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Acute Uveitis in Neovascular Glaucoma Patient after a Single Dose of Travoprost
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作者 Lijun Wang jing zhu +1 位作者 Qian Feng Junfeng Yang 《Case Reports in Clinical Medicine》 2024年第8期275-282,共8页
A 38-year-old man with no history of uveitis developed neovascular glaucoma (NVG) due to proliferative diabetic retinopathy (PDR). He had a history of ocular surgery with placement of glaucoma drainage implants (GDI),... A 38-year-old man with no history of uveitis developed neovascular glaucoma (NVG) due to proliferative diabetic retinopathy (PDR). He had a history of ocular surgery with placement of glaucoma drainage implants (GDI), ultrasonic phacoemulsification, and intraocular lens implantation in both eyes. The patient had undergone a recent pars plana vitrectomy with complete panretinal photocoagulation (PRP) to clear vitreous hemorrhage in his right eye. To prevent progressive optic nerve damage, travoprost was tentatively administered because of inadequate intraocular pressure (IOP) control following surgery, laser treatment, and topical administration of many other IOP-lowering drugs. The patient experienced severe vision loss associated with acute anterior and intermediate uveitis. We consider it a rare complication due to the NVG patient’s vulnerability following ocular surgery. Given that acute uveitis developed rapidly and required time to resolve, systemic corticosteroid treatment could be considered to accelerate the resolution of inflammation. 展开更多
关键词 TRAVOPROST UVEITIS GLAUCOMA Prostaglandin Analogues Intraocular Pressure
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Stabilizing zinc anode using zeolite imidazole framework functionalized separator for durable aqueous zinc-ion batteries 被引量:1
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作者 Weisong Zhang Xinyan zhu +8 位作者 Ling Kang Ziyu Peng jing zhu Liang Pan Lei Dai Shude Liu Ling Wang Yongguang Liu Zhangxing He 《Journal of Energy Chemistry》 SCIE EI CAS CSCD 2024年第3期23-31,I0003,共10页
Aqueous zinc-ion batteries(AZIBs) hold great promise as a viable alternative to lithium-ion batteries owing to their high energy density and environmental friendliness.However,AZIBs are consistently plagued by the for... Aqueous zinc-ion batteries(AZIBs) hold great promise as a viable alternative to lithium-ion batteries owing to their high energy density and environmental friendliness.However,AZIBs are consistently plagued by the formation of zinc dendrites and concurrent side reactions,which significantly diminish their overall service life,In this study,the glass fiber separator(GF) is modified using zeolite imidazole salt framework-8(ZIF-8),enabling the development of efficient AZIBs.ZIF-8,which is abundant in nitrogen content,efficiently regulates the desolvation of [Zn(H_(2)O)_(6)]^(2+) to inhibit hydrogen production.Moreover,it possesses abundant nanochannels that facilitate the uniform deposition of Zn~(2+) via a localized action,thereby hindering the formation of dendrites.The insulating properties of ZIF-8 help prevent Zn^(2+) and water from trapping electron reduction at the layer surface,which reduces corrosion of the zinc anode.Consequently,ZIF-8-GF achieves the even transport of Zn^(2+) and regulates the homogeneous deposition along the Zn(002) crystal surface,thus significantly enhancing the electrochemical performance of the AZIBs,In particular,the Zn|Zn symmetric cell with the ZIF-8-GF separator delivers a stable cycle life at0.5 mA cm^(-2) of 2300 h.The Zn|ZIF-8-GF|MnO_(2) cell exhibits reduced voltage polarization while maintaining a capacity retention rate(93.4%) after 1200 cycles at 1.2 A g^(-1) The unique design of the modified diaphragm provides a new approach to realizing high-performance AZIBs. 展开更多
