Helicobacter pylori infection may result in poor gastric cleanliness in magnetically controlled capsule gastroscopy examination: A singlecenter retrospective study

Objective:Magnetically controlled capsule gastroscopy(MCCG)is an effective method for screening gastric diseases;however,its performance may be affected by gastric cleanliness.We aimed to explore the correlation between Helicobacter pylori infection and the degree of gastric cleanliness in the MCCG.Methods:This retrospective study enrolled 297 participants from October 2020 to April 2024 at Sir Run Run Shaw Hospital,Zhejiang University School of Medicine.Participant characteristics,MCCG examination results,and(13)C-urea breath test(C13-UBT)results were collected.The gastric cleanliness in MCCG examinations was assessed using a gastric cleanliness score.Binary logistic regression was used to analyze the relationships among participant characteristics,H.pylori infection,and gastric cleanliness.Chi-square tests and Fisher's exact tests were used to analyze the relationships among gastric lesions,H.pylori infection,and gastric cleanliness.Results:Among the participants,24.2%had H.pylori infection,and 17.5%had poor gastric cleanliness.Hypertension(odds ratio[OR]:2.63;95%confidence interval[CI]:1.36e5.09;p?0.004)was associated with a greater likelihood of H.pylori infection.H.pylori infection(OR:3.76;95%CI:1.99e7.09;p<0.001)was an independent risk factor for poor gastric cleanliness in the MCCG.A significant disparity was noted in the prevalence of focal erosions(p<0.001),gastric ulcers(p?0.001),and positive gastric lesions(p?0.027)between the 2 groups with and without H.pylori infection.The proportion of positive gastric lesions was not significantly different between the good gastric cleanliness group and the poor gastric cleanliness group(25.7%vs.21.2%;p?0.490).Conclusion:The findings of this study revealed that H.pylori infection was associated with hypertension.H.pylori infection may lead to poor gastric cleanliness.Institutions are advised to perform C13-UBT before MCCG,and participants should be informed of the risk of poor gastric cleanliness if the results are positive.The decision to perform H.pylori eradication before MCCG should take into account patient willingness and the benefit-to-risk ratio.

Design,Fabrication and Assembly of the Solar Upper Transition Region Imager(SUTRI)

The Solar Upper Transition Region Imager(SUTRI)focuses on the solar transition region to achieve dynamic imaging observation of the upper transition region.In this paper,we report the optical system design,mechanical design,ultrasmooth mirror manufacture and measurement,EUV multilayer film coating,prelaunch installation and calibration for the SUTRI payload at IPOE,Tongji University.Finally,the SUTRI carried by the SATech-01 satellite was successfully set to launch.All functions of this telescope were normal,and the observation results obtained in orbit were consistent with the design.

Cardiovascular Diseases Detecting via Pulse Analysis

In this research, we have performed pulse analysis on the data of 127 subjects collected from Department of Cardiology at Shandong Provincial Hospital in China. By taking the first and third derivatives of an entire pulse wave, we have firstly identified the locations of wave foot, systolic peak, and reflected point. Then we calculated Reverse Shoulder Index (RSI) and Ratio of Distance of the evaluated subjects, and correlated them to age, the history of hypertension, and different cardiovascular diseases of the subjects.

Bioinspired coacervate-based bioinks for construction of multiscale tissue engineering scaffolds

Engineering hydrogels that resemble biological tissues of various lengths via conventional fabrication techniques remains challenging.Three-dimensional(3D)bioprinting has emerged as an advanced approach for constructing complex biomimetic 3D architectures,which are currently restricted by the limited number of available bioinks with high printability,biomimicry,biocompatibility,and proper mechanical properties.Inspired by ubiquitous coacervation phenomena in biology,we present a unique mineral-biopolymer coacervation strategy that enables the hierarchical assembly of nanoclay and recombinant human collagen(RHC).This system was observed to undergo a coacervation transition(liquid‒liquid phase separation)spontaneously.The formed dense phase separated from its supernatant is the coacervate of clay-RHC-rich complexes,where polymer chains are sandwiched between silicate layers.Molecular dynamics simulation was first used to verify and explore the coacervation process.Then,the coacervates were demonstrated to be potential bioinks that exhibited excellent self-supporting and shear-thinning viscoelastic properties.Through extrusion-based printing,the versatility of the bioink was demonstrated by reconstructing the key features of several biological tissues,including multilayered lattice,vascular,nose,and ear-like structures,without the need for precrosslinking operations or support baths.Furthermore,the printed scaffolds were cytocompatible,elicited minimal inflammatory responses,and promoted bone regeneration in calvarial defects.

