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痰湿体质概述
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作者 景彩 张昌云 +3 位作者 张昕 于慧娟 焦凤丽 谭奇纹 《河南中医》 2024年第4期635-641,共7页
王琦院士提出,体质的三个关键科学问题为体质可分、体病相关、体质可调。基于体质可分,痰湿质临床模型较丰富,动物模型较少;基于体病相关,痰湿质与心脑血管疾病、糖尿病、脂肪肝等疾病的发病相关;基于体质可调,痰湿质的调理中药以二陈... 王琦院士提出,体质的三个关键科学问题为体质可分、体病相关、体质可调。基于体质可分,痰湿质临床模型较丰富,动物模型较少;基于体病相关,痰湿质与心脑血管疾病、糖尿病、脂肪肝等疾病的发病相关;基于体质可调,痰湿质的调理中药以二陈汤为主,针灸多选脾俞、阴陵泉、足三里、丰隆等穴位,作用机制可能与PI3K-Akt信号通路、糖酵解/糖原异生等有关。目前,研究还存在以下问题:(1)有的研究没有说明体质的疾病情况,有的研究甚至没有痰湿质重要的基线资料,如腰围、体重等,这样会影响后期的系统评价等研究质量;(2)部分研究混淆了痰湿质和痰湿证,甚至混淆了痰湿质积分和痰湿证候积分;(3)目前只有较少的临床研究有伦理和临床注册,不同研究样本量差距较大,在观察性研究中,混杂因素较多,多为相关性分析;部分试验研究缺乏系统设计,非随机的对照研究较多,干预后缺乏随访。今后,还应渐进式深入研究痰湿体质,在临床中辨体与辨病相结合,在研究方法中定性与定量相融合;合理计算或适当增加样本量,同时构建痰湿体质动态生物数据库,多领域交叉融合分析,开展前瞻性队列研究;运用多维组学,构建深度学习的多维动态模型,观察痰湿质的指标和靶标与相关疾病严重程度的关系;综合比较中药或适宜技术各方面优势,为痰湿质的防病调体提供更广阔的思路。 展开更多
关键词 痰湿体质 体质可分 体病相关 体质可调
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Artificial intelligence-driven radiomics study in cancer:the role of feature engineering and modeling 被引量:1
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作者 Yuan-Peng Zhang Xin-Yun Zhang +11 位作者 Yu-Ting Cheng Bing Li Xin-Zhi Teng Jiang Zhang Saikit Lam Ta Zhou Zong-Rui Ma Jia-Bao Sheng Victor CWTam Shara WYLee Hong Ge jing cai 《Military Medical Research》 SCIE CAS CSCD 2024年第1期115-147,共33页
Modern medicine is reliant on various medical imaging technologies for non-invasively observing patients’anatomy.However,the interpretation of medical images can be highly subjective and dependent on the expertise of... Modern medicine is reliant on various medical imaging technologies for non-invasively observing patients’anatomy.However,the interpretation of medical images can be highly subjective and dependent on the expertise of clinicians.Moreover,some potentially useful quantitative information in medical images,especially that which is not visible to the naked eye,is often ignored during clinical practice.In contrast,radiomics performs high-throughput feature extraction from medical images,which enables quantitative analysis of medical images and prediction of various clinical endpoints.Studies have reported that radiomics exhibits promising performance in diagnosis and predicting treatment responses and prognosis,demonstrating its potential to be a non-invasive auxiliary tool for personalized medicine.However,radiomics remains in a developmental phase as numerous technical challenges have yet to be solved,especially in feature engineering and statistical modeling.In this review,we introduce the current utility of radiomics by summarizing research on its application in the diagnosis,prognosis,and prediction of treatment responses in patients with cancer.We focus on machine learning approaches,for feature extraction and selection during feature engineering and for imbalanced datasets and multi-modality fusion during statistical modeling.Furthermore,we introduce the stability,reproducibility,and interpretability of features,and the generalizability and interpretability of models.Finally,we offer possible solutions to current challenges in radiomics research. 展开更多
关键词 Artificial intelligence Radiomics Feature extraction Feature selection Modeling INTERPRETABILITY Multimodalities Head and neck cancer
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城镇燃气管道结构完整性内检测技术研究现状与挑战
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作者 关鹏 田晓江 +2 位作者 蔡婧 高观玲 成楚 《产业科技创新》 2024年第4期71-74,共4页
本文对城镇燃气管道结构完整性内检测技术进行了综述,介绍了其研究背景、发展现状、存在的问题以及未来研究方向。通过对多种检测方法的比较和分析,指出了当前内检测技术的发展趋势和亟待解决的问题。
关键词 城镇燃气管道 结构完整性 内检测技术 管道中心线定位 管道测径
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电针预处理通过抑制NF-kB/NLRP3信号通路介导炎症和凋亡改善大鼠脑卒中后痉挛
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作者 孙秀颀 蔡静 +5 位作者 张安邦 庞博 陈春艳 查琪琪 全菲 叶涛 《南方医科大学学报》 CAS CSCD 北大核心 2024年第11期2102-2109,共8页
目的探讨电针预处理诱导NF-κB/NLRP3信号通路及炎症和凋亡在脑卒中后挛治疗中的潜在机制。方法SPF级雄性SD大鼠18只随机分为:假手术组(sham),模型组(I/R),电针治疗组(I/R+EP),每组6只。假手术组仅暴露不做阻塞,模型组进行中动脉闭塞模... 目的探讨电针预处理诱导NF-κB/NLRP3信号通路及炎症和凋亡在脑卒中后挛治疗中的潜在机制。方法SPF级雄性SD大鼠18只随机分为:假手术组(sham),模型组(I/R),电针治疗组(I/R+EP),每组6只。假手术组仅暴露不做阻塞,模型组进行中动脉闭塞模型,电针组使用电针治疗曲鬓穴和百会穴,持续治疗3 d。采用HE、Nissl、TUNEL染色检测大鼠脑组织病理变化情况。ELISA法检测各组IL-4、IL-6、TNF-α、TMAO的水平变化情况。采用qRT-PCR、Western blotting和免疫组化检测NF-κB p65、NLRP3、caspase-3、caspase-9 mRNA和蛋白水平。结果与假手术组相比,模型组的神经功能评分增加(P<0.05),肌张力增增加(P<0.05),新事物识别时间减少(P<0.05),海马细胞排列不均、松散和轮廓不清晰(P<0.05),细胞凋亡数量显着增加(P<0.05),促炎因子IL-6和TNF-α,NF-B p65、NLRP3、caspase-3和caspase-9水平上升(P<0.05)。与模型组相比,电针治疗组神经功能评分下降,肌张力评分下降,新事物识别时间增加(P>0.05),海马细胞排列紧密规则,染色均匀,轮廓清晰(P<0.05),活神经元数量增加(P<0.05),细胞凋亡明显减少(P<0.05),促炎因子IL-6和TNF-α水平下降,抑炎因子IL-4水平上升(P<0.05)。此外,电针治疗抑制了脑组织中NLRP3、caspase-3、caspase-9和NF-B p65的表达(P<0.05)。结论电针预处理有助于缓解大鼠脑卒中后痉挛,这是因为它阻断了NF-B/NLRP3通路,抑制炎症反应和细胞凋亡。 展开更多
