,and the bedding parallel fractures are always associated with low resistivity zones.The results above may help optimize sweet spots in fine grained sedimentary rocks,and improve future fracturing design and optimize well spacing. 展开更多
关键词 Bedding parallel fracture Fine-grained sedimentary rocks Image logs Lucaogou Formation
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黄连素通过保护肠道黏膜屏障缓解阿霉素诱导的心肌毒性的研究
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作者 朱续昌 邵宏安 +4 位作者 周小扣 肖珺文 刘文涛 金莱 李庆国 《中国心血管病研究》 CAS 2023年第5期434-439,共6页
目的探究黄连素是否在阿霉素(doxorubicin,Dox)诱导的心肌毒性发挥心脏保护作用及其潜在机制。方法将30只小鼠随机分为对照组(Control组),模型组(Dox组),治疗组(Dox+BBR,200 mg/kg组)。监测小鼠化疗后的病死率,全自动生化分析仪检测小... 目的探究黄连素是否在阿霉素(doxorubicin,Dox)诱导的心肌毒性发挥心脏保护作用及其潜在机制。方法将30只小鼠随机分为对照组(Control组),模型组(Dox组),治疗组(Dox+BBR,200 mg/kg组)。监测小鼠化疗后的病死率,全自动生化分析仪检测小鼠血清中肌酸激酶同工酶(CK-MB),肌钙蛋白(cTnl)的含量;超声心动图评价小鼠心功能。心电图检测小鼠心率,检测小鼠心电QRS波时程、QT间期。彩色激光多普勒检测小鼠肠道血流,Elisa检测小鼠血清中脂多糖(Lipopolysaccharide,LPS)的变化。黄连素治疗结束后,苏木素-伊红(HE)染色观察细胞形态与结构。Western blot检测心脏中组织因子(Tissue factor,TF)、组织因子途径抑制物(Tissue factor pathway inhibitor,TFPI)、基质金属蛋白酶-9(Matrix metalloproteinase,MMP-9)及凋亡相关蛋白Bax、Bcl-2的表达。结果黄连素降低了阿霉素诱导小鼠的死亡率,改善了心脏挛缩,显着抑制了血清中心肌损伤标志物的水平。心电图结果显示,黄连素缓解了心脏传导系统的异常。Dox+BBR组肠道微循环血流量高于Dox组。相比之下,Dox+BBR组血清中LPS水平较低(P<0.05)。与对照组相比,TF、MMP-9和Bax的表达水平显著降低(P<0.05),而TFPI和Bcl-2在心脏中的表达水平显著升高(P<0.05)。结论黄连素通过改善肠道黏膜屏障功能,减少内毒素入血,抑制心脏中TF的表达和炎症的产生,发挥心脏保护功能。 展开更多
关键词 阿霉素 肠道 内毒素 黄连素
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UCN enhances TGF-β-mediated mitoinhibition of VSMCs via counteracting TGF-β-induced cPLA2 expression and activation 被引量:1
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作者 ZHU Chao CAO Chang-chun +3 位作者 WANG Xiao-fei YUAN Jie jin lai LI Sheng-nan 《中国药理学与毒理学杂志》 CAS CSCD 北大核心 2016年第10期1008-1009,共2页
OBJECTIVE Urocortins(UCNs)and transforming growth factor-β(TGF-β)have been demonstrated to participate in various cardiovascular diseases,many of which involve VSMCs proliferation.And cytosolic phospholipase A2(c PL... OBJECTIVE Urocortins(UCNs)and transforming growth factor-β(TGF-β)have been demonstrated to participate in various cardiovascular diseases,many of which involve VSMCs proliferation.And cytosolic phospholipase A2(c PLA2)-mediated arachidonic acid(AA)release is an important cause of vascular smooth muscle cells(VSMCs)proliferation.The work was to investigate the regulation of VSMCs proliferation by UCN/TGF-βand whether c PLA2 was a link between their signaling pathways.METHODS VSMC proliferation was measured by MTT assay and immunofluorescence microscopy.Using cell flow cytometry,the changes in the cell cycle phases were investigated.si RNA was used to knockdown Smad2 and smad3 genes.Lentiviral Vector Particle was performed to over express c PLA2 gene.RESULTS Both UCN and TGF-βinhibited VSMCs proliferation and an additive effect was observed when the cells were treated with UCN plus TGF-β.TGF-βincreased the percentage of cells in G1-phase while UCN increased the cell percentage in G2-phase with a concomitant decrease in S-phase.Neither knockdown of smad2 nor smad3 reversed the role of TGF-β.Furthermore,c PLA2expression was increased by TGF-βbut decreased by UCN and UCN attenuated TGF-β-induced c PLA2 expression.In primary VSMCs,TGF-βinduced c PLA2 phosphorylation,and this effect was also attenuated by UCN.Similar to UCN,the c PLA2 inhibitor,pyrrophenone(PYR),also played a role in enhancing TGF-β-mediated mitoinhibition.Inversely,over-expression of c PLA2 eliminated the effect of UCN on the mitoinhibition.CONCLUSION The pretreatment with UCN counteracted TGF-β-mediated c PLA2 expression and activation,thereby contributing to TGF-β-mediated mitoinhibition of VSMCs. 展开更多