锡林河流域不同植被带土壤绿菌门微生物群落的空间分布特征

【目的】为了探究锡林河流域中游不同植被带土壤绿菌门(Chlorobi)成员的空间分布特征及驱动因子。【方法】本文选择典型河滨带环境为研究对象,沿河流中心至河流阶地(陆向)方向,在无植被带(BC)、水莎草沼泽(BS)、灯芯草沼泽化草甸(LF)、鹅绒委陵菜草甸(HF)、河流阶地羊草草原(LT)、丘陵坡地大针茅典型草原(HT)中分别采集0-10 cm土壤样品。基于16S rRNA基因高通量测序分析土壤绿菌门微生物群落的组成、丰度及空间分布特征;结合土壤理化因子分析绿菌门微生物群落空间异质性的驱动因子。【结果】在属水平上共检测到来自绿菌目(Chlorobiales)和Ignavibacteriales目的9个类群。Chlorobiales1、2、6及Ignavibacteriales7、9类群的最高相对丰度低于0.40%;Ignavibacteriales3、4、5、8类群的最高相对丰度介于0.54%-1.06%。Chlorobiales1、2类群在HF、LT和HT的相对丰度显著高于BS(P<0.05),Chlorobiales1类群的相对丰度与pH和总有机碳含量呈极显著正相关(P<0.01);Chlorobiales2类群的相对丰度与粉黏粒含量呈极显著正相关(P<0.01);Ignavibacteriales3、5、7、9和Ignavibacterium4类群在LF的相对丰度显著高于BC(P<0.05),与含水量呈极显著正相关(P<0.01);Chlorobiales6和Ignavibacteriales8类群在BS的相对丰度显著高于其他植被带(P<0.05),与氨态氮含量呈极显著正相关(P<0.01)。变异权重分析表明,土壤含水量解释了绿菌门微生物群落空间变异的65.7%。【结论】锡林河流域不同植被带土壤绿菌门微生物群落存在明显的空间异质性;土壤含水量是不同植被带绿菌门微生物群落空间异质性的主要驱动因子。

Soil particle and moisture-related factors determine landward distribution of bacterial communities in a lateral riverside continuum of the Xilin River Basin

Continuous landscape components along the lateral riverside are affected by both hydrologic connectivity and disconnectivity.In recent years,anthropogenic activities and climate changes have caused wetland shrinkage and land degradation along the lateral riverside of many arid and semiarid regions.Since microorganisms are major drivers of soil biochemical cycling,it is essential to examine soil microbial communities along the lateral landscape continuum to understand their ecosystem functioning and predict future land changes.Here,we collected samples along a lateral riverbed center-riverbed edge-oxbow lake-floodplain-terrace continuum(i.e.,landward distribution)in the Xilin River Basin,Inner Mongolia,China.The floodplain had the highest microbial diversity and heterogeneity,with Bacteroidetes,β-andγ-Proteobacteria being the most abundant taxa.In contrast,the terrace had the lowest microbial diversity and heterogeneity,with Acidobacteria,Actinobacteria,Verrucomicrobia,Gemmatimonadetes,andα-Proteobacteria as the most abundant taxa.Silt particle,salinity,and moisture were the most influential factors for landward variation of bacterial communities along the riverside continuum.Altogether,we demonstrate that dominant bacterial lineages,soil particles,and moisture-related factors are valuable indicators of this continuum,which can be leveraged for the early prediction of drought-induced wetland shrinkage and grassland desertification.

Mitochondria as the Essence of Yang Qi in the Human Body

The concept of Yang Qi in Traditional Chinese Medicine(TCM)has many similarities with mitochondria in modern medicine.Both are indispensable to human beings and closely related to life and death.This article discusses the similarities in various aspects between mitochondria and Yang Qi,including body temperature,aging,newborns,circadian rhythm,immunity,and meridian.It is well-known that Yang Qi is vital for human health.Interestingly,decreased mitochondrial function is thought to be key to the development of various diseases.Here,we further explain diseases induced by Yang Qi deficiency,such as cancer,chronic fatigue syndrome,sleep disorder,senile dementia,and metabolic diseases,from the perspective of mitochondrial function.We aim to establish similarities and connections between two important concepts,and hope our essay can stimulate further discussion and investigation on unifying important concepts in western medicine and alternative medicine,especially TCM,and provide unique holistic insights into understanding human health.

Skin Microbiome,Metabolome and Skin Phenome,from the Perspectives of Skin as an Ecosystem

Skin is a complex ecosystem colonized by millions of microorganisms,including bacteria,fungi,and viruses.Skin microbiota is believed to exert critical functions in maintaining host skin health.Profiling the structure of skin microbial community is the first step to overview the ecosystem.However,the community composition is highly individualized and extremely complex.To explore the fundamental factors driving the complexity of the ecosystem,namely the selection pressures,we review the present studies on skin microbiome from the perspectives of ecology.This review summarizes the following:(1)the composition of substances/nutrients in the cutaneous ecological environment that are derived from the host and the environment,highlighting their proposed function on skin microbiota;(2)the features of dominant skin commensals to occupy ecological niches,through self-adaptation and microbe–microbe interactions;(3)how skin microbes,by their structures or bioactive molecules,reshape host skin phenotypes,including skin immunity,maintenance of skin physiology such as pH and hydration,ultraviolet(UV)protection,odor production,and wound healing.This review aims to re-examine the host–microbe interactions from the ecological perspectives and hopefully to give new inspiration to this field.