Anticancer,Anti-inflammatory,Analgesic,and Anxiolytic Effects of Koumine and Their Molecular Mechanisms

Koumine is an indole alkaloid monomer extracted from the Chinese herb Gelsemium elegans,which has a variety of pharmacological effects.This paper provides a comprehensive summary of the pharmacological effects and molecular mechanisms of koumine,with a particular emphasis on its mechanisms of action in the context of anticancer,anti-inflammatory,analgesic,and anxiolytic properties.The aim is to provide a theoretical foundation for further research and the application of koumine in clinical practice.

Research on Purification Processand PharmacologicalAction of Andrographolide

This paper reviews the purification process,content determination methods and pharmacological action of Andrographolide,aiming to provide new ideas for the subsequent study of Andrographolide and its related drug development and application.

Anti-Tumor and Anti-Diabetic Effects of Sarsasapogenin

In this paper,the pharmacological effects and molecular mechanisms of sarsasapogenin,such as anti-oxidant,anti-inflammatory and anti-diabetic effects,are reviewed in order to provide a theoretical basis for the subsequent development and clinical application of sarsasapogenin.

中海客滚船超市玻璃幕墙的设计

通过合理利用规范的要求,对超市区域的定义作调整,解决了玻璃幕墙作为分隔壁的防火分隔级别问题,有效地控制其重量和成本。

Pharmacological Action and Molecular Mechanism of Glaucocalyxin B

Glaucocalyxin B(GLB)not only has many pharmacological actions such as anti-Parkinson's disease,preventing neuron injury,anti-neuritis and anti-rheumatoid arthritis,but also has good anti-tumor activity,especially with obvious therapeutic effect on cervical cancer,gastric cancer and breast cancer.In this paper,the pharmacological action and molecular mechanism of GLB are reviewed,in order to provide a theoretical basis for the development and clinical application of GLB.

Anti-tumor,Anti-allergy,Anti-angiogenesis and Hepatoprotective Effects of Deoxypodophyllotoxin and Its Molecular Mechanism

Deoxypodophyllotoxin not only has pharmacological effects such as anti-allergy,anti-angiogenesis and liver protection,but also has good anti-tumor activity.It can play an anti-tumor role by inhibiting cell viability,inducing apoptosis,blocking cell cycle and inhibiting cell migration.In this paper,the related research on pharmacological effect and mechanism of deoxypodophyllotoxin is reviewed,to lay a foundation for the follow-up study of deoxypodophyllotoxin and drug development.

Anti-tumor Activity of Isovanillin and Its Molecular Mechanism

Taking isovanillin and the important products synthesized from raw materials of isovanillin as objects,this paper reviews its pharmacological effects and molecular mechanisms,including inhibiting tumor angiogenesis,blocking cancer cell self-repair,inducing cancer cell DNA fragmentation,cytotoxicity,inhibiting tumor growth,regulating brain nerves,inhibiting renin and other pharmacological effects,etc.,which provide new ideas for the in-depth research and development of isovanillin.

Antitumor Effect and Molecular Mechanism of Ophiopogonin B

Ophiopogonin B is a kind of saponin active substance extracted and purified from Ophiopogon japonicus,and plays an antitumor role by inhibiting cancer cell adhesion,invasion and proliferation,and inducing tumor cell apoptosis and autophagy.This paper reviews recent studies on antitumor effects and molecular mechanisms of ophiopogonin B,in order to provide a theoretical basis for subsequent development and clinical application of ophiopogonin B.

Pharmacological Action and Molecular Mechanism of Formononetin

Formononetin is an isoflavone phytoestrogen mainly existing in leguminous plants such as Trifolium pretense,Spatholobus suberectus,etc.Studies have proved that formononetin has good anti-inflammatory,antitumor,antioxidant,antidepressant,anxiolytic and other pharmacological effects.This paper summarizes the pharmacological action and molecular mechanism of formononetin,in order to provide a theoretical basis for the development and clinical application of formononetin.

Pharmacological Effects and Molecular Mechanism of Synephrine Hydrochloride

Synephrine hydrochloride,an alkaloid compound extracted from immature bitter orange,has many pharmacological effects such as anticancer effect,antioxidant effect and antidepression effect.In this paper,the pharmacological effects and mechanism of synephrine hydrochloride were reviewed in order to provide a theoretical basis for the development and application of synephrine hydrochloride.

