Research efforts on electromagnetic interference(EMI)shielding materials have begun to converge on green and sustainable biomass materials.These materials offer numerous advantages such as being lightweight,porous,and...Research efforts on electromagnetic interference(EMI)shielding materials have begun to converge on green and sustainable biomass materials.These materials offer numerous advantages such as being lightweight,porous,and hierarchical.Due to their porous nature,interfacial compatibility,and electrical conductivity,biomass materials hold significant potential as EMI shielding materials.Despite concerted efforts on the EMI shielding of biomass materials have been reported,this research area is still relatively new compared to traditional EMI shielding materials.In particular,a more comprehensive study and summary of the factors influencing biomass EMI shielding materials including the pore structure adjustment,preparation process,and micro-control would be valuable.The preparation methods and characteristics of wood,bamboo,cellulose and lignin in EMI shielding field are critically discussed in this paper,and similar biomass EMI materials are summarized and analyzed.The composite methods and fillers of various biomass materials were reviewed.this paper also highlights the mechanism of EMI shielding as well as existing prospects and challenges for development trends in this field.展开更多
Prolife ration of neural stem cells is crucial for promoting neuronal regeneration and repairing cerebral infarction damage.Transcranial magnetic stimulation(TMS)has recently emerged as a tool for inducing endogenous ...Prolife ration of neural stem cells is crucial for promoting neuronal regeneration and repairing cerebral infarction damage.Transcranial magnetic stimulation(TMS)has recently emerged as a tool for inducing endogenous neural stem cell regeneration,but its underlying mechanisms remain unclea r In this study,we found that repetitive TMS effectively promotes the proliferation of oxygen-glucose deprived neural stem cells.Additionally,repetitive TMS reduced the volume of cerebral infa rction in a rat model of ischemic stro ke caused by middle cerebral artery occlusion,im p roved rat cognitive function,and promoted the proliferation of neural stem cells in the ischemic penumbra.RNA-sequencing found that repetitive TMS activated the Wnt signaling pathway in the ischemic penumbra of rats with cerebral ischemia.Furthermore,PCR analysis revealed that repetitive TMS promoted AKT phosphorylation,leading to an increase in mRNA levels of cell cycle-related proteins such as Cdk2 and Cdk4.This effect was also associated with activation of the glycogen synthase kinase 3β/β-catenin signaling pathway,which ultimately promotes the prolife ration of neural stem cells.Subsequently,we validated the effect of repetitive TMS on AKT phosphorylation.We found that repetitive TMS promoted Ca2+influx into neural stem cells by activating the P2 calcium channel/calmodulin pathway,thereby promoting AKT phosphorylation and activating the glycogen synthase kinase 3β/β-catenin pathway.These findings indicate that repetitive TMS can promote the proliferation of endogenous neural stem cells through a Ca2+influx-dependent phosphorylated AKT/glycogen synthase kinase 3β/β-catenin signaling pathway.This study has produced pioneering res ults on the intrinsic mechanism of repetitive TMS to promote neural function recove ry after ischemic stro ke.These results provide a stro ng scientific foundation for the clinical application of repetitive TMS.Moreover,repetitive TMS treatment may not only be an efficient and potential approach to support neurogenesis for further therapeutic applications,but also provide an effective platform for the expansion of neural stem cells.展开更多
In unconsolidated sandstone reservoirs,presence of numerous movable grains and a complex grain size composition necessitates a clear understanding of the physical clogging process for effective groundwater recharge in...In unconsolidated sandstone reservoirs,presence of numerous movable grains and a complex grain size composition necessitates a clear understanding of the physical clogging process for effective groundwater recharge in groundwater-source heat pump systems.To investigate this,a series of seepage experiments was conducted under in situ stress conditions using unconsolidated sandstone samples with varying grain compositions.The clogging phenomenon arises from the combined effects of grain migration and compaction,wherein the migration of both original and secondary crushed fine-grain particles blocks the seepage channels.Notably,grain composition influences the migration and transport properties of the grains.For samples composed of smaller grains,the apparent permeability demonstrates a transition from stability to decrease.In contrast,samples with larger grains experience a skip at the stability stage and directly enter the decrease stage,with a minor exception of a slight increase observed.Furthermore,a unique failure mode characterized by diameter shrinkage in the upper part of the sample is observed due to the combined effects of grain migration and in situ stress-induced compaction.These testing results contribute to a better understanding of the clogging mechanism caused by the coupled effects of grain migration and compaction during groundwater recharge in unconsolidated sandstone reservoirs used in groundwater-source heat pump systems.展开更多
Given the diversity of geographical and cultural backgrounds,it is difficult to find precise counterparts of many food-related vocabularies in the unique dietary culture of the Hexi Corridor in the target language,mak...Given the diversity of geographical and cultural backgrounds,it is difficult to find precise counterparts of many food-related vocabularies in the unique dietary culture of the Hexi Corridor in the target language,making it challenging to fully convey the essence of its local dietary culture in translation.To achieve the purpose of translation,the theory of multimodal discourse analysis provides an ideal translation approach through the language mode,image mode,sound mode,and the synergistic effect of multimodalities,which can accurately address the deficiencies in the translation of dietary culture.Through this research,it is not only possible to highlight the unique charm of the dietary culture of the Hexi Corridor but also to build a bridge for its international dissemination,promoting cross-border cultural exchanges and mutual understanding.展开更多