关键词 Aqueous zinc-ion batteries Separators modifications ZIF-8 Zn deposition Dendrite-free
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金沙江下游梯级联合调度对川渝河段防洪效果评价
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作者 黄可 荆柱 +2 位作者 李继清 肖扬帆 郑威 《人民长江》 北大核心 2024年第3期21-28,82,共9页
金沙江下游四级梯级水库联合调度为长江川渝河段提供了防洪安全保障,对其防洪调度效果进行评价,可以科学衡量与评估川渝河段防洪调度效果,促进流域洪水资源化利用。基于金下四级联合防洪调度方案,建立防洪、发电、生态和航运4个准则下... 金沙江下游四级梯级水库联合调度为长江川渝河段提供了防洪安全保障,对其防洪调度效果进行评价,可以科学衡量与评估川渝河段防洪调度效果,促进流域洪水资源化利用。基于金下四级联合防洪调度方案,建立防洪、发电、生态和航运4个准则下的评价指标体系,采用改进的层次分析法和熵权法,构建川渝河段梯级水库防洪调度效果评价模型,综合考虑防洪和兴利效益,评估不同来水频率和不同起调水位的梯级水库防洪调度效果;对比溪-向两库联合调度与金下四级联合调度效果,分析乌东德、白鹤滩水库建成投产对于川渝河段防洪调度及洪水资源化利用的综合效果。结果表明:①随着乌-白两库起调水位升高,金下四级防洪调度效果系数呈现先升高后降低的趋势。②对于20,30,50 a一遇和100 a一遇洪水,乌东德和白鹤滩水库分别从(965 m和795 m)、(975 m和790 m)、(955 m和790 m)、(952 m和795 m)起调时,金下四级防洪调度效果系数最大,梯级水库联合防洪调度方案最优。③乌东德、白鹤滩水库建成投产后,川渝河段洪水资源化利用效果提升。研究成果可用于多功能、多保护对象的梯级水库防洪调度效果评价,为地区防洪调度决策提供依据。 展开更多
关键词 联合防洪调度 洪水资源化 效果评价 层次分析法 金沙江下游梯级水库 川渝河段
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Targeting GPR65 alleviates hepatic inflammation and fibrosis by suppressing the JNK and NF-κB pathways
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作者 Kun Zhang Meng-Xia Zhang +9 位作者 Xiao-Xiang Meng jing zhu Jia-Jun Wang Yi-Fan He Ye-Hua Li Si-Cong Zhao Zhe-Min Shi Li-Na Zheng Tao Han Wei Hong 《Military Medical Research》 SCIE CAS CSCD 2024年第4期500-520,共21页
Background:G-protein coupled receptors(GPCRs)are recognized as attractive targets for drug therapy.However,it remains poorly understood how GPCRs,except for a few chemokine receptors,regulate the progression of liver ... Background:G-protein coupled receptors(GPCRs)are recognized as attractive targets for drug therapy.However,it remains poorly understood how GPCRs,except for a few chemokine receptors,regulate the progression of liver fibrosis.Here,we aimed to reveal the role of GPR65,a proton-sensing receptor,in liver fibrosis and to elucidate the underlying mechanism.Methods:The expression level of GPR65 was evaluated in both human and mouse fibrotic livers.Furthermore,Gpr65-deficient mice were treated with either bile duct ligation(BDL)for 21 d or carbon tetrachloride(CCl4)for 8 weeks to investigate the role of GPR65 in liver fibrosis.A combination of experimental approaches,including Western blotting,quantitative real-time reverse transcription-polymerase chain reaction(qRT-PCR),and enzyme-linked immunosorbent assay(ELISA),confocal microscopy and rescue studies,were used to explore the underlying mechanisms of GPR65’s action in liver fibrosis.Additionally,the therapeutic potential of GPR65 inhibitor in the development of liver fibrosis was investigated.Results:We found that hepatic macrophage(HM)-enriched GPR65 was upregulated in both human and mouse fibrotic livers.Moreover,knockout of Gpr65 significantly alleviated BDL-and CCl4-induced liver inflammation,injury and fibrosis in vivo,and mouse bone marrow transplantation(BMT)experiments further demonstrated that the protective effect of Gpr65knockout is primarily mediated by bone marrow-derived macrophages(BMMs).Additionally,in vitro data demonstrated that Gpr65 silencing and GPR65 antagonist inhibited,while GPR65 overexpression and application of GPR65 endogenous and exogenous agonists enhanced the expression and