Objectives:This study aims to investigate the environmental and individual factors contributing to male nurses'psychological well-being and to explore the psychological mechanisms that may explain the links betwee...Objectives:This study aims to investigate the environmental and individual factors contributing to male nurses'psychological well-being and to explore the psychological mechanisms that may explain the links between nurses'practice environment and work engagement,thereby presenting the implications for nurse managers.Methods:A total of 161 male nurses from three tertiary first-class hospitals in Changsha City in China participated in the study.We collected the data using the Practice Environment Scale of the Nursing Work Index,the Psychological Capital Questionnaire,and the Utrecht Work Engagement Scale.Results:Scores of male nurses'practice environment(2.88±0.31),psychological capital(4.42±0.62),and work engagement(3.17±1.39)were all above the midpoint;however,the subscales"the nursing staffing and resources adequacy"(2.72±0.48),"hope"(4.33±0.72),and"dedication"(2.96±1.61)scored lowest.Nurses'practice environment and psychological capital positively predicted nurses'work engagement;psychological capital fully mediated the influence of nurses'practice environment on work engagement.Conclusions:Creating a supportive nursing practice environment can increase male nurses'work engagement by developing their psychological capital.Nurse managers can then provide reasonable workload and pathways for male nurses to achieve goals,thereby fostering their hope.展开更多
The tree of Litsea cubeba is widely spread in China, Indonesia and other part of Southeast Asia. The essential oil of Litsea cubeba (EOLC) is obtained by steam distillation from the pepper-like fruits tree Litsea cube...The tree of Litsea cubeba is widely spread in China, Indonesia and other part of Southeast Asia. The essential oil of Litsea cubeba (EOLC) is obtained by steam distillation from the pepper-like fruits tree Litsea cubeba. The EOLC consists of about 29 active compounds. Among them, citral is the main component;the content of citral is nearly 80% of the EOLC. Due to the special function group, citral is easy to react with many chemicals. Thus, EOLC is usually applied as starting material to carry out aldol condensation, reduction, and six-member ring forming reaction. The EOLC is extensively employed to synthesis of geranal nitriles, pseudonoe, ionone, methyl ionone, Vitamin E and Vitamin A. These products are broadly applied in the fields of fragrance, perfume, medicine and so on. This paper presents comprehensive utilization of EOLC as raw materials to synthesize many active chemicals.展开更多
Carya cathayensis Sarg is distributed near Tianmu mountain areas in Zhejiang Province and Anhui Province, China. Kernel of Carya cathayensis Sarg, which is well-known for the daintiness and nutritional content, is pop...Carya cathayensis Sarg is distributed near Tianmu mountain areas in Zhejiang Province and Anhui Province, China. Kernel of Carya cathayensis Sarg, which is well-known for the daintiness and nutritional content, is popular and very delicious food in eastern China. In this paper, we investigated the physiochemical properties and nutrient gradients of the kernel oil of Carya cathayensis Sarg. The results showed that the kernel oil of Carya cathayensis Sarg contained 63% of fat, 9.1% of proteins, 3.6% of starch and 4.6% of soluble proteins (based ration of weight). The compositions of the fatty acids were very similar to olive oil, and the total unsaturated fatty acids were 94%. Meanwhile, the kernel oil of Carya cathayensis Sarg also contained some polyphenols such as vanillic acid, ferulic acid, 3-methoxybenzoic acid and quercetin. The content of total polyphenols was 9.7 μg/g. Furthermore, the kernel oil of Carya cathayensis Sarg also contained some trace amount of squalene, β-Sitosterol, Vitamin E.展开更多
Nowadays, people are busier and busier for working and living, and suffer a lot of pressure on their body or mind. Therefore, people are prone to have fatigue activity and decrease their working efficiency and happine...Nowadays, people are busier and busier for working and living, and suffer a lot of pressure on their body or mind. Therefore, people are prone to have fatigue activity and decrease their working efficiency and happiness. It was reported that fatigue is a common symptom in the community, with up to half of the general population complaining of fatigue. More and more researchers devoted themselves to studying natural active ingredients in organism as the anti-fatigue drugs to release fatigue symptom. However, these natural ingredients were difficult to obtain from plants, animals and microorganisms by separating and purifying. In addition, some active substances have many side effects. In our study, we employed tea seed oil as main ingredients blended with bis-(carboxyethylgermanium) sesquioxide (Ge-132) to investigate the effects of anti-fatigue on mice by administrating mice with low dose, intermediate dose and high dose of tea seed oil complex for 0, 2 or 4 weeks. The specific tests of studying effects of anti-fatigue were body weight, weight-loaded force swimming, blood urea nitrogen, blood lactic acid and hepaticglycogen. And the results showed that appropriate level of tea seed oil complex could decrease the body weight and prolong the weight-loaded swimming time, and had an active effect on the bloodurea nitrogen, hepatic glycogen and blood lactic acid level mice, which significantly embodied the anti-fatigue activity of tea seed oil complex.展开更多