关键词 脑卒中后痉挛 电针预处理 NF-κB/NLRP3信号通路 炎症反应 细胞凋亡
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Exploration of the Integrated Training Model for Information Technology Teachers
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作者 Haitao Sang Bo Chen +1 位作者 Zongliang Ye jing cai 《Journal of Contemporary Educational Research》 2024年第1期31-38,共8页
With the acceleration of the social information process,information awareness and information skills have become the basic qualities of every citizen.The establishment of the training mechanism for scientific and tech... With the acceleration of the social information process,information awareness and information skills have become the basic qualities of every citizen.The establishment of the training mechanism for scientific and technological innovation talents from the beginning of higher education is insufficient to meet the needs of the development of the times.It is imperative to improve the training of information technology innovation talents and explore a new training model.This paper describes the general situation of the development of education in the field of information technology from a domestic and international perspective.It then analyzes the existing problems,explores new exploration models and implementation suggestions,and puts forward prospects at the end of the paper. 展开更多
关键词 Information technology discipline Personnel training Model exploration
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EZH2 Contributes to Anoikis Resistance and Promotes Epithelial Ovarian Cancer Peritoneal Metastasis by Regulating m6A 被引量:1
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作者 Shao-hai WANG Lin LIU +8 位作者 Ke-yong BAO Yi-fan ZHANG Wen-wen WANG Shi DU Na-er JIA Suo SUO jing cai Jian-feng GUO Gang LV 《Current Medical Science》 SCIE CAS 2023年第4期794-802,共9页
Objective:Histone modification has a significant effect on gene expression.Enhancer of zeste homolog 2(EZH2)contributes to the epigenetic silencing of target chromatin through its roles as a histone-lysine N-methyltra... Objective:Histone modification has a significant effect on gene expression.Enhancer of zeste homolog 2(EZH2)contributes to the epigenetic silencing of target chromatin through its roles as a histone-lysine N-methyltransferase enzyme.The development of anoikis resistance in tumor cells is considered to be a critical step in the metastatic process of primary malignant tumors.The purpose of this study was to investigate the effect and mechanism of anoikis resistance in ovarian adenocarcinoma peritoneal metastasis.Methods:In addition to examining EZH2 protein expression in ovarian cancer omental metastatic tissues,we established a model of ovarian cancer cell anoikis and a xenograft tumor model in nude mice.Anoikis resistance and ovarian cancer progression were tested after EZH2 and N6-methyladenosine(m6A)levels were modified.Results:EZH2 expression was significantly higher in ovarian cancer omental metastatic tissues than in normal ovarian tissues.Reducing the level of EZH2 decreased the level of m6A and ovarian cancer cell anoikis resistance in vitro and inhibited ovarian cancer progression in vivo.M6a regulation altered the effect of EZH2 on anoikis resistance.Conclusion:Our results indicate that EZH2 contributes to anoikis resistance and promotes ovarian adenocarcinoma abdominal metastasis by m6A modification.Our findings imply the potential of the clinical application of m6A and EZH2 for patients with ovarian cancer. 展开更多
关键词 ANOIKIS heterografts N6-methyladenosine enhancer of zeste homolog 2 ovarian neoplasms
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Multi-View & Transfer Learning for Epilepsy Recognition Based on EEG Signals
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作者 Jiali Wang Bing Li +7 位作者 Chengyu Qiu Xinyun Zhang Yuting Cheng Peihua Wang Ta Zhou Hong Ge Yuanpeng Zhang jing cai 《Computers, Materials & Continua》 SCIE EI 2023年第6期4843-4866,共24页
