针对2013年1月23日辽宁灯塔M_(S)5.1地震,利用引潮力附加构造应力(Additional Tectonic Stress Caused By Tidal Force,ATSCTF)计算模型,计算得到震中位置(41.5°N,123.2°E)在地震前5周以及震后3周(2012年12月16日—2013年2月1...针对2013年1月23日辽宁灯塔M_(S)5.1地震,利用引潮力附加构造应力(Additional Tectonic Stress Caused By Tidal Force,ATSCTF)计算模型,计算得到震中位置(41.5°N,123.2°E)在地震前5周以及震后3周(2012年12月16日—2013年2月15日)的ATSCTF变化。地震发生时,ATSCTF垂直方向分量处于高相位点附近,显示引潮力对本次正断层走滑型地震具有诱发作用。以ATSCTF变化周期的各低相位点时间(2012年12月19日、2013年1月4日、2013年1月18日、2013年2月2日)数据分别为背景,各周期期后数据分别与背景逐日相减,计算研究区(36°N~46°N,118°E~128°E)范围内,National Oceanic and Atmospheric Administration(NOAA)卫星射出长波辐射数据(Outgoing Long Wave Radiation,OLR)在各ATSCTF周期时段分布及其变化。结果显示,无震的ATSCTF变化的A、B、D周期,震中附近OLR无变化;发震的ATSCTF变化的C周期,在空间上,该地区震前OLR仅震中及其南侧区域发生了显著连续升高变化过程,在时间上经历了初始微异常→异常加强→高峰→衰减→发震→平静的演化过程,与岩石应力加载—破裂经历:初始微动破裂→扩张破裂→应力闭锁→地震爆发→平静的力学演化过程中各阶段红外辐射特征一致;显示引潮力对处于临界状态的活动断层具有诱发作用,而OLR是地震构造应力应变过程辐射表征。展开更多
Objective Diabetic foot ulcer(DFU)is one of the most serious complications of diabetes.Leukocyte-and platelet-rich fibrin(L-PRF)is a second-generation autologous platelet-rich plasma.This study aims to investigate the...Objective Diabetic foot ulcer(DFU)is one of the most serious complications of diabetes.Leukocyte-and platelet-rich fibrin(L-PRF)is a second-generation autologous platelet-rich plasma.This study aims to investigate the clinical effects of L-PRF in patients with diabetes in real clinical practice.Methods Patients with DFU who received L-PRF treatment and standard of care(SOC)from 2018 to 2019 in Tongji Hospital were enrolled.The clinical information including patient characteristics,wound evaluation(area,severity,infection,blood supply),SOC of DFU,and images of ulcers was retrospectively extracted and analyzed.L-PRF treatment was performed every 7±2 days until the ulcer exhibited complete epithelialization or an overall percent volume reduction(PVR)greater than 80%.Therapeutic effectiveness,including overall PVR and the overall and weekly healing rates,was evaluated.Results Totally,26 patients with DFU were enrolled,and they had an ulcer duration of 47.0(35.0,72.3)days.The severity and infection of ulcers varied,as indicated by the Site,Ischemia,Neuropathy,Bacterial Infection,and Depth(SINBAD)scores of 2–6,Wagner grades of 1–4,and the Perfusion,Extent,Depth,Infection and Sensation(PEDIS)scores of 2–4.The initial ulcer volume before L-PRF treatment was 4.94(1.50,13.83)cm3,and the final ulcer volume was 0.35(0.03,1.76)cm3.The median number of L-PRF doses was 3(2,5).A total of 11 patients achieved complete epithelialization after the fifth week of treatment,and 19 patients achieved at least an 80%volume reduction after the seventh week.The overall wound-healing rate was 1.47(0.63,3.29)cm3/week,and the healing rate was faster in the first 2 weeks than in the remaining weeks.Concurrent treatment did not change the percentage of complete epithelialization or healing rate.Conclusion Adding L-PRF to SOC significantly improved wound healing in patients with DFU independent of the ankle brachial index,SINBAD score,or Wagner grade,indicating that this method is appropriate for DFU treatment under different clinical conditions.展开更多
