Objective:The mechanism of Yupingfeng Powder in the treatment of non-small cell lung cancer was analyzed by network pharmacology and molecular docking method.Methods:Search the related literature and TCMSP database,qu...Objective:The mechanism of Yupingfeng Powder in the treatment of non-small cell lung cancer was analyzed by network pharmacology and molecular docking method.Methods:Search the related literature and TCMSP database,query the chemical composition and action target of Yupingfeng powder,query the disease database of Genecards,OMIM,DisGeNET,Drugbank,etc.,use"non-small cell lung cancer"as the keyword to search the disease-related target,select the intersection target with Yupingfeng powder as the research target,and use Cytoscape 3.7.2 software to construct the active component-target network map.The protein-protein interaction network map was constructed by using STRING database,and the treatment core targets were further screened by topological parameters,and GO analysis and KEGG signal pathway enrichment analysis were carried out.Finally,molecular docking was verified.Results:37 active components of Yupingfeng Powder were screened,including 146 common targets and 44 core targets.GO analysis and KEGG analysis show that the core target participates in many biological processes such as angiogenesis and cell proliferation,and acts on a variety of signal pathways such as AGE-RAGE,IL-17,TNF,MAPK and so on.Molecular docking shows that the core compound has good docking activity with the target.Conclusion:Network pharmacological analysis shows that Yupingfeng powder in the treatment of non-small cell lung cancer involves multi-target and multi-pathway mechanism,and the drug and target have good docking activity,which can provide theoretical basis for follow-up experimental research.展开更多
BaTiO_(3)ceramics are difficult to withstand high electric fields,so the energy storage density is relatively low,inhabiting their applications for miniaturized and lightweight power electronic devices.To address this...BaTiO_(3)ceramics are difficult to withstand high electric fields,so the energy storage density is relatively low,inhabiting their applications for miniaturized and lightweight power electronic devices.To address this issue,we added Sr_(0.7)Bi_(0.2)TiO_(3)(SBT)into BaTiO_(3)(BT)to destroy the long-range ferroelectric domains.Ca^(2+)was introduced into BT-SBT in the form of CaTiO_(3)(CT),which has the effect of inhibiting the movement of A-site defects to reduce dielectric loss and refining the grains to increase the breakdown field strength.In addition,we have increased the density and grain uniformity of ceramics by repeated rolling of the green samples through the viscous polymer processing(VPP),to further increase the breakdown electric field.The BT-SBT-CT ceramics exhibit the high recoverable energy storage density of 4.0 J·cm^(-3)under electric field of 480 kV·cm^(-1).Its recoverable energy storage density varies by less than 8%in the temperature range of 30-150℃,indicating good temperature stability of the energy storage performance.In this work,the energy storage performance of barium titanate-based ceramics was greatly improved by transforming ferroelectrics into relaxor ferroelectrics and VPP method,which can bring new inspiration for the research of energy storage ceramics.展开更多
基金Priority Theme Setting of Traditional Chinese Medicine for Malignant Tumor and Implementation Scheme Design of Evidence-based Research(No.K-858)Beijing Municipal Commission of Science and Technology(No.D161100005116001)。
文摘Objective:The mechanism of Yupingfeng Powder in the treatment of non-small cell lung cancer was analyzed by network pharmacology and molecular docking method.Methods:Search the related literature and TCMSP database,query the chemical composition and action target of Yupingfeng powder,query the disease database of Genecards,OMIM,DisGeNET,Drugbank,etc.,use"non-small cell lung cancer"as the keyword to search the disease-related target,select the intersection target with Yupingfeng powder as the research target,and use Cytoscape 3.7.2 software to construct the active component-target network map.The protein-protein interaction network map was constructed by using STRING database,and the treatment core targets were further screened by topological parameters,and GO analysis and KEGG signal pathway enrichment analysis were carried out.Finally,molecular docking was verified.Results:37 active components of Yupingfeng Powder were screened,including 146 common targets and 44 core targets.GO analysis and KEGG analysis show that the core target participates in many biological processes such as angiogenesis and cell proliferation,and acts on a variety of signal pathways such as AGE-RAGE,IL-17,TNF,MAPK and so on.Molecular docking shows that the core compound has good docking activity with the target.Conclusion:Network pharmacological analysis shows that Yupingfeng powder in the treatment of non-small cell lung cancer involves multi-target and multi-pathway mechanism,and the drug and target have good docking activity,which can provide theoretical basis for follow-up experimental research.
基金financially supported by the National Key R&D Program of China(No.2021YFB3800602)the National Nature Science Foundation of China-NSAF(No.52172129)+1 种基金the Natural Science Foundation of Shaanxi Province(Nos.2021GXLH-Z-025 and 2020JM-004)Beilin 2021 Applied Technology Research and Development Project(No.GX2118)。
文摘BaTiO_(3)ceramics are difficult to withstand high electric fields,so the energy storage density is relatively low,inhabiting their applications for miniaturized and lightweight power electronic devices.To address this issue,we added Sr_(0.7)Bi_(0.2)TiO_(3)(SBT)into BaTiO_(3)(BT)to destroy the long-range ferroelectric domains.Ca^(2+)was introduced into BT-SBT in the form of CaTiO_(3)(CT),which has the effect of inhibiting the movement of A-site defects to reduce dielectric loss and refining the grains to increase the breakdown field strength.In addition,we have increased the density and grain uniformity of ceramics by repeated rolling of the green samples through the viscous polymer processing(VPP),to further increase the breakdown electric field.The BT-SBT-CT ceramics exhibit the high recoverable energy storage density of 4.0 J·cm^(-3)under electric field of 480 kV·cm^(-1).Its recoverable energy storage density varies by less than 8%in the temperature range of 30-150℃,indicating good temperature stability of the energy storage performance.In this work,the energy storage performance of barium titanate-based ceramics was greatly improved by transforming ferroelectrics into relaxor ferroelectrics and VPP method,which can bring new inspiration for the research of energy storage ceramics.