Fusarium head blight(FHB) or scab caused by Fusarium graminearum is a major threat to wheat production in China as well as in the world. To combat this disease, multiple efforts have been carried out internationally. ...Fusarium head blight(FHB) or scab caused by Fusarium graminearum is a major threat to wheat production in China as well as in the world. To combat this disease, multiple efforts have been carried out internationally. In this article, we review our long-time effort in identifying the resistance genes and dissecting the resistance mechanisms by both forward and reverse genetics approaches in the last two decades. We present recent progress in resistance QTL identification, candidate functional gene discovery, marker-assisted improvement of FHB resistant varieties, and findings in investigating association of signal molecules, such as Ca^(++),SA, JA, and ET, with FHB response, with the assistance from rapidly growing genomics platforms. The information will be helpful for designing novel and efficient approaches to curb FHB.展开更多
A series of metal-organic frameworks MOF-808-X(6-connected)were synthesized by regulating the ZrOCl2·8H2O/1,3,5-benzenetricarboxylic acid(BTC)molar ratio(X)and tested for the direct synthesis of dimethyl carbonat...A series of metal-organic frameworks MOF-808-X(6-connected)were synthesized by regulating the ZrOCl2·8H2O/1,3,5-benzenetricarboxylic acid(BTC)molar ratio(X)and tested for the direct synthesis of dimethyl carbonate(DMC)from CO2 and CH3OH with 1,1,1-trimethoxymethane(TMM)as a dehydrating agent.The effect of the ZrOCl2·8H2O/BTC molar ratio on the physicochemical properties and catalytic performance of MOF-808-X was investigated.Results showed that a proper ZrOCl2·8H2O/BTC molar ratio during MOF-808-X synthesis was fairly important to reduce the redundant BTC or zirconium clusters trapped in the micropores of MOF-808-X.MOF-808-4,with almost no redundant BTC or zirconium clusters trapped in the micropores,exhibited the largest surface area,micropore size,and the number of acidic-basic sites,and consequently showed the best activity among all MOF-808-X,with the highest DMC yield of 21.5% under the optimal reaction conditions.Moreover,benefiting from the larger micropore size,MOF-808-4 outperformed our previously reported UiO-66-24(12-connected),which had even more acidic-basic sites and larger surface area than MOF-808-4,mainly because the larger micropore size of MOF-808-4 provided higher accessibility for the reactant to the active sites located in the micropores.Furthermore,a possible reaction mechanism over MOF-808-4 was proposed based on the in situ FT-IR results.The effects of different reaction parameters on DMC formation and the reusability of MOF-808-X were also studied.展开更多
Platinum group metals(PGMs)usually exhibit promising aerobic catalytic abilities,providing a green and feasible oxidative desulfurization method.However,often,the PGM nanoparticles(NPs)get leached,and the catalysts ar...Platinum group metals(PGMs)usually exhibit promising aerobic catalytic abilities,providing a green and feasible oxidative desulfurization method.However,often,the PGM nanoparticles(NPs)get leached,and the catalysts are deactivated.In this work,Pt NPs with particle sizes of approximately 4–5 nm were encapsulated effectively and uniformly on the surface of vanadium pentoxide(V2O5)nanosheets(with thicknesses of approximately six atomic layers)through strong metal-support interactions.The synthesized catalysts promote catalytic aerobic oxidation reactions,realizing deep desulfurization(99.1%,<5μg g^(–1))under atmospheric pressure and 110℃reaction temperature.Remarkable degrees of sulfur removal could be achieved for oils with different initial S-concentrations and substrates.Additionally,the as-prepared catalysts could be recycled for reuse at least seven times.展开更多
A method for aerosol extinction profile retrieval using ground-based multi-axis differential optical absorption spectroscopy(MAX-DOAS)is studied,which is based on a look-up table algorithm.The algorithm uses parametri...A method for aerosol extinction profile retrieval using ground-based multi-axis differential optical absorption spectroscopy(MAX-DOAS)is studied,which is based on a look-up table algorithm.The algorithm uses parametric method to represent aerosol extinction profiles and simulate different atmospheric aerosol states through atmospheric radiation transfer model.Based on the method,aerosol extinction profile was obtained during six cloud-free days.The O4 differential air mass factor(dAMF)measured by MAX-DOAS is compared with the corresponding model results under different atmospheric conditions(R^2=0.78).The aerosol optical thickness,aerosol weight factor in boundary layer,and the height of the boundary layer are obtained after the process of minimization and look-up table method.The retrieved aerosol extinction in boundary layer is compared with PM2.5 data measured by ground point instrument.The diurnal variation trends of the two methods are in good agreement.The correlation coefficients of the two methods are 0.71 when the aerosol optical thickness is smaller than 0.5.The results show that the look-up table method can obtain the aerosol state of the troposphere and provide validation for other instrument data.展开更多
AIM: To determine the prevalence and factors associated with amblyopia among children aged 30-83 mo in central south of China.METHODS: A population-based, cross-sectional study was conducted in children aged 30-83 mo ...AIM: To determine the prevalence and factors associated with amblyopia among children aged 30-83 mo in central south of China.METHODS: A population-based, cross-sectional study was conducted in children aged 30-83 mo in Changsha(an urban city) and Zhangjiajie(a rural area) in central south of China. Clinical examinations including ocular alignment, ocular motility, visual acuity(VA), prism cover test, cycloplegic refraction, slit lamp examination and fundus examination were performed by trained study ophthalmologists and optometrists. Unilateral amblyopia was defined as a 2-line difference between eyes with VA<20/32 in the worse eye and with coexisting anisometropia [≥1.00 D spherical eutivalent(SE) for hyperopia, ≥3.00 D SE for myopia, and ≥1.50 D for astigmatism], strabismus, or past or present visual axis obstruction. Bilateral amblyopia was defined as VA in both eyes <20/40(≥ 48-month-old) and <20/50(< 48-month-old), with coexisting hyperopia ≥4.00 D SE, myopia ≤-6.00 D SE, and astigmatism ≥2.50 D, or past or present visual axis obstruction.RESULTS: There were 8042 children enrolled and 7713 children were screened. The amblyopia prevalence in children aged 30-83 mo was 1.09%(95% confidence interval, 0.86%-1.35%) with no age(P=0.81), gender(P=0.46) or area distribution(P=0.93) differences. Of these, 0.68% were unilateral cases and 0.41% were bilateral cases. Underlying causes included anisometropia(40%), binocular refractive error(36%), strabismus(14%) and deprivation(10%). Hyperopia combined with astigmatism was the frequent refractive error for ametropic and anisometropic amblyopia.CONCLUSION: In this rural and urban Chinese population, 1.09% of children with 30-83 mo of age had amblyopia, a prevalence rate similar to that of many other studies. Anisometropia and refractive error are the most common causes of unilateral and bilateral amblyopia respectively.展开更多