Predicting warm-sector torrential rainfall over South China,which is famous for its destructive power,is one of the most challenging issues of the current numerical forecast field.Insufficient understanding of the key...Predicting warm-sector torrential rainfall over South China,which is famous for its destructive power,is one of the most challenging issues of the current numerical forecast field.Insufficient understanding of the key mechanisms underlying this type of event is the root cause.Since understanding the energetics is crucial to understanding the evolutions of various types of weather systems,a general methodology for investigating energetics of torrential rainfall is provided in this study.By applying this methodology to a persistent torrential rainfall event which had concurrent frontal and warm-sector precipitation,the first physical image on the energetics of the warm-sector torrential rainfall is established.This clarifies the energy sources for producing the warm-sector rainfall during this event.For the first time,fundamental similarities and differences between the warm-sector and frontal torrential rainfall are shown in terms of energetics.It is found that these two types of rainfall mainly differed from each other in the lower-tropospheric dynamical features,and their key differences lay in energy sources.Scale interactions(mainly through downscale energy cascade and transport)were a dominant factor for the warm-sector torrential rainfall during this event,whereas,for the frontal torrential rainfall,they were only of secondary importance.Three typical signals in the background environment are found to have supplied energy to the warm-sector torrential rainfall,with the quasi-biweekly oscillation having contributed the most.展开更多
In our study, we employed Camellia seed oil as the main ingredients blended with Eucommia Extract to investigate the effects of anti-hypertensive on mice by administrating mice with low dose, middle dose and high dose...In our study, we employed Camellia seed oil as the main ingredients blended with Eucommia Extract to investigate the effects of anti-hypertensive on mice by administrating mice with low dose, middle dose and high dose of Camellia seed oil complex for 4 weeks. The specific tests of studying effects of anti-hypertensive were body weight, blood systolic pressure (BSP), diastolic blood pressure (DBP), pm meam blood pressure (MBP) and heart rate (HR). And the results showed that appropriate level of Camellia seed oil complex could decrease the body weight and had an active effect on the cardiovascular system of mice, which significantly embodied the anti-hypertensive activity of Camellia seed oil complex.展开更多
Self-standing carbon-based substrates with satisfied structural stability and property adjustability have promising applications in flexible lithium(Li)metal batteries(FLMBs).Current strategies for modifying carbon ma...Self-standing carbon-based substrates with satisfied structural stability and property adjustability have promising applications in flexible lithium(Li)metal batteries(FLMBs).Current strategies for modifying carbon materials are normally carried out on powder carbon,and very few of them are suitable for self-standing carbon substrates.Herein,a pore-forming strategy based on the redox chemistry of metallic oxide nanodots is developed to prepare two porous carbon substrates for anode and cathode.Starting with cotton cloth,the resulting hollow carbon fibers substrate with nanopores effectively prevents from Li dendrites formation and large volume change in lithium metal anode(LMA).Simulations indicate that the porous structure leads to homogeneous ion flux,Li-ion concentration,and electric field during Li deposition.Li symmetrical cell based on this substrate remains stable for 8300 h with an ultralow voltage hysteresis of 9 mV.Via a similar route,porous carbon cloth substrate is obtained for subsequently seeding V_(2)O_(5)nanowires to prepare the cathode.The assembled FLMBs pouch cell delivers a capacity of 8.2 mAh with a high capacity retention of~100%even under dramatic deformation.The demonstrated strategy has far-reaching potential in preparing free-standing porous carbon-based materials for flexible energy storage devices.展开更多