关键词 urocortins TGF-BETA CPLA2 vascular smooth muscle cells mitoinhibition
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Pore structure evolution of lacustrine organic-rich shale from the second member of the Kongdian formation in the Cangdong Sag,Bohai Bay Basin,China
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作者 Xiao-Ping Liu Ming Guan +6 位作者 Zhi-Jun jin Zhe Cao jin lai Lun-Ju Zheng Wen-Qi Li Biao Sun Shan-Yong Chen 《Petroleum Science》 SCIE CAS CSCD 2022年第2期459-471,共13页
Pyrolysis experiments were conducted on lacustrine organic-rich shale from Cangdong Sag in Bohai Bay Basin,China,to investigate the impact of hydrocarbon generation on shale pore structure evolution.Thermal evolution ... Pyrolysis experiments were conducted on lacustrine organic-rich shale from Cangdong Sag in Bohai Bay Basin,China,to investigate the impact of hydrocarbon generation on shale pore structure evolution.Thermal evolution is found to control the transformation of organic matter,hydrocarbon products characteristics,and pore structure changes.Furthermore,pore volume and specific surface area increase with increasing maturity.In low-mature stage,the retained oil content begins to increase,pore volumes show slight changes,and primary pores are occluded by the generated crude oil of high molecular weight and density.In the oil-window stage,the retained oil content rapidly increases and reaches maximum,and pore volumes gradually increase with increasing thermal maturity.At high mature stage,the retained oil content begins to decrease,and the pore volume increases considerably owing to the expulsion of liquid hydrocarbon.In over mature stage,natural gas content significantly increases and kerogen transforms to asphalt.Numerous organic pores are formed and the pore size gradually increases,resulting from the connection of organic pores caused the increasing thermal stress.This study lays a foundation for understanding variation of hydrocarbon products during the thermal evolution of lacustrine shales and its relationship with the evolution of shale reservoirs. 展开更多
关键词 Lacustrine shale Pyrolysis Thermal maturity Pore structure evolution Hydrocarbon generation evolution
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基于点云目标检测的路考智能评判系统研究
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作者 谈东奎 肖祖德 +2 位作者 朱波 金来 张捷 《现代电子技术》 2023年第2期1-8,共8页
针对现有科目三路考评判系统需要依靠人工辅助完成项目评判,以致评判主观性较强且准确性不高的问题,文中利用激光雷达的高测距精度特性,提出一种基于点云目标检测的路考智能评判系统。该系统分为目标检测和智能评判两个模块,目标检测模... 针对现有科目三路考评判系统需要依靠人工辅助完成项目评判,以致评判主观性较强且准确性不高的问题,文中利用激光雷达的高测距精度特性,提出一种基于点云目标检测的路考智能评判系统。该系统分为目标检测和智能评判两个模块,目标检测模块针对路考场景三维点云数据设计预处理、滤波、聚类、后处理和包围盒/框的目标检测算法进行环境感知,智能评判模块针对直线跟车行驶、变更车道和行人闯入等场景设计路考评判规则,最后结合目标检测结果完成路考智能评判。为验证路考智能评判系统的有效性,在智能电动汽车平台上进行实车道路驾驶试验。试验结果表明,所提系统能实时、可靠地完成路考项目的自动评判,评判准确率可达0.945,22 m距离内的平均测距精度高于99.55%,且整体算法的平均耗时仅为3.655 ms,能够为智能化、安全化和公平化的路考提供一种有效的解决方案。 展开更多
关键词 路考 智能评判系统 目标检测算法 智能评判模块 规则设计 激光雷达 环境感知
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船用液压螺母壁厚计算研究
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作者 金来 张裕东 《河南科技》 2020年第8期58-59,共2页
在船舶轴系中,液压螺母用于无键螺旋桨的安装。其结构尺寸受轴系设备的影响,但合理的设计不仅可以提高其安全性,还可以节约材料,降低造船成本。本文探讨了液压螺母壁厚计算的问题,为液压螺母的设计和计算提供了参考。
关键词 液压螺母 壁厚 螺旋桨安装
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Application of geophysical well logs in solving geologic issues:Past,present and future prospect 被引量:2
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作者 jin lai Yang Su +7 位作者 Lu Xiao Fei Zhao Tianyu Bai Yuhang Li Hongbin Li Yuyue Huang Guiwen Wang Ziqiang Qin 《Geoscience Frontiers》 SCIE CAS CSCD 2024年第3期85-118,共34页