release of tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)and transforming growth factor-β(TGF-β),all of which subsequently promoted the activation of hepatic stellate cells(HSCs)and the damage of hepatocytes(HCs).Mechanistically,GPR65 overexpression,the acidic pH and GPR65 exogenous agonist induced up-regulation of TNF-αand IL-6 via the Gαq-Ca^(2+)-JNK/NF-κB pathways,while promoted the expression of TGF-βthrough the Gαq-Ca^(2+)-MLK3-MKK7-JNK pathway.Notably,pharmacological GPR65 inhibition retarded the development of inflammation,HCs injury and fibrosis invivo.Conclusions:GPR65 is a major regulator that modulates the progression of liver fibrosis.Thus,targeting GPR65 could be an effective therapeutic strategy for the prevention of liver fibrosis. 展开更多
关键词 GPR65 Hepatic fibrosis Hepatic macrophages Inflammation c-Jun N-terminal kinase Nuclear factorκB
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Multiple-dimensioned defect engineering for graphite felt electrode of vanadium redox flow battery
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作者 Yingqiao Jiang Yinhui Wang +7 位作者 Gang Cheng Yuehua Li Lei Dai jing zhu Wei Meng jingyu Xi Ling Wang Zhangxing He 《Carbon Energy》 SCIE EI CAS CSCD 2024年第2期143-153,共11页
The scarcity of wettability,insufficient active sites,and low surface area of graphite felt(GF)have long been suppressing the performance of vanadium redox flow batteries(VRFBs).Herein,an ultra-homogeneous multipledim... The scarcity of wettability,insufficient active sites,and low surface area of graphite felt(GF)have long been suppressing the performance of vanadium redox flow batteries(VRFBs).Herein,an ultra-homogeneous multipledimensioned defect,including nano-scale etching and atomic-scale N,O codoping,was used to modify GF by the molten salt system.NH_(4)Cl and KClO_(3) were added simultaneously to the system to obtain porous N/O co-doped electrode(GF/ON),where KClO_(3) was used to ultra-homogeneously etch,and O-functionalize electrode,and NH4Cl was used as N dopant,respectively.GF/ON presents better electrochemical catalysis for VO_(2)+/VO_(2)+ and V3+/V2+ reactions than only O-functionalized electrodes(GF/O)and GF.The enhanced electrochemical properties are attributed to an increase in active sites,surface area,and wettability,as well as the synergistic effect of N and O,which is also supported by the density functional theory calculations.Further,the cell using GF/ON shows higher discharge capacity,energy efficiency,and stability for cycling performance than the pristine cell at 140 mA cm^(−2) for 200 cycles.Moreover,the energy efficiency of the modified cell is increased by 9.7% from 55.2% for the pristine cell at 260 mA cm^(−2).Such an ultra-homogeneous etching with N and O co-doping through“boiling”molten salt medium provides an effective and practical application potential way to prepare superior electrodes for VRFB. 展开更多
关键词 graphite felt molten salt N O co-doping ultra-homogeneous etching vanadium redox flow battery
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Regulating interfacial behavior of zinc metal anode via metal-organic framework functionalized separator
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作者 Ruotong Li Liang Pan +6 位作者 Ziyu Peng Ningning Zhao Zekun Zhang jing zhu Lei Dai Ling Wang Zhangxing He 《Journal of Energy Chemistry》 SCIE EI CAS CSCD 2024年第6期213-220,I0006,共9页