Anti-cancer,Anti-inflammatory,Antioxidant and Other Pharmacological Effects of Wedelactone and Their Molecular Mechanisms

Wedelolide is a coumarin-like active substance extracted from Ecliptae Herba.It not only has pharmacological effects of anti-pulmonary fibrosis,anti-arthritis,blood vessel protection and liver protection,but also effectively inhibits the proliferation of cancer cells and induces apoptosis of cancer cells,thereby delaying the further development of malignant tumors.In this paper,the pharmacological effects and mechanisms of wedelactone were reviewed to lay a foundation for further study and clinical application of wedelactone.

Design and Experimental Demonstration of Software Defined Space Optical Network (SDSON) Architecture Based on Cloud Platform

Space information network is used for real time acquiring, transmitting and processing the space information on the space platform, which provides significant communication services for communication, navigation positioning and science exploration. In this paper, the architecture of Software Defined Space Optical Network (SDSON) based on cloud platform is designed by means of Software Defined Optical Network (SDON) and cloud services. The new architecture combining centralized and distributed management-control mechanism is a multi-layer and multi-domain architecture with powerful computing and storage ability. Moreover, reliable service and unreliable service communication models employed in the space information network are proposed considering the characteristic of Disruption/Delay Tolerant Network (DTN). Finally, the functional verification and demonstration are performed on our optical experimental network platform.

Design and Implementation of Hybrid Light and Microwave Switches Based on Wavelength Selective Switch for Future Satellite Networks

A hybrid switching node structure with light and microwave links is proposed, which is applicable to the future data relay satellite systems, aiming at the development trend of coexistence of light- link and microwave-link in the future. An experimental system for the light and microwave hybrid switching node based on wavelength selective optical switches (WSS) and optical transceiver modules, is established. It is shown by our experiment that this hybrid switching node can realize the dynamic bandwidth allocation and wavelength routing while the bit error rate of light link is less than 10?12, which provides a method for solving the hybrid switching problem of light-link and microwave-link on the future data relay satellite systems.

Simultaneously enhancing the strength and ductility of as-extruded AlN/AZ91 composites via nano-precipitation and pyramidal slip

Age hardening is often used to optimize the mechanical properties of as-deformed Mg-based materials in industry,whereas the improvement of strength is usually accompanied by the significant loss of ductility,which hinders the application of Mg-based materials in structural components.In the present work,high strength-ductility synergy(the yield strength of 263±9 MPa,ultimate tensile strength of 398±7 MPa and elongation to fracture of 34%±1%)was realized in as-extruded AlN/AZ91 composites after optimiz-ing aging processes.Microstructural characterization shows that AlN particles induced a large number of geometrically necessary dislocations around the AlN/Mg interface during extrusion,which decreased the nucleation barrier and provided more heterogeneous nucleation sites forγ-Mg 17 Al 12 continuous precipi-tation.Meanwhile,95%of residual dislocations in as-extruded AlN/AZ91 composites were annihilated dur-ing peak-aging,suppressing the growth and coarsening of continuous precipitates.Therefore,high density of nano-sizedγ-Mg 17 Al 12 continuous precipitates was produced in as-extruded AlN/AZ91 composites af-ter peak-aging.During tension,gliding dislocations bypassed sphericalγ-Mg 17 Al 12 nano-precipitates by Orowan looping rather than cutting mechanism,which induced a strong block on dislocation motion.So high yield strength was mainly attributed to the high density of non-shearableγ-Mg 17 Al 12 nano-precipitates with spherical morphology,which was different from other Mg-Al-based systems.The results of texture evolution and slip trace analysis demonstrated that the suppression of extension twinning and less basal slip was due to the enhanced activity of pyramidalc+aslip in as-extruded AlN/AZ91 com-posites after peak-aging during the room temperature tension,meanwhile,the dislocation density of as-extruded AlN/AZ91 composites was significantly decreased during peak-aging,then higher elongation to fracture was achieved.

“空间信息网络基础理论与关键技术”重大研究计划结题综述

本文介绍了“空间信息网络基础理论与关键技术”重大研究计划的立项背景、科学目标、总体布局和实施思路,重点阐述了该计划在“空间信息网络模型与高效组网机理”“空间动态网络高速传输理论与方法”“空间信息稀疏表征与融合处理”三个方面取得的突破性创新进展,并提出了下一步发展建议。