Epilepsy is a central nervous system disorder in which brain activity becomes abnormal.Electroencephalogram(EEG)signals,as recordings of brain activity,have been widely used for epilepsy recognition.To study epilep-ti... Epilepsy is a central nervous system disorder in which brain activity becomes abnormal.Electroencephalogram(EEG)signals,as recordings of brain activity,have been widely used for epilepsy recognition.To study epilep-tic EEG signals and develop artificial intelligence(AI)-assist recognition,a multi-view transfer learning(MVTL-LSR)algorithm based on least squares regression is proposed in this study.Compared with most existing multi-view transfer learning algorithms,MVTL-LSR has two merits:(1)Since traditional transfer learning algorithms leverage knowledge from different sources,which poses a significant risk to data privacy.Therefore,we develop a knowledge transfer mechanism that can protect the security of source domain data while guaranteeing performance.(2)When utilizing multi-view data,we embed view weighting and manifold regularization into the transfer framework to measure the views’strengths and weaknesses and improve generalization ability.In the experimental studies,12 different simulated multi-view&transfer scenarios are constructed from epileptic EEG signals licensed and provided by the Uni-versity of Bonn,Germany.Extensive experimental results show that MVTL-LSR outperforms baselines.The source code will be available on https://github.com/didid5/MVTL-LSR. 展开更多
关键词 Multi-view learning transfer learning least squares regression EPILEPSY EEG signals
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Benchmarking gene set of gymnosperms for assessing genome and annotation completeness in BUSCO
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作者 Jun-Jie Wu Yu-Wei Han +2 位作者 Chen-Feng Lin jing cai Yun-Peng Zhao 《Horticulture Research》 SCIE CSCD 2023年第9期278-280,共3页
Dear Editor,Gymnosperms,naked-seed plants,are phylogenetically sister to the flowering plants(angiosperms),of which the origin can be traced back to the Devonian period.Despite their f lourishing diversity in the Meso... Dear Editor,Gymnosperms,naked-seed plants,are phylogenetically sister to the flowering plants(angiosperms),of which the origin can be traced back to the Devonian period.Despite their f lourishing diversity in the Mesozoic era,only∼1000 living species of gymnosperms exist in the modern flora(∼0.4%of the number of angiosperms)[1].However,they account for at least 39%of the world’s forests[2]and hold great economic and cultural importance in horticulture,medicine,and the timber industry[3]. 展开更多
关键词 period. culture SPITE
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不同性别痰湿体质者肠道菌群特征研究 被引量:1
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作者 于慧娟 景彩 +4 位作者 肖宁 张昌云 张昕 臧晓明 谭奇纹 《山东中医杂志》 2022年第5期510-516,共7页
目的:通过16S rDNA技术,进行高通量测序分析,从微观角度探讨不同性别痰湿体质受试者肠道菌群的特征和差异。方法:60位20~50岁痰湿体质受试者,男女各半。严格按照纳入标准和排除标准收集60份粪便标本。Illumina MiSeq高通量测序平台被用... 目的:通过16S rDNA技术,进行高通量测序分析,从微观角度探讨不同性别痰湿体质受试者肠道菌群的特征和差异。方法:60位20~50岁痰湿体质受试者,男女各半。严格按照纳入标准和排除标准收集60份粪便标本。Illumina MiSeq高通量测序平台被用于在338F_806R区域进行16S rDNA测序,以检测肠道菌群。结果:偏最小二乘回归分析法(PLS-DA)分析显示,男女受试者明显区分并聚成两个类群,可以明显区分为两个不同的组,说明痰湿体质男性和女性肠道菌群组成在OTU水平上具有显著差异。菌群Alpha多样性分析显示,女性痰湿体质者肠道菌群多样性高于男性。肠道菌群的群落组成分析结果显示,在门水平上,经Kruskal-Wallis秩和检验,梭菌门、Tenericutes门、蓝细菌门(0.01<P≤0.05)为男女受试者肠道菌群在门水平差异明显的菌门。拟杆菌属(0.01<P≤0.05)、大肠杆菌-志贺菌属(0.001<P≤0.01)为男女受试者肠道菌群在属水平差异明显的菌属。结论:男女痰湿体质受试者肠道菌群的不同可能是代谢性疾病及其合并症的发生率存在性别差异的原因。 展开更多
关键词 痰湿体质 性别 肠道菌群 16S核糖体DNA 代谢性疾病
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16S rDNA基因测序分析阳虚质人群肠道菌群特征的研究 被引量:12
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作者 张昌云 景彩 +6 位作者 肖宁 张昕 于慧娟 李洋 臧晓明 朱雪松 谭奇纹 《山东中医杂志》 2020年第7期697-703,710,共8页
目的:研究阳虚质和平和质肠道微生物菌落构成变化,探讨阳虚质肠道菌群特点。方法:选取阳虚质及平和质人群,每组各30例,提取两组人群新鲜粪便样本中细菌DNA,运用Illumina MiSeq高通量测序平台对样本DNA进行338F806R区16S rDNA测序以检测... 目的:研究阳虚质和平和质肠道微生物菌落构成变化,探讨阳虚质肠道菌群特点。方法:选取阳虚质及平和质人群,每组各30例,提取两组人群新鲜粪便样本中细菌DNA,运用Illumina MiSeq高通量测序平台对样本DNA进行338F806R区16S rDNA测序以检测肠道菌群。应用I-Sanger生信云平台分析门水平和属水平的肠道菌群结构变化。结果:PLS-DA显示阳虚质与平和质在肠道菌群组成上差异有统计学意义(P<0.05)。阳虚质Alpha多样性有下降趋势。在门水平上两组优势菌门都是厚壁菌门、变形菌门、拟杆菌门、放线菌门,阳虚质拟杆菌门/厚壁菌门的比值低于平和质。属水平上与平和质相比,阳虚质中粪栖杆菌、直肠真杆菌属、拟杆菌属、巨单胞菌属、罗氏菌属丰度下降。埃希氏杆菌/志贺氏杆菌属、链球菌属、消化链球属、柯林斯菌属等菌属丰度上升。阳虚质拟杆菌丰度低于平和质,差异具有统计学意义(P<0.05)。结论:阳虚质多样性呈下降趋势,丰度最高的菌门为厚壁菌门,其次为变形菌门,拟杆菌属相对丰度的显著下降是阳虚质肠道菌群的特征。 展开更多
