混合式教学模式下大学语文精品“金课”构建策略

本文探讨了基于线上线下混合式教学模式的大学语文精品“金课”的构建策略。首先,文章介绍了线上线下混合式教学模式“金课”的构建内涵,强调其具有综合性和挑战性,以及培养学生综合能力的重要性。其次,文章着重讨论了在线课程建设策略,包括选择合适的在线教学平台、组建“金课”教师团队、设计教学内容、组织在线教学等,通过多种教学策略的结合,为大学语文精品“金课”构建工作赋能,旨在为相关人员提供参考。

比较视野下国内中日韩高等教育研究热点与前沿探赜

借助比较视野范式,结合可视化软件CiteSpace可视化分析功能,对来自CNKI的中日韩三国高等教育研究文献进行文献计量与可视化分析。近几年国内研究聚焦于中日韩三国的高等教育经费、学生入学资助与学生贷款,并且关注高等教育教育经济、人才培养、课程体系建设等问题。需要在高等教育培养模式、评价机制等方面进一步研究,在高等教育普及化阶段更多地关注民办高校发展、职业院校课程建设、高等院校毕业生就业问题等,以进一步推动相关研究的深入。

山皮条水提物急性毒性试验及镇痛抗炎药效研究

目的:考察山皮条水提物小鼠灌胃给药急性毒性和镇痛抗炎作用。方法:采用半数致死量(LD_(50))法测定山皮条水提物小鼠灌胃给药急性毒性反应;采用醋酸致小鼠扭体试验和二甲苯致小鼠耳肿胀试验分别观察山皮条水提物的镇痛、抗炎作用。结果:在本实验条件和所设计剂量范围内,山皮条水提物24 h内小鼠单次灌胃给药LD_(50)为15. 48 g/kg·bw (相当于生药量85. 05 g/kg·bw),95%可信区间为14. 07～16. 99 g/kg·bw (相当于生药量77. 31～93. 35 g/kg·bw);与模型对照组比较,山皮条水提物在3. 15 g/kg·bw、6. 30 g/kg·bw (相当于生药量17. 31 g/kg·bw、34·62 g/kg·bw)剂量下,能明显抑制醋酸所致小鼠扭体反应(P <0. 01),在6. 30 g/kg·bw (相当于生药量34. 62 g/kg·bw)剂量下能降低二甲苯所致的小鼠耳肿胀度(P <0. 01)。结论:山皮条水提物具有明显的抗炎、镇痛作用,但具有一定的毒性。

The Crustal Velocity Structure Inference of Epicenter of the M8(1/2) Earthquake at Tancheng,Shandong,China,in 1668

The deep structure features around Tancheng M8 /2 earthquake occurred in 1668 have been analyzed. Based on the crustal velocity structure obtained from travel-time tomographic inversion, especially the low velocity zones in middle crust and Moho depths, the deep velocity structure distribution in the area of 34° ~ 36°N, 118° ~ 119°E is scanned along the latitude, longitude and oblique directions, and the corresponding crustal velocity profiles are obtained. By comparison, we take the area with velocity features coincident to the deep structure of the 1668 Tancheng M8/2 earthquake as the deduced epicenter, which is at 34. 8° ~35. 2°N, 118. 2° ~ 118. 7°E, and the reasonable location is 35. isN, 118. 6°E, and the focal depth is 20km.

Characteristics of S-wave Envelope Broadening in the Changbaishan Tianchi Volcano

High-frequency S-wave seismogram envelopes of microearthquakes broaden with increasing travel distance,a phenomenon known as S-wave envelope broadening. Multiple forward scattering and diffraction for the random inhomogeneities along the seismic ray path are the main causes of S-wave envelope broadening,so the phenomenon of S-wave envelope broadening is used to study the inhomogeneity of the medium. The peak delay time of an S-wave,which is defined as the time lag from the direct S-wave onset to the maximum amplitude arrival of its envelope,is accepted to quantify S-wave envelope broadening. 204 small earthquake records in Changbaishan Tianchi volcano were analyzed by the S-wave envelope broadening algorithm. The results show that S-wave envelope broadening in the Changbaishan Tianchi volcano is obvious,and that the peak delay time of S-wave has a positive correlation with the hypocenter distance and frequency of the S-wave. The relationships between the S-wave peak delay time and the hypocenter distance for different frequency bands were obtained using the statistics method. The results are beneficial to the understanding of the S-wave envelope broadening phenomena and the quantitative research on the inhomogeneities of the crust medium in the Changbaishan Tianchi volcano region.

水痘⁃带状疱疹病毒感染中性粒细胞引发自噬的作用研究

前期研究发现,细胞自噬能为人体快速提供能量,消灭掉入侵的细菌和病毒,同时对人体抗衰老有非常重要的意义;另外中性粒细胞具有免疫防御功能,并且水痘-带状疱疹病毒能引起细胞自噬,那么探讨水痘-带状疱疹病毒感染导致中性粒细胞自噬的作用机制显得尤为重要。本研究发现水痘-带状疱疹病毒感染诱导中性粒细胞发生自噬性死亡,有助于进一步研究自噬抑制剂在抗病毒感染中的应用。其中,在人神经视网膜上皮细胞(ARPE-19)中可观察到水痘-带状疱疹病毒粒子,同时可检测到带状疱疹病毒的糖蛋白E;另外,HL-60细胞经维A酸(ATRA)刺激后诱导分化成成熟的中性粒细胞,细胞核呈分叶状,RT-PCR检测细胞的CD14/CD11b表达量升高7倍,髓过氧化物酶MPO升高1.6倍;病毒感染后细胞活力随感染剂量增加逐渐降低,Beclin-1和LC3b Ⅱ的表达与病毒的量及感染时间呈现正相关,自噬抑制剂3-ma能有效抑制由病毒感染导致的中性粒细胞自噬的发生。