The transportation of the proton,the smallest ion in nature,is rudimentary in chemical and biological reactions[1,2],such as photosynthesis[3],enzyme catalysis[4],and Brensted acid/base reactions[5],and currently even...The transportation of the proton,the smallest ion in nature,is rudimentary in chemical and biological reactions[1,2],such as photosynthesis[3],enzyme catalysis[4],and Brensted acid/base reactions[5],and currently even imperative in some devices,namely proton exchange membrane fuel cells(PEMFCs)[6,7].The processes of these elementary reactions,like proton transfer,appear to be astonishingly analogous.展开更多
Nut shell of Camellia oleifera Abel which has large scale of plantation in mountainous region of southern China is abundant renewable resource. The nut shell is suitable for preparation of furfural, as the content of ...Nut shell of Camellia oleifera Abel which has large scale of plantation in mountainous region of southern China is abundant renewable resource. The nut shell is suitable for preparation of furfural, as the content of which is as much as 16% (based the dried nut shell). In early time, mineral acids were employed as typically catalyst for preparing of furfural from the nut shells. These mineral acids could pollute water and corrode equipment. In this paper we used various mineral acids coating with niobic acid as catalysts to investigate reactions for preparation of furfural. Among these catalysts, the catalyst of sulfuric acid coating with niobic acid was found to be very effective, which had higher hammett acidity and better effect of hydrolysis of the nut shells;The catalysts of sulfuric acid coating with niobic acid was characterized, and the conditions of preparation of the catalyst were investigated. The optimum conditions were: sulfuric acid as coating acid, the concentration of sulfuric 1.1 mol/L, impregnation time 8 h, calcination time 8 h and calcination temperature 450°C. Then hydrolysis of the nut shells was explored, the optimum conditions were as follows: dose of catalyst 20%, ratio of solid to liquid 1:15, reaction temperature 100°C, reaction time 4 h;Under this condition, the yield of furfural was 8.7%.展开更多
Constructing potential anodes for sodium-ion batteries(SIBs)with a wide temperature property has captured enormous interests in recent years.Fe1-xS,a zero-band gap material confirmed by density states calculation,is a...Constructing potential anodes for sodium-ion batteries(SIBs)with a wide temperature property has captured enormous interests in recent years.Fe1-xS,a zero-band gap material confirmed by density states calculation,is an ideal electrode for fast energy storage on account of its low cost and high theoretical capacity.Herein,Fe1-xS nanosheet wrapped by nitrogen-doped carbon(Fe1-xS@NC)is engineered through a post-sulfidation strategy using Fe-based metal-organic framework(Fe-MOF)as the precursor.The obtained Fe1-xS@NC agaric-like structure can well shorten the charge diffusion pathway,and significantly enhance the ionic/electronic conductivities and the reaction kinetics.As expected,the Fe1-xS@NC electrode,as a prospective SIB anode,delivers a desirable capacity up to 510.2 mA h g^-1 at a high rate of8000 mA g^-1.Additionally,even operated at low temperatures of 0 and-25°C,high reversible capacities of 387.1 and 223.4 mA h g^-1 can still be obtained at 2000 mA g^-1,respectively,indicating its huge potential use at harsh temperatures.More noticeably,the full battery made by the Fe1-xS@NC anode and Na3 V2(PO4)2 O2 F cathode achieves a remarkable rate capacity(186.8 mA h g^-1 at 2000 m A g^-1)and an impressive cycle performance(183.6 m A h g^-1 after 100 cycles at700 mA g^-1)between 0.3 and 3.8 V.Such excellent electrochemical performance is mainly contributed by its pseudocapacitive-dominated behavior,which brings fast electrode kinetics and robust structural stability to the whole electrode.展开更多
Angiogenesis occurs during the process of tumor growth,invasion and metastasis,and is essential for the survival of solid tumors.As an integrin significantly ove rexpressed in human tumor vascular endothelial cells,α...Angiogenesis occurs during the process of tumor growth,invasion and metastasis,and is essential for the survival of solid tumors.As an integrin significantly ove rexpressed in human tumor vascular endothelial cells,αvβ3 is a suitable targeting site for anti-angiogenesis of tumor.We designed and prepared a selfassembling peptide(SAP)with the ability to targeting αvβ3 and self-assembly.SAP formed nanoparticles in solution and transformed into nanofibrous network once specifically binding to integrin αvβ3 on the surface of human umbilical vein endothelial cells(HUVECs).The SAP network stably anchored on HUVECs over 24h,which consequently resulted in high-efficient inhibition of vascularization.In vitro anti-angiogenesis experiment displayed that the inhibition rate of tube-formation reached 94.9%.In vivo anti-angiogenesis array based on chick chorioallantoic membrane(CAM)model exhibited that the SAP had an inhibition rate up to 63.1%.These results indicated the outstanding anti-angiogenic ability of SAP,potentially for tumor therapy.展开更多