基金地震数值预测联合实验室开放基金项目(2020LNEF03)APSCO Earthquake Research Project PhaseⅡ:Integrating Satellite and Ground Observations for Earthquake Signatures and Precursors(WX0519502)。
文摘针对2013年1月23日辽宁灯塔M_(S)5.1地震,利用引潮力附加构造应力(Additional Tectonic Stress Caused By Tidal Force,ATSCTF)计算模型,计算得到震中位置(41.5°N,123.2°E)在地震前5周以及震后3周(2012年12月16日—2013年2月15日)的ATSCTF变化。地震发生时,ATSCTF垂直方向分量处于高相位点附近,显示引潮力对本次正断层走滑型地震具有诱发作用。以ATSCTF变化周期的各低相位点时间(2012年12月19日、2013年1月4日、2013年1月18日、2013年2月2日)数据分别为背景,各周期期后数据分别与背景逐日相减,计算研究区(36°N~46°N,118°E~128°E)范围内,National Oceanic and Atmospheric Administration(NOAA)卫星射出长波辐射数据(Outgoing Long Wave Radiation,OLR)在各ATSCTF周期时段分布及其变化。结果显示,无震的ATSCTF变化的A、B、D周期,震中附近OLR无变化;发震的ATSCTF变化的C周期,在空间上,该地区震前OLR仅震中及其南侧区域发生了显著连续升高变化过程,在时间上经历了初始微异常→异常加强→高峰→衰减→发震→平静的演化过程,与岩石应力加载—破裂经历:初始微动破裂→扩张破裂→应力闭锁→地震爆发→平静的力学演化过程中各阶段红外辐射特征一致;显示引潮力对处于临界状态的活动断层具有诱发作用,而OLR是地震构造应力应变过程辐射表征。
基金supported by grants from the National Natural Science Foundation of China(No.81100581)the Bethune Merck Diabetes Research Fund(No.2018)+1 种基金the Fund of the Sichuan Provincial Western Psychiatric Association's CSPC LEADING Scientific Research Project(No.WL2021104)the China International Medical Foundation-Senmei China Diabetes Research Fund(No.Z-2017-26-1902-5).
文摘Objective Diabetic foot ulcer(DFU)is one of the most serious complications of diabetes.Leukocyte-and platelet-rich fibrin(L-PRF)is a second-generation autologous platelet-rich plasma.This study aims to investigate the clinical effects of L-PRF in patients with diabetes in real clinical practice.Methods Patients with DFU who received L-PRF treatment and standard of care(SOC)from 2018 to 2019 in Tongji Hospital were enrolled.The clinical information including patient characteristics,wound evaluation(area,severity,infection,blood supply),SOC of DFU,and images of ulcers was retrospectively extracted and analyzed.L-PRF treatment was performed every 7±2 days until the ulcer exhibited complete epithelialization or an overall percent volume reduction(PVR)greater than 80%.Therapeutic effectiveness,including overall PVR and the overall and weekly healing rates,was evaluated.Results Totally,26 patients with DFU were enrolled,and they had an ulcer duration of 47.0(35.0,72.3)days.The severity and infection of ulcers varied,as indicated by the Site,Ischemia,Neuropathy,Bacterial Infection,and Depth(SINBAD)scores of 2–6,Wagner grades of 1–4,and the Perfusion,Extent,Depth,Infection and Sensation(PEDIS)scores of 2–4.The initial ulcer volume before L-PRF treatment was 4.94(1.50,13.83)cm3,and the final ulcer volume was 0.35(0.03,1.76)cm3.The median number of L-PRF doses was 3(2,5).A total of 11 patients achieved complete epithelialization after the fifth week of treatment,and 19 patients achieved at least an 80%volume reduction after the seventh week.The overall wound-healing rate was 1.47(0.63,3.29)cm3/week,and the healing rate was faster in the first 2 weeks than in the remaining weeks.Concurrent treatment did not change the percentage of complete epithelialization or healing rate.Conclusion Adding L-PRF to SOC significantly improved wound healing in patients with DFU independent of the ankle brachial index,SINBAD score,or Wagner grade,indicating that this method is appropriate for DFU treatment under different clinical conditions.