关键词 阳虚质 平和质 肠道菌群 16S rDNA 拟杆菌属
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敏感驱动基因阳性非小细胞肺癌脑膜转移药物治疗的管理 被引量:2
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作者 陆志琴 蔡婧 +1 位作者 曾治民 刘安文 《中国肺癌杂志》 CAS CSCD 北大核心 2020年第8期710-718,共9页
脑膜转移(leptomeningeal metastasis,LM)是晚期非小细胞肺癌(non-small cell lung cancer,NSCLC)严重并发症之一,虽然发生率不高,但临床症状表现严重,预后差。驱动基因阳性NSCLC较驱动基因阴性患者更容易发生LM。目前,LM的治疗方法主... 脑膜转移(leptomeningeal metastasis,LM)是晚期非小细胞肺癌(non-small cell lung cancer,NSCLC)严重并发症之一,虽然发生率不高,但临床症状表现严重,预后差。驱动基因阳性NSCLC较驱动基因阴性患者更容易发生LM。目前,LM的治疗方法主要包括分子靶向治疗、系统化疗、全脑放疗、鞘内化疗及免疫治疗等。尽管治疗手段很多,但LM的疗效仍不令人满意。本文就敏感驱动基因阳性NSCLC LM的药物治疗方面作一综述。 展开更多
关键词 肺肿瘤 脑膜转移 驱动基因阳性 药物治疗
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Towards an Artificial Intelligence Framework for Data-Driven Prediction of Coronavirus Clinical Severity 被引量:31
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作者 Xiangao Jiang Megan Coffee +10 位作者 Anasse Bari Junzhang Wang Xinyue Jiang Jianping Huang Jichan Shi Jianyi Dai jing cai Tianxiao Zhang Zhengxing Wu Guiqing He Yitong Huang 《Computers, Materials & Continua》 SCIE EI 2020年第4期537-551,共15页
The virus SARS-CoV2,which causes the Coronavirus disease COVID-19 has become a pandemic and has spread to every inhabited continent.Given the increasing caseload,there is an urgent need to augment clinical skills in o... The virus SARS-CoV2,which causes the Coronavirus disease COVID-19 has become a pandemic and has spread to every inhabited continent.Given the increasing caseload,there is an urgent need to augment clinical skills in order to identify from among the many mild cases the few that will progress to critical illness.We present a first step towards building an artificial intelligence(AI)framework,with predictive analytics(PA)capabilities applied to real patient data,to provide rapid clinical decision-making support.COVID-19 has presented a pressing need as a)clinicians are still developing clinical acumen given the disease’s novelty,and b)resource limitations in a rapidly expanding pandemic require difficult decisions relating to resource allocation.The objectives of this research are:(1)to algorithmically identify the combinations of clinical characteristics of COVID-19 that predict outcomes,and(2)to develop a tool with AI capabilities that will predict patients at risk for more severe illness on initial presentation.The predictive models learn from historical data to help predict specifically who will develop acute respiratory distress syndrome(ARDS),a severe outcome in COVID-19.Our experimental results based on two hospitals in Wenzhou,Zhejang,China identify features most predictive of ARDS in COVID-19 initial presentation which would not have stood out to clinicians.A mild increase in elevated alanine aminotransferase(ALT)(a liver enzyme)),a presence of myalgias(body aches),and an increase in hemoglobin,in this order,are the clinical features,on presentation,that are the most predictive.Those two centers’COVID-19 case series symptoms on initial presentation can help predict severe outcomes.Predictive models that learned from historical data of patients from two Chinese hospitals achieved 70%to 80%accuracy in predicting severe cases. 展开更多
关键词 SARS-CoV2 COVID-19 CORONAVIRUS infectious diseases artificial intelligence predictive analytics
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How do Chinese medicines that tonify the kidney inhibit dopaminergic neuron apoptosis? 被引量:11
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作者 Shaogang Lin Shuifen Ye +6 位作者 Jinmu Huang Yun Tian Yihui Xu Mengqi Wu jingxia Wang Songying Wu jing cai 《Neural Regeneration Research》 SCIE CAS CSCD 2013年第30期2820-2826,共7页
Wistar rats were intragastrical y perfused with Chinese medicines used for tonifying the kidney. These included 0.180 g/mL of Herba Epimedi (Epimedium), Semen Cuscutae (Dodder Seed), or Herba Cistanches (Desertli... Wistar rats were intragastrical y perfused with Chinese medicines used for tonifying the kidney. These included 0.180 g/mL of Herba Epimedi (Epimedium), Semen Cuscutae (Dodder Seed), or Herba Cistanches (Desertliving Cistanche), 0.04 mg/mL monoamine oxidase-B inhibitor selegiline, or distil ed water for 14 consecutive days to prepare drug-containing serum or blank serum. MES23.5 cells in the logarithmic phase were cultured in media supplemented with 15%drug-containing serum for 24 hours, fol owed by incubation in culture solution containing 100μmol/L H2O2 for 3 hours. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and flow tometry results showed that al drug-containing serums improved the survival rate of H 2 O 2-injured MES23.5 cells, inhibited pro-apoptotic FasL and caspase-3 expression, promoted anti-apoptotic Bcl-2 expression. However, drug-containing serums had little influence on Fas expression in H 2 O 2-injured MES23.5 cells. Enzyme-linked immunosorbent assay results showed that serum containing Herba Cistanches or Herba Epimedi increased the expression of nerve growth factor, brain-derived neurotrophic factor, and glial cellline-derived neurotrophic factor in injured MES23.5 cells;serum containing Semen Cuscutae only increased brain-derived neurotrophic factor expres-sion; while expression of the above neurotrophic factors remained the same in cells treated with serum containing selegiline. These findings indicate that Chinese medicines used to tonify the kid-ney can protect nerve cells by regulating the expression of apoptosis-related factors and neuro-trophic factors in MES23.5 cells. 展开更多
关键词 neural regeneration traditional Chinese medicine drug-containing serum MES23.5 dopaminergicnerve cells neurotrophic factors apoptosis factors Parkinson's disease NEUROPROTECTION
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Protective effects of kidney-tonifying Chinese herbal preparation on substantia nigra neurons in a mouse model of Parkinson's disease 被引量:7
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作者 jing cai Yun Tian +3 位作者 Ruhui Lin Xuzheng Chen Zhizhen Liu Jindong Xie 《Neural Regeneration Research》 SCIE CAS CSCD 2012年第6期413-420,共8页
The Chinese herbs Herba Epimedii, Fructus Ligustri Lucidi and Rhizoma Polygonati were injected into Parkinson's disease mice established via intraperitoneal injection of 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridin... The Chinese herbs Herba Epimedii, Fructus Ligustri Lucidi and Rhizoma Polygonati were injected into Parkinson's disease mice established via intraperitoneal injection of 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine hydrochloride. The selective monoamine oxidase B inhibitor selegiline was used as a positive control drug. After successive administration for 4 weeks, Herba Epimedii could downregulate the expression of caspase-3 and increase the brain-derived neurotrophic factor level, as well as increase tyrosine hydroxylase activity in the substantia nigra of Parkinson's disease mouse models. Rhizoma Polygonaticould downregulate the expression of caspase-3 and FasL, and increase neural growth factor and brain-derived neurotrophic factor levels. Fructus Ligustn Lucidi could downregulate caspase-3 expression. Rhizoma Polygonati and Fructus Ligustn Lucidi did not produce obvious effects on tyrosine hydroxylase activity. Herba Epimedii and Fructus Ligustri Lucidi yielded similar effects on apoptosis-promoting factors to those elicited by selegiline. Herba Epimedii and Rhizoma Polygonati significantly increased the levels of neurotrophic factors compared with selegiline. Herba Epimedii significantly increased tyrosine hydroxylase activity compared with selegiline. It is indicated that the kidney-tonifying Chinese herbal preparation can downregulate the expression of apoptosis-promoting factors, increase neurotrophic factors levels in the substantia nigra and striatum, as well as increase tyrosine hydroxylase activity in the substantia nigra of Parkinson's disease mouse models, thereby exerting a stronger or similar neuroprotective effects compared with selegiline. 展开更多
关键词 kidney-tonifying Chinese herbal preparation Herba Epimedii Fructus Ligustri Lucidi Rhizoma Polygonati Parkinson's disease substantia nigra and striatum substantia nigra neuron neural regeneration
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A de novo originated gene depresses budding yeast mating pathway and is repressed by the protein encoded by its antisense strand 被引量:7
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作者 Dan Li Yang Dong +3 位作者 Yu Jiang Huifeng Jiang jing cai Wen Wang 《Cell Research》 SCIE CAS CSCD 2010年第4期408-420,共13页