LncMIR31HG acts as a host gene for miR-31,also known as LncHIFCAR(long non-coding HIF-1 co-activating RNA),whose deregulation has been reported to promote the development of various human cancers,including lung cancer...LncMIR31HG acts as a host gene for miR-31,also known as LncHIFCAR(long non-coding HIF-1 co-activating RNA),whose deregulation has been reported to promote the development of various human cancers,including lung cancer,colorectal cancer,etc.1,2 However,the biological functions and molecular mechanisms of MIR31HG in gastric cancer are unclear.展开更多
文摘Objectives:This study aims to investigate the environmental and individual factors contributing to male nurses'psychological well-being and to explore the psychological mechanisms that may explain the links between nurses'practice environment and work engagement,thereby presenting the implications for nurse managers.Methods:A total of 161 male nurses from three tertiary first-class hospitals in Changsha City in China participated in the study.We collected the data using the Practice Environment Scale of the Nursing Work Index,the Psychological Capital Questionnaire,and the Utrecht Work Engagement Scale.Results:Scores of male nurses'practice environment(2.88±0.31),psychological capital(4.42±0.62),and work engagement(3.17±1.39)were all above the midpoint;however,the subscales"the nursing staffing and resources adequacy"(2.72±0.48),"hope"(4.33±0.72),and"dedication"(2.96±1.61)scored lowest.Nurses'practice environment and psychological capital positively predicted nurses'work engagement;psychological capital fully mediated the influence of nurses'practice environment on work engagement.Conclusions:Creating a supportive nursing practice environment can increase male nurses'work engagement by developing their psychological capital.Nurse managers can then provide reasonable workload and pathways for male nurses to achieve goals,thereby fostering their hope.
文摘The tree of Litsea cubeba is widely spread in China, Indonesia and other part of Southeast Asia. The essential oil of Litsea cubeba (EOLC) is obtained by steam distillation from the pepper-like fruits tree Litsea cubeba. The EOLC consists of about 29 active compounds. Among them, citral is the main component;the content of citral is nearly 80% of the EOLC. Due to the special function group, citral is easy to react with many chemicals. Thus, EOLC is usually applied as starting material to carry out aldol condensation, reduction, and six-member ring forming reaction. The EOLC is extensively employed to synthesis of geranal nitriles, pseudonoe, ionone, methyl ionone, Vitamin E and Vitamin A. These products are broadly applied in the fields of fragrance, perfume, medicine and so on. This paper presents comprehensive utilization of EOLC as raw materials to synthesize many active chemicals.
文摘Carya cathayensis Sarg is distributed near Tianmu mountain areas in Zhejiang Province and Anhui Province, China. Kernel of Carya cathayensis Sarg, which is well-known for the daintiness and nutritional content, is popular and very delicious food in eastern China. In this paper, we investigated the physiochemical properties and nutrient gradients of the kernel oil of Carya cathayensis Sarg. The results showed that the kernel oil of Carya cathayensis Sarg contained 63% of fat, 9.1% of proteins, 3.6% of starch and 4.6% of soluble proteins (based ration of weight). The compositions of the fatty acids were very similar to olive oil, and the total unsaturated fatty acids were 94%. Meanwhile, the kernel oil of Carya cathayensis Sarg also contained some polyphenols such as vanillic acid, ferulic acid, 3-methoxybenzoic acid and quercetin. The content of total polyphenols was 9.7 μg/g. Furthermore, the kernel oil of Carya cathayensis Sarg also contained some trace amount of squalene, β-Sitosterol, Vitamin E.
文摘Nowadays, people are busier and busier for working and living, and suffer a lot of pressure on their body or mind. Therefore, people are prone to have fatigue activity and decrease their working efficiency and happiness. It was reported that fatigue is a common symptom in the community, with up to half of the general population complaining of fatigue. More and more researchers devoted themselves to studying natural active ingredients in organism as the anti-fatigue drugs to release fatigue symptom. However, these natural ingredients were difficult to obtain from plants, animals and microorganisms by separating and purifying. In addition, some active substances have many side effects. In our study, we employed tea seed oil as main ingredients blended with bis-(carboxyethylgermanium) sesquioxide (Ge-132) to investigate the effects of anti-fatigue on mice by administrating mice with low dose, intermediate dose and high dose of tea seed oil complex for 0, 2 or 4 weeks. The specific tests of studying effects of anti-fatigue were body weight, weight-loaded force swimming, blood urea nitrogen, blood lactic acid and hepaticglycogen. And the results showed that appropriate level of tea seed oil complex could decrease the body weight and prolong the weight-loaded swimming time, and had an active effect on the bloodurea nitrogen, hepatic glycogen and blood lactic acid level mice, which significantly embodied the anti-fatigue activity of tea seed oil complex.