Geophysical well logs are widely used in geological fields,however,there are considerable incompatibilities existing in solving geological issues using well log data.This review critically fills the gaps between geolo... Geophysical well logs are widely used in geological fields,however,there are considerable incompatibilities existing in solving geological issues using well log data.This review critically fills the gaps between geology and geophysical well logs,as assessed from peer reviewed papers and from the authors’personal experiences,in the particular goal of solving geological issues using geophysical well logs.The origin and history of geophysical logging are summarized.Next follows a review of the state of knowledge for geophysical well logs in terms of type of specifications,vertical resolution,depth of investigations and demonstrated applications.Then the current status and advances in applications of geophysical well logs in fields of structural geology,sedimentary geology and petroleum geology are discussed.Well logs are used in structural and sedimentary geology in terms of structure detection,in situ stress evaluation,sedimentary characterization,sequence stratigraphy division and fracture prediction.Well logs can also be applied in petroleum geology fields of optimizing sweet spots for hydraulic fracturing in unconventional oil and gas resource.Geophysical well logs are extending their application in other fields of geosciences,and geological issues will be efficiently solved via well logs with the improvements of advanced well log suits.Further work is required in order to improve accuracy and diminish uncertainties by introducing artificial intelligence.This review provides a systematic and clear descriptions of the applications of geophysical well log data along with examples of how the data is displayed and processed for solving geologic problems. 展开更多
关键词 Geophysical well logs Sequence stratigraphy Source rock Unconventional oil and gas resources Artificial intelligence
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中高危骨髓增生异常综合征及其转化急性髓系白血病异基因造血干细胞移植时机与疗效的临床研究 被引量:5
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作者 宋晓露 王晓刚 +3 位作者 彭也 金莱 陈一瑞 蓝建平 《中国实用内科杂志》 CAS CSCD 北大核心 2021年第10期867-872,共6页
目的探讨中高危骨髓增生异常综合征(MDS)及其转化急性髓系白血病(MDS-AML)异基因造血干细胞移植(allo-HSCT)治疗的时机和疗效。方法回顾性分析2014年2月至2020年6月于浙江省人民医院行异基因造血干细胞移植的中高危MDS患者20例及MDS-AM... 目的探讨中高危骨髓增生异常综合征(MDS)及其转化急性髓系白血病(MDS-AML)异基因造血干细胞移植(allo-HSCT)治疗的时机和疗效。方法回顾性分析2014年2月至2020年6月于浙江省人民医院行异基因造血干细胞移植的中高危MDS患者20例及MDS-AML患者12例。预处理采用改良马利兰+环磷酰胺方案23例,氟达拉+环磷酰胺减剂量方案2例,序贯CLAG/FLAG+改良马利兰+环磷酰胺增强方案7例。结果32例患者中31例获得造血重建。中位随访14(1~59)个月,移植后预期3年总生存率(OS)(45.5±11.4)%;3年无白血病生存率(LFS)(48.5±11.4)%;3年累计复发率(8.9±6.0)%(3/31),非复发死亡率(11.8±6.4)%。急性移植物抗宿主病(aGVHD)累计发生率为(63.6%±8.6)%,其中Ⅱ~Ⅳ度aGVHD发生率为(38.0±8.7)%。慢性移植物抗宿主病(cGVHD)3年累计发生率为(35.6±11.5)%。多因素分析显示,移植前病程≥6个月是影响OS(P=0.012)及LFS(P=0.011)的独立危险因素。MDSAML患者中移植前CR组3年OS及LFS显著优于非CR组(P=0.013,P=0.018)。结论对于中高危MDS尽早alloHSCT可获得更好生存;MDS-AML患者移植前有效降低肿瘤负荷可使生存获益。 展开更多
关键词 骨髓增生异常综合征 异基因造血干细胞移植 总生存
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白血病合并尖端赛多孢菌感染1例报道并文献复习 被引量:3
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作者 金莱 彭也 +2 位作者 宋晓露 王晓刚 蓝建平 《中国实用内科杂志》 CAS CSCD 北大核心 2018年第A02期95-97,共3页
血液系统恶性疾病患者,因为自身免疫力低,并且经大剂量化疗后粒细胞缺乏,或者造血干细胞移植后需长期服用免疫抑制剂,极易发生真菌感染。近年来越来越多的罕见真菌感染被报道,也越来越得到临床医生地重视。
关键词 白血病 尖端赛多孢菌 感染
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异基因造血干细胞移植患者血流感染病原菌谱及耐药性--单中心回顾性分析 被引量:3
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作者 丁丽敏 宋晓露 +4 位作者 王晓刚 彭也 陈一瑞 金莱 蓝建平 《中华血液学杂志》 CAS CSCD 北大核心 2021年第10期807-813,共7页