Recent transcription profiling studies have revealed an unexpectedly large proportion of antisense transcripts in eukaryotic genomes. These antisense genes seem to regulate gene expression by interacting with sense ge... Recent transcription profiling studies have revealed an unexpectedly large proportion of antisense transcripts in eukaryotic genomes. These antisense genes seem to regulate gene expression by interacting with sense genes. Previ- ous studies have focused on the non-coding antisense genes, but the possible regulatory role of the antisense protein is poorly understood. In this study, we found that a protein encoded by the antisense gene ADF1 acts as a transcription suppressor, regulating the expression of sense gene MDF1 in Saccharomyces cerevisiae. Based on the evolutionary, ge- netic, cytological and biochemical evidence, we show that the protein-coding sense gene MDF1 most likely originated de novo from a previously non-coding sequence and can significantly suppress the mating efficiency of baker's yeast in rich medium by binding MATa2 and thus promote vegetative growth. These results shed new light on several im- portant issues, including a new sense-antisense interaction mechanism, the de novo origination of a functional gene, and the regulation of yeast mating pathway. 展开更多
关键词 de novo sense-antisense interaction mating pathway Saccharomyces cerevisiae
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Hydrate-based carbon dioxide capture from simulated integrated gasification combined cycle gas 被引量:5
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作者 Chungang Xu Xiaosen Li +1 位作者 jing cai Zhaoyang Chen 《Journal of Natural Gas Chemistry》 EI CAS CSCD 2012年第5期501-507,共7页
The equilibrium hydrate formation conditions for CO2/H2 gas mixtures with different CO2 concentrations in 0.29 mol% TBAB aqueous solution are firstly measured.The results illustrate that the equilibrium hydrate format... The equilibrium hydrate formation conditions for CO2/H2 gas mixtures with different CO2 concentrations in 0.29 mol% TBAB aqueous solution are firstly measured.The results illustrate that the equilibrium hydrate formation pressure increases remarkably with the decrease of CO2 concentration in the gas mixture.Based on the phase equilibrium data,a three stages hydrate CO2 separation from integrated gasification combined cycle (IGCC) synthesis gas is investigated.Because the separation efficiency is quite low for the third hydrate separation,a hybrid CO2 separation process of two hydrate stages in conjunction with one chemical absorption process (absorption with MEA) is proposed and studied.The experimental results show H2 concentration in the final residual gas released from the three stages hydrate CO2 separation process was approximately 95.0 mol% while that released from the hybrid CO2 separation process was approximately 99.4 mol%.Thus,the hybrid process is possible to be a promising technology for the industrial application in the future. 展开更多
关键词 integrated gasification combined cycle (IGCC) gas hydrate CO2 separation H2 purification chemical absorption
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Joint optimization of maintenance inspection and spare provisioning for aircraft deteriorating parts 被引量:4
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作者 jing cai Xin Li Xi Chen 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2017年第6期1133-1140,共8页
With the wide application of condition based maintenance(CBM) in aircraft maintenance practice, the joint optimization of maintenance and inventory management, which can take full advantage of CBM and reduce the aircr... With the wide application of condition based maintenance(CBM) in aircraft maintenance practice, the joint optimization of maintenance and inventory management, which can take full advantage of CBM and reduce the aircraft operational cost, is receiving increasing attention. In order to optimize the inspection interval, maintenance decision and spare provisioning together for aircraft deteriorating parts, firstly, a joint inventory management strategy is presented, then, a joint optimization of maintenance inspection and spare provisioning for aircraft parts subject to the Wiener degradation process is proposed based on the strategy.Secondly, a combination of the genetic algorithm(GA) and the Monte Carol method is developed to minimize the total cost rate.Finally, a case study is conducted and the proposed joint optimization model is compared with the existing optimization model and the airline real case. The results demonstrate that the proposed model is more beneficial and effective. In addition, the sensitivity analysis of the proposed model shows that the lead time has higher influence on the optimal results than the urgent order cost and the corrective maintenance cost, which is consistent with the actual situation of aircraft maintenance practices and inventory management. 展开更多