基金supported by the National Key R&D Program of China (Grant No. 2018YFC1507400)the National Natural Science Foundation of China (Grant Nos. 42075002 and 42030610)
文摘Predicting warm-sector torrential rainfall over South China,which is famous for its destructive power,is one of the most challenging issues of the current numerical forecast field.Insufficient understanding of the key mechanisms underlying this type of event is the root cause.Since understanding the energetics is crucial to understanding the evolutions of various types of weather systems,a general methodology for investigating energetics of torrential rainfall is provided in this study.By applying this methodology to a persistent torrential rainfall event which had concurrent frontal and warm-sector precipitation,the first physical image on the energetics of the warm-sector torrential rainfall is established.This clarifies the energy sources for producing the warm-sector rainfall during this event.For the first time,fundamental similarities and differences between the warm-sector and frontal torrential rainfall are shown in terms of energetics.It is found that these two types of rainfall mainly differed from each other in the lower-tropospheric dynamical features,and their key differences lay in energy sources.Scale interactions(mainly through downscale energy cascade and transport)were a dominant factor for the warm-sector torrential rainfall during this event,whereas,for the frontal torrential rainfall,they were only of secondary importance.Three typical signals in the background environment are found to have supplied energy to the warm-sector torrential rainfall,with the quasi-biweekly oscillation having contributed the most.
文摘In our study, we employed Camellia seed oil as the main ingredients blended with Eucommia Extract to investigate the effects of anti-hypertensive on mice by administrating mice with low dose, middle dose and high dose of Camellia seed oil complex for 4 weeks. The specific tests of studying effects of anti-hypertensive were body weight, blood systolic pressure (BSP), diastolic blood pressure (DBP), pm meam blood pressure (MBP) and heart rate (HR). And the results showed that appropriate level of Camellia seed oil complex could decrease the body weight and had an active effect on the cardiovascular system of mice, which significantly embodied the anti-hypertensive activity of Camellia seed oil complex.
基金supported by NSFC(22035001,21574018,51433003)the National Science and Engineering Council of Canada,and the Fundamental Research Funds for the Central Universities(2412019ZD002)。
文摘Self-standing carbon-based substrates with satisfied structural stability and property adjustability have promising applications in flexible lithium(Li)metal batteries(FLMBs).Current strategies for modifying carbon materials are normally carried out on powder carbon,and very few of them are suitable for self-standing carbon substrates.Herein,a pore-forming strategy based on the redox chemistry of metallic oxide nanodots is developed to prepare two porous carbon substrates for anode and cathode.Starting with cotton cloth,the resulting hollow carbon fibers substrate with nanopores effectively prevents from Li dendrites formation and large volume change in lithium metal anode(LMA).Simulations indicate that the porous structure leads to homogeneous ion flux,Li-ion concentration,and electric field during Li deposition.Li symmetrical cell based on this substrate remains stable for 8300 h with an ultralow voltage hysteresis of 9 mV.Via a similar route,porous carbon cloth substrate is obtained for subsequently seeding V_(2)O_(5)nanowires to prepare the cathode.The assembled FLMBs pouch cell delivers a capacity of 8.2 mAh with a high capacity retention of~100%even under dramatic deformation.The demonstrated strategy has far-reaching potential in preparing free-standing porous carbon-based materials for flexible energy storage devices.
基金Financial supports from Scientific Research Projects in Colleges and Universities in Hebei Province,China(ZD2020409 and ZD2019307)the National Natural Science Foundation of China(21301048)+1 种基金the Fundamental Research Funds for the Central Universities(3142018010 and 3142019013)the Natural Science Foundation of Hebei Province of China(E2019508214)。
文摘The transportation of the proton,the smallest ion in nature,is rudimentary in chemical and biological reactions[1,2],such as photosynthesis[3],enzyme catalysis[4],and Brensted acid/base reactions[5],and currently even imperative in some devices,namely proton exchange membrane fuel cells(PEMFCs)[6,7].The processes of these elementary reactions,like proton transfer,appear to be astonishingly analogous.