目的了解浙江省人民医院异基因造血干细胞移植(allo-HSCT)患者血流感染临床特点、病原菌谱、耐药性及危险因素。方法回顾性分析2014年10月至2019年9月浙江省人民医院血液科210例allo-HSCT患者中发生血流感染的病原学分布、耐药性、感染... 目的了解浙江省人民医院异基因造血干细胞移植(allo-HSCT)患者血流感染临床特点、病原菌谱、耐药性及危险因素。方法回顾性分析2014年10月至2019年9月浙江省人民医院血液科210例allo-HSCT患者中发生血流感染的病原学分布、耐药性、感染危险因素及转归。结果210例allo-HSCT患者中49例发生血流感染,共分离出病原菌59株,以革兰阴性菌为主(67.8%),其中以大肠埃希菌最为常见(23.7%),碳青霉烯类耐药革兰阴性菌(CRO)占42.5%;革兰阳性菌占23.7%,未发现万古霉素及利奈唑胺耐药的葡萄球菌株;真菌占8.5%。单因素分析提示血流感染影响因素有性别、移植前疾病状态、预处理方案;多因素分析显示血流感染主要与预处理方案强度有关(OR=3.043,95%CI 1.236~7.492,P=0.015)。49例血流感染患者中粒细胞缺乏(粒缺)血流感染占77.6%,非粒缺占22.4%;移植前活动性感染患者发生血流感染占81.0%,移植前无活动性感染患者占16.9%。生存分析结果显示,血流感染患者总生存(OS)时间短于未发生血流感染患者,CRO感染患者比无CRO感染患者OS时间短,粒缺时间>14 d患者OS时间较粒缺时间≤14 d患者短,移植前是否合并活动性感染及感染时是否处于粒缺状态与OS时间无明显相关性。结论本研究提示积极预防耐药菌血流感染、缩短粒缺时间、移植前控制感染、适合的预处理方案,能降低移植死亡率、改善预后。 展开更多
关键词 异基因造血干细胞移植 血流感染 病原菌 耐药性 生存期
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How high can fracture porosity become in the ultra-deep subsurface? 被引量:1
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作者 jin lai Fei Zhao +5 位作者 Mei Zhang Tianyu Bai Yuyue Huang Dong Li Guiwen Wang Ziqiang Qin 《Geoscience Frontiers》 SCIE CAS CSCD 2023年第5期233-240,共8页
Knowledge of how high can fracture porosity become in the ultra-deep burial conditions is important but remains problematic.Fracture aperture and porosity are measured using X-ray computed tomography(CT)at atmospheric... Knowledge of how high can fracture porosity become in the ultra-deep burial conditions is important but remains problematic.Fracture aperture and porosity are measured using X-ray computed tomography(CT)at atmospheric pressure and then calculated by image logs.Special attention is paid to how high fracture porosity can become in ultra-deep(>6000 m)settings,and which situations will result in high fracture porosities.In situ stress magnitudes,which can be calculated using well logs,control fracture performances,and dissolution along fracture improve fracture porosity at ultra-deep burial depths.Low horizontal stress difference(Dr<25 MPa),very high fracture density will result in a high fracture porosity.Fracture porosity can keep as high as 2.0%in relatively low in situ stress conditions even at ultra-deep burial depths.In intense in situ stress conditions(Dr>45 MPa),a high degree of dissolution along the fracture dramatically increases fracture porosity.Dissolution will result in the vuggy fracture planes and improve fracture porosity up to 2.0%.The results provide insights into the detection,characterization,and modeling of subsurface fractures. 展开更多
关键词 Fracture porosity Image log Ultra-deep In-situ stress DISSOLUTION
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Role of bedding planes played in enhancing dissolution in sandstones
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作者 jin lai Xiaojiao PANG +4 位作者 Meng BAO Bing WANG Jianan YIN Guiwen WANG Xuechun FAN 《Frontiers of Earth Science》 SCIE CSCD 2022年第3期587-600,共14页
Diagenesis exerts an important control on porosity evolution,and research of diagenesis and diagenetic minerals provides insights into reservoir quality evaluation and CO_(2) storage.Thin section,XRD(X-ray diffraction... Diagenesis exerts an important control on porosity evolution,and research of diagenesis and diagenetic minerals provides insights into reservoir quality evaluation and CO_(2) storage.Thin section,XRD(X-ray diffraction),CT(Computed Tomography),scanning electron microscopy(SEM),and NMR(Nuclear Magnetic Resonance)tests were used to investigate composition,texture,pore spaces,and diagenesis of sandstones in Paleogene Dongying Formation in Bohai Bay Basin,China,with special aims to unravel diagentic dissolution along bedding planes.The oversized pores,remnants in feldspar-hosted pores,and kaolinite within feldspar grains indicate a high degree of dissolution the framework grains experienced during