关键词 joint optimization maintenance spare provision aircraft part Wiener process
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Low contrast medium and radiation dose for hepatic computed tomography perfusion of rabbit VX2 tumor 被引量:2
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作者 cai-Yuan Zhang Yan-Fen Cui +4 位作者 Chen Guo jing cai Ya-Fang Weng Li-Jun Wang Deng-Bin Wang 《World Journal of Gastroenterology》 SCIE CAS 2015年第17期5259-5270,共12页
AIM:To evaluate the feasibility of low contrast medium and radiation dose for hepatic computed tomography(CT) perfusion of rabbit VX2 tumor.METHODS:Eleven rabbits with hepatic VX2 tumor underwent perfusion CT scanning... AIM:To evaluate the feasibility of low contrast medium and radiation dose for hepatic computed tomography(CT) perfusion of rabbit VX2 tumor.METHODS:Eleven rabbits with hepatic VX2 tumor underwent perfusion CT scanning with a 24-h interval between a conventional tube potential(120 k Vp) protocol with 350 mg I/m L contrast medium and filtered back projection,and a low tube potential(80 k Vp) protocol with 270 mg I/m L contrast medium with iterative reconstruction.Correlation and agreement among perfusion parameters acquired by the conventional and low dose protocols were assessed for the viable tumor component as well as whole tumor.Image noise and tumor-to-liver contrast to noise ratio during arterial and portal venous phases were evaluated.RESULTS:A 38% reduction in contrast medium dose(360.1 ± 13.3 mg I/kg vs 583.5 ± 21.5 mg I/kg,P < 0.001) and a 73% decrease in radiation dose(1898.5 m Gy·cm vs 6951.8 m Gy·cm) were observed.Interestingly,there was a strong positive correlation in hepatic arterial perfusion(r = 0.907,P < 0.001;r = 0.879,P < 0.001),hepatic portal perfusion(r = 0.819,P = 0.002;r = 0.831,P = 0.002),and hepatic blood flow(r = 0.945,P < 0.001;r = 0.930,P < 0.001) as well as a moderate correlation in hepatic perfusion index(r = 0.736,P = 0.01;r = 0.636,P = 0.035) between the low dose protocol with iterative reconstruction and the conventional protocol for the viable tumor component and the whole tumor.These two imaging protocols provided a moderate but acceptable agreement for perfusion parameters and similar tumorto-liver CNR during arterial and portal venous phases(5.63 ± 2.38 vs 6.16 ± 2.60,P = 0.814;4.60 ± 1.27 vs 5.11 ± 1.74,P = 0.587).CONCLUSION:Compared with the conventional protocol,low contrast medium and radiation dose with iterative reconstruction has no significant influence on hepatic perfusion parameters for rabbits VX2 tumor. 展开更多
关键词 LOW radiation dose LOW concentrationcontrast MEDIUM PERFUSION COMPUTED tomography Liver VX2 tumor
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Effect of temperature fluctuation on hydrate-based CO_2 separation from fuel gas 被引量:2
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作者 Xiaosen Li Chungang Xu +2 位作者 Zhaoyang Chen Huijie Wu jing cai 《Journal of Natural Gas Chemistry》 EI CAS CSCD 2011年第6期647-653,共7页
A new method of temperature fluctuation is proposed to promote the process of hydrate-based CO2 separation from fuel gas in this work according to the dual nature of CO2 solubility in hydrate forming and non-hydrate f... A new method of temperature fluctuation is proposed to promote the process of hydrate-based CO2 separation from fuel gas in this work according to the dual nature of CO2 solubility in hydrate forming and non-hydrate forming regions [1].The temperature fluctuation operated in the process of hydrate formation improves the formation of gas hydrate observably.The amount of the gas consumed with temperature fluctuation is approximately 35% more than that without temperature fluctuation.It is found that only the temperature fluctuation operated in the period of forming hydrate leads to a good effect on CO2 separation.Meanwhile,with the proceeding of hydrate formation,the effect of temperature fluctuation on the gas hydrate gradually reduces,and little effect is left in the completion term.The CO2 separation efficiencies in the separation processes with the effective temperature fluctuations are improved remarkably. 展开更多