BACKGROUND Human-derived mesenchymal stromal cells have been shown to improve cognitive function following experimental stroke.The activity of exosomes has been verified to be comparable to the therapeutic effects of ...BACKGROUND Human-derived mesenchymal stromal cells have been shown to improve cognitive function following experimental stroke.The activity of exosomes has been verified to be comparable to the therapeutic effects of mesenchymal stromal cells.However,the effects of exosomes derived from human umbilical cord mesenchymal stem cells(HUC-MSCs)(ExoCtrl)on post-stroke cognitive impairment(PSCI)have rarely been reported.Moreover,whether exosomes derived from C-C chemokine receptor type 2(CCR2)-overexpressing HUC-MSCs(ExoCCR2)can enhance the therapeutic effects on PSCI and the possible underlying mechanisms have not been studied.AIM To investigate the effects of ExoCtrl on PSCI and whether ExoCCR2 can enhance therapeutic effects on PSCI.METHODS Transmission electron microscopy,qNano®particles analyzer,and Western blotting were employed to determine the morphology and CCR2 expression of ExoCtrl or ExoCCR2.ELISA was used to study the binding capacity of exosomes to CC chemokine ligand 2(CCL2)in vivo.After the intravenous injection of ExoCtrl or ExoCCR2 into experimental rats,the effect of ExoCtrl and ExoCCR2 on PSCI was assessed by Morris water maze.Remyelination and oligodendrogenesis were analyzed by Western blotting and immunofluorescence microscopy.QRT-PCR and immunofluorescence microscopy were conducted to compare the microglia/macrophage polarization.The infiltration and activation of hematogenous macrophages were analyzed by Western blotting and transwell migration analysis.RESULTS CCR2-overexpressing HUC-MSCs loaded the CCR2 receptor into their exosomes.The morphology and diameter distribution between ExoCtrl and ExoCCR2 showed no significant difference.ExoCCR2 bound significantly to CCL2 but ExoCtrl showed little CCL2 binding.Although both ExoCCR2 and ExoCtrl showed beneficial effects on PSCI,oligodendrogenesis,remyelination,and microglia/macrophage polarization,ExoCCR2 exhibited a significantly superior beneficial effect.We also found that ExoCCR2 could suppress the CCL2-induced macrophage migration and activation in vivo and in vitro,compared with ExoCtrl treated group.CONCLUSION CCR2 over-expression enhanced the therapeutic effects of exosomes on the experimental PSCI by promoting M2 microglia/macrophage polarization,enhancing oligodendrogenesis and remyelination.These therapeutic effects are likely through suppressing the CCL2-induced hematogenous macrophage migration and activation.Key words:Cognitive impairment;Stroke;Exosomes;C-C chemokine receptor type 2;Microglia/macrophage polarization;Remyelination.展开更多
For the purpose of enhancing air convection and controlling solar radiation, a new crushed-rock slope embankment design combined with a sun-shade measure is proposed. A newly designed embankment was constructed in the...For the purpose of enhancing air convection and controlling solar radiation, a new crushed-rock slope embankment design combined with a sun-shade measure is proposed. A newly designed embankment was constructed in the Tuotuohe section of the Qinghai-Tibet Railway and a field-testing experiment was carried out to determine its convection and temperature characteristics. The results show that distinct air convection occurred in the crushed-rock layer of the new embankment, especially in cold seasons, which was enhanced when it flowed upwards along the slope. This preliminarily indicated that the new design of the embankment slope was good for reinforcing air convection in the crushed-rock layer. The frequent fluctuations of the convection speed and the environmental wind speed were in good agreement, suggesting that the convection in the crushed rock primarily came from the ambient wind. It was also preliminarily determined that the new embankment had a better cooling effect and sun-shade effect for decreasing the temperature of the embankment slope compared with a traditional crushed-rock slope embankment, and the mean temperature difference between them was up to 1.7 °C. The mean annual temperature at the bottom boundary of the crushed-rock layer was obviously lower than that at the top boundary, and heat flux calculation showed that the shallow soil beneath the embankment slope was weakly releasing heat, all of which indicated that the new embankment slope design was beneficial to the thermal stability of the embankment. This study is helpful in providing some references for improved engineering design and maintenance of roadbeds in permafrost regions.展开更多
Acoustic modal behavior is reported for an L-shape hydrophone array during the passage of a strong nonlinear internal wave packet. Acoustic track is nearly parallel to the front of nonlinear internal waves. Through mo...Acoustic modal behavior is reported for an L-shape hydrophone array during the passage of a strong nonlinear internal wave packet. Acoustic track is nearly parallel to the front of nonlinear internal waves. Through modal decomposition at the vertical array, acoustic modes are identified. Modal evolution along the horizontal array then is examined during a passing internal wave. Strong intensity fluctuations of individual modes are observed before and during the internal waves packet passes the fixed acoustic track showing a detailed evolution of the waveguide modal behavior. Acoustic refraction created either uneven distribution of modal energy over the horizontal array or additional returns observable at the entire L-shape array. Acoustic ray-mode simulations are used to phenomenologically explain the observed modal behavior.展开更多