Aqueous zinc ion batteries(AZIBs)are one of the promising energy storage devices.However,uncontrolled dendrite and side reactions have seriously hindered its further application.In this study,the metal-organic framewo... Aqueous zinc ion batteries(AZIBs)are one of the promising energy storage devices.However,uncontrolled dendrite and side reactions have seriously hindered its further application.In this study,the metal-organic framework(MOF)functionalized glass fiber separator(GF-PFC-31)was used to regulate interfacial behavior of zinc metal anode,enabling the development of high-performance AZIBs.In PFC-31,there areπ-πinteractions between two adjacent benzene rings with a spacing of 3.199 A.This spacing can block the passage of[Zn(H_(2)O)_6]^(2+)(8.6 A in diameter)through the GF-PFC-31 separator to a certain extent,which promotes the deposition process of Zn ions.In addition,the sulfonic acid group(-S03H)contained in GF-PFC-31 can form a hydrogen bonding network with H_(2)O,which can provide a desolvation effect and reduce the side reaction.Consequently,GF-PFC-31 separator achieves uniform deposition of Zn ions.The Zn‖GF-PFC-31‖Zn symmetric cell exhibits stable cycle life(3000 h at 1.2 mA cm^(-2),2000 h at 0.3 mA cm^(-2),and 2000 h at 5.0 mA cm^(-2)),and Zn‖GF-PFC-31‖MnO_(2) full cell with GF-PFC-31 separator can cycle for 1000 cycles at 1.2 A g^(-1)with capacity retention rate of 82.5%.This work provides a promising method to achieve high-performance AZIBs. 展开更多
关键词 Aqueous zinc ion batteries Interfacial behavior Metal-organic framework Sulfonic acid group SEPARATOR
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两种新型多功能人工晶状体矫正老视的疗效比较 被引量:1
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作者 朱晶 鲁铭 肖泽锋 《国际眼科杂志》 CAS 北大核心 2023年第1期39-42,共4页
目的:比较双焦点人工晶状体(AtLisa tri 809MP)与三焦点人工晶状体(AtLisa tri 839MP)植入术后矫正老视疗效的差异。方法:纳入于我院行白内障超声乳化吸除联合人工晶状体植入术的患者共40例51眼进行分析,其中A组20例25眼植入809MP双焦... 目的:比较双焦点人工晶状体(AtLisa tri 809MP)与三焦点人工晶状体(AtLisa tri 839MP)植入术后矫正老视疗效的差异。方法:纳入于我院行白内障超声乳化吸除联合人工晶状体植入术的患者共40例51眼进行分析,其中A组20例25眼植入809MP双焦点人工晶状体,B组20例26眼植入839MP三焦点人工晶状体。收集两组患者术后3mo时远中近视力数值、离焦曲线分析,并通过满意度调查问卷进行统计分析。结果:术后3mo两组裸眼远视力与最佳矫正视力均无差异(P>0.05);中距离视力(80cm)B组显著优于A组(P<0.01);近距离视力改善程度A组、B组无差异(P>0.05)。术后3mo离焦曲线结果A组在0、-3D处形成2个波峰;B组在0、-2.5D处形成2个波峰;两组患者术后均有不同程度的眩光、光晕等表现,但总体满意度较高,视近满意度较高。结论:两种类型人工晶状体均可以为患者提供兼顾远、近的全程视力,术后近距离视物脱镜率高,均可提高良好的近距离视力,三焦点人工晶状体中距离视力更好。 展开更多
关键词 双焦点人工晶状体 三焦点人工晶状体 视觉质量 离焦曲线
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Is Escalated Radiation Dose in Definitive Chemoradiotherapy Better for Inoperable Esophageal Carcinoma? A Meta-Analysis and Systematic Review
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作者 Xiaochuan Gan Qitao Gou +1 位作者 jing zhu Tao Zhang 《Advances in Bioscience and Biotechnology》 2023年第4期172-189,共18页
Purpose: This study aimed to compare the survival benefits between different total radiation doses in definitive chemoradiotherapy (dCRT) for inoperable esophageal carcinoma (EC) based on modern radiotherapy technique... Purpose: This study aimed to compare the survival benefits between different total radiation doses in definitive chemoradiotherapy (dCRT) for inoperable esophageal carcinoma (EC) based on modern radiotherapy techniques. Methods: A systematic review was performed by searching the databases of PubMed, EMBASE, Cochrane Central Register of Controlled Trials and Web of Science. All studies published prior to November 30, 2022, comparing radiation dose and disease-related outcomes in EC patients. The hazard ratio (HR) and odds ratio (OR) were used to describe the risk of outcomes and toxicities. Results: Seven prospective trials involving 1124EC patients were enrolled for analyses. The results revealed that