burial.The CO_(2)-rich or organic acids are responsible for the feldspar dissolution.Grain size plays the primary role in enhancing bedding dissolution process,and bedding planes in fine-medium grained sandstones with high content of feldspars are frequently enlarged by dissolution.The CT scanning image confirms dissolution pores are distributed discontinuously along the bedding planes.The dissolution pores along bedding planes have large pore size,and correspond to the right peak of the bi-modal T_(2)(transverse relaxation time)spectrum.The laminated sandstones and siltstones,or sandstones with cross beddings help improve framework grain dissolution.These new findings help improve the understanding of diagenetic models,and have implications in reservoir quality prediction and resource assessments in sandstones. 展开更多
关键词 DISSOLUTION SANDSTONES DIAGENESIS bedding plane Dongying Formation
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Influence of previous laparoscopic surgical and pathological diagnosis of endometriosis on pregnancy outcomes in women with adenomyosis
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作者 Zhao Tian jin lai +5 位作者 Qing-Jie Zhai Yi Li Yue Wang Xiao-Hong Chang Hong-Lan Zhu Heng Cui 《Gynecology and Obstetrics Clinical Medicine》 2022年第3期147-150,共4页
Objectives:Previous studies demonstrated that endometriosis and adenomyosis are closely linked to lots of adverse pregnancy outcomes while the role of endometriosis in pregnant women with adenomyosis has not been expl... Objectives:Previous studies demonstrated that endometriosis and adenomyosis are closely linked to lots of adverse pregnancy outcomes while the role of endometriosis in pregnant women with adenomyosis has not been explored yet.The present study aimed to evaluate the influence of previous laparoscopic surgical and pathological diagnosis of endometriosis on pregnancy outcomes in women with adenomyosis.Methods:A total of 60 pregnant women who were diagnosed with adenomyosis before or during pregnancy were included in this study.Among them,8 were also diagnosed with endometriosis by previous laparoscopic surgery.The demographic characteristics and pregnancy outcomes were compared between women with adenomyosis only and those with the surgical history of endometriosis.Results:Compared with women with adenomyosis only,those concomitant with the surgical history of endometriosis had significantly higher age at delivery[37.5(36.25–39.75)vs.35(33.25–37),P=0.016]and an increased risk of postpartum hemorrhage(PPH)(adjusted OR:5.992,95%CI:1.03–34.857,P=0.046)while no significant differences were found in other adverse pregnancy outcomes between these two groups.Then we further detected the risk factor of PPH in women with adenomyosis and found that the surgical history of endometriosis(OR:6.995,95%CI:1.16–42.171,P=0.034)and assisted reproductive technology(ART)(OR:5.062,95%CI:1.494–17.146,P=0.009)were the parameters closely associated with the occurrence of PPH.Conclusions:The history of previous laparoscopic surgical and pathological diagnosis of endometriosis in pregnant women with adenomyosis may increase the risk of PPH,which still needs to be verified by future studies with a large sample size.Besides,pregnancy through ART is also an increased risk factor for PPH in women with adenomyosis.Pregnant women with adenomyosis who conceived with the surgical history of endometriosis or by ART should be closely monitored for the reason of being at high risk of PPH. 展开更多
关键词 ADENOMYOSIS ENDOMETRIOSIS Adverse pregnancy outcomes Assisted reproductive technology
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