关键词 gas hydrate CO2 fuel gas temperature fluctuation
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Effects of glossy privet fruit on neural cell apoptosis in the cortical parietal lobe and hippocampal CA1 region of vascular dementia rats 被引量:2
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作者 jing cai Fan Zhou Jian DU 《Neural Regeneration Research》 SCIE CAS CSCD 2008年第11期1192-1196,共5页
BACKGROUND: Glossy privet fruit inhibits neural cell apoptosis following the onset of vascular dementia. OBJECTIVE: To confirm glossy privet fruit effects on neural cell apoptosis in the cortical parietal lobe and h... BACKGROUND: Glossy privet fruit inhibits neural cell apoptosis following the onset of vascular dementia. OBJECTIVE: To confirm glossy privet fruit effects on neural cell apoptosis in the cortical parietal lobe and hippocampal CAI region of rat models of vascular dementia using molecular biology techniques. DESIGN, TIME AND SETTING: The neural cell morphology experiment was performed at the Laboratory of Flow Cells and Biochemistry, Academy of Integrative Medicine, Fujian University of Traditional Chinese Medicine, and the Basic Room of Pathology, Academy of Chinese Medicine from December 2006 to May 2008. MATERIALS: A total of 60 Wistar rats were used to establish vascular dementia models using a photochemical reaction method. Glossy privet fruit was purchased from Fujian, China. Hydergine was co-produced by Sandoz, Switzerland and Huajin, China. METHODS: The 60 Wistar rats were randomly divided into 6 equal sized groups (n = 10), i.e. model, blank, high, moderate and low doses of Chinese medicine, and hydergine control groups. Rats in the model group were treated with distilled water (1 mL/100 g) by gavage following model establishment. Rats in the blank group underwent experimental procedures as for the model group, except that rat models were created without illumination. Rats in the high, moderate and low doses of Chinese medicine groups, and the hydergine control group respectively received high, moderate and low doses of glossy privet fruit, and hydergine suspension (1 mL/100 g) by gavage, once a day, for 30 days. MAIN OUTCOME MEASURES: Morphology of neural cells from the rat cortical parietal lobe and hippocampal CA1 region of all groups was observed with an electron microscope. Positive neural cells in the injury site of the rat cortical parietal lobe and hippocampal CA1 region were investigated using the Fas immunohistochemieal method. Absorbance of Fas-positive neurons was detected by the MPIAS-500 multimedia color imaging analysis system. RESULTS: Neural cells were normal, and nuclei were regular in the right cortical parietal lobe and hippoeampal CA1 region in the blank group. Karyopyknosis, an integral nuclear membrane, vacuole and apoptotic bodies were presented in the model group. The quantity and morphology of neural cells were normal in all doses of Chinese medicine groups, and the hydergine control group. Compared with the model group, absorbance was reduced at the injury site of rat cortical parietal lobe and hippocampal CA1 region in the blank, high, moderate and low doses of Chinese medicine, and hydergine control groups (P 〈 0.05). The decrease was particularly significant in the blank group (P 〈 0.01 ), followed by the high dose of Chinese medicine group (P 〈 0.01). Compared with the model group, the percentage of apoptosis was decreased at the injury site of the rat cortical parietal lobe and hippocampal CAI region in the blank, high, moderate and low doses of Chinese medicine, and hydergine control groups (P 〈 0.01) and this decrease was significant in the high dose of Chinese medicine group (P 〈 0.01). CONCLUSION: Glossy privet fruit, a kidney-tonifying Chinese herbal medicine, can inhibit cell apoptosis by reducing apoptotic signals induced by cerebral ischemia/hypoxia. 展开更多
关键词 glossy privet fruit cell apoptosis vascular dementia
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