the effect on overall survival (HR = 0.99, 95% CI = 0.85 - 1.16, P = 0.94), local progression-free survival (HR = 0.83, 95% CI = 0.58 - 1.17, P = 0.29), local regional progression-free survival (HR = 0.94, 95% CI = 0.76 - 1.17, P = 0.61), progression-free survival (HR = 0.90, 95% CI = 0.71 - 1.13, P = 0.35) was similar in the high-dose and standard-dose groups. Additionally, a high radiation dose exhibited a potential disadvantage in respiratory toxicities when compared with a standard dose (4.8% vs 2.2%, OR 2.11, P = 0.06). Conclusions: The efficacy of the HD group (≥60 Gy) and the SD group (approximately 50 Gy) for inoperable local advanced EC was similar. However, the HD group exhibited a high radiation dose exhibited a potential disadvantage in respiratory toxicities when compared with a standard dose. Simultaneously, the final results of several ongoing prospective trials regarding the optimal radiation dose in dCRT are awaited. 展开更多
关键词 Esophageal Carcinoma CHEMORADIOTHERAPY HIGH-DOSE LOW-DOSE META-ANALYSIS
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金沙江下游梯级水库群协同防洪调度策略研究 被引量:4
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作者 荆柱 李肖男 +3 位作者 何小聪 徐杨 陈永生 施勇 《人民长江》 北大核心 2023年第9期33-40,75,共9页
2021年起,金沙江下游乌东德、白鹤滩水电站相继建成投产,在提升了长江流域防洪能力和洪水资源化利用水平的同时,也对新形势下梯级水库群调度决策带来了新的挑战。对金沙江下游梯级水库群协同防洪时的调度策略展开研究,统筹防洪安全和发... 2021年起,金沙江下游乌东德、白鹤滩水电站相继建成投产,在提升了长江流域防洪能力和洪水资源化利用水平的同时,也对新形势下梯级水库群调度决策带来了新的挑战。对金沙江下游梯级水库群协同防洪时的调度策略展开研究,统筹防洪安全和发电效益,提出了不同来水条件下梯级水库群协同防洪调度的具体策略。结果表明:在面向川渝河段进行防洪调度时,若金沙江下游来水较小,可依据中长期预报来水情况,优先启用乌东德或溪洛渡水库拦蓄洪水;若金沙江下游来水较大,则建议乌东德、白鹤滩、溪洛渡水库按照三库剩余防洪库容比例进行同步拦蓄,使各库泄流能力尽量均衡。此外,为确保金沙江下游梯级水库群打捆运用的灵活性和可靠性,向家坝水库应预留约5亿m^(3)库容用于拦蓄乌东德、白鹤滩、溪洛渡水库三库拦蓄后的多余洪量及溪洛渡-向家坝区间洪量。研究成果可以在确保防洪安全的前提下提升水库群汛期发电效益,为提升梯级水库群调度决策科学水平提供关键技术支撑。 展开更多
关键词 梯级水库 联合调度 协同防洪 调度策略 川渝河段 金沙江下游
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Rapamycin reverses ferroptosis by increasing autophagy in MPTP/MPP+-induced models of Parkinson's disease 被引量:8
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作者 Tongyu Liu Peihan Wang +5 位作者 Huan Yin Xiangfei Wang jing Lv Jiang Yuan jing zhu Yunfu Wang 《Neural Regeneration Research》 SCIE CAS CSCD 2023年第11期2514-2519,共6页
Parkinson’s disease is a neurodegenerative disorder,and fe rroptosis plays a significant role in the pathological mechanism underlying Parkinson’s disease.Rapamycin,an autophagy inducer,has been shown to have neurop... Parkinson’s disease is a neurodegenerative disorder,and fe rroptosis plays a significant role in the pathological mechanism underlying Parkinson’s disease.Rapamycin,an autophagy inducer,has been shown to have neuroprotective effects in Parkinson’s disease.However,the link between rapamycin and ferroptosis in Parkinson’s disease is not entirely clear.In this study,rapamycin was administe red to a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson’s disease mouse model and a 1-methyl-4-phenylpyridinium-induced Parkinson’s disease PC12 cell model.The results showed that rapamycin improved the behavioral symptoms of Parkinson’s disease model mice,reduced the loss of dopamine neurons in the substantia nigra pars compacta,and reduced the expression of ferroptosis-related indicators(glutathione peroxidase 4,recombinant solute carrier family 7,member 11,glutathione,malondialdehyde,and reactive oxygen species).In the Parkinson’s disease cell model,rapamycin improved cell viability and reduced ferro ptosis.The neuroprotective effect of rapamycin was attenuated by a ferroptosis inducer(methyl(1S,3R)-2-(2-chloroacetyl)-1-(4-methoxycarbonylphenyl)-1,3,4,9-tetrahyyridoindole-3-carboxylate)and an autophagy inhibitor(3-methyladenine).Inhibiting ferro ptosis by activating autophagy may be an important mechanism by which rapamycin exerts its neuroprotective effects.Therefo re,the regulation of ferroptosis and autophagy may provide a therapeutic target for drug treatments in Parkinson’s disease. 展开更多