Beam Scheduling with Various Mission Demands in Data Relay Satellite Systems

Beam scheduling is one of the most important issues regarding data relay satellite systems,which can improve the utilization efficiency of limited system resources by programming beam allocation for relay missions.The ever-increasing relay missions create a substantial challenge for beam scheduling due to an increase in different mission demands.The cooperative usage of different beams further increases the complexity of this problem.Therefore,we develop a novel optimization method to solve the beam scheduling problem for the scenario of various mission demands in the data relay satellite system(DRSS).Based on the analysis of mission demands and resource features,we first construct a heterogeneous parallel machines scheduling model to formulate the beam scheduling problem in the DRSS.To solve this complicated model,we investigate the matching method between mission demands and beam resources,and introduce two concepts,the loose duration and the number of available beams,to make the matching process more effective.Then,the following three algorithms are proposed.Our first approach,the maximized completion probability algorithm(MCPA),applies a greedy strategy based on the new concepts to allocate beams for missions;and two improved versions of this algorithm are also presented,which employ the strategies of mission insertion optimization and mission sequence optimization,respectively.Our simulation results show that the proposed algorithms are superior to the existing algorithms in terms of the scheduled missions,the weight of scheduled missions,and the processing time,which significantly improves the performance of beam scheduling in the DRSS.

Amino acids essential for the interaction between cellular heat shock protein 90 and a Kaposi's sarcoma-associated herpesvirus-encoded protein kinase ORF36

Dear Editor,Protein-protein interactions（PPIs）often play important roles in biological processes（Zhang et al.,2016）.The split Renilla luciferase complementation assay（SRLCA）is one of the methods in studying PPIs.SRLCA is based on the complementation of the N-terminal domains of Renilla luciferase（LN）and C-terminal domains of Renilla luciferase （LC） non-functional halves of Renilla luciferase fused to possibly interacting proteins and emit luminescence （Deng et al., 2011; Jiang et al., 2010） （Supplementary Figure S1A）.

Experimental Analysis on Influence of Temperature and Bolted Torque to DC Contact Resistance of Terminal Connector in UHV Valve Hall

The overheating problems of terminal connectors severely threaten the operation of ultra-high voltage projects and cause enormous losses of economy,so a higher currentcarrying reliability of the connectors has an important engineering significance with the development of transmission capacity.In this paper,a bivariate mathematical model of contact resistance as functions of temperature and tightening torque was deduced based on the large current temperature rise tests.To perform such analysis,four typical terminal connectors,namely:overlapping terminal of aluminum plates,overlapping terminal of copper plates,overlapping terminal of plates with clad layer and overlapping terminal of copper rod with aluminum clamp,were chosen for the experiments.The changing rules of DC resistance with different tightening torques and different currents were studied.Then the empirical formula of contact resistance was deduced.Finally,temperature calculations of different terminal connectors were realized to verify the effectiveness of the bivariate mathematical model.

Hybrid Beamforming Design for Uplink mmWave Systems with a Predefined Low-Resolution Codebook

In millimeter wave(mmWave)systems,desirable spectral efficiency can be realized by the hybrid beamformer in which a large sized analog beamformer and a small sized baseband digital beamformer are cascade-connected together to reduce the system cost.However,most of works focus on the beamforming(or combining)method design with an impractical analog beamformer where the infinite-resolution phase shifts(PSs)are adopted.In this paper,a more practical hybrid beamformer with low-resolution PSs is considered and the hybrid receiver beamforming method under the multiuser uplink communication circumstance is studied.Since the system performance is mainly constrained by the interuser interference,we propose a novel two-stage hybrid receiver beamforming against the inter-user interference with comparable computational complexity than that of the recently presented method.Moreover,to enhance the performance of systems with many users,we propose a novel multiuser selection algorithm by exploiting the multiuser diversity gain.Finally,from the simulation results,we can verify the superiority of the proposed method over the comparing method in error probability and spectrum efficiency.

Animal models of T-cell acute lymphoblastic leukemia: mimicking the human disease

T-cell acute lymphoblastic leukemia(T-ALL)is a heterogeneous group of hematological tumors composed of distinct subtypes that vary in their genetic abnormalities.In the past decade,large-scale genomic analysis has shed new light on providing potentially important oncogenic or tumor suppressive candidates involved in the disease progression.Following in silico analysis,functional studies are usually performed to vigorously investigate the biological roles of candidate genes.For this purpose,animal models faithfully recapitulating the human disease are widely applied to decipher the mechanism underlying T-cell transformation.Conversely,an increased understanding of T-ALL biology,including identification of oncogene NOTCH1,TAL1 and MYC as well as tumor suppressor phosphatase and tensin homolog(PTEN),has significantly improved the development of T-ALL animal models.These progresses have opened opportunities for development of new therapeutic strategy to benefit T-ALL patients.In this review,we particularly summarize the mouse and zebrafish models used in T-ALL research and also the most recent advances from these in vivo studies.