文摘Nut shell of Camellia oleifera Abel which has large scale of plantation in mountainous region of southern China is abundant renewable resource. The nut shell is suitable for preparation of furfural, as the content of which is as much as 16% (based the dried nut shell). In early time, mineral acids were employed as typically catalyst for preparing of furfural from the nut shells. These mineral acids could pollute water and corrode equipment. In this paper we used various mineral acids coating with niobic acid as catalysts to investigate reactions for preparation of furfural. Among these catalysts, the catalyst of sulfuric acid coating with niobic acid was found to be very effective, which had higher hammett acidity and better effect of hydrolysis of the nut shells;The catalysts of sulfuric acid coating with niobic acid was characterized, and the conditions of preparation of the catalyst were investigated. The optimum conditions were: sulfuric acid as coating acid, the concentration of sulfuric 1.1 mol/L, impregnation time 8 h, calcination time 8 h and calcination temperature 450°C. Then hydrolysis of the nut shells was explored, the optimum conditions were as follows: dose of catalyst 20%, ratio of solid to liquid 1:15, reaction temperature 100°C, reaction time 4 h;Under this condition, the yield of furfural was 8.7%.
基金financially supported by the National Natural Science Foundation of China (21873018, 21573036 and 21274017)the open project of Jilin Province Key Laboratory of Organic Functional Molecular Design & Synthesis (130028655)
文摘Constructing potential anodes for sodium-ion batteries(SIBs)with a wide temperature property has captured enormous interests in recent years.Fe1-xS,a zero-band gap material confirmed by density states calculation,is an ideal electrode for fast energy storage on account of its low cost and high theoretical capacity.Herein,Fe1-xS nanosheet wrapped by nitrogen-doped carbon(Fe1-xS@NC)is engineered through a post-sulfidation strategy using Fe-based metal-organic framework(Fe-MOF)as the precursor.The obtained Fe1-xS@NC agaric-like structure can well shorten the charge diffusion pathway,and significantly enhance the ionic/electronic conductivities and the reaction kinetics.As expected,the Fe1-xS@NC electrode,as a prospective SIB anode,delivers a desirable capacity up to 510.2 mA h g^-1 at a high rate of8000 mA g^-1.Additionally,even operated at low temperatures of 0 and-25°C,high reversible capacities of 387.1 and 223.4 mA h g^-1 can still be obtained at 2000 mA g^-1,respectively,indicating its huge potential use at harsh temperatures.More noticeably,the full battery made by the Fe1-xS@NC anode and Na3 V2(PO4)2 O2 F cathode achieves a remarkable rate capacity(186.8 mA h g^-1 at 2000 m A g^-1)and an impressive cycle performance(183.6 m A h g^-1 after 100 cycles at700 mA g^-1)between 0.3 and 3.8 V.Such excellent electrochemical performance is mainly contributed by its pseudocapacitive-dominated behavior,which brings fast electrode kinetics and robust structural stability to the whole electrode.
基金the National Natural Science Foundation of China(Nos.51890891,51725302,21807020,51573031 and 51573032)Science Fund for Creative Research Groups of the National Natural Science Foundation of China(No.11621505)+1 种基金CAS Interdisciplinary Innovation Team,Jilin Province Key Laboratory of Organic Functional Molecular Design and Synthesis(No.130028911)Key Laboratory of Biomedical Effects of Nanomaterials and Nanosafety,CAS(No.NSKF201807)。
文摘Angiogenesis occurs during the process of tumor growth,invasion and metastasis,and is essential for the survival of solid tumors.As an integrin significantly ove rexpressed in human tumor vascular endothelial cells,αvβ3 is a suitable targeting site for anti-angiogenesis of tumor.We designed and prepared a selfassembling peptide(SAP)with the ability to targeting αvβ3 and self-assembly.SAP formed nanoparticles in solution and transformed into nanofibrous network once specifically binding to integrin αvβ3 on the surface of human umbilical vein endothelial cells(HUVECs).The SAP network stably anchored on HUVECs over 24h,which consequently resulted in high-efficient inhibition of vascularization.In vitro anti-angiogenesis experiment displayed that the inhibition rate of tube-formation reached 94.9%.In vivo anti-angiogenesis array based on chick chorioallantoic membrane(CAM)model exhibited that the SAP had an inhibition rate up to 63.1%.These results indicated the outstanding anti-angiogenic ability of SAP,potentially for tumor therapy.
基金supported by the Natural Science Foundation of Chongqing(China)(No.cstc2019jcyj-zdxmX0033).
文摘LncMIR31HG acts as a host gene for miR-31,also known as LncHIFCAR(long non-coding HIF-1 co-activating RNA),whose deregulation has been reported to promote the development of various human cancers,including lung cancer,colorectal cancer,etc.1,2 However,the biological functions and molecular mechanisms of MIR31HG in gastric cancer are unclear.