AIM:To determine the effects of intravitreal resveratrol(RSV)on murine laser-induced choroidal neovascularization(CNV).METHODS:The toxicity of RSV to choroidal endothelial cell(CEC)was measured using thiazolyl blue te...AIM:To determine the effects of intravitreal resveratrol(RSV)on murine laser-induced choroidal neovascularization(CNV).METHODS:The toxicity of RSV to choroidal endothelial cell(CEC)was measured using thiazolyl blue tetrazolium bromide(M一)assay.Effects of RSV on choroidal endothelial cell(CEC)migration were evaluated with a modified Boyden chamber assay,while tube formation was evaluated in a 2-D gel assay.CNV was induced by laser photocoagulation in mice.The effects of intravitreal injection of RSV on CNV development were evaluated by fluorescein angiography(FA),confocal analysis of isolectin B4 labeled choroidal flat mounts,and histologic examination of CNV membranes.Immunostaining was used to analyze the expression and phosphorylation of vascular endothelial growth factor receptor 2(VEGFR2).RESULTS:No significant cell toxicity was observed in CEC if the concentration of RSV was less than 200 pmol/L(P>0.05).RSV inhibited vascular endothelial growth factor(VEGF)-induced CEC migration(P<0.05)and tube formation(P<0.05)invitro.Furthermore,intravitrealinjectionof RSV significantly inhibited laser induced CNV formation in mice.The FA leakage,CNV volume and CNV area analysis revealed that there were 41%,45%,and 58%reduction in RSV-treated eyes(1.691±0.1032,178163±78623μm^3 and 6508±619.0μm^2,respectively)compared with those in control(2.724±0.08447,379676±98382μm3and16576±2646μm^2,respectively;P<0.05).Phospho-VEGFR2expression was much weaker in the sections of CNV lesions in RSV injected mice compared with that in control(P<0.05).CONCLUSION:Intravitreal injection of RSV exerts an inhibitory effect on CNV,which may through suppressing endothelial cell migration,tube formation and VEGFR2 phosphorylation.展开更多
Total laryngectomy affects the speaking functions of many patients.Speech deprivation has great impacts on the quality of life of patients,especially on self-efficacy.Learning esophageal speech represents a way to hel...Total laryngectomy affects the speaking functions of many patients.Speech deprivation has great impacts on the quality of life of patients,especially on self-efficacy.Learning esophageal speech represents a way to help laryngectomees speak again.The purpose of this study was to determine the influence of collective esophageal speech training on self-efficacy of laryngectomees.In this study,28 patients and 30 family members were included.The participants received information about training via telephone or a WeChat group.Collective esophageal speech training was used to educate laryngectomees on esophageal speech.Before and after collective esophageal speech training,all participants completed the General Self-Efficacy Scale(GSES)to assess their perceptions on self-efficacy.Through the training,laryngectomees recovered their speech.After the training,the self-efficacy scores of laryngectomees were higher than those before the training,with significant differences noted(P<0.05).However,family members'scores did not change significantly.In conclusion,collective esophageal speech training is not only convenient and economical,but also improves self-efficacy and confidence of laryngectomees.Greater self-efficacy is helpful for laryngectomees to master esophageal speech and improve their quality of life.In addition,more attention should be focused on improving the self-efficacy of family members and making them give full play to their talent and potential on laryngectomees'voice rehabilitation.展开更多
Voltage-controlled magnetic skyrmions have attracted special attention because they satisfy the requirements for well-controlled high-efficiency and energy saving for future skyrmion-based neuron device applications.I...Voltage-controlled magnetic skyrmions have attracted special attention because they satisfy the requirements for well-controlled high-efficiency and energy saving for future skyrmion-based neuron device applications.In this work,we propose a compact leaky-integrate-fire(LIF)spiking neuron device by using the voltage-driven skyrmion dynamics in a multiferroic nanodisk structure.The skyrmion dynamics is controlled by well tailoring voltage-induced piezostrains,where the skyrmion radius can be effectively modulated by applying the piezostrain pulses.Like the biological neuron,the proposed skyrmionic neuron will accumulate a membrane potential as skyrmion radius is varied by inputting the continuous piezostrain spikes,and the skyrmion radius will return to the initial state in the absence of piezostrain.Therefore,this skyrmion radius-based membrane potential will reach a definite threshold value by the strain stimuli and then reset by removing the stimuli.Such the LIF neuronal functionality and the behaviors of the proposed skyrmionic neuron device are elucidated through the micromagnetic simulation studies.Our results may benefit the utilization of skyrmionic neuron for constructing the future energy-efficient and voltage-tunable spiking neural networks.展开更多
Among the many strategies to fabricate the silicon/carbon composite,yolk/double-shells structure can be regarded as an effective strategy to overcome the intrinsic defects of Si-based anode materials for Li-ion batter...Among the many strategies to fabricate the silicon/carbon composite,yolk/double-shells structure can be regarded as an effective strategy to overcome the intrinsic defects of Si-based anode materials for Li-ion batteries(LIBs).Hereon,a facile and inexpensive technology to prepare silicon/carbon composite with yolk/double-shells structure is proposed,in which the double buffering carbon shells are fabricated.The silicon/carbon nanoparticles with core-shell structure are encapsulated by SiO_(2)and external carbon layer,and it shows the yolk/double-shells structure via etching the SiO_(2)sacrificial layer.The multiply shells structure not only significantly improves the electrical conductivity of composite,but also effectively prevents the exposure of Si particles from the electrolyte composition.Meanwhile,the yolk/double-shells structure can provide enough space to accommodate the volume change of the electrode during charge/discharge process and avoid the pulverization of Si particles.Moreover,the as-prepared YDS-Si/C shows excellent performance as anode of LIBs,the reversible capacity is as high as 1066 mA h g^(-1) at the current density of 0.5 A g^(-1) after 200 cycles.At the same time,the YDS-Si/C has high capacity retention and good cyclic stability.Therefore,the unique architecture design of yolk/double-shells for Si/C composite provides an instructive exploration for the development of next generation anode materials of LIBs with high electrochemical performances and structural stability.展开更多
基金National Natural Science Foundation of China(32201491)Young Elite Scientists Sponsorship Program by CAST(2023QNRC001)The authors extend their appreciation to the Deanship of Scientific Research at Northern Border University,Arar,KSA for funding this research work through the project number“NBU-FPEJ-2024-1101-02”.