关键词 AUTOPHAGY behavior ferroptosis MPTP Parkinson’s disease PC12 cell RAPAMYCIN tyrosine hydroxylase
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免疫检查点抑制剂致孤立性促肾上腺皮质激素缺乏症患者的临床特征分析
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作者 竺晶 谢骥 胡晓霞 《中国肿瘤临床》 CAS CSCD 北大核心 2023年第4期186-189,共4页
目的:探讨免疫检查点抑制剂(immune checkpoint inhibitors,ICIs)导致孤立性促肾上腺皮质激素缺乏症(isolated adrenocorticotropic hormone deficiency,IAD)患者的临床特征,为早期发现ICIs导致的内分泌免疫相关不良事件提供理论依据。... 目的:探讨免疫检查点抑制剂(immune checkpoint inhibitors,ICIs)导致孤立性促肾上腺皮质激素缺乏症(isolated adrenocorticotropic hormone deficiency,IAD)患者的临床特征,为早期发现ICIs导致的内分泌免疫相关不良事件提供理论依据。方法:通过截至2022年7月检索万方、维普、中国知网、PubMed、Web of Science、Embase、Cochrane Library数据库,共纳入文献54篇,收集的70例患者中男性51例、女性19例,年龄为34~87岁,平均年龄(64.17±11.33)岁,收集使用ICIs导致IAD患者的临床资料进行统计学分析。结果:与IAD最相关的肿瘤类型为非小细胞肺癌35.7%(25/70),其次为恶性黑色素瘤24.3%(17/70)。最常见导致IAD的ICIs为程序性细胞死亡-1(programmed cell death-1,PD-1)抑制剂87.1%(61/70)。使用PD-1、程序性细胞死亡-1配体(programmed cell death-ligand 1,PD-L1)、PD-1联合细胞毒性T淋巴细胞抗原-4(cytotoxic T lymphocyte antigen 4,CTLA-4)抑制剂诊断IAD的中位时间分别为180.0、364.0、87.5天。IAD患者最常见的实验室指标异常为低钠血症、嗜酸性粒细胞升高。IAD患者行糖皮质激素替代治疗后临床症状均得到改善。结论:PD-1联合CTLA-4抑制剂导致IAD的发生时间最短,ICIs治疗过程中及停药后均需监测皮质醇、促肾上腺皮质激素水平,使用ICIs治疗的患者,尤其是男性患者,若出现低钠血症、嗜酸性粒细胞升高,需警惕IAD的可能性。 展开更多
关键词 免疫检查点抑制剂 肾上腺功能减退 不良反应
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作业数据驱动的大规模因材施教——上海市闵行区“智慧教育示范区”创建实践 被引量:4
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作者 朱靖 刘太如 《中国教育信息化》 2023年第10期73-82,共10页
在“智慧教育示范区”创建和基础教育数字化转型的大背景下,为了打造优质均衡的教育体系,满足每个学生的发展需求,上海市闵行区在区域层面构建了区校两级作业系统,梳理了作业业务的构成要素,对作业业务各个环节进行量化。通过伴随式采... 在“智慧教育示范区”创建和基础教育数字化转型的大背景下,为了打造优质均衡的教育体系,满足每个学生的发展需求,上海市闵行区在区域层面构建了区校两级作业系统,梳理了作业业务的构成要素,对作业业务各个环节进行量化。通过伴随式采集数据,形成区域作业数据驱动大规模因材施教的模型,并将知识状态追踪模型、学科核心能力评价模型、学习品质模型、学生综合画像模型等四个模型作为子模型。通过模型应用,开展基于知识状态的个性化辅导、学习策略和学习意志力的分层教学、学习投入的分层教学等实践,形成通过作业数据发掘差异的新路径。基于区域探索性数据分析,证明通过作业数据可以发掘学生的“材”,且发掘的结果既符合教师已有经验,又能弥补经验的不足。经实践证明,精准“施教”具有可行性,可为数据驱动的大规模因材施教提供参考。 展开更多
关键词 作业数据 因材施教 施教模型 学习策略 学习意志力 学习投入
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Selective laser trabeculoplasty as adjunctive treatment for open-angle glaucoma vs following incisional glaucoma surgery in Chinese eyes
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作者 jing zhu Juan Guo 《World Journal of Clinical Cases》 SCIE 2023年第4期780-787,共8页
BACKGROUND Selective laser trabeculoplasty(SLT)is a relatively safe and effective therapy in lowering intraocular pressures(IOP)for glaucoma.AIM To study the long-term effects of SLT on IOP and number of glaucoma medi... BACKGROUND Selective laser trabeculoplasty(SLT)is a relatively safe and effective therapy in lowering intraocular pressures(IOP)for glaucoma.AIM To study the long-term effects of SLT on IOP and number of glaucoma medications used in Chinese eyes.METHODS This is a retrospective study in which 75 eyes of 70 patients with open-angle glaucoma(OAG,n=36)and eyes with prior glaucoma surgery(PGS,n=39)were included.Changes in mean IOP and number of glaucoma medications used evaluated at 1 d,1 wk,1 mo,3 mo,6 mo,12 mo,and 36 mo after laser treatment.RESULTS All patients(33 male,37 female)were Chinese.The mean age was 44.34±16.14years.Mean pre-SLT IOP was 22.75±2.08 mmHg in OAG and 22.52±2.62 mmHg in PGS.Mean IOP was significantly reduced 1 d,1 wk,1 mo and 3 mo after laser treatment(P<0.05,respectively).Whereas,there were no significant differences between baseline and SLT treated groups at the 6th month both in OAG(P=0.347,P>0.05)and in PGS(P=0.309,P>0.05).Six months after SLT treatment,some patients received retreatment of SLT or were given more topical IOP-lowering medication to control the IOP.By the end of our study,the average IOP decreased to 20.73±1.82 mmHg in OAG and 20.49±1.53 mmHg in PGS groups.The number of glaucoma medications used was significantly reduced until the end of 3 years compared to baseline.CONCLUSION SLT could reduce IOP as adjunctive treatment both in OAG and PGS groups.SLT significantly reduced the number of glaucoma medications used 3-years following treatment in glaucoma patients. 展开更多
关键词 Selective laser trabeculoplasty Open-angle glaucoma Intraocular pressure Prior glaucoma surgery Adjunctive treatment
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巨噬细胞抑制因子1在非小细胞肺癌诊断及靶向治疗疗效预测中的临床价值 被引量:13
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作者 辛影 朱晶 柳影 《中国现代医学杂志》 CAS 2018年第18期39-44,共6页
目的探讨巨噬细胞抑制因子1(MIC-1)在非小细胞肺癌(NSCLC)诊断及靶向治疗疗效预测中的应用价值。方法选取2013年1月-2015年1月该院收治的Ⅲb期、Ⅳ期NSCLC患者94例、肺部良性疾病78例及体检健康者70例分别作为NSCLC组、良性组及对照组,... 目的探讨巨噬细胞抑制因子1(MIC-1)在非小细胞肺癌(NSCLC)诊断及靶向治疗疗效预测中的应用价值。方法选取2013年1月-2015年1月该院收治的Ⅲb期、Ⅳ期NSCLC患者94例、肺部良性疾病78例及体检健康者70例分别作为NSCLC组、良性组及对照组,采用双抗体夹心酶联免疫吸附实验检测MIC-1水平。NSCLC组均接受靶向治疗,单因素和多因素Cox回归分析NSCLC组中位生存时间的影响因素。结果 NSCLC组血清MIC-1水平高于良性组和对照组,且良性组高于对照组(P<0.05);NSCLC组不同TNM分期的MIC-1水平比较,差异有统计学意义(P<0.05),不同年龄、性别、靶向治疗方案及表皮生长因子受体(EGFR)基因突变的比较,差异无统计学意义(P>0.05)。NSCLC组均接受靶向治疗,治疗3和5个月MIC-1水平均较治疗前和治疗1个月降低(P<0.05);治疗前,治疗1、3及5个月组间比较,差异有统计学意义(P<0.05);治疗5个月时,治疗有效率32.98%;Kaplan-Meier法估计生存率,NSCLC组中位生存时间(MST)为17.9个月。以1 390 pg/ml为临界值,将其分为MIC-1≤1 390 pg/ml组(59例)和MIC-1>1 390 pg/ml组(35例),两组3年生存率分别为33.90%和14.29%(P<0.05)。Cox回归分析显示,TNM分期、EGFR基因突变及MIC-1水平是影响NSCLC组MST的危险因素。结论血清MIC-1水平与Ⅲb期、Ⅳ期NSCLC组TNM分期和靶向治疗效果有关,可用于预测患者预后。 展开更多
关键词 非小细胞肺癌 巨噬细胞抑制因子1 检测 靶向治疗 临床疗效 中位生存时间
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连续视程与三焦点人工晶状体植入术后视觉质量的比较 被引量:3
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作者 鲁铭 朱晶 肖泽锋 《国际眼科杂志》 CAS 北大核心 2021年第7期1166-1169,共4页
目的:比较Tecnis Symfony连续视程人工晶状体与Zeiss三焦点人工晶状体(At Lisa tri 839MP)植入术后患者视觉质量的差异。方法:选取2019-01/2020-12于我院行白内障超声乳化吸除联合人工晶状体植入术的患者42例53眼,其中A组22例29眼植入Te... 目的:比较Tecnis Symfony连续视程人工晶状体与Zeiss三焦点人工晶状体(At Lisa tri 839MP)植入术后患者视觉质量的差异。方法:选取2019-01/2020-12于我院行白内障超声乳化吸除联合人工晶状体植入术的患者42例53眼,其中A组22例29眼植入Tecnis Symfony连续视程人工晶状体,B组20例24眼植入Zeiss三焦点人工晶状体。观察两组患者术后3mo时远中近视力,绘制离焦曲线,并评估生活质量,记录并发症发生情况。结果:术后3mo,两组患者视力均明显改善,两组患者裸眼远(5m)、中(80cm)距离视力及最佳矫正远距离视力(5m)无差异(均P>0.05),但B组患者裸眼中(60cm)、近(40cm)距离视力优于A组(均P<0.05)。术后3mo绘制离焦曲线示A组在+1.0~-2.0D段跨度平稳形成平台期;B组在0、-2.5D处形成两个波峰;0D处两组远视力无显著差异(P>0.05),-2.5、-3.5D处B组近视力显著优于A组(均P<0.01)。两组患者术后脱镜率均在90%以上,均出现不同程度眩光、光晕等光学现象,但生活质量总体满意度较高,A组阅读速度明显高于B组,且夜间视物满意度较高(均P<0.05)。结论:两种类型人工晶状体植入术后脱镜率均在90%以上,可为患者提供兼顾远、中、近的全程视力,Symfony连续视程人工晶状体植入术后流畅阅读及夜间视物满意度较高;Zeiss三焦点人工晶状体植入术后近距离视力更好,更适合近距离工作者。 展开更多
关键词 连续视程人工晶状体 三焦点人工晶状体 视觉质量 离焦曲线
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连续视程IOL植入术后患者主观视觉质量及阅读能力的临床观察 被引量:1
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作者 朱晶 鲁铭 肖泽锋 《国际眼科杂志》 CAS 北大核心 2022年第3期452-456,共5页