文摘Research efforts on electromagnetic interference(EMI)shielding materials have begun to converge on green and sustainable biomass materials.These materials offer numerous advantages such as being lightweight,porous,and hierarchical.Due to their porous nature,interfacial compatibility,and electrical conductivity,biomass materials hold significant potential as EMI shielding materials.Despite concerted efforts on the EMI shielding of biomass materials have been reported,this research area is still relatively new compared to traditional EMI shielding materials.In particular,a more comprehensive study and summary of the factors influencing biomass EMI shielding materials including the pore structure adjustment,preparation process,and micro-control would be valuable.The preparation methods and characteristics of wood,bamboo,cellulose and lignin in EMI shielding field are critically discussed in this paper,and similar biomass EMI materials are summarized and analyzed.The composite methods and fillers of various biomass materials were reviewed.this paper also highlights the mechanism of EMI shielding as well as existing prospects and challenges for development trends in this field.
基金supported by the National Natural Science Foundation of China,Nos.81672261(to XH),81972151(to HZ),82372568(to JL)the Natural Science Foundation of Guangdong Province,Nos.2019A1515011106(to HZ),2023A1515030080(to JL)。
文摘Prolife ration of neural stem cells is crucial for promoting neuronal regeneration and repairing cerebral infarction damage.Transcranial magnetic stimulation(TMS)has recently emerged as a tool for inducing endogenous neural stem cell regeneration,but its underlying mechanisms remain unclea r In this study,we found that repetitive TMS effectively promotes the proliferation of oxygen-glucose deprived neural stem cells.Additionally,repetitive TMS reduced the volume of cerebral infa rction in a rat model of ischemic stro ke caused by middle cerebral artery occlusion,im p roved rat cognitive function,and promoted the proliferation of neural stem cells in the ischemic penumbra.RNA-sequencing found that repetitive TMS activated the Wnt signaling pathway in the ischemic penumbra of rats with cerebral ischemia.Furthermore,PCR analysis revealed that repetitive TMS promoted AKT phosphorylation,leading to an increase in mRNA levels of cell cycle-related proteins such as Cdk2 and Cdk4.This effect was also associated with activation of the glycogen synthase kinase 3β/β-catenin signaling pathway,which ultimately promotes the prolife ration of neural stem cells.Subsequently,we validated the effect of repetitive TMS on AKT phosphorylation.We found that repetitive TMS promoted Ca2+influx into neural stem cells by activating the P2 calcium channel/calmodulin pathway,thereby promoting AKT phosphorylation and activating the glycogen synthase kinase 3β/β-catenin pathway.These findings indicate that repetitive TMS can promote the proliferation of endogenous neural stem cells through a Ca2+influx-dependent phosphorylated AKT/glycogen synthase kinase 3β/β-catenin signaling pathway.This study has produced pioneering res ults on the intrinsic mechanism of repetitive TMS to promote neural function recove ry after ischemic stro ke.These results provide a stro ng scientific foundation for the clinical application of repetitive TMS.Moreover,repetitive TMS treatment may not only be an efficient and potential approach to support neurogenesis for further therapeutic applications,but also provide an effective platform for the expansion of neural stem cells.
基金supported by the National Key Research and Development Program of China(Grant No.2022YFE0137200)National Natural Science Foundation of China(Grant Nos.52309147 and 52179114).
文摘In unconsolidated sandstone reservoirs,presence of numerous movable grains and a complex grain size composition necessitates a clear understanding of the physical clogging process for effective groundwater recharge in groundwater-source heat pump systems.To investigate this,a series of seepage experiments was conducted under in situ stress conditions using unconsolidated sandstone samples with varying grain compositions.The clogging phenomenon arises from the combined effects of grain migration and compaction,wherein the migration of both original and secondary crushed fine-grain particles blocks the seepage channels.Notably,grain composition influences the migration and transport properties of the grains.For samples composed of smaller grains,the apparent permeability demonstrates a transition from stability to decrease.In contrast,samples with larger grains experience a skip at the stability stage and directly enter the decrease stage,with a minor exception of a slight increase observed.Furthermore,a unique failure mode characterized by diameter shrinkage in the upper part of the sample is observed due to the combined effects of grain migration and in situ stress-induced compaction.These testing results contribute to a better understanding of the clogging mechanism caused by the coupled effects of grain migration and compaction during groundwater recharge in unconsolidated sandstone reservoirs used in groundwater-source heat pump systems.
基金Department of Science and Technology of Guangdong Technology College in 2024“A Study on the English Translation of Characteristic Cuisines of the Hexi Corridor from the Perspective of Multimodal Discourse Analysis”(2024QNSK019)。
文摘Given the diversity of geographical and cultural backgrounds,it is difficult to find precise counterparts of many food-related vocabularies in the unique dietary culture of the Hexi Corridor in the target language,making it challenging to fully convey the essence of its local dietary culture in translation.To achieve the purpose of translation,the theory of multimodal discourse analysis provides an ideal translation approach through the language mode,image mode,sound mode,and the synergistic effect of multimodalities,which can accurately address the deficiencies in the translation of dietary culture.Through this research,it is not only possible to highlight the unique charm of the dietary culture of the Hexi Corridor but also to build a bridge for its international dissemination,promoting cross-border cultural exchanges and mutual understanding.