目的:比较双眼及单眼植入Tecnis Symfony连续视程人工晶状体(IOL)术后患者主观视觉质量、阅读流畅性及术后满意度的差异。方法:对我院48例71眼行白内障超声乳化吸除联合IOL植入术的患者进行回顾性分析,根据植入IOL类型不同分为2组,其中2... 目的:比较双眼及单眼植入Tecnis Symfony连续视程人工晶状体(IOL)术后患者主观视觉质量、阅读流畅性及术后满意度的差异。方法:对我院48例71眼行白内障超声乳化吸除联合IOL植入术的患者进行回顾性分析,根据植入IOL类型不同分为2组,其中23例46眼双眼植入Symfony IOL为双眼组,25例25眼一眼植入Symfony IOL,另一眼植入非球面单焦点IOL为单眼组。收集两组患者术后3、6mo远、中、近距离视力数据、对比敏感度、术后阅读流畅性、阅读速度及患者满意度调查,并对结果进行统计学分析。结果:术后3mo,单眼组植入Symfony IOL眼的裸眼远距离视力(UDVA)、最佳矫正视力(BCVA)与植入单焦点IOL眼比较无差异(P>0.05)。术后6mo时单眼及双眼植入Symfony IOL患者UDVA均较术前显著提高,平均视力达到0.1以下(LogMAR视力),两组间无差异(P>0.05)。组间比较UDVA、BCVA、裸眼中距离视力(UIVA)、裸眼近距离视力(UNVA)均无差异(P>0.05)。术后6mo两组患者在明视、暗视及暗视眩光状态下各空间频率对比敏感度比较均无差异(P>0.05)。两组患者术后6mo远中近距离视物满意度较高;双眼组中近距离流畅阅读满意度高于单眼组(P<0.05);双眼组阅读速度略高于单眼组,但组间比较无差异(P>0.05)。结论:双眼及单眼植入Symfony连续视程IOL均可为患者提供兼顾远、中、近的全程视力,术后脱镜率均在90%以上,包容性及可预测性好,术后中距离流畅阅读及满意度较高,更适合中距离工作的患者。 展开更多
关键词 Symfony连续视程 人工晶状体(IOL) 视觉质量 对比敏感度 阅读流畅性 患者满意度
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受阻酚/丁腈橡胶体系的阻尼性能及分子动力学模拟 被引量:7
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作者 杨瑞宁 吴丝竹 +2 位作者 祝静 尹超 赵秀英 《高分子材料科学与工程》 EI CAS CSCD 北大核心 2018年第12期36-44,共9页
以实验与分子动力学模拟方法相结合,研究了受阻酚/丁腈橡胶体系(AO-60/NBR、AO-70/NBR、AO-80/NBR)的氢键网络结构与阻尼性能之间的量化关系。红外光谱结果表明三体系中均存在分子间和分子内2种类型氢键;变温红外测试结果和高温下径向... 以实验与分子动力学模拟方法相结合,研究了受阻酚/丁腈橡胶体系(AO-60/NBR、AO-70/NBR、AO-80/NBR)的氢键网络结构与阻尼性能之间的量化关系。红外光谱结果表明三体系中均存在分子间和分子内2种类型氢键;变温红外测试结果和高温下径向分布函数的变化分析表明分子间氢键的强度大小顺序为:AO-80/NBR>AO-70/NBR>AO-60/NBR。分子模拟所得氢键网络结构与动态力学热分析数据表明,3种体系中分子间氢键数量对阻尼性能的影响趋势相似。分子间氢键数量的增加导致分子间相互作用增大,自由体积分数降低,分子链堆砌更紧密,因而断键与成键过程中耗能增大,阻尼性能得以提升。线性回归分析中,体系的结合能与阻尼性能线性相关(R2=0.95),证明分子间氢键是提高阻尼性能的主要因素。这一系列研究将对高阻尼橡胶复合材料的研制提供一定的参考数据和理论指导。 展开更多
关键词 阻尼性能 氢键 分子动力学模拟 受阻酚 丁腈橡胶
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90例结直肠癌中前列腺特异性膜抗原的表达研究 被引量:1
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作者 郑又文 马永琛 +5 位作者 陈善稳 朱静 于妍斐 王鹏远 杨兴 陈国卫 《中国肿瘤临床》 CAS CSCD 北大核心 2018年第16期827-831,共5页
目的:探讨结直肠癌(colorectal cancer,CRC)患者中前列腺特异性膜抗原(prostate-specific membrane antigen,PSMA)的表达及临床病理影响因素。方法:选取90例CRC患者的组织切片,应用免疫组织化学检测癌组织和癌旁正常组织的PSMA、血管标... 目的:探讨结直肠癌(colorectal cancer,CRC)患者中前列腺特异性膜抗原(prostate-specific membrane antigen,PSMA)的表达及临床病理影响因素。方法:选取90例CRC患者的组织切片,应用免疫组织化学检测癌组织和癌旁正常组织的PSMA、血管标志蛋白CD31的表达水平,并对PSMA的表达水平与CRC临床病理因素的关系进行分析。结果:PSMA在正常结直肠组织中免疫组织化学染色为阴性,在CRC组织中有较高比例免疫组织化学染色。但染色阳性部位不在肿瘤细胞,而是在肿瘤新生血管内皮细胞,总染色率为76.7%。PSMA染色评分在不同年龄及组织学类型中具有显著性差异,高年龄组(≥60岁)及普通型腺癌组的PSMA染色评分更高(P<0.05)。结论:PSMA在90例CRC患者中高比例表达,表达部位为肿瘤新生血管内皮细胞,与部分临床病理因素有关,可能成为CRC诊断及治疗的特异性标志物。 展开更多
关键词 结直肠癌 前列腺特异性膜抗原 免疫组织化学染色
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双特异探针技术早期检测先天性白内障晶状体蛋白突变基因的研究 被引量:1
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作者 曹雨娟 邵珺 +4 位作者 虞瑛青 姚勇 朱靖 田玉景 曹葭 《国际眼科杂志》 CAS 北大核心 2018年第6期1004-1009,共6页
目的:利用DNA探针杂交技术,结合显色探针技术建立一种新型、高灵敏的免疫检测体系,用于早期先天性白内障的筛查。方法:选取3个常染色体显性遗传的先天性白内障家系中患者14例,取静脉血并提取mR NA,建立CRYAB的捕获探针及显色探针。利用... 目的:利用DNA探针杂交技术,结合显色探针技术建立一种新型、高灵敏的免疫检测体系,用于早期先天性白内障的筛查。方法:选取3个常染色体显性遗传的先天性白内障家系中患者14例,取静脉血并提取mR NA,建立CRYAB的捕获探针及显色探针。利用DNA探针,通过碱基配对原则形成三明治结构(捕获探针-DNA探针-显色探针)检测入选者的血样。1家系6例患者静脉血利用酶联免疫吸附测定(ELISA)法检测αB-晶状体蛋白。结果:最佳条件下,双特异探针技术可检测到最低浓度的先天性白内障晶状体蛋白的突变基因,各突变位点检测率为99.5%~99.7%;ELISA法检测样本αB-晶状体蛋白上调,阳性率为85.9%。双特异探针技术敏感性更高,检测位点更多,ELISA法仅局限于蛋白检测水平,精确性不高。结论:双特异探针检测技术操作简单,灵敏度高,可重复性高,经济实惠,在临床上用于产前诊断、优生优育具有重要的应用价值。 展开更多
关键词 双特异探针技术 先天性白内障 晶状体蛋白基因
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亭子口水利枢纽汛期运行水位动态控制策略研究 被引量:1
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作者 荆柱 朱利明 +3 位作者 巴欢欢 凌洪政 李肖男 袁玉娇 《人民长江》 北大核心 2022年第8期15-22,共8页
亭子口水利枢纽是嘉陵江干流唯一的控制性工程,汛期由于运行水位受限,存在电站机组出力受阻、弃水较多等问题,其综合效益尚未得到充分发挥。基于预报预泄的原则,结合水文预报水平和洪水传播时间等因素,提出了亭子口水库主汛期运行水位... 亭子口水利枢纽是嘉陵江干流唯一的控制性工程,汛期由于运行水位受限,存在电站机组出力受阻、弃水较多等问题,其综合效益尚未得到充分发挥。基于预报预泄的原则,结合水文预报水平和洪水传播时间等因素,提出了亭子口水库主汛期运行水位动态控制策略,明确了动态控制的运用方式和实施条件,并对亭子口水库汛期运行水位动态控制后的风险和效益进行了分析。结果表明:亭子口水库汛期运行水位上浮至448.00~452.00 m时,不仅可以通过预报预泄确保库区及下游的防洪安全,主汛期还可增发电量0.64亿~1.37亿kW·h,汛末蓄满率可提高6%左右。研究成果可有效提升亭子口水库洪水资源化利用水平。 展开更多
关键词 汛期运行水位 动态控制 预报预泄 洪水资源化 亭子口水库
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