基金supported by National Key Research and Development Program (2016YFD0101802, 2016YFD0101004)National Basic Research Program of China (2004CB117205, 2012CB125902)+5 种基金National Key Technology R&D Program of China (2002AA224161)National Science and Technology Major Project (2009ZX08009-049B, 2012ZX08009003)Jiangsu Collaborative Innovation Initiative for Modern Crop Production,'111' project B08025Natural Science Foundation of Jiangsu Province (BK20131316)Innovation Team Program for Jiangsu Universities (2014)the long-term funding from the National Science Foundation of China (30025030,30430440,30721140555,31030054,30671295)
文摘Fusarium head blight(FHB) or scab caused by Fusarium graminearum is a major threat to wheat production in China as well as in the world. To combat this disease, multiple efforts have been carried out internationally. In this article, we review our long-time effort in identifying the resistance genes and dissecting the resistance mechanisms by both forward and reverse genetics approaches in the last two decades. We present recent progress in resistance QTL identification, candidate functional gene discovery, marker-assisted improvement of FHB resistant varieties, and findings in investigating association of signal molecules, such as Ca^(++),SA, JA, and ET, with FHB response, with the assistance from rapidly growing genomics platforms. The information will be helpful for designing novel and efficient approaches to curb FHB.
基金financially supported by the Natural Science Foundation of Shanxi Province,China(201601D102006)the Science Foundation for Young Scientists of Shanxi Province,China(201701D221052)+2 种基金the National Natural Science Foundation of China(21776294)the Key Science and Technology Program of Shanxi Province,China(MD2014-09,MD2014-10)the Independent Research Project of the State Key Laboratory of Coal Conversion(2018BWZ002)~~
文摘A series of metal-organic frameworks MOF-808-X(6-connected)were synthesized by regulating the ZrOCl2·8H2O/1,3,5-benzenetricarboxylic acid(BTC)molar ratio(X)and tested for the direct synthesis of dimethyl carbonate(DMC)from CO2 and CH3OH with 1,1,1-trimethoxymethane(TMM)as a dehydrating agent.The effect of the ZrOCl2·8H2O/BTC molar ratio on the physicochemical properties and catalytic performance of MOF-808-X was investigated.Results showed that a proper ZrOCl2·8H2O/BTC molar ratio during MOF-808-X synthesis was fairly important to reduce the redundant BTC or zirconium clusters trapped in the micropores of MOF-808-X.MOF-808-4,with almost no redundant BTC or zirconium clusters trapped in the micropores,exhibited the largest surface area,micropore size,and the number of acidic-basic sites,and consequently showed the best activity among all MOF-808-X,with the highest DMC yield of 21.5% under the optimal reaction conditions.Moreover,benefiting from the larger micropore size,MOF-808-4 outperformed our previously reported UiO-66-24(12-connected),which had even more acidic-basic sites and larger surface area than MOF-808-4,mainly because the larger micropore size of MOF-808-4 provided higher accessibility for the reactant to the active sites located in the micropores.Furthermore,a possible reaction mechanism over MOF-808-4 was proposed based on the in situ FT-IR results.The effects of different reaction parameters on DMC formation and the reusability of MOF-808-X were also studied.
文摘Platinum group metals(PGMs)usually exhibit promising aerobic catalytic abilities,providing a green and feasible oxidative desulfurization method.However,often,the PGM nanoparticles(NPs)get leached,and the catalysts are deactivated.In this work,Pt NPs with particle sizes of approximately 4–5 nm were encapsulated effectively and uniformly on the surface of vanadium pentoxide(V2O5)nanosheets(with thicknesses of approximately six atomic layers)through strong metal-support interactions.The synthesized catalysts promote catalytic aerobic oxidation reactions,realizing deep desulfurization(99.1%,<5μg g^(–1))under atmospheric pressure and 110℃reaction temperature.Remarkable degrees of sulfur removal could be achieved for oils with different initial S-concentrations and substrates.Additionally,the as-prepared catalysts could be recycled for reuse at least seven times.
基金Project supported by the National Natural Science Foundation of China(Grant Nos.41875040,41705012,and 1605013)
文摘A method for aerosol extinction profile retrieval using ground-based multi-axis differential optical absorption spectroscopy(MAX-DOAS)is studied,which is based on a look-up table algorithm.The algorithm uses parametric method to represent aerosol extinction profiles and simulate different atmospheric aerosol states through atmospheric radiation transfer model.Based on the method,aerosol extinction profile was obtained during six cloud-free days.The O4 differential air mass factor(dAMF)measured by MAX-DOAS is compared with the corresponding model results under different atmospheric conditions(R^2=0.78).The aerosol optical thickness,aerosol weight factor in boundary layer,and the height of the boundary layer are obtained after the process of minimization and look-up table method.The retrieved aerosol extinction in boundary layer is compared with PM2.5 data measured by ground point instrument.The diurnal variation trends of the two methods are in good agreement.The correlation coefficients of the two methods are 0.71 when the aerosol optical thickness is smaller than 0.5.The results show that the look-up table method can obtain the aerosol state of the troposphere and provide validation for other instrument data.
基金Supported by chia funding of Yale-China Association, the National Natural Science Foundation of China (No.81570847)the Natural Science Foundation of Hunan Province (No.2016JJ4095)+1 种基金the Programs ofScience-Technology Commission of Hunan Province (No.2015JC3036)Department of Science and Technology, Hunan (No. 2015TP2007)
文摘AIM: To determine the prevalence and factors associated with amblyopia among children aged 30-83 mo in central south of China.METHODS: A population-based, cross-sectional study was conducted in children aged 30-83 mo in Changsha(an urban city) and Zhangjiajie(a rural area) in central south of China. Clinical examinations including ocular alignment, ocular motility, visual acuity(VA), prism cover test, cycloplegic refraction, slit lamp examination and fundus examination were performed by trained study ophthalmologists and optometrists. Unilateral amblyopia was defined as a 2-line difference between eyes with VA<20/32 in the worse eye and with coexisting anisometropia [≥1.00 D spherical eutivalent(SE) for hyperopia, ≥3.00 D SE for myopia, and ≥1.50 D for astigmatism], strabismus, or past or present visual axis obstruction. Bilateral amblyopia was defined as VA in both eyes <20/40(≥ 48-month-old) and <20/50(< 48-month-old), with coexisting hyperopia ≥4.00 D SE, myopia ≤-6.00 D SE, and astigmatism ≥2.50 D, or past or present visual axis obstruction.RESULTS: There were 8042 children enrolled and 7713 children were screened. The amblyopia prevalence in children aged 30-83 mo was 1.09%(95% confidence interval, 0.86%-1.35%) with no age(P=0.81), gender(P=0.46) or area distribution(P=0.93) differences. Of these, 0.68% were unilateral cases and 0.41% were bilateral cases. Underlying causes included anisometropia(40%), binocular refractive error(36%), strabismus(14%) and deprivation(10%). Hyperopia combined with astigmatism was the frequent refractive error for ametropic and anisometropic amblyopia.CONCLUSION: In this rural and urban Chinese population, 1.09% of children with 30-83 mo of age had amblyopia, a prevalence rate similar to that of many other studies. Anisometropia and refractive error are the most common causes of unilateral and bilateral amblyopia respectively.
基金the National Natural Science Foundation of China,No.81871847 and No.81672261
文摘BACKGROUND Human-derived mesenchymal stromal cells have been shown to improve cognitive function following experimental stroke.The activity of exosomes has been verified to be comparable to the therapeutic effects of mesenchymal stromal cells.However,the effects of exosomes derived from human umbilical cord mesenchymal stem cells(HUC-MSCs)(ExoCtrl)on post-stroke cognitive impairment(PSCI)have rarely been reported.Moreover,whether exosomes derived from C-C chemokine receptor type 2(CCR2)-overexpressing HUC-MSCs(ExoCCR2)can enhance the therapeutic effects on PSCI and the possible underlying mechanisms have not been studied.AIM To investigate the effects of ExoCtrl on PSCI and whether ExoCCR2 can enhance therapeutic effects on PSCI.METHODS Transmission electron microscopy,qNano®particles analyzer,and Western blotting were employed to determine the morphology and CCR2 expression of ExoCtrl or ExoCCR2.ELISA was used to study the binding capacity of exosomes to CC chemokine ligand 2(CCL2)in vivo.After the intravenous injection of ExoCtrl or ExoCCR2 into experimental rats,the effect of ExoCtrl and ExoCCR2 on PSCI was assessed by Morris water maze.Remyelination and oligodendrogenesis were analyzed by Western blotting and immunofluorescence microscopy.QRT-PCR and immunofluorescence microscopy were conducted to compare the microglia/macrophage polarization.The infiltration and activation of hematogenous macrophages were analyzed by Western blotting and transwell migration analysis.RESULTS CCR2-overexpressing HUC-MSCs loaded the CCR2 receptor into their exosomes.The morphology and diameter distribution between ExoCtrl and ExoCCR2 showed no significant difference.ExoCCR2 bound significantly to CCL2 but ExoCtrl showed little CCL2 binding.Although both ExoCCR2 and ExoCtrl showed beneficial effects on PSCI,oligodendrogenesis,remyelination,and microglia/macrophage polarization,ExoCCR2 exhibited a significantly superior beneficial effect.We also found that ExoCCR2 could suppress the CCL2-induced macrophage migration and activation in vivo and in vitro,compared with ExoCtrl treated group.CONCLUSION CCR2 over-expression enhanced the therapeutic effects of exosomes on the experimental PSCI by promoting M2 microglia/macrophage polarization,enhancing oligodendrogenesis and remyelination.These therapeutic effects are likely through suppressing the CCL2-induced hematogenous macrophage migration and activation.Key words:Cognitive impairment;Stroke;Exosomes;C-C chemokine receptor type 2;Microglia/macrophage polarization;Remyelination.
基金supported by the Western Project Program of the Chinese Academy of Sciences (No. KZCX2-XB3-19)the National Key Basic Research Program of China, 973 Program (No. 2012CB026101)
文摘For the purpose of enhancing air convection and controlling solar radiation, a new crushed-rock slope embankment design combined with a sun-shade measure is proposed. A newly designed embankment was constructed in the Tuotuohe section of the Qinghai-Tibet Railway and a field-testing experiment was carried out to determine its convection and temperature characteristics. The results show that distinct air convection occurred in the crushed-rock layer of the new embankment, especially in cold seasons, which was enhanced when it flowed upwards along the slope. This preliminarily indicated that the new design of the embankment slope was good for reinforcing air convection in the crushed-rock layer. The frequent fluctuations of the convection speed and the environmental wind speed were in good agreement, suggesting that the convection in the crushed rock primarily came from the ambient wind. It was also preliminarily determined that the new embankment had a better cooling effect and sun-shade effect for decreasing the temperature of the embankment slope compared with a traditional crushed-rock slope embankment, and the mean temperature difference between them was up to 1.7 °C. The mean annual temperature at the bottom boundary of the crushed-rock layer was obviously lower than that at the top boundary, and heat flux calculation showed that the shallow soil beneath the embankment slope was weakly releasing heat, all of which indicated that the new embankment slope design was beneficial to the thermal stability of the embankment. This study is helpful in providing some references for improved engineering design and maintenance of roadbeds in permafrost regions.
基金Supported by U.S. Office of Naval Research,Ocean Acoustics Program(322OA)under Nos.N00014-11-1-0701 and N00014-13-1-0306
文摘Acoustic modal behavior is reported for an L-shape hydrophone array during the passage of a strong nonlinear internal wave packet. Acoustic track is nearly parallel to the front of nonlinear internal waves. Through modal decomposition at the vertical array, acoustic modes are identified. Modal evolution along the horizontal array then is examined during a passing internal wave. Strong intensity fluctuations of individual modes are observed before and during the internal waves packet passes the fixed acoustic track showing a detailed evolution of the waveguide modal behavior. Acoustic refraction created either uneven distribution of modal energy over the horizontal array or additional returns observable at the entire L-shape array. Acoustic ray-mode simulations are used to phenomenologically explain the observed modal behavior.
基金Supported by the National Natural Science Foundation of China(No.81703134,No.81770952)Henan Province Nature Science Foundation of China(No.162300410296)Hunan Province Nature Science Foundation of China(No.2018JJ3772)。
文摘AIM:To determine the effects of intravitreal resveratrol(RSV)on murine laser-induced choroidal neovascularization(CNV).METHODS:The toxicity of RSV to choroidal endothelial cell(CEC)was measured using thiazolyl blue tetrazolium bromide(M一)assay.Effects of RSV on choroidal endothelial cell(CEC)migration were evaluated with a modified Boyden chamber assay,while tube formation was evaluated in a 2-D gel assay.CNV was induced by laser photocoagulation in mice.The effects of intravitreal injection of RSV on CNV development were evaluated by fluorescein angiography(FA),confocal analysis of isolectin B4 labeled choroidal flat mounts,and histologic examination of CNV membranes.Immunostaining was used to analyze the expression and phosphorylation of vascular endothelial growth factor receptor 2(VEGFR2).RESULTS:No significant cell toxicity was observed in CEC if the concentration of RSV was less than 200 pmol/L(P>0.05).RSV inhibited vascular endothelial growth factor(VEGF)-induced CEC migration(P<0.05)and tube formation(P<0.05)invitro.Furthermore,intravitrealinjectionof RSV significantly inhibited laser induced CNV formation in mice.The FA leakage,CNV volume and CNV area analysis revealed that there were 41%,45%,and 58%reduction in RSV-treated eyes(1.691±0.1032,178163±78623μm^3 and 6508±619.0μm^2,respectively)compared with those in control(2.724±0.08447,379676±98382μm3and16576±2646μm^2,respectively;P<0.05).Phospho-VEGFR2expression was much weaker in the sections of CNV lesions in RSV injected mice compared with that in control(P<0.05).CONCLUSION:Intravitreal injection of RSV exerts an inhibitory effect on CNV,which may through suppressing endothelial cell migration,tube formation and VEGFR2 phosphorylation.
文摘Total laryngectomy affects the speaking functions of many patients.Speech deprivation has great impacts on the quality of life of patients,especially on self-efficacy.Learning esophageal speech represents a way to help laryngectomees speak again.The purpose of this study was to determine the influence of collective esophageal speech training on self-efficacy of laryngectomees.In this study,28 patients and 30 family members were included.The participants received information about training via telephone or a WeChat group.Collective esophageal speech training was used to educate laryngectomees on esophageal speech.Before and after collective esophageal speech training,all participants completed the General Self-Efficacy Scale(GSES)to assess their perceptions on self-efficacy.Through the training,laryngectomees recovered their speech.After the training,the self-efficacy scores of laryngectomees were higher than those before the training,with significant differences noted(P<0.05).However,family members'scores did not change significantly.In conclusion,collective esophageal speech training is not only convenient and economical,but also improves self-efficacy and confidence of laryngectomees.Greater self-efficacy is helpful for laryngectomees to master esophageal speech and improve their quality of life.In addition,more attention should be focused on improving the self-efficacy of family members and making them give full play to their talent and potential on laryngectomees'voice rehabilitation.
基金the National Natural Science Foundation of China(Grant Nos.11902316,51902300,and 11972333)the Natural Science Foundation of Zhejiang Province,China(Grant Nos.LQ19F010005,LY21F010011,and LZ19A020001).
文摘Voltage-controlled magnetic skyrmions have attracted special attention because they satisfy the requirements for well-controlled high-efficiency and energy saving for future skyrmion-based neuron device applications.In this work,we propose a compact leaky-integrate-fire(LIF)spiking neuron device by using the voltage-driven skyrmion dynamics in a multiferroic nanodisk structure.The skyrmion dynamics is controlled by well tailoring voltage-induced piezostrains,where the skyrmion radius can be effectively modulated by applying the piezostrain pulses.Like the biological neuron,the proposed skyrmionic neuron will accumulate a membrane potential as skyrmion radius is varied by inputting the continuous piezostrain spikes,and the skyrmion radius will return to the initial state in the absence of piezostrain.Therefore,this skyrmion radius-based membrane potential will reach a definite threshold value by the strain stimuli and then reset by removing the stimuli.Such the LIF neuronal functionality and the behaviors of the proposed skyrmionic neuron device are elucidated through the micromagnetic simulation studies.Our results may benefit the utilization of skyrmionic neuron for constructing the future energy-efficient and voltage-tunable spiking neural networks.
基金the National Natural Science Foundation of China(No.21703191)Key Project of Strategic New Industry of Hunan Province(No.2016GK4005 and No.2016GK4030)Research Innovation Project for Graduate students of Hunan Province(No.CX2017B302)。
文摘Among the many strategies to fabricate the silicon/carbon composite,yolk/double-shells structure can be regarded as an effective strategy to overcome the intrinsic defects of Si-based anode materials for Li-ion batteries(LIBs).Hereon,a facile and inexpensive technology to prepare silicon/carbon composite with yolk/double-shells structure is proposed,in which the double buffering carbon shells are fabricated.The silicon/carbon nanoparticles with core-shell structure are encapsulated by SiO_(2)and external carbon layer,and it shows the yolk/double-shells structure via etching the SiO_(2)sacrificial layer.The multiply shells structure not only significantly improves the electrical conductivity of composite,but also effectively prevents the exposure of Si particles from the electrolyte composition.Meanwhile,the yolk/double-shells structure can provide enough space to accommodate the volume change of the electrode during charge/discharge process and avoid the pulverization of Si particles.Moreover,the as-prepared YDS-Si/C shows excellent performance as anode of LIBs,the reversible capacity is as high as 1066 mA h g^(-1) at the current density of 0.5 A g^(-1) after 200 cycles.At the same time,the YDS-Si/C has high capacity retention and good cyclic stability.Therefore,the unique architecture design of yolk/double-shells for Si/C composite provides an instructive exploration for the development of next generation anode materials of LIBs with high electrochemical